Browsing by Author "Dogan, Erkan"

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Associations Between the Standardized Uptake Value of 18f-Fdg Pet/Ct and Demographic, Clinical, Pathological, Radiological Factors in Lung Cancer
(E-century Publishing Corp, 2015) Sunnetcioglu, Aysel; Arisoy, Ahmet; Demir, Yusuf; Ekin, Selami; Dogan, Erkan
Objectives: F-18-fluoro-2-deoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) is extensively used to diagnose and stage of lung cancer. The aim of the current study was to investigate the correlation of demographic, clinical, pathological and radiological factors with primer tumor FDG Uptake in patients with lung cancer. Materials and methods: This cross-sectional, clinical study was performed on a total of 57 lung cancer patients newly diagnosed that underwent FDG PET/CT. In addition to descriptive variables, histopathological diagnosis, tumor site and size, hemoglobin level, red cell distribution width, neutrophil to lymphocyte ratio were noted for each patient. The correlation of these variables to SUVmax values in FDG PET/CT was investigated. Results: A total of 57 patients (4 women, 53 men) with an average age of 60.8 +/- 9.4 (range: 33-89) participated in the study. Histopathological diagnoses were consistent with squamous cell carcinoma (28, 49.1%), adenocarcinoma (15, 26.3%) and small cell cancer (14, 24.6%). The SUVmax of primary tumor was positively correlated with tumor size (P<0.001). The tumor SUVmax of squamous cell carcinoma (SqCC) (17.49 +/- 8.37) was higher than that of adenocarcinoma (AC) (12.80 +/- 4.77) and small cell carcinoma (SCC) (12.40 +/- 5.80) (P=0.038). Conclusion: SUVmax value was significantly higher for squamous cell carcinoma and it SUVmax values in PET scans was found to be positively correlated with tumor size. This study suggests that, tumor size and histologic subtype had influences upon FDG uptake in lung cancer.
Clinicopathological Characteristics of Hepatocellular Carcinoma in Turkey
(Asian Pacific Organization Cancer Prevention, 2012) Dogan, Erkan; Yalcin, Suayib; Koca, Dogan; Olmez, Aydemir
Background: Hepatocellular carcinoma (HCC), the main malignant tumor of the liver, is very common and highly lethal. The aim of this study was to determine its clinicopathologic characteristics and risk factors in Turkey. Materials and methods: In this study, patients who were diagnosed as suffering from HCC in the period between August 2004 and December 2011 were evaluated retrospectively. Results: A total of 98 patients were included, with a median age 61 (range: 16 to 82). Seventy nine (80.6%) were male 59 (60.2%) were infected with hepatitis B virus (HBV) and 15 (15.3%) with HCV, another 15 (15.3%) being alcohol abusers. Seventy two (73.5%) were at advanced stage and 54 (55.1%) had elevated serum alpha-fetoprotein (AFP). Surgery, chemoembolization, systemic chemotherapy and application of the tyrosine kinase inhibitor sorafenib were the major treatment options. Conclusions: According to our findings HCC is mostly diagnosed in advanced stage and age, being five times more common in males than females. Main risk factors of HCC are HBV infection, HCV infection and alcohol abuse. Elevation in AFP may facilitate early diagnosis of HCC in high risk groups.
Contribution of Diffusion Weighted Mri To Diagnosis and Staging in Gastric Tumors and Comparison With Multi-Detector Computed Tomography
(Assoc Radiology & oncology, 2017) Arslan, Harun; Ozbay, Mehmet Fatih; Calli, Iskan; Dogan, Erkan; Celik, Sebahattin; Batur, Abdussamet; Kotan, Mehmet Cetin
Background. Diagnostic performance of Diffusion-Weighted magnetic resonance Imaging (DWI) and Multi-Detector Computed Tomography (MDCT) for TNM (Tumor, Lymph node, Metastasis) staging of gastric cancer was compared. Patients and methods. We used axial T2-weighted images and DWI (b-0,400 and b-800 s/mm(2)) protocol on 51 pre-operative patients who had been diagnosed with gastric cancer. We also conducted MDCT examinations on them. We looked for a signal increase in the series of DWI images. The depth of tumor invasion in the stomach wall (tumor (T) staging), the involvement of lymph nodes (nodal (N) staging), and the presence or absence of metastases (metastatic staging) in DWI and CT images according to the TNM staging system were evaluated. In each diagnosis of the tumors, sensitivity, specificity, positive and negative accuracy rates of DWI and MDCT examinations were found through a comparison with the results of the surgical pathology, which is the gold standard method. In addition to the compatibilities of each examination with surgical pathology, kappa statistics were used. Results. Sensitivity and specificity of DWI and MDCT in lymph node staging were as follows: N1: DWI: 75.0%, 84.6%; MDCT: 66.7%, 82%;N2: DWI: 79.3%, 77.3%; MDCT: 69.0%, 68.2%; N3: DWI: 60.0%, 97.6%; MDCT: 50.0%, 90.2%. The diagnostic tool DWI seemed more compatible with the gold standard method (surgical pathology), especially in the staging of lymph node, when compared to MDCT. On the other hand, in T staging, the results of DWI and MDCT were better than the gold standard when the T stage increased. However, DWI did not demonstrate superiority to MDCT. The sensitivity and specificity of both imaging techniques for detecting distant metastasis were 100%. Conclusions. The diagnostic accuracy of DWI for TNM staging in gastric cancer before surgery is at a comparable level with MDCT and adding DWI to routine protocol of evaluating lymph nodes metastasis might increase diagnostic accuracy.
Cutaneous Metastases From Transitional Cell Carcinoma of the Bladder (In a Case With Two Primaries)
(Aves, 2010) Ugurluer, Gamze; Dogan, Erkan; Turan, Nedim
Cutaneous metastases from primary genitourinary malignancies are rare and, like all metastases, have a poor prognosis. Very few cases of skin metastases from urothelial carcinoma have been reported in the past and most of them were treated with chemotherapy. Here we present a case of cutaneous metastases from a primary bladder transitional cell carcinoma who was admitted to our clinic with pain and bleeding of the lesion on the dorsum of the hand which did not respond to chemotherapy and was treated with palliative radiotherapy.
Investigation of Levels of Oxidative Stress and Antioxidant Enzymes in Colon Cancers
(derman Medical Publ, 2017) Dusak, Ahmet; Atasoy, Nurhayat; Demir, Halit; Dogan, Erkan; Gursoy, Tulay; Sarikaya, Eren
Aim: Free radicals play a key role in the development of degenerative diseases, none the less, effects of harmful reactive species can be controlled by natural defense mechanisms in the body. In this study, we aimed to investigate enzyme activities of superoxide dismutase (SOD), glutathione (GSH) reductase, glutathione peroxidase (GSH-Px), and malondialdehyde (MDA) in blood serum samples of patients with colon cancer. Material and Method: This retrospective study included patients diagnosed with colon cancer (n=25) and age-and sex-matched healthy individuals as the control group (n=25). Serum levels of SOD, GSH, GSH-Px, and MDA were analyzed using the spectrophotometric method. Results: Enzyme levels of SOD, GSH, GSH-Px, and MDA were found to be statistically significantly (p< 0.05), compared to the control group. There was a significant increase in the MDA levels (p< 0.05), whereas the SOD, GSH, and GSH-Px levels decreased in the patients with colon cancer, compared to the control group (p< 0.05). MDA levels were significantly higher in the patients with colon cancer, while antioxidant enzymes including SOD, GSH, and GSH-Px activities were significantly lower in these patients, compared to the control group (p< 0.05). Discussion: Our study, for the first time, suggests a relationship between colon cancer, oxidative stress, and antioxidant parameters. This is also the first study to investigate the levels of oxidative stress levels and antioxidant enzymes such as SOD, GSH, and GSH-Px activities in the literature. Also, decreased GSH-Px activity may increase MDA production, suggesting that serum SOD, GSH, GSH-Px and MDA levels can affect the etiopathogenesis of colon cancer.
Multicenter Epidemiologic Study on Hepatocellular Carcinoma in Turkey
(Asian Pacific Organization Cancer Prevention, 2014) Can, Alper; Dogan, Erkan; Bayoglu, Ibrahim Vedat; Tatli, Ali Murat; Besiroglu, Mehmet; Kocer, Murat; Alacacioglu, Ahmet
Background: Hepatocellular cancer (HCC) is one of the important health problems in Turkey, being very common and highly lethal. The aim of this study was to determine clinical, demographic features and risk factors. Materials and Methods: Nine hundred and sixth-three patients with HCC from 13 cities in Turkey were included in this study. Results: Only 205 (21%) of the 963 patients were women, with a male: female predominance of 4.8:1 and a median age of 61 years. The etiologic risk factors for HCC were hepatitis B in 555 patients (57.6%), 453 (81%) in men, and 102 (19%) in women, again with male predominance, hepatitis C in 159 (16.5%), (14.9% and 22.4%, with a higher incidence in women), and chronic alcohol abuse (more than ten years) in 137 (14.2%) (16.8% and 4.9%, higher in males). The Child-Pugh score paralleled with advanced disease stage amd also a high level of AFP. Conclusions: According to our findings the viral etiology (hepatitis B and hepatitis C infections) in the Turkish population was the most important factor in HCC development, with alcohol abuse as the third risk factor. The Child-Pugh classification and AFP levels were determined to be important prognostic factors in HCC patients.
Port Kateterizasyonu: 156 Hastalık Klinik Deneyimimiz
(2021) Yesıltas, Serdar; Aycan, Abdurrahman; Dogan, Erkan; Gönüllü, Edip; Koca, Dogan
Amaç: Ülkemizde pratikte çeşitli klinik ve cerrahi branşlar tarafından uygulanabilen port kateterizasyonu, malignite hastaları başta olmak üzere uzun süreli parenteral tedavi gerektiren hasta gruplarında son derece konforlu bir işlemdir. Yöntem: Bu çalışmada yerel etik kurul onayı alındıktan sonra anestezi uzmanı tarafından port kateterizasyon uygulanmış olan 156 hasta retrospektif olarak değerlendirildi. Bulgular: Hastaların %98,1’ine malignite (özofagus Ca: %37,3, mide: %24,8) nedeni ile işlem uygulandı. En sık uygulama yeri sağ internal juguler vendi (%65,4). Altmış iki hastada 2 veya daha fazla ponksiyon gerekti. Hastaların %1,9’unda port cebi enfeksiyonu nedeni ile port çıkarıldı. Sonuç: Biz bu çalışmada port kateterizasyon deneyimimizi sunduk ve ulusal literatüre katkı sunmayı amaçladık.
Spinal Metastasis of Unknown Primary Accompanied by Neurologic Deficit or Vertebral Instability
(Elsevier Science inc, 2018) Aycan, Abdurrahman; Celik, Sebahattin; Kuyumcu, Fetullah; Akyol, Mehmet Edip; Arslan, Mehmet; Dogan, Erkan; Arslan, Harun
BACKGROUND AND OBJECTIVE: Spinal bone metastases are common. They are mostly localized to the lumbar, thoracic, and cervical spine. The most common primaries to result in spinal metastases include lung, breast, and prostate carcinomas in adults as opposed to leukemia, Ewing sarcoma, rhabdomyosarcoma, and neuroblastoma in children. In patients diagnosed with cancer, bone metastases are found in 40% and spinal metastases in 10%. In this study, we reviewed 25 patients diagnosed with a spinal metastasis of unknown primary who presented with low back pain or acute-onset neurologic deficits and underwent operative treatment. METHODS: The retrospective study included 25 patients with a spinal metastasis of unknown primary who presented to our clinic with acute-onset vertebral fracture or neurologic deficit. Statistical descriptions were obtained for each patient. Survival analysis was performed using the Kaplan-Meier method. RESULTS: The 25 patients included 17 men (68%) and 8 women (32%), with a mean age of 55 years (range, 14-81 years). Eleven patients (44%) presented with varying degrees of motor deficits ranging from flaccid paralysis to paraplegia. Motor deficits were completely reversed in 4 patients postoperatively. The tumors were localized to the upper thoracic spine (T1-4) in 2 patients, in the midthoracic spine (T5-8) in 2 patients, in the lower thoracic spine (T9-12) in 8 patients, in the cervical 7 in 1 patient, and in the lumbar spine in 12 patients. In 10 patients, the tumor affected multiple spinal regions. Nonosseous tumors were not present in 10 patients. Ten patients had an extradural tumor. Costal involvement was detected in 2 patients. The tumors were pathologically identified as lung cancer (n = 3), lymphoma (n = 5), breast cancer (n = 3), gastric cancer (n = 2), liver cancer (n = 2), prostate cancer (n = 2), renal cell carcinoma (n = 2), malignant melanoma (n = 1), plasmacytoma (n = 1), bladder cancer (n = 1), paraganglioma (n = 1), Ewing sarcoma (n = 1), and yolk sac carcinoma (n = 1). Posterior instrumentation was performed in patients with instability. In addition, decompression was performed in patients with neurologic deficit. CONCLUSIONS: Considering that 10% of patients with cancer are diagnosed by vertebral metastasis, presence of malignancy should be suspected and a detailed examination should be performed in patients presenting with vertebral fractures caused by no or minor trauma. Moreover, in patients presenting with neurologic deficit, soft tissue metastases leading to spinal cord compression should be kept inmind and further examinations should be promptly administered.