Browsing by Author "Dogan, Murat"

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A 3-Day Boy With a Right Preauricular Swelling
(Springer, 2010) Akgun, Cihangir; Peker, Erdal; Akbayram, Sinan; Dogan, Murat; Tuncer, Oguz; Kirimi, Ercan
A 3-day-old boy was admitted for right preauricular swelling. Examination showed a toxic looking neonate with poor neonatal reflexes. There was erythema and swelling of 4 x 3 cm at the level of the right cheek. Laboratory investigation pointed to a bacterial infection. With parenteral antibiotics, the lesion resolved completely.
Acquired Methemoglobinemia Due To Application of Prilocaine During Circumcision
(Elsevier Science inc, 2012) Akbayram, Sinan; Akgun, Cihangir; Dogan, Murat; Gundogdu, Mustafa; Caksen, Huseyin; Oner, Ahmet Faik
Acute Appendicitis in Two Children With Henoch-Schonlein Purpura
(Maney Publishing, 2012) Bilici, Salim; Akgun, Cihangir; Melek, Mehmet; Peker, Erdal; Akbayram, Sinan; Bulut, Gulay; Dogan, Murat
In Henoch-Schonlein purpura (HSP), involvement of the ileum and ascending colon with vasculitis can mimic appendicitis and cause unnecessary appendicectomy. A 13-year-old boy presented with signs of HSP and abdominal pain. He was treated with prednisolone (2 mg/kg/day) for 10 days, but there was no improvement. At laparotomy he had acute suppurative appendicitis. A 12-year-old girl presented with HSP associated with abdominal pain and bloody diarrhoea and at laparotomy was also found to have suppurative appendicitis. Both patients had vasculitic areas in the ileum. In HSP, although suppurative appendicitis is rare, it should always be considered and appropriate investigations, including ultrasonography, undertaken.
Acute Itp Due To Insect Bite: Report of 2 Cases
(Sage Publications inc, 2011) Akbayram, Sinan; Akgun, Cihangir; Dogan, Murat; Caksen, Huseyin; Oner, Ahmet Faik
Immune thrombocytopenic purpura (ITP) of childhood is a common hematologic disorder. Immune thrombocytopenic purpura is characterized by increased destruction of antibody-coated platelets in the reticuloendothelial system. In the majority of children with acute ITP, thrombocytopenia occurs within 1 to 3 weeks after an infectious disease. Immune thrombocytopenic purpura may also occur after rubella, rubeola, chickenpox, or live virus vaccination. Here we report 2 cases with acute ITP that were developed after honeybee and insect bite.
Acute Respiratory Distress Syndrome Occurred After Hanging Result of the Attached To Rope: a Case Report
(Aves, 2012) Kaya, Avni; Okur, Mesut; Akbayram, Sinan; Avcu, Serhat; Acikgoz, Mehmet; Dogan, Murat; Akil, Muhammed
A-13-year-old male patient was admitted to our emergency unit because of near-hanging while playing with a rope. On physical examination, his general condition was not good, his state of consciousness was evaluated to be stuporous and his spontaneous respiration was weak. The patient had been intubated. The Glasgow coma score was 7. Rope marks were observed on his neck. Thorax computed tomography revealed widespread ground-glass appearance and bilateral parenchymal consolidation in the lungs. This findings correlated with acute respiratory distress syndrome. This case was reported for reminding that acute respiratory distress syndrome can be associated with near-hanging. (Turk Arch Ped 2012; 47: 302-4)
An Analysis of Children With Brucellosis Associated With Isolated Thrombocytopenia
(Sage Publications inc, 2011) Akbayram, Sinan; Dogan, Murat; Akgun, Cihangir; Peker, Erdal; Parlak, Mehmet; Oner, Ahmet Faik
Hematologic abnormalities of mild anemia and leucopenia have been frequently associated with acute brucellosis, but thrombocytopenia are less frequently seen. In the present study, we documented 5 (2.6%) isolated thrombocytopenic patients with the manifestations of brucellosis observed during the course of active infection. Five (2.6%) patients, 4 boys and 1 girl, with ages ranging from 2 to 14 years, had isolated thrombocytopenic at diagnosis. In 5 (2.6%) patients, platelet counts ranged from 39 000 to 120 000/mm(3). Tube agglutination tests for brucellosis were positive for all patients (1/160-1/1280). All patients recovered completely, and their thrombocytopenia returned to normal by 2 to 4 weeks after antibiotic treatment of brucellosis. In our study, we present 5 patients with Brucella-induced thrombocytopenia mimicking idiopathic thrombocytopenic purpura to emphasize the isolated thrombocytopenia and the resolution of thrombocyte counts following treatment of brucellosis.
An Analysis of Children With Brucellosis Associated With Pancytopenia
(informa Healthcare, 2011) Akbayram, Sinan; Dogan, Murat; Akgun, Cihangir; Peker, Erdal; Parlak, Mehmet; Caksen, Huseyin; Oner, Ahmet Faik
Brucellosis produces a variety of nonspecific hematologic abnormalities. Hematologic complications of mild anemia and leukopenia have been frequently associated with acute brucellosis, but pancytopenia is less frequently seen. In this study, records of children with brucellosis aged under or equal to 16 years, admitted to Yuzuncu Yil University Hospital between 2004 and 2010, were analyzed retrospectively. Over this time period, 187 patients with brucellosis were diagnosed. Twenty-five (13.3%%) of 187 patients had pancytopenia during admission to hospital. The diagnosis of brucellosis was confirmed by standard tube agglutination test in all patients; titers were 1:320 in 1 patient and 1:1280 in 24 patients. Blood culture was positive for Brucella melitensis in 3 patients (12%%). Fever was the most common manifestation, followed by malaise, anorexia, sweating, and weight loss. Fever and splenomegaly were the common signs in most patients. In addition, arthritis was observed in 5 patients, and epistaxis, headache, and abdominal pain were observed in 3 patients. The common bone marrow aspiration findings consisted of increased megakaryocytes and hyperplasia of erythroid series, with a shift to the left of the granulocytic series. Histiocytic hyperplasia was observed in the bone marrow smear of 2 patients. Mild hemophagocytosis was observed in the bone marrow of 3 patients. All patients recovered completely, and their peripheral blood counts returned to normal by 2 to 6 weeks after antibiotic treatment of brucellosis. In conclusion, the authors would like to emphasize that brucellosis should be considered in the differential diagnosis of children with pancytopenia.
Arachnoid Cyst Causing Subfalcine Herniation in a Child Failure To Thrive
(Nobel Ilac, 2011) Dogan, Murat; Yilmaz, Cahide; Ustyol, Lokman; Caksen, Huseyin
Arachnoid cysts represent only 1% in all intracranial masses. The signal and density of arachnoid cysts are mostly the same as cerebrospinal fluid unless be complicated. They do not have calcification and do not retain contrast material but they are benign lesions. Although they can be seen in all ages, they are mostly detected in children. Male-female ratio is In this case report., 18 months-old-boy with subfalcine herniation because of an arachnoid cyst who was brought to our hospital only with complaint of failure to thrive was presented due to its atypical and rare presentation.
Assessment of Antioxidant Enzymes, Total Sialic Acid, Lipid Bound Sialic Acid, Vitamins and Selected Amino Acids in Children With Phenylketonuria
(Springernature, 2018) Ekin, Suat; Dogan, Murat; Gok, Fazilet; Karakus, Yagmur
Background: In this study, children with phenylketonuria and healthy control subjects were assessed for glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), catalase (CAT) activity, malondialdehyde (MDA), glutathione (GSH), retinol, cholecalciferol, alpha-tocopherol, phylloquinone, total sialic acid (TSA), lipid bound sialic acid (LSA), total antioxidant (TAS), total oxidation (TOS), and amino acid levels, and the relationships of these variables with phenylketonuria were evaluated. METHODS: The study included 60 children with phenylketonuria and 30 control subjects. Children with phenylketonuria were divided into hyperphenylalaninemia (HPA) and amino acid mixture (AAM) groups. RESULTS: The HPA group had significantly lower levels of GSH-Px, CAT, GSH, TAS, alpha-aminobutyric acid, and taurine levels (p < 0.01, p < 0.05, p < 0.05, p < 0.001, p < 0.01, p < 0.05, respectively) than the control group. Additionally, the AAM group had significantly lower levels of CAT, TAS, and phylloquinones (p < 0.05, p < 0.05, p < 0.05, respectively) than the control group. It was observed in our study that in the HPA group, a significantly strong positive linear correlation was observed between phenylalanine and alpha-aminoadipic acid (r = 0.777; p = 0.002). CONCLUSIONS: It was concluded that the levels of alpha-aminoadipic acid and phylloquinone might be an appropriate choice for the determination of phenylketonuria in parallel with the levels of phenylalanine. alpha-aminobutyric acid and phylloquinone as a supplement can decrease HPA damage.
Association of Attention Deficit Hyperactivity Disorder and Autism Spectrum Disorders With Mean Platelet Volume and Vitamin D
(int Scientific information, inc, 2017) Garipardic, Mesut; Dogan, Murat; Bala, Keziban Asli; Mutluer, Tuba; Kaba, Sultan; Aslan, Oktay; Ustyol, Lokman
Background: The purpose of this study was to assess the values of the mean platelet volume (MPV) in children with attention deficit hyperactivity disorder (ADHD) and with autism spectrum disorders (ASDs) to determine the risk of cardiovascular disease in these 2 disorder groups. Material/Methods: The study included a total of 79 patients with ADHD or ASDs and controls in the Van region of Turkey. The control group included subjects of matching age and sex with no ADHD, ASDs, or chronic disease and taking no vitamins. The hematological parameters of the patients, including MPV, vitamin B12, and vitamin D, were assessed. Results: The study included a total of 79 children and adolescents aged 2-18 years (32 females and 47 males). Of the patients, 36 were in the ADHD group, 18 in the ASDs group, and 25 in the control group. There was no statistically significant difference in hematological parameters between the groups, but there were significant differences in terms of vitamin D and vitamin B12. The patient groups showed lower levels of vitamin B12 and vitamin D. In the ADHD group, there was a negative correlation between both vitamins and MPV (p<0.05). Partial correlation analysis of the ADHD group showed that MPV in particular was negatively correlated to vitamin D, and not to vitamin B12 (p: 0.03). Conclusions: Both ADHD and ASDs may accompany increased risk for cardiovascular disease due to the presence of vitamin B12 and D deficiency and their own characteristics. Therefore, these disorders should be closely followed up.
The Association of Oxidant Status and Antioxidant Capacity in Children With Acute and Chronic Itp
(Lippincott Williams & Wilkins, 2010) Akbayram, Sinan; Dogan, Murat; Akgun, Cihangir; Mukul, Yurdaguel; Peker, Erdal; Bay, Ali; Oner, Ahmet Faik
Purpose: This study was undertaken to investigate oxidant and antioxidant systems in patients with immune thrombocytopenic purpura (ITP). With this purpose, we measured the levels of serum malondialdehyde (MDA), total antioxidant capacity (TAC), total oxidant status (TOS), and other oxidative stress parameters. Patients and Methods: Fifty-two pediatric patients with ITP (25 acute, 27 chronic) and 21 healthy children were included in the study. Patients with acute ITP were studied, before and after, methylprednisolone treatment. Results: Hemoglobin, hematocrit, platelet count, and TAC were statistically significantly lower in patients with acute ITP before treatment than those in the control group (P<0.05). In addition, in this group, MDA, TOS levels, and OSI (oxidative stress index) were found to be higher than those in the control group. In chronic ITP group, although hemoglobin hematocrit, platelet counts, and TAC levels were statistically significantly lower than those in the control groups, the mean platelet volume, MDA, TOS, and OSI were found to be statistically significantly higher (P<0.05). Platelet count and mean platelet volume values were statistically significantly lower in patients with acute ITP before treatment than after treatment (P<0.05). We also found a positive correlation between thrombocyte count and TAC, in patients with acute ITP before treatment (r: 0.601, P<0.001) and acute ITP after treatment (r: 0.601, P<0.001) and chronic ITP (r: 0.601, P<0.001). A negative correlation was found between thrombocyte count and serum MDA levels, in patients with acute ITP before treatment (r: -0.356, P<0.001) and acute ITP after treatment (r: -0.356, P<0.001) and chronic ITP (r: -0.356, P<0.001). We also found a negative correlation between thrombocyte count and serum OSI, in patients with acute ITP before treatment (r: -0.494, P<0.001) and acute ITP after treatment (r: -0.494, P<0.001) and chronic ITP (r: -0.494, P<0.001). A negative correlation was found between thrombocyte count and TOS, in patients with acute ITP before treatment (r: -0.470, P<0.001) and acute ITP after treatment (r: -0.470, P<0.001) and chronic ITP (r: -0.470, P<0.001). In conclusion, increased MDA, TOS and OSI, and decreased TAC levels were found in patients with acute and chronic ITP. Conclusions: On the basis of these findings, we suggest that free oxygen radicals may have an effect on the structural and functional damage of platelets, and on the mechanism of thrombocytopenia in both, acute and chronic ITP.
Association of Pulmonary Hemosiderosis and Celiac Disease
(Nobel Ilac, 2011) Dogan, Murat; Bektas, Mehmet Selcuk; Dogan, Sekibe Zehra; Aktar, Fesih; Cesur, Yasar
Idiopathic pulmonary hemosiderosis (IPH) is a rare disease of unknown autoimmune etiology mainly affecting children and adolescents. We report the case of an 6-years-old boy with cough and tiredness. There were no gastrointestinal symptoms were not determined. Body weight and height were in normal percentiles. Physical examination revealed cutaneous and mucosal pallor, due to severe anemia (hemoglobin 3 g/dL). Infiltrations were seen at the chest X-rays at both lungs, but markedly at left lung. In sputum examinations, hemosiderin-laden macrophages were seen. The diagnosis of IPH was made. The association of IPH and Celiac disease (CD) is well known. Searching associated CD was performed and then confirmed by biological and histological examinations. A gluten-free diet was initiated. Evolution was favorable. Searching for CD in IPH should be done, even in the absence of gastrointestinal symptoms.
Atypical Presentation of Herpes Zoster in a Case With Acute Myeloblastic Leukemia
(Elsevier Science Bv, 2013) Aktar, Fesih; Akbayram, Sinan; Akdeniz, Necmettin; Aktar, Sirac; Akgun, Cihangir; Dogan, Murat; Oner, Ahmet Faik
Herpes zoster (HZ) is often associated with painful erythematous vesicular eruptions of the skin or mucous membranes. Approximately 10% to 30% of the population will suffer from HZ during their lifetime. HZ is infrequent in healthy children. However, diminished cellular immunity seems to increase risk of reactivation because incidence increases with age and in immunocompromised states. We report a 7 year old girl with acute myeloblastic leukemia HZ infection on the right palmar, elbow and forearm region (C7, C8 and T1 dermatomes). We want to indicate unusual localization of HZ on the acute myeloblastic leukemia child patient.
Benidipine Hydrochloride Intoxication in a Child
(Elsevier Science inc, 2012) Akbayram, Sinan; Akgun, Cihangir; Dogan, Murat; Geylani, Hadi; Sari, Nesim; Taskin, Alparslan Gokmen; Caksen, Huseyin
Bilateral Brachial Plexus Palsy and Right Horner Syndrome Due To Congenital Cervicothoracal Syringomyelia
(Elsevier Science Bv, 2010) Cagan, Eren; Sayin, Refah; Dogan, Murat; Peker, Erdal; Cagan, Havva Hasret; Caksen, Hueseyin
Syringomyelia (SM) is a disorder in which a cyst forms within the spinal cord. This cyst, called a syrinx, expands and elongates over time, destroying the center of the cord. Horner syndrome is an infrequent illness caused by a lesion of the cervical sympathetic nerve fiber. Its clinical features are facial anhidrosis, ptosis, miosis, and hypochromia iridis of the affected side. A full-term male newborn infant was admitted with weakness in bilateral upper extremities and narrowing of the palpebral fissure on the right side. Ophthalmologic examination revealed a smaller right pupil. Muscle power in bilateral upper limbs was 1/5. Chest X-ray and cranial magnetic resonance imaging were normal. Magnetic resonance imaging of the cervicothoracic spine showed SM at C4-T2 level. Electromyographic examination revealed bilateral brachial plexus palsy. The diagnosis was of brachial plexus palsy and congenital Homer syndrome due to congenital cervicothoracic SM. According to our best knowledge, this association has not been reported in the literature. (C) 2009 Elsevier B.V. All rights reserved.
Bio-Element Status in Children With Acute Rheumatic Fever: Before Treatment and After Clinical Improvement
(Springer, 2010) Cemek, Mustafa; Buyukokuroglu, Mehmet Emin; Buyukben, Ahmet; Aymelek, Fatih; Yilmaz, Fatma; Dogan, Murat; Yildirim, Derya
Acute rheumatic fever (ARF) is an autoimmune multisystem disease. Bio-elements are required in different quantities by an organism to maintain its physiologic function. Monitoring the status of bio-elements is critical in human health. This study aimed to determine possible changes in levels of bio-elements in children with ARF before and after treatment. Levels of trace and major elements in children with ARF were investigated. The study included 33 children with ARF (17 boys and 16 girls) and 20 healthy control children (11 boys and 9 girls). The ages ranged from 5 to 16 years (mean 11.4 +/- A 3.82 years) in the study group and from 6 to 15 years (mean, 10.7 +/- A 3.22 years) in the control group. Trace and major element concentrations (total of 14 elements) in the serum were measured by inductively coupled plasma-optical emission spectroscopy. Before treatment, the levels of the major elements potassium (K) and magnesium (Mg) in children with ARF were higher than in the control group, whereas the calcium (Ca) level was lower. Before treatment, the levels of trace elements iron (Fe), selenium (Se), zinc (Zn), aluminum (Al), and barium (Ba) were lower, whereas the copper (Cu), beryllium (Be), cadmium (Cd), chromium (Cr), gallium (Ga), and strontium (Sr) levels were higher in the serum of the patients with ARF than in the control patients. The major findings show that the homeostasis of some trace and major elements were altered in the children with ARF and that these alterations may be a contributing factor in the pathogenesis of this disease.
Blepharophimosis, Ptosis, and Epicanthus Inversus Syndrome: Expanding the Phenotype
(Alliance Communications Group Division Allen Press, 2016) Kaba, Sultan; Dogan, Murat; Bulan, Keziban; Demir, Nihat; Uner, Abdurrahman; Bulut, Mehmet Deniz; Kocaman, Selami
We present a 3-month-old girl who displayed typical clinical characteristics of blepharophimosis, ptosis, and epicanthus inversus syndrome (BPES). She was referred to our clinic with an initial diagnosis of Down syndrome. Clinical features of elevated follicle stimulating hormone and low estradiol levels in the case were diagnosed as BPES syndrome and were consistent with BPES type 2. To date, there are no cases of BPES with cleft palate and cardiomyopathy, suggesting that these novel findings can be part of this condition.
Brucellosis Concomitant With Acute Leukemia
(All india inst Medical Sciences, 2007) Bay, Ali; Oner, Ahmet Faik; Dogan, Murat; Acikgoz, Mehmet; Dilek, Imdat
We present two patients with brucellosis concomitant with acute leukemia. Co-existence of acute leukemia with brucellosis which may have similar symptoms, have not been reported earlier. The first case presented with generalized arthralgia, fever, paleness, and pancytopenia. The second patient had mild leucopenia and thrombocytopenia. She presented with fever. We carried out the chemotherapy for both ALL and brucellosis simultaneously. While the first patient's fever disappeared within 3 days, the second patient's fever had continued on subfebril level for five days and then disappeared. We achieved the remission in both patients and no reactivation was observed during the follow-up period.
A Case of Carbamazepine Intoxication in A Young Boy
(Elsevier Science inc, 2010) Dogan, Murat; Yilmaz, Cahide; Temel, Hayrettin; Caksen, Huseyin; Taskin, Gokmen
Ceftriaxone-Induced Toxic Hepatitis
(Baishideng Publishing Group inc, 2009) Peker, Erdal; Cagan, Eren; Dogan, Murat
Toxic hepatitis or drug-induced liver injury encompasses a spectrum of clinical disease ranging from mild biochemical abnormalities to acute liver failure. The advantages of along half-life, wide spectrum, high tissue penetration rate, and a good safety profile, make ceftriaxone, a third-generation cephalosporin, a frequent choice in the treatment of childhood infections. Previous studies have reported a few cases of high aspartate aminotransferase and alanine aminotransferase levels, along with three cases of hepatitis caused by ceftriaxone. Here, we report a case of drug-induced toxic hepatitis in a patient who was treated with ceftriaxone for acute tonsillitis. (C) 2009 The WJG Press and Baishideng. All rights reserved.