Browsing by Author "Dogan, Mustafa"

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Discovery and Environmental Implications of Santorini Tephras (Cape Riva and Minoan) in Sediments of Lake Yayla (West Anatolia)
(Sage Publications Ltd, 2025) Dogan, Mustafa; Ozdemir, Yavuz; Bozkurt, Yunus; Senkul, Cetin
Throughout the long eruption history of the Santorini volcano, the Cape Riva/Y-2 and Minoan/Z-2 eruptions had a profound impact on the environment. The Minoan eruptions also had a significant impact on society. These two tephras, as well as the Y-2 tephra individually, have been recorded for the first time in a lacustrine area in western Anatolia. This study examines the geochemical properties of Y-2 (23 cm) and Z-2 tephra layers (19 cm; 14 cm pure and 5 cm mixed) from 18 m sediment cores in Lake Yayla (Denizli-Buldan). Additionally, high-resolution mu XRF, fossil pollen, charcoal, and dating analyses were conducted on the cores to determine the chronologies and environmental effects of the tephra layers. Fossil pollen findings show consistent forest and steppe/grassland vegetation before and after the Z-2 tephra, with the forest impact lasting for 240 years after the eruption. Increased aquatic vegetation and changes in specific taxa (e.g. Pinus sp. and Amaranthaceae increased, while Quercus deciduous, Olea europaea, and cereals decreased) were observed following the Minoan eruption. Charcoal analysis indicates heightened fire activity post-Minoan eruption, while XRF data reveal no associated climatic change. At the same time, no correlation has been identified between the Cape Riva eruption and ecological changes (climate, vegetation, and fire activity). Contribution to dating the tephra was provided by radiocarbon dating from the lowest part of the tephra layer (17,684 +/- 63 years BP). This study sheds light on the extensive impacts of the Y-2 and Z-2 tephra eruptions, focusing on their dating, geochemistry, environmental effects, tephra transport directions, and thicknesses. It demonstrates the presence of a significant geological event for the settlements in the B & uuml;y & uuml;k Menderes Valley.
Discovery and Environmental Implications of Santorini Tephras (Cape Riva and Minoan) in Sediments of Lake Yayla (West Anatolia) (Sept, 10.1177/09596836241275007, 2024)
(Sage Publications Ltd, 2025) Dogan, Mustafa; Ozdemir, Yavuz; Bozkurt, Yunus; Gurboga, Sule; Senkul, Cetin
Revealing Molecular Diagnosis With Whole Exome Sequencing in Patients With Inherited Retinal Disorders
(Wiley, 2025) Yavas, Cuneyd; Arvas, Yunus Emre; Dogan, Mustafa; Gezdirici, Alper; Aslan, Elif Sibel; Karapapak, Murat; Eroz, Recep
Inherited retinal diseases (IRDs) constitute a heterogeneous group of clinically and genetically diverse conditions, standing as a primary cause of visual impairment among individuals aged 15-45, with an estimated incidence of 1:2000. Our study aimed to comprehensively evaluate the genetic variants underlying IRDs in the Turkish population. This study included 50 unrelated Turkish IRD patients and their families. Genomic DNA was extracted from each participant, and candidate variants were identified via next-generation sequencing to determine their pathogenicity. We detected variants in 58% of the patients, of which six novel variants were identified. Among these, 16 cases exhibited variants associated with retinitis pigmentosa and Stargardt disease, while 13 presented variants linked to other retinal diseases. The spectrum of identified variants included 21 homozygous cases and five compound heterozygous variants, both indicative of autosomal recessive inheritance. Three cases revealed heterozygous variants suggestive of autosomal dominant inheritance, and two cases featured hemizygous variants suggestive of X-linked inheritance. Importantly, no matches with copy number variants were detected in our analysis. This study comprehensively portrays clinical and genetic profiles within the Turkish population affected by IRDs. Identifying novel variants and delineating inheritance patterns contribute to a deeper understanding of the genetic diagnosis of IRDs, paving the way for more precise diagnostic and therapeutic interventions.