Browsing by Author "Dogan, Sekibe Zehra"

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Association of Pulmonary Hemosiderosis and Celiac Disease
(Nobel Ilac, 2011) Dogan, Murat; Bektas, Mehmet Selcuk; Dogan, Sekibe Zehra; Aktar, Fesih; Cesur, Yasar
Idiopathic pulmonary hemosiderosis (IPH) is a rare disease of unknown autoimmune etiology mainly affecting children and adolescents. We report the case of an 6-years-old boy with cough and tiredness. There were no gastrointestinal symptoms were not determined. Body weight and height were in normal percentiles. Physical examination revealed cutaneous and mucosal pallor, due to severe anemia (hemoglobin 3 g/dL). Infiltrations were seen at the chest X-rays at both lungs, but markedly at left lung. In sputum examinations, hemosiderin-laden macrophages were seen. The diagnosis of IPH was made. The association of IPH and Celiac disease (CD) is well known. Searching associated CD was performed and then confirmed by biological and histological examinations. A gluten-free diet was initiated. Evolution was favorable. Searching for CD in IPH should be done, even in the absence of gastrointestinal symptoms.
A Case of Leptospirosis With Multiple Organ Dysfunction
(Aves Yayincilik, Ibrahim Kara, 2010) Okur, Mesut; Akgun, Cihangir; Bektas, Mehmet Selcuk; Kaya, Avni; Temel, Hayrettin; Acikgoz, Mehmet; Dogan, Sekibe Zehra
Leptospirosis is a zoonotic infection caused by a spirochete of the genus Leptospira, which may affect both humans and animals and is common worldwide. The disease may lead to distinct clinical pictures in humans varying from subclinical infection to multiple organ dysfunction and even death. In this paper, we presented a 8-year-old male patient admitted with the complaints of fever, malaise, fatigue and night sweating, who had been feeding a pet rabbit in the house, and who had jaundice of the sclera and skin, a rash, gastrointestinal bleeding and hepatosplenomegaly found on examination. He developed encephalopathy, bleeding diathesis, hepatic and renal failure; and was diagnosed with leptospirosis based on the clinical symptoms and laboratory tests. After 14-days of therapy with crystallized penicillin and intensive supportive treatment, the neurological and hematological anomalies improved as well as the renal and hepatic dysfunction. In conclusion, we would like to emphasize that the probability of leptospirosis should be considered in children presenting with jaundice, encephalopathy, multiple organ dysfunction and bleeding diathesis if there are any environmental risk factors.
Dermatological Findings of Vitamin B12 Deficiency and Resolving Time of These Symptoms
(Taylor & Francis Ltd, 2014) Demir, Nihat; Dogan, Murat; Koc, Ahmet; Kaba, Sultan; Bulan, Keziban; Ozkol, Hatice Uce; Dogan, Sekibe Zehra
Aim: The mucocutaneous changes observed during vitamin B12 deficiency in children have been published only as case studies and small case series. In this study, we aimed to demonstrate the frequency of mucocutaneous changes (particularly hyperpigmentation) seen during vitamin B12 deficiency and resolving time of these symptoms with vitamin B12 treatment. Material and methods: This prospective study was conducted at the pediatrics outpatient clinic of Harran and Yuzuncu Yil University Faculty of Medicine, among 57 patients, aged between 6 and 24 months, who were diagnosed with vitamin B12 deficiency following various examinations and tests. A detailed examination was performed in respect to skin and mucosal findings. Patients with vitamin B12 deficiency were administered intramuscular cyanocobalamin. Prospective examination was continued, and resolving time of symptoms after treatment was recorded. Results: The mean age of the patients enrolled in the study was found to be 12.75 +/- 4.75. Hyperpigmentation was reported in 49 (85.96%) patients enrolled in the study; atrophic glossitis in 40 (70.17%), brittle and matt hair in 13 (22.80%), skin lesions (particularly diaper dermatitis) in eight (15.78%) and cheilosis in four (7.01%) patients. Three months after the treatment initiation, hyperpigmentation improved in 87.75%, atrophic glossitis in 97.5% and brittle and matt hair in 92.3% of the patients. Five patients (8.77%) with continuing pigmentation by the end of sixth months were considered as nonresponsive to the treatment. Conclusion: Deficiency of vitamin B12 should be considered in the differential diagnosis of infants who present with skin and mucosal lesions.
Hormone Disorder and Vitamin Deficiency in Attention Deficit Hyperactivity Disorder (Adhd) and Autism Spectrum Disorders (Asds)
(Walter de Gruyter Gmbh, 2016) Bala, Keziban Asli; Dogan, Murat; Kaba, Sultan; Mutluer, Tuba; Aslan, Oktay; Dogan, Sekibe Zehra
Background: The aim of this study was to analyze thyroid hormones and antibodies, ferritin, vitamins B12 and D, adrenal and gonadal steroid levels, and celiac antibodies in children diagnosed with attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). Methods: Between February 2014 and July 2014, a total of 77 children and adolescents (31 girls, 46 boys) who were admitted to the Van Training and Research Hospital were included in the study. The study population was divided into three groups including ADHD (n=34), ASD (n=16), and age-and sex-matched healthy controls (n=27). The diagnosis of ADHD was made on the basis of Diagnostic and Statistical Manual of Mental Disorders - Fifth Edition (DSM-5) and DSM-4 Turkish version with the diagnostic interview and Disruptive Behavior Disorder Rating Scale (DBDRS). The diagnosis of ASD was based on the DSM-4 and DSM-5 Turkish version with the diagnostic interview and the Childhood Autism Rating Scale (CARS). The blood samples were obtained between 8: 00 and 9: 00 A.M. Results: There was a statistically significant difference in vitamin B12 and D levels and ferritin values among the three groups. The ASD group had the highest ferritin and the lowest vitamins B12 and D levels. Vitamin D levels of the ADHD group were significantly lower compared to the healthy controls. Conclusions: Our study results highlight the importance of supplementation of vitamins B12 and D in the ASD and ADHD patients.
Immune Thrombocytopenic Purpura in a Case of Propionic Acidemia: Case Report
(Lippincott Williams & Wilkins, 2014) Bulan, Keziban; Dogan, Murat; Kaba, Sultan; Dogan, Sekibe Zehra; Akbayram, Sinan; Oner, Ahmet F.
Mean Platelet Volume and Vitamin D Deficiency
(Galenos Yayincilik, 2016) Bala, Keziban Asli; Dogan, Murat; Kaba, Sultan; Garipardic, Mesut; Aslan, Oktay; Dogan, Sekibe Zehra; Kocaman, Selami
Aim: To evaluate whether vitamin D deficiency has an effect on mean platelet volume (MPV). Materials and Methods: This was a retrospective study. The children followed-up at the pediatrics endocrinology polyclinic and diagnosed as nutritional rickets were included in this study. The patient group was created, and by screening the files of 478 case files, those compatible with the patient group for age and gender, were taken as the control group. Results: A total of 684 children and adolescents cases between the ages 0.1-18 years were included in the study. The cases were divided into 3 groups according to the vitamin D levels. Those with vitamin D levels of less than 15 ng/mL were classified as the vitamin D deficiency group, those between 15-20 ng/mL were classified as the insufficiency group, and those between 20-100 ng/mL were classified as the normal Vitamin D level group. There was no statistically significant difference between the groups in terms of age and gender. There was no significant difference observed between the groups in terms of the MPV levels. There was no statistically significant correlation determined in the correlation analysis between the vitamin D level and the MPV (p>0.05). In the multiple regression analysis, it was observed that vitamin D had no statistically significant effect on MPV. In the performed partial correlation analysis, when hemoglobin, hematocrit, calcium, phosphorus and parathyroid hormone were selected as controlling factors, again, there was no statistically significant correlation observed between the MPV and the vitamin D (r=-0.19, p>0.05). Conclusion: In the pathophysiology of the cardiac dysfunctions appearing as a result of vitamin D deficiency, we wished to emphasize that the hypothesis of the probable effect of vitamin D on MPV should be questioned in more detail.
Thrombocytopenia Associated With Galsulfase Treatment
(Sage Publications Ltd, 2011) Dogan, Murat; Cesur, Yasar; Peker, Erdal; Oner, Ahmet F.; Dogan, Sekibe Zehra
Mucopolysaccharidosis type VI (MPS VI), or Maroteaux-Lamy syndrome, is a lysosomal storage disorder that results from a deficiency of the enzyme N-acetylgalactosamine-4-sulfatase or arylsulfatase B (ASB). It is a relatively rare disorder, with an estimated incidence of 1 in 248,000 to 1 in 300,000. The diagnosis is made on the basis of findings of elevated urine glycosaminoglycans and a deficiency of ASB activity in leukocytes or cultured fibroblasts. In treatment of MPS VI, enzyme replacement therapy (galsulfase; human recombinant ASB enzyme) became available. Infusions of galsulfase were generally well tolerated. But in some patients, infusion-associated reactions including rash, urticaria, headache, hypotension, nausea, and vomiting were documented and were managed successfully by interrupting or slowing the rate of infusion and/or by the administration of antihistamines, antipyretics, corticosteroids, or oxygen. Here, we report a case with MPS VI who developed thrombocytopenia after third dose of therapy. To the best of our knowledge, this is the first report about thrombocytopenia associated with galsulfase therapy in the literature. Additionally, with this report, we want to share our approach for this case.