Browsing by Author "Donmez, Muhammet Irfan"

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Comparison of Ceftriaxone and Cefazolin Sodium Antibiotic Prophylaxis in Terms of Sirs/Urosepsis Rates in Patients Undergoing Percutaneous Nephrolithotomy
(Galenos Yayincilik, 2019) Taken, Kerem; Asik, Alper; Eryilmaz, Recep; Aslan, Rahmi; Donmez, Muhammet Irfan; Gunes, Mustafa
Objective: The aim of this study is to compare ceftriaxone and cefazoline sodium antibiotic prophylaxis in terms of development of Systemic Inflammatory Response syndrome (SIRS)/urosepsis in patients undergoing percutaneous nephrolithotomy (PCNL). Materials and Methods: Patients who underwent PCNL between June 2015 and October 2015 in our hospital were prospectively randomized to ceftriaxone (n=30) and cefazoline sodium (n=32) antibiotic prophylaxis groups. Patients with predisposing conditions to SIRS were excluded. Intraoperative urine cultures from renal pelvis and stone cultures were obtained from all patients. Clinical and laboratory findings of the patients who developed postoperative fever were evaluated. SIRS and urosepsis rates were compared between two groups. Results: There were 7 patients in ceftriaxone group (23.3%) and 4 patients in cefazoline sodium group (12.5%) who developed SIRS (p=0.264). Sepsis was observed in 2 patients in both groups (p=0.826). Prolonged duration of surgery in ceftriaxone group and renal pelvis urine culture positivity in cefazoline group were found to be statistically significant in patients who developed SIRS (p=0.02, p=0.015, respectively). Conclusion: There was no significant difference between two groups in terms of SIRS and sepsis following PCNL. Therefore, cefazoline, which has a narrower antimicrobial spectrum, may be preferred for prophylaxis.
Erectile Dysfunction Is a Marker for Obstructive Sleep Apnea
(Taylor & Francis Ltd, 2016) Taken, Kerem; Ekin, Selami; Arisoy, Ahmet; Gunes, Mustafa; Donmez, Muhammet Irfan
Purpose: To investigate the prevalence of erectile dysfunction (ED) in patients with obstructive sleep apnea (OSA) with and without any other comorbidities. Methods: The patient group was newly diagnosed as having OSA (apnea-hypopnea index [AHI]>5/h) using a polysomnographic examination. A group of subjects with simple snoring were included into the control group. Clinically relevant comorbidities were systematically assessed in face-to-face interviews. All patients were asked to complete the 15-item International Index of Erectile Function (IIEF-15) questionnaire for the evaluation of ED. The patients with OSA and ED were evaluated according to these comorbidities. Results: Of the 94 patients, 39 patients were excluded because of severe diseases. OSA was observed in 38 (69.1%) of the 55 patients. ED was seen in 24 (63.2%) patients with OSA, and in 8 (47.1%) patients without OSA (p>0.05). There were no statistical differences between the groups' ages, IIEF scores, and body mass index (BMI) scores. There were statistically significant differences between the groups' AHI scores (p<0.05). There was a significant correlation between the groups' AHI scores, BMI, and age (p<0.05). There was no statistically significant difference in patients with OSA, with and without comorbidity in terms of ED. Conclusion: The rate of ED was higher in patients with OSA who had no other comorbidities. Therefore, ED can be a sensitive marker of OSA.
Hospital Readmissions Due To Subcapsular Renal Hematoma After Flexible and Rigid Ureterorenoscopy
(Galenos Yayincilik, 2018) Taken, Kerem; Gunes, Mustafa; Ergun, Muslum; Donmez, Muhammet Irfan
Objective: The aim of this study is to compare the rates of hospitalization due to subcapsular renal hematoma (SRH) following flexible ureterorenoscopy (FURS) and semirigid ureterorenoscopy (RURS) for the treatment of ureteral and renal stones. Materials and Methods: Patients who have been treated with FURS and RURS at two different institutions between March 2009 and February 2014 were enrolled in the study. Patient files and hospital records were reviewed. Pneumatic lithotriptor was used in RURS while holmium:yttrium aluminium garnet laser was used for FURS. Subcapsular hematoma diagnosis was based on clinical and radiological findings. Comparative analysis of patients with SRH in terms of age, sex, stone size/position, degree of preoperative hydronephrosis, duration of surgery and size of hematoma was done. Results: A total of 1187 patients were found to have undergone ureteroscopic intervention due to ureteal or renal stones. RURS was performed in 992 (83.6%) patients and FURS was performed in 195 patients (16.4%). Of the 992 patients who underwent RURS, postoperative SRH occurred in 6 patients (0.6%). Postoperative SRH occurred in 3 patients (1.5%) who underwent FURS. Of the 9 patients who developed SRH, blood transfusions were needed in three patients and one patient was treated with percutaneous drainage catheter insertion. No patient underwent open surgery. There was no statistically significant difference between the two types of surgeries with regard to age, stone size/localization, degree of preoperative hydronephrosis, duration of surgery and size of SRH (p>0.05). Conclusion: SRH is a rare complication following RURS and FURS. There is no statistically significant difference in the risk for this specific complication between FURS and RURS.
Oxidative Dna Damage To Sperm Cells and Peripheral Blood Leukocytes in Infertile Men
(int Scientific Literature, inc, 2016) Taken, Kerem; Alp, Hamit Hakan; Eryilmaz, Recep; Donmez, Muhammet Irfan; Demir, Murat; Gunes, Mustafa; Sekeroglu, Mehmet Ramazan
Background: Oxidative DNA damage is associated with male infertility. The aim of this study was to evaluate the oxidative DNA damage of sperm cells and blood leukocytes and to determine the levels of MDA and NO levels in seminal and blood plasma of idiopathic infertile men. Material/Methods: The study enrolled 52 patients, including 30 infertile and 22 fertile men. MDA, NO, and 8-OHdG/10(6)dG were estimated using spectrophotometry and high-pressure liquid chromatography ( HPLC)-based methods in seminal and blood plasma. The association with the sperm parameters was assessed, particularly sperm counts and motility. Results: The mean sperm concentration and sperm motility of the fertile men were significantly higher than that of the infertile men. The mean MDA and NO concentration in the seminal and blood samples of the infertile men were higher than that of fertile men. Also, the mean numbers of sperm cells and leukocytes 8-OHdG/10(6)dG of the infertile men were significantly higher than that of fertile men (p=0.04 and p<0.001, respectively). Sperm motility and sperm count were negatively correlated with leukocyte and sperm cell 8-OHdG/10(6)dG ratio. However, progressive motility was significantly negatively correlated with sperm cell and leukocyte 8-OHdG/10(6)dG ratio (R=-0.357, p=0.026; R=-0.388, p=0.024, respectively). Conclusions: Oxidative stress is an important factor in male infertility. Therefore, biochemical detection of 8-OHdG/10(6)dG in sperm cells and blood leukocytes may be an additional tool in the diagnosis of male infertility.
Response To Letter To the Editor 'serum Irisin Concentration in Patients With Bladder Cancer
(Springer, 2022) Taken, Kerem; Aslan, Rahmi; Eryilmaz, Recep; Alp, Hamit Hakan; Huyut, Zubeyir; Donmez, Muhammet Irfan
Serum Irisin Is a Novel Biomarker for Bladder Cancer Detection
(Springer, 2022) Taken, Kerem; Aslan, Rahmi; Eryilmaz, Recep; Alp, Hamit Hakan; Huyut, Zubeyir; Donmez, Muhammet Irfan
Background This study intended to investigate irisin levels in bladder cancer patients and healthy controls. Objective Our aim was to evaluate if serum irisin could be used as a diagnostic tool in bladder cancer and further, if it could differentiate muscle-invasive and non-muscle-invasive bladder cancer patients. Methods In this study, 90 primary bladder cancer patients in addition to 30 age-matched healthy individuals for the control group were prospectively included. Bladder cancer patients were divided into two subgroups as non-muscle-invasive (60 patients) and muscle-invasive (30 patients). Blood samples were obtained before the diagnosis of the disease. Serum irisin levels were measured using ELISA. Demographic data as well as tumor grade and stage were noted. Results Mean serum irisin level was significantly lower in the bladder cancer patients compared to the control group (4.53 +/- 2.55 vs. 16.5 +/- 5.67, p < 0.001). Also, serum irisin level was statistically lower in the muscle-invasive bladder cancer group compared to the non-muscle-invasive counterparts (3.19 +/- 1.47 vs. 5.18 +/- 2.73, p < 0.001). Serum irisin could differentiate bladder cancer patients from healthy individuals with a sensitivity of 86.2% and a specificity of 89.7% at a cut-off value of 8.689 (AUC = 0.859). Moreover, to discriminate between NMIBC and MIBC, the sensitivity was 75% and the specificity was 73.7% at a cut-off value of 3.97 (AUC = 0.732). Conclusion Our results showed that serum irisin levels can be used for the diagnosis of bladder cancer. Also, it can help distinguish high-grade and stage tumor.