Browsing by Author "Dulger, H"

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Antithyroid Antibody Levels in Patients With Breast Cancer
(Amer Assoc Clinical Chemistry, 2004) Sekeroglu, MR; Dulger, H; Alici, S; Algun, E; Noyan, T
Effect of Glucose Concentration on Peritoneal Inflammatory Cytokines in Continuous Ambulatory Peritoneal Dialysis Patients
(Hindawi Ltd, 2004) Sayarlioglu, H; Topal, C; Sayarlioglu, M; Dulger, H; Dogan, E; Erkoc, R
OBJECTIVE : It is known that glucose concentrations of peritoneal dialysis solutions are detrimental to the peritoneal membrane. In order to determine the effect of glucose concentration on cytokine levels of peritoneal fluid of continuous ambulatory peritoneal dialysis (CAPD) patients, a cross-sectional study was performed. Methods: Nine non-diabetic CAPD patients participated in two 8-h dwell sessions of overnight exchanges in consecutive days, with 1.36% and 3.86% glucose containing peritoneal dialysis solutions (Baxter - Eczacibasi). Peritoneal dialysis fluid tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 levels were measured. Results: TNF-alpha levels after 1.36% and 3.86% glucose used dwells were 23 +/- 14 pg/ml and 28 +/- 4 pg/ml, respectively (p = 0.78). The IL-6 levels were 106 +/- 57 pg/ml and 115 +/- 63 pg/ ml ( p = 0.81), respectively. Conclusion: In our in vivo study we found that the glucose concentration of the conventional lactate-based CAPD solution has no effect on basal IL-6 and TNF-alpha levels of peritoneal fluid. Further in vivo studies with non-lactate-based CAPD solutions are needed in order to determine the effect of glucose concentration per se on cytokine release.
Effects of Scorpion Envenomation on Blood Constituents in Rats
(indian veterinary Journal, 2004) Sahin, A; Ozbek, H; Dulger, H; Ozturk, G; Dagoglu, G
The Effects of Short Term (3 Weeks) Testosterone Treatment on Serum Inflammatory Markers in Men Undergoing Coronary Artery Stenting
(Elsevier Ireland Ltd, 2006) Guler, N; Batyraliev, T; Dulger, H; Ozkara, C; Tuncer, M; Aslan, S; Agirbasli, M
Objective: Inflammation markers can predict restenosis after successful intracoronary stenting. There is evidence that testosterone suppresses the expression of the inflammatory cytokines. We hypothesized that testosterone therapy after coronary stenting can reduce the inflammation markers. Methods: We selected 41 men with coronary artery disease who underwent successful stent implantation for a > 70% diameter stenosis of a major coronary artery. Patients, who had stable angina and positive exercise test results, were recruited after diagnostic coronary angiography. Twenty-five men were treated with 3 doses of i.m. testosterone administration once a week for 3 weeks following diagnostic angiography. Sixteen patients were recruited as a control group and they received standard therapy. First venous blood samples were obtained after angiography. Stents were implanted 3 weeks after diagnostic angiography. Second venous blood samples were taken 24 h after the coronary stenting. Results: Baseline biochemical or hematological parameters were similar between the control and treatment groups. After coronary stenting, free testosterone, total testosterone, and sex hormone binding globulin were significantly elevated in the testosterone group (P < 0.0001, P < 0.0001 and P=0.02; respectively). After coronary stent implantation, there was a significant increase in IL-6 and CRP levels in the control group only (P=0.02 and P=0.038), while TNF-alpha levels were increased significantly in both groups (P=0.016 and P=0.014; respectively). Statistical analysis revealed that testosterone treatment prior to stent implantation attenuated IL-6 and hs-CRP levels significantly (P=0.042 and P=0.043; respectively). Conclusions: The present study shows that 3 weeks testosterone treatment prior to intracoronary stenting results in a significant suppression in hs-CPP and IL-6 levels after the stent implantation. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
Evaluation of Antioxidant Status in Children With Acute Bacterial Meningitis and Encephalitis
(Taylor & Francis Ltd, 2003) Çaksen, H; Dede, S; Cemek, M; Dulger, H; Cemek, F
Antioxidant status was investigated in children with acute bacterial meningitis and encephalitis to investigate the possible role of free radicals in children with meningitis and encephalitis. Our study included 16 children with acute bacterial meningitis, 13 with encephalitis, and 17 control subjects. Serum ceruloplasmin, uric acid, albumin, bilirubin superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPx) levels were studied in all subjects within 6 h of admission. There was a statistically significant difference between the groups for all parameters except for serum uric acid. All antioxidant activities except for albumin level were increased in the study groups. Albumin level was higher in the control group than those of meningitis and encephalitis groups. When the values of meningitis and encephalitis were compared, there was a statistically significant difference between the groups for serum SOD, GPx, ceruloplasmin, and albumin. In conclusion, our study showed that serum SOD, GPx, catalase, and ceruloplasmin were higher in children with acute bacterial meningitis and serum SOD, GPx, catalase, ceruloplasmin, and total bilirubin levels were increased in children with encephalitis. These findings suggest that antioxidant status was almost similar in both acute bacterial meningitis and encephalitis conditions in childhood.
Lipid Peroxidation and Antioxidant Status in Children With Acute Purulent Meningitis and Encephalitis
(Taylor & Francis Ltd, 2004) Çaksen, H; Cemek, M; Dede, S; Dulger, H; Cemek, F
In this study, lipid peroxidation and antioxidant status were investigated in children with acute bacterial meningitis and encephalitis. The aim was to determine whether there was a possible role of free radicals in meningitis and encephalitis in childhood. Our study included 16 children with acute bacterial meningitis, 13 with encephalitis, and 17 control subjects. Serum malondialdehyde (MDA), reduced glutathione (GSH), vitamin C, vitamin E, beta-carotene, and retinol levels were studied in all subjects within 6 h of admission. There was a statistically significant difference for serum MDA, GSH, and vitamin C between the groups. Serum MDA and vitamin C levels were higher, and serum GSH levels were lower in the study groups compared to the control group. Vitamin C levels were similar in both the encephalitis and control groups, but they were significantly lower in the children with encephalitis than the meningitis group. In conclusion, our study showed that serum MDA and GSH levels were affected in children with both meningitis and encephalitis, but vitamin C level was affected only in children with meningitis. Serum vitamin E, beta-carotene, and retinol levels were not changed in childhood meningitis and encephalitis.
Nightmares and Serum Cholesterol Level: a Preliminary Report
(Canadian Psychiatric Assoc, 2005) Agargun, MY; Gulec, M; Cilli, AS; Kara, H; Sekeroglu, R; Dulger, H; Inci, R
Objective: To examine whether there is a relation between nightmares and serum lipid levels. Methods: Fifteen subjects who met DSM-IV criteria for the diagnosis of nightmare disorder and 15 healthy control subjects participated in the study. We used an enzymatic colorimetric method for cholesterol and triglyceride determination. We measured high-density lipoprotien (HDL) cholesterol using the direct HDL-cliolesterot method. Low-density lipoprotein (LDL) was calculated according to the Friedewald formula. Results: Patients with nightmare disorder had. lower serum triglyceride, lower total cholesterol, and lower LDL levels than healthy control Subjects. Conclusion: These findings suggest that nightmares are associated with low serum lipid levels.