Browsing by Author "Dundar, Serkan"

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Association Between CRP Levels in Systemic Circulation and Peri-Implant Bone Loss
(Quintessence Publishing Co inc, 2025) Casir, Metin; Altindal, Dicle; Talmac, Ahmet Cemil; Dundar, Serkan; Ertugrul, Abdullah Seckin
Objective: The aim of this retrospective study was to evaluate the effects of high preoperative C-reactive protein (CRP) levels on early peri-implant alveolar bone loss. Method and materials: Fifty-eight implants in 20 patients with high preoperative CRP levels and 54 implants in 20 patients with low preoperative CRP levels were evaluated. For measurement of the peri-implant alveolar bone loss, the implant platform was accepted as the reference point. On both the mesial and distal sides, the vertical distances between the reference point and the first visible bone's highest coronal level were measured. Numerical data were compared between groups using the independent sample t test or the Mann-Whitney U test. Correlations between variables were investigated with the Spearman rho test. Results: The mean CRP level of the low CRP group was 0.37 +/- 0.21 mg/L, while that of the high CRP group was 1.71 +/- 0.60 mg/L. In the high CRP group, implant failure was observed in two patients. The mesial bone loss and distal bone loss values in the group with high CRP levels were found to be significantly higher than the group with low CRP levels (P < .05). There was a significant positive correlation between the CRP levels, and distal bone loss and mesial bone loss measurements. Conclusion: The results show that high preoperative CRP levels result in an increased risk for peri-implant alveolar bone loss, and suggest that preoperative CRP levels can be important for early peri-implant alveolar bone loss.
An Experimental Investigation of the Effects of Chronic Stress on Bone-To Contact
(Korean Acad Oral & Maxillofacial Surgery, 2019) Dundar, Serkan; Bozoglan, Alihan; Yaman, Ferhan; Kirtay, Mustafa; Bulmus, Ozgur; Aydinyurt, Hacer Sahin; Yanen, Cenk
Objectives: This study aimed to investigate the effects of chronic restraint stress on the osseointegration of titanium implants. Materials and Methods: Twenty adult male Wistar albino rats were used in the study. After surgical insertion of titanium implants into the metaphyseal part of the tibial bone, rats were randomly divided into two groups: a control group (CNT group) and an experimental restraint stress group (RS group). In the CNT group, titanium implants were inserted surgically, and rats received no further treatment during the 47-day experimental period. In the RS group, restraint stress was applied for 3 hours per day for 45 days, beginning 2 days after implant surgery. Weight of the rats was measured prior to surgery and at the end of the study to analyze the effects of stress. At the end of the experimental period, rats were euthanized, and implants and surrounding bone tissues were used for undecalcified histological analysis. Serum cortisol levels were assessed in cardiac blood samples from the rats following centrifugation. Results: Average weight of rats in the RS group was lower than that of rats in the CNT group after the experimental protocol had been completed (P<0.05). Further, serum cortisol levels were higher in the RS group than in the CNT group (P<0.05). There were no significant differences in bone-implant connection levels between the two groups (P>0.05). Conclusion: The data analyzed in this study suggest that chronic restraint stress did not adversely affect rats during a 45-day osseointegration period.