Browsing by Author "Durak, H."

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Brain Scintigraphy in Brain Death: the Experience of Nuclear Medicine Department in Dokuz Eylul University, School of Medicine
(Yuzuncu Yil Universitesi Tip Fakultesi, 2014) Sürücü, E.; Aslan, M.; Demir, Y.; Durak, H.
We investigated the propriety between the findings of brain death scintigraphy and the patient outcomes after the scan. We figured out the benefits of scintigraphic findings to the diagnosis. This study was performed in our department between 2006-2011 and patients were evaluated retrospectively. Pre-diagnosis of brain death and final diagnosis were compared. 24 patients were referred to our nuclear medicine department between 2006-2011. All patients underwent brain scintigraphy following IV injection of 20 mCi of Tc 99m DTPA or 10 mCi Tc 99m HMPAO with one-second dynamic images in 128x128 matrix for a period of 60 seconds. Anterior, posterior, right and left lateral static images were obtained with 5-minute in 256x256 matrix after dynamic images. Patients were referred by the departments of internal medicine intensive care and anaesthesiology intensive care. No blood flow into the middle, anterior and posterior cerebral arteries and no activity in the venous sinuses were accepted as showing the brain death. 22 of 24 patients were reported that findings in brain scan were consistent with brain death as in the prediagnosis. Brain death was not reported in two patients with Tc-99m HMPAO scan and brain death was suspicious in one patient with Tc-99m DTPA scan. Two patients with Tc-99m HMPAO scan were died two weeks after the brain scan and the patient with Tc-99m DTPA was died one day after the brain scan. Brain scintigraphy is a non-invasive procedure supporting the clinical diagnosis and it can be also easily performed and can exclude the negative and suspicious patients. © 2014, Yuzuncu Yil Universitesi Tip Fakultesi, Universitas Indonesia. All rights reserved.
Multiple Leiomyosarcoma Foci in 18f-Fdg Pet-Ct
(Elsevier Doyma Sl, 2013) Surucu, E.; Aslan, M.; Karahan, P.; Durak, H.
Paleomagnetic Constraints on the Early Miocene Closure of the Southern Neo-Tethys (Van Region; East Anatolia): Inferences for the Timing of Eurasia-Arabia Collision
(Elsevier B.V., 2020) Gülyüz, E.; Durak, H.; Özkaptan, M.; Krijgsman, W.
Oligocene-Miocene convergence of the Eurasian and Arabian plates resulted in (i) the gradual closure of the Neo-Tethys Ocean that formed an open marine connection between the Indian Ocean and the proto-Mediterranean until the early Miocene and (ii) Eurasia-Arabia continental collision. Remnants of the Neo-Tethys basin are found scattered over eastern Anatolia. The Van region of SE Anatolia contains a unique stratigraphic succession (Van Formation) of this ancient marine corridor, showing a gradual transition from deep-marine marls to continental clastics and shallow marine deposits. This formation is considered a key unit for the late stage evolution of the Neo-Tethys Ocean as it contains one of the youngest marine deposits of the southern Neo-Tethys branch in SE Anatolia. Here, we present new magnetostratigraphic and Anisotropy of Magnetic Susceptibility (AMS) data to better constrain the timing of the marine-continental transition and the style of deformation in the Van region. The Van Formation was sampled in ~2-m stratigraphic resolution, with ~350 paleomagnetic cores drilled in stratigraphic order. These cores were analyzed with thermal and alternating field demagnetization, resulting in a magnetic polarity pattern that could straightforwardly be correlated to the standard Geomagnetic Polarity Time Scale (GPTS). The base of the section has an age of ~19.5 Ma, the marine-continental transition is dated at 18.8 Ma, and the top of the succession has an age of ~16.8 Ma. The AMS data show a conspicuous change from extensional to contractional patterns, coinciding with the end of open marine environments, at an age of ~19 Ma. We hypothesize that the closure of the marine basin and the concomitant change in stress regime in the Van region are related to the onset of Eurasia-Arabia collision and the terminal subduction of the Neo-Tethys oceanic lithosphere. © 2019 Elsevier B.V.
The Value of F-18 Fdg Pet/Ct for Detecting Primary Foci in the Metastatic Cancer of Unknown Primary Origin
(Yuzuncu Yil Universitesi Tip Fakultesi, 2014) Sürücü, E.; Aşcıoğlu, M.Ş.; Şengöz, T.; Demir, Y.; Durak, H.
Cancers of unknown primary origin (CUP) have poor prognosis and the median survival for patients with CUP is approximately 1 year. This survival can be extended by the identification of the primary origin and treating with specific therapy. F-18 FDG PET/CT scans of 75 patients (39 female, 36 male, mean age 60 ±12) with CUP referred to our clinic between January 2009 and January 2011 were evaluated retrospectively. Whole body images were obtained 60 minutes after the injection of approximately 370 MBq (10 mCi) F-18 FDG by PET/CT (Gemini-TOF-Philips). Emission scans were obtained for 1.5 min per bed position and transmission scans were obtained with low dose CT using 50 mA and 120 kvp. The tumor was identified histopathologically in 58 of 75 patients. 4 of 58 patients were treated as CUP. 17 of 75 patients could not be followed, so final diagnosis could not be made. In 54 patients, the primary was identified as 17 lung, 8 colorectal, 7 breast, 3 stomach, 3 pancreas, 2 endometrial, 2 nasopharynx, 2 gallbladder cancers, 2 lymphoma, 2 peritoneum, 1 maxillary sinus, 1 salivary gland carcinoma, 1 brain tumor, 1 leiomyosarcoma, 1 ovary cancer and 1 multiple myeloma. If reports are considered, F-18 FDG PET/CT helped to detect primary origin in 65% of these 58 patients, 38 of 54 primary sites were true positive (70%). There were 6 false positive sites (10.3%), 16 false negative (27.5%) results in F-18 FDG PET/CT. After the retrospective evaluation of the false negative patients, we have realized that primary sites were ignored in 5 of 14 patients, so actually F-18 FDG PET/CT helped in 74% of the patients showing 43 of 54 primary sites (80%). In first evaluation, F-18 FDG PET/CT missed 2 breast cancers, 1 lymphoma, 1 colon cancer and 1 intra maxillary sinus cancer. F-18 FDG PET/CT is an important imaging tool for detecting primary origin in the patients with CUP. F-18 FDG PET/CT helped in 74% of the patients showing the primary sites. In the patients with CUP, lung, breast, colon and the physiologic uptake areas should be scrutinized carefully for any tumor location. © 2014, Yuzuncu Yil Universitesi Tip Fakultesi, Universitas Indonesia. All rights reserved.