Browsing by Author "Duran, Latif"

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Serum Paraoxonase and Arylesterase Activities and Oxidative Stress Levels in Patients With Ssri Intoxication
(Springer, 2014) Kati, Celal; Karadas, Sevdegul; Aslan, Mehmet; Gonullu, Hayriye; Duran, Latif; Demir, Halit
Oxidative stress is a critical route of damage in various psychological stress-induced disorders, such as depression. Paraoxonase-1 (PON1) plays an important role as an endogenous free-radical scavenging molecule. The aim of this study was to evaluate the influence of serum PON1 activity and oxidative stress in patients with selective serotonin reuptake inhibitor (SSRI) intoxication. A total of 11 patients with SSRI intoxication and 20 healthy controls were enrolled. The serum total antioxidant capacity (TAC) and malondialdehyde (MDA) levels, as well as the paraoxonase and arylesterase activities, were measured spectrophotometrically. The serum TAC levels and the paraoxonase and arylesterase activities were significantly lower (for all, p < 0.001), whereas the serum MDA levels were significantly higher in the patients with SSRI intoxication than in the controls (p < 0.001). These results indicated that decreased PON1 activity and increased oxidative stress represent alternative mechanisms in SSRI toxicity. More studies are needed to elucidate the role of PON1 activity in the etiology of SSRI intoxication.
Serum Prolidase Enzyme Activity and Oxidative Stress Levels in Patients With Acute Hemorrhagic Stroke
(Taylor & Francis Ltd, 2014) Gonullu, Hayriye; Aslan, Mehmet; Karadas, Sevdegul; Kati, Celal; Duran, Latif; Milanlioglu, Aysel; Demir, Halit
Background. It has been indicated that oxidative damage contributes to secondary brain injury in both ischemic and hemorrhagic stroke patients. Collagen is a major component of the extracellular matrix, and prolidase plays a role in collagen synthesis. The aim of this study was to evaluate the serum prolidase activity, nitric oxide (NO) levels, total antioxidant capacity (TAC) and total oxidant status (TOS) in patients with acute hemorrhagic stroke. Methods. Twenty-five patients with acute hemorrhagic stroke and 25 controls were enrolled. Serum prolidase activity, catalase activity, NO levels, TAC and TOS were measured spectrophotometrically. Oxidative stress index (OSI) was calculated. Results. Serum TAC levels and catalase activity were significantly lower in acute hemorrhagic stroke patients than controls (both, p < 0.001), while NO levels, TOS levels, OSI values and prolidase activity were significantly higher (all, p < 0.01). When patients with acute hemorrhagic stroke were divided according to gender, no differences were observed between females and males in respect to serum prolidase enzyme activity, NO levels, TAC levels, TOS levels and OSI values (all, p > 0.05). Conclusions. Findings from the study suggest an association between increased oxidative stress levels, decreased antioxidant levels and increased prolidase enzyme activity in patients with acute hemorrhagic stroke compared with controls. More studies are needed to elucidate mechanistic pathways on oxidative stress in patients with acute hemorrhagic stroke.
Türkiye’nin Dört Büyük İlinde Trafik Kazalarına Karışan veya Alkol Şüphesi Bulunan Sürücülerin Yol Kenarı Kontrollerinde Kandaki Alkol Konsantrasyonlarının Değerlendirilmesi
(2022) Karabağ, Gökmen; Duran, Latif; Sever, Demet; Asirdizer, Mahmut; Can, Hale Nur; Dursun, Recep; Arıca, Enes
Amaç: Önceki çalışmalar, alkollü araç kullanma ve/veya uyuşturucu etkisi altında araç kullanma (AUAK) ile trafik kazalarında artan ölüm ve yaralanma riski arasında bir ilişki olduğunu ortaya koymuştur. Bu çalışmanın amacı, Türkiye’nin dört büyük şehrinde trafik kazası geçirdikten sonra veya yol kenarı trafik kontrolünde alkollü olduğu şüphesi bulunan sürücülerin kanlarındaki alkol konsantrasyonlarının (BAC) araştırılmasıdır. Yöntem: Bu çalışmada, Türkiye’nin dört büyük ilindeki (Van, Manisa, Diyarbakır ve Samsun) üniversite hastanelerinde sürücülerin beş yıllık (1 Ocak 2015 - 31 Aralık 2019 tarihleri arasında) BAC için laboratuar kayıtlarını geriye dönük olarak inceledik. Bulgular: Üç yüz kırk iki olguda (%7,1) BAC’ler eşik değerin (0,01 g/100 mL) üzerindeydi. Alkol tayini için gönderilen olguların %11,3’ü kadın, %88,7’si erkek olup, yaş ortalaması 35,3±13,1’dir. Üç yüz kırk iki alkol pozitif olguda, olguların %58,8’inde BAC’ler %0,101’in üzerindeydi. Olguların BAC pozitifliği Manisa’da %9,4, Van’da %6,3, Samsun’da %5,3 ve Diyarbakır’da %5 idi. Kadınların %4,4’ünde (n=24) ve erkeklerin %7,4’ünde (n=318) BAC pozitif bulundu (p<0,05). Sonuç: Bu çalışma, bu alandaki sınırlı sayıdaki çok merkezli çalışmalardan biridir; çalışmada trafikte alkollü araç kullanmaya sıfır tolerans gösterilmesi, cezaların caydırıcılığının artırılması ve yol kenarı tarama testlerinin daha yaygın olarak kullanılması gerektiği sonucuna varılmıştır.
The Value of Electroencephalography in Differential Diagnosis of Altered Mental Status in Emergency Departments
(Pakistan Medical Assoc, 2014) Duran, Latif; Balci, Kemal; Yardan, Turker; Kati, Celal; Akdemir, Hizir Ufuk; Karadas, Sevdegul; Altuntas, Mehmet
Objective To evaluate the value of electroencephalography in patients with altered mental status in emergency departments Methods Demographical characteristics types and aetiologies of seizures and clinical outcomes of the patients were recorded Patients were divided into 4 groups according to the complaints of admission findings and symptoms of seizure stroke and symptoms of stroke related seizures syncope and metabolic abnormalities and other causes of altered mental status The electroencephalography findings were classified into 3 groups epileptiform discharges paroxysmal electroencephalography abnormalities and background slowing Electroencephalography abnormalities in each subgroup were evaluated SPSS 21 was used for statistical analysis Results Of the total 190 patients in the study 117(61 6%) had pathological electroencephalography findings The main reason for electroencephalography in the emergency department was the presence of seizure findings and symptoms in 98(51 6%) patients The ratio of electroencephalography abnormality was higher in patients who were admitted with complaints of metabolic abnormality related consciousness disturbances (p<0 001) A total of 124(65 3%) patients had neuroimagings Electroencephalography abnormalities were found to be significantly higher in patients with neuroimagings compared to those without neuroimagings (p<0 003) Conclusion Despite advanced neuroimaging techniques electroencephalography is still an important tool in the differential diagnosis of altered mental status such as epileptic seizures metabolic abnormalities pseudo seizures and syncope