Browsing by Author "Duran, Memet"

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Erythrocyte Catalase and Carbonic Anhydrase Activities in Lung Cancer
(Asian Pacific Organization Cancer Prevention, 2010) Cobanoglu, Ufuk; Demir, Halit; Duran, Memet; Sehitogullari, Abidin; Mergan, Duygu; Demir, Canan
Aim: To study the relationship between the pathogenesis of lung cancer and antioxidant status and acidic media by measuring the activities of erythrocyte catalase (CAT) and carbonic anhydrase (CA). Methods: A total of 26 patients with lung cancer and 15 healthy individuals were included in the study. The CAT and CA activities of erythrocytes were defined. The catalase (CAT) activity of erythrocytes was measured using Aebi's method. Carbonic anhydrase (CA) activity was analyzed by CO2 hydration. Results: It was found that erythrocyte CA and CAT activities were significantly lower in patients with lung cancer compared to controls (p<0.05). Of the 26 patients with lung cancer, seven (26.9%) had metastasis, and the CA and CAT levels in patients with metastasis were significantly decreased (p=0,0001). Conclusions: Development of oxidative stress due to lung cancer may be related to the balance between prooxidant and antioxidant reactions. Catalase may have a preventive effect for malignant lung cancers and the gene of the antioxidant enzymes may be one of the anti-oncogenes, and inactivation of one of these genes in the process of carcinogenesis may lead to tumor development. This may be an explanation for the very low levels of antioxidant CAT in patients with lung cancer compared to healthy individuals. Carbonic anhydrase (CA) in tumor cells may be an indicator of the acid-base balance in lung cancer. Decreased levels of CA in patients with lung cancer may provide a convenient media for tumor development, growth and metastasis by creating an acidic media.
Some Mineral, Trace Element and Heavy Metal Concentrations in Lung Cancer
(Asian Pacific Organization Cancer Prevention, 2010) Cobanoglu, Ufuk; Demir, Halit; Sayir, Fuat; Duran, Memet; Mergan, Duygu
Objective: We aimed to determine the relationship between some mineral, trace element and heavy metal levels in the patients of lung cancer by measuring serum levels of copper (Cu), lead (Pb), zinc (Zn), iron (Fe), cobalt (Co), cadmium (Cd), manganese (Mn), magnesium (Mg). Methods: A total of 50 lung cancer and human health (30 lung cancer and 20 healthy human) were included in the study. Venous blood samples of each lung cancer were obtained, and serum Cu, Pb, Zn, Fe, Cd, Co, Mn, Mg levels were analysed by Atomic Absorption Spectrophotometer measurements. Results: Mg value measured in lung cancer group were lower than the control group and this was statistically significant (P<0.01). Serum Cu level was significantly lower with lung cancer compared to healthy human (P<0.01). Pb level was significantly higher than those of controls (P<0.01). The serum Zn level was significantly lower in serum of lung cancer group than controls (P<0.01). Serum Mn and Co levels were found increased in lung cancer group than controls (P<0.01). Cd value was higher in lung cancer but it was not statistically significant (p>0.01). The mean concentration of Fe in the serum of lung cancer patients was higher than in the controls, but the difference was not significant (p>0.01). There was a positive correlation between Cd and Pb level, and between Mn and Fe levels in lung cancer. There was a negative correlation between Co and Zn levels of healthy human. There was a negative correlation between Co and Mg levels of lung cancer. Conclusions: Serum Cu, Pb, Zn, Fe, Mg, Co, Mn and Cd might be play a role in the patients of lung cancers. Zn may protective as potent lung cancer. In addition, it is suggested that low levels of zinc can induce the pathogenesis of lung cancer.
The Patients Were Followed With Lung Cancer in Our Clinic, for the Evaluation of Clinical, Radiological, Epidemiological and Complementary Therapies
(2012) Duran, Memet; Özbay, Bülent
2008-2012 yılları arasında akciğer kanseri tanısıyla kliniğimizde takipli 14 hastanın klinik, epidemiyolojik özellikleri, tedavileri ve ortalama sürveyleri incelendi. Hastaların 9'u erkek (%64), 5'i kadın (%35), yaş ortalaması 60±11,9 idi. Olguların %78,5'i aktif sigara içicisiydi. Hastaların %42,8 küçük hücreli, %21,4 squamöz hücreli, %28,5 adenokarsinom ve %7,1 küçük hücreli (KHK) ve squamöz hücreli metakron akciğer kanseri olduğu görüldü. Erkeklerde KHK, kadınlarda adenokanserin ensık olduğu saptandı. Küçük hücreli dışı kanser olgularının ortalama sürveyi:12.5 ay idi. Hastalardan; radyoterapi alanların 12.2 ay, kemoterapi alanların 13 ay ve ek olarak alternatif tedavi kullananların ortalama surveyi 13.9 ay idi. KHK sınırlı hastalık grubunun ortalama surveyi 36,2 ay iken alternatif tedavi kullananların 40,6 ay idi. KHK yaygın hastalıkta alternatif tedavi kullanım sıklığı %100 ve ortalama survey 21 ay idi. Sonuç olarak bölgemizde bayan akciğer kanseri vakalarının (özellikle adenokanser) arttığını ve bu vakaların %100'ünün biomassa maruz kaldıklarını saptadık. Hastaların (özellikle KHK) ortalama sürveylerinin daha uzun ve alternatif tedavi kullanımının ülkemizdeki diğer bölgelere ve batılı ülkelere göre çok daha fazla oranda olduğunu saptadık.