Browsing by Author "Duzenli, Ufuk"

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Alterations in Oxidative Stress Markers in Laryngeal Carcinoma Patients
(Lippincott Williams & Wilkins, 2018) Bozan, Nazim; Demir, Halit; Gursoy, Tulay; Ozkan, Huseyin; Duzenli, Ufuk; Sankaya, Eren; Cankaya, Hakan
Background: Data describing how laryngeal cancer affects oxidative stress markers and antioxidants are limited. This study investigated serum antioxidant enzyme activities and oxidative stress markers before and after laryngectomies in patients with laryngeal cancer. Methods: A total of 29 patients with laryngeal cancer and 25 healthy control subjects were enrolled. Serum malondialdehyde (MDA) levels and superoxide dismutase (SOD), glutathione peroxidase (GSHPx), catalase (CAT), paraoxonase (PON), and arylesterase activities were measured spectrophotometrically. Blood samples were obtained from each patient just before surgery and 1 month after a laryngectomy. Results: The serum PON, arylesterase, CAT, SOD, and GSHPx activities were significantly decreased (all p < 0.001) and serum MDA levels were significantly increased (p < 0.001) in patients with laryngeal cancer, compared with control subjects. In laryngeal cancer patients, the serum GSHPx and arylesterase activity levels increased significantly following laryngectomies (both p < 0.001), whereas the MDA levels decreased significantly (p = 0.007). Conclusion: In patients with laryngeal cancer, the oxidant/antioxidant balance shifted toward oxidative stress. In addition, following laryngectomies, laryngeal cancer patients had increases in serum antioxidant enzyme activities and decreases in oxidative stress markers. Copyright (C) 2018, the Chinese Medical Association. Published by Elsevier Taiwan LLC.
Assessment of Vertical Triangular Spreader Graft Technique for Reconstruction of Middle Vault and Internal Nasal Valve Angle
(Lippincott Williams & Wilkins, 2018) Kocak, Omer Faruk; Duzenli, Ufuk
Background: Rhinoplasty is a surgical procedure to smooth out the nasal deformities and to fix nasal breathing problems. Spreader grafts and flaps are used to prevent some complications such as middle vault collapse, narrowing the internal nasal valve and inverted V deformity. To obtain more stable middle vault, spreader grafts and flaps could be used together. Many researchers have tried different graft and flap techniques to reach more successful aesthetic and functional results. In this research, we investigated effects of triangular graft on the internal nasal valve angle, nasal breathing, and aesthetic outcomes when it used together with sprader flap. Methods: In this prospective study, 3 different groups were formed as: the spreader flap group (group 1); the spreader flap with the rectangular spreader graft group (group 2); and the spreader flap with the triangular spreader graft group (group 3). Preoperative nasal obstruction symptom evaluation (NOSE) scale was used to evaluate nasal breathing and visual analog scale (VAS) was used to evaluate aesthetic appearance. And also, measurement of the internal nasal valve angle was performed for each patients. These evaluations were repeated at postoperative 3rd month. Preoperative and postoperative comparisons between study groups were performed. Results: There were 12 patients in group 1, 14 patients in group 2, and 10 patients in group 3. In each group, statistically significant decrease in NOSE scores (P< 0.05) and statistical significant increase in VAS scores (P< 0.05) were observed. And also, increased internal nasal valve angle after surgery was detected in all groups (P< 0.05). Postoperative NOSE and VAS scores were found similar in 3 different groups (P> 0.05). On the contrary, the internal nasal valve angles were found statistically significant increased in group 3 according to other groups (P< 0.05). Conclusion: The results of this prospective study presented that the use of triangular spreader graft with spreader flap was an appropriate technique to obtain successful aesthetic and functional outcomes with widening the internal nasal valve angle.
The Effect of Nitrous Oxide on the Outcomes of Underlay Tympanoplasty: a Prospective Study
(Sage Publications inc, 2019) Duzenli, Ufuk; Bozan, Nazim; Turan, Mahfuz; Agirbas, Semra; Tekeli, Arzu Esen; Kiroglu, Ahmet Faruk
The main aims of tympanoplasty are eradication of chronic middle ear disease, repair of the tympanic membrane, and restoration of hearing. Nitrous oxide (N2O) is not a commonly preferred anesthetic agent for tympanoplasty because this agent may increase middle ear pressure and displace the graft. In this study, we researched the surgical outcomes of the underlay tympanoplasty performed with N2O anesthesia. Patients who underwent tympanoplasty were included in this prospective study. A type 1 tympanoplasty was performed in all patients using the underlay technique. Patients were randomized to groups that did and did not receive N2O. Preoperative and postoperative hearing thresholds were evaluated, postoperative pain scores were recorded, and the differences between the groups were statistically evaluated. There were 44 patients who received N2O and 44 who did not. The graft success rate was 93.2% in the N2O-receiving group and 84.1% in the nonreceiving group (P > .05). Hearing levels improved significantly after surgery in each group (P < .05), but the difference between the groups was not significant (P > .05). The postoperative pain score was 3.72 +/- 1.3 in the N2O-receiving group and 4.45 +/- 2.3 in the nonreceiving group (P > .05). Nitrous oxide is a cheap, safe, and readily available anesthetic agent that provides acceptable success rates in patients undergoing tympanoplasty.
The Effect of Perioperative Iv Corticosteroids on Hearing Outcome Following Stapedotomy
(deomed Publ, Istanbul, 2018) Celik, Cagri; Ceylan, Mehmet Emrah; Aliyeva, Aynur; Duzenli, Ufuk; Dalgic, Abdullah
Objective: The purpose of this study is to investigate the effect of steroids on postoperative hearing outcome in patients with a clinical diagnosis of otosclerosis, who received intraoperative steroid treatment during surgery for conductive-type hearing loss. Methods: Between January 2014 and January 2017, 106 patients, comprising 43 men (40.6%) and 63 women (59.4%) between the ages of 18-64 (mean age: 44.1 +/- 11.5 years), who had been diagnosed with otosclerosis resulting in conductive-type hearing loss, were included in the study. The audiometric values obtained for patients who had received intraoperative intravenous steroids were analysed on a retrospective basis by comparing the pre- and post-operative situation. The group of all patients was then subdivided into two groups on the basis of whether or not they had received intraoperative steroids. These groups were then evaluated in terms of pre- and post-operative bone and air conduction levels and the differences investigated statistically. Results: Postoperative bone conduction averages for all the patients in both Group 1 and Group 2 were significantly improved at all frequencies, except at 4000 Hz, compared to the preoperative mean value. However, there was no statistically significant difference observed between patients who did receive intra-operative single-dose IV corticosteroid injections and patients who did not receive IV corticosteroid injections group in terms of preoperative and postoperative air-bone conduction levels. Conclusion: It is not necessary routinely to administer systemic corticosteroids in order to prevent perioperative sensorineural hearing loss during surgery for otosclerosis. However, perioperative corticosteroids may be helpful in preventing sensorineural hearing loss when there are conditions present that can lead to inner ear damage during the operation.
Effect of Silver Nitrate Application on the Success of Endoscopic Dacryocystorhinostomy
(Sage Publications inc, 2022) Cetin, Yaser S.; Akin, Ramazan; Duzenli, Ufuk; Turan, Mahfuz; Bozan, Nazim
Objectives To compare the clinical outcomes of patients undergoing additional procedures in endoscopic endonasal dacryocystorhinostomy (End-DCR) surgery and discuss the factors affecting the success of End-DCR surgery in light of relevant literature. Methods The study included 155 patients who underwent End-DCR surgery in our clinic due to epiphora. This was a prospective randomized, single-blind, controlled trial. Group I (control) included 54 patients who did not undergo silicone stent insertion or silver nitrate application, group II included 51 patients who underwent silicone stent insertion only, and group III included 50 patients who underwent silver nitrate application only. Statistical analysis was performed on follow-up data regarding anatomic and functional success rates. Results Revision surgery was performed in 16 patients who developed persistent epiphora in the postoperative period, including 6 in group I, 7 in group II, and 3 in group III (P = .4). The most common reason for revision surgery was stenosis of the neo-ostium (n = 8), followed by granulation tissue formation (n = 5) and synechia formation (n = 3). Granuloma formation was the most common postoperative complication, and a significant difference was found among the groups with regard to granuloma formation (P = .04). At postoperative month 12, the functional success rate was estimated to be 88%, 86%, and 94%, and the anatomic success rate was estimated to be 94%, 92%, and 96% in groups I, II, and III, respectively, with no significant difference, found among the 3 groups with regard to both rates (P = .79 and P = .76, respectively). Conclusion The results indicated that stenting and silver nitrate application did not affect surgical success. Our preliminary results on silver nitrate cauterization showed that it is an effective, inexpensive, and practical method to reduce granulation formation in the postoperative period.
Evaluation of the Relationship Between Nasal Septum Deviation and Oxidative Stress Markers
(Lippincott Williams & Wilkins, 2019) Duzenli, Ufuk; Bozan, Nazim; Sonkaya, Yasin; Cetin, Yaser Said; Demir, Halit
Introduction: Nasal septum deviation (NSD) may lead to chronic hypoxia and increased oxidative stress. The main goal of this study was to investigate the effect of NSD on malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), and glutathione (GSH) levels. Methods: There were 30 patients with NSD and 30 healthy subjects in this study. Malondialdehyde, CAT, SOD, and GSH levels were determined in the control and study groups. The measurements were done preoperatively and postoperatively. Study group patients completed the Nasal Obstruction Symptom Evaluation questionnaire preoperatively and postoperatively to determine the success of the septoplasty. Results: Higher CAT, SOD, and GSH levels and lower MDA levels were found in the control group compared with the study group (P<0.05). After septoplasty, Nasal Obstruction Symptom Evaluation scores improved significantly and CAT, SOD, and GSH levels increased significantly (all, P<0.05). Malondialdehyde levels did not decrease significantly after surgery (P>0.05). Conclusions: Nasal obstruction due to nasal septal deviation led to lower antioxidant enzyme levels, and correction of the septum led to an increase in antioxidant levels.
Gradenigo Syndrome Induced by Suppurative Otitis Media
(Lippincott Williams & Wilkins, 2018) Bozan, Nazim; Duzenli, Ufuk; Yalinkilic, Abdulzaziz; Ayral, Abdurrahman; Parlak, Mehmet; Turan, Mahfuz; Kiroglu, Ahmet Faruk
Gradenigo syndrome was defined as a clinical triad of otitis media, severe orbito-facial pain, and ipsilateral sixth cranial nerve palsy. It may occur as a complication of either acute or chronic otitis media. Herein, we will report a case of Gradenigo syndrome induced by suppurative chronic otitis media that was promptly diagnosed and aggressively treated.
A Honey Bee Can Threat Ear: Sudden Sensorineural Hearing Loss
(W B Saunders Co-elsevier inc, 2017) Duzenli, Ufuk; Bozan, Nazim; Ayral, Abdurrahman; Yalinkilic, Abdulaziz; Kiroglu, Ahmet Faruk
Sudden sensorineural hearing loss is an otologic emergency. Many etiological factors can lead to this pathology. Honey bee (Apis mellifera) sting may lead to local and systemic reactions due to sensitization of the patient. In this paper we described a sudden sensorineural hearing loss occurred after honey bee sting. (C) 2017 Elsevier Inc. All rights reserved.
An Investigation of 8-Hydroxy and 8-Iso F2α Levels in Patients With Larynx Carcinoma
(dergipark Akad, 2020) Cetin, Yaser Said; Duzenli, Ufuk; Berkoz, Mehmet; Ozkan, Huseyin; Bozan, Nazim
Objective: 8-hydroxy-2'-deoxyguanosine (8-OHdG) and 8-iso-prostaglandin F-2(alpha) (8-iso-PGF(2)(alpha)) are indicators of oxidative stress in the human body. The aim of the present study was to investigate serum 8-OHdG and 8-iso-PGF(2)(alpha) levels in patients with larynx carcinoma and to compare them with healthy controls. Methods: A total of 50 patients, consisting of 25 patients with larynx carcinoma (study group) and 25 healthy subjects (control group), were enrolled in the present study. Serum 8-OHdG concentration was measured using an ELI-SA kit, whereas an enzyme immunoassay kit was utilized for the measurement of serum 8-iso-PGF(2)(alpha) levels. TNM stages of the patients were recorded from the patient records in the study group. Results: 8-OHdG and 8-iso-(2)(alpha) levels were significantly higher in patients with larynx carcinoma than the control subjects. 8-OHdG levels were significantly higher in patients with LN metastases than the patients without LN metastases in the study group. Conclusion: The findings of the present study showed the presence of significantly increased serum 8-OHdG and 8-iso-PGF(2)(alpha) levels in patients with larynx carcinoma, which may support the role of oxidative stress in the development laryngeal cancers.
Meatal Obstruction Following Canal Wall Down Mastoidectomy
(Pakistan Medical Assoc, 2017) Bozan, Nazim; Duzenli, Ufuk; Kundi, Pinar; Turan, Mahfuz; Kiroglu, Ahmet Faruk
Chronic otitis media (COM) is completely treated with a single procedure in most patients but may require multiple surgeries in some cases. The main goals of open cavity mastoidectomy are to completely eradicate the disease, create a large enough meatus for examination and mastoid air cells, and provide a self-cleaning epithelized dry cavity, and achieve maximum hearing. In this report, we present a very rare case of COM who underwent revision mastoidectomy in our clinic due to meatal obstruction in the right ear, total sensorineural hearing loss, and pain and tenderness in the postauricular region.
The Relationship Between Platelet Indices and Abo Blood Groups in Healthy Adults
(Wiley, 2019) Celik, Hakim; Duzenli, Ufuk; Aslan, Mehmet; Altiparmak, Ibrahim Halil; Kirmit, Adnan; Kara, Erdal; Karakilcik, Ali Ziya
Background ABO blood groups have been suggested to have a high correlation with cardiovascular diseases (CVDs). It has also been postulated that platelet indices, including mean platelet volume (MPV) and platelet distribution width (PDW), are very important in the development and progression of CVDs. However, despite these common associations with CVDs, as far as we know, there are no studies investigating platelet indices in ABO blood groups. Thus, the aim of this study was to investigate whether platelet indices are associated with ABO blood groups. Methods The study included 301 healthy volunteers (99 women and 202 men; mean age: 32.59 +/- 7.52 years) whose blood groups were determined by the gel column method using agglutination techniques. Platelet indices were studied by an automated blood counter. Results No considerable differences in age, gender, or Rh factors were observed among ABO blood groups. MPV was detected to be considerably lower in O and A blood group subjects than in AB and B blood group subjects. Similarly, PDW was significantly lower in O and A blood group subjects than in B blood group subjects. Additionally, MPV in the O blood group subjects was significantly lower than in the non-O blood group subjects. Conclusions Because MPV and PDW are used as markers of CVDs, individuals with O and A blood groups in this study may be considered to have a lower risk of CVDs than AB and B blood group subjects. However, prospective cohort studies involving a greater number of volunteers are needed to elucidate these relationships.
The Relationship Between Preoperative Smoking Cessation, Anxiety, and Postoperative Anxiety and Pain: a Prospective Clinical Trial at a University Hospital in the East of Turkey on 120 Participants
(Pakistan Medical Assoc, 2022) Tekeli, Arzu Esen; Demirkiran, Hilmi; Kacar, Cemal; Duzenli, Ufuk; Gulhas, Nurcin
Objective: To reveal the relationship between smoking cessation before surgery, pre- and post-operative anxiety, and pain among chronic smokers. Method: The cross sectional prospective clinical study was conducted in 2018 on the east of Turkey, in Van Yiiziincii Yil University Dursun Oda ba Medical Center in city of Van. After approval from the ethics committee participants of either gender aged 20-60 years scheduled to undergo rhinoplasty surgery and graded as American Society of Anaesthesiologists I-II were included.The participants were categorised into smokers group S and non-smokers group NS. Spielberger State-Trait Anxiety Inventory values for preoperative period, postoperative 0, which is the moment when the modified Aldrete score is >9, as well as for 2, 4 and 6 hours, and visual analogue scale values for the postoperative 0, 2, 4 and 6 hours were recorded. Data was analysed using SPSS 26. Results: Of the 120 patients, there were 60(50%) in group S; 28(46.7%) females, 32(52.3%) males, overall mean age 33.0 +/- 9.7 years. In group NS, there were 34(56.7%) females and 26(43.3%) males with an overall mean age of 34.7 +/- 10.1 years (p>0.05). Group S had Spielberger State Trait Anxiety Inventory preoperative and postoperative values significantly higher than group NS (p<0.05). While the values for postoperative 4 and 6 hours increased in group S, corresponding values decreased in group NS (p<0.05). Conclusion: High anxiety scores in preoperative period appeared to be associated with stress from surgery and anaesthesia and could have been caused by smoking dependency during the preoperative and postoperative periods.
Residual Dizziness in Elderly Patients After Benign Paroxysmal Positional Vertigo
(Karger, 2022) Cetin, Yaser Said; Cagac, Aydin; Duzenli, Ufuk; Bozan, Nazim; Elasan, Sadi
Introduction: The aim of this study was to compare the effects of Brandt-Daroff (BD) exercise and shopping exercise (SE) on the resolution of residual dizziness (RD) in patients with benign paroxysmal positional vertigo (BPPV) following a successful modified Epley canalith repositioning maneuver (CRP). Methods: This single-blind, randomized clinical trial included patients with posterior semicircular canal type of BPPV. Following the modified Epley maneuver, patients that experienced RD were randomly assigned to 3 groups: (i) BD, (ii) SE, and (iii) control groups. Primary outcomes were quantified using the Dizziness Handicap Inventory (DHI). Results: Following CRP, 240 (63%) participants experienced RD. All these patients were followed up weekly for RD. After the resolution of RD, patients were followed up monthly for recurrence. Mean time to recovery was 16.4 +/- 10 (range, 5-49) days in the BD group, 11.5 +/- 4.6 (range, 6-32) days in the SE group, and 23.4 +/- 16.8 (range, 6-89) days in the control group. The SE group recovered significantly faster than the BD and control groups (p < 0.001). Baseline emotional DHI (E-DHI) scores were significantly correlated with the duration of pre-CRP symptoms (p < 0.001). Correlation analysis indicated that patients with obesity and diabetes mellitus (DM) recovered later than patients without these comorbidities. Conclusion: We found that RD improved significantly in the SE group compared to the BD and control groups. Additionally, a significant relationship was established between RD and high anxiety levels and DM, and obesity had a negative impact on the resolution of RD.
Role of N-Acetyl Cysteine and Acetyl-L Combination Treatment on Dna-Damage Genes Induced by Radiation in Hei-Oc1 Cells
(Taylor & Francis Ltd, 2018) Duzenli, Ufuk; Altun, Zekiye; Olgun, Yuksel; Aktas, Safiye; Pamukoglu, Ayca; Cetinayak, Hasan Oguz; Olgun, Levent
Purpose: The aim of the present study was to evaluate the effect of acetyl-l-carnitine (ALC) and N-acetyl cysteine (NAC) on ionizing radiation (IR)-induced cytotoxicity and change in DNA damage-related genes in House Ear Institute-Organ of Corti 1 (HEI-OC1) cells. Methods: HEI-OC1 cells were irradiated with 5 Gy radiation and treated by eight combinations of NAC and/or ALC: control, NAC, ALC, IR, NAC + IR, ALC + NAC, ALC + IR, and ALC + NAC + IR. Cell viability, apoptotic cell death, and DNA damage were measured at the 72nd hour. Eighty-four IR-induced DNA-damage-related genes were determined by RT-PCR gene array and >10-fold changes were considered significant. Results: IR decreased cell viability by about 50% at 72 hours of incubation. In particular, the ALC and/or NAC combination before IR protected the HEI-OC1 cells (p < .05). Single and combination treatment prior to IR led to lower apoptotic cell death (p < .05). There was a significant lower DNA damage in ALC + NAC + IR group compared to IR group (p < .05). Expressions of Brca2, Xpc, Mlh3, Rad51, Xrcc2, Hus1, Rad9a, Cdkn1a, Gadd45a which are the DNA-repair genes were found to be significantly higher in NAC + ALC + IR group than those in individual treatment of ALC or NAC. Conclusions: ALC and/or NAC treatment prior to IR led to higher cell viability and lower apoptotic cell damage compared to the IR group. The results of the study show that the ALC + NAC combination treatment inhibits DNA damage and induces DNA-repair genes to repair radiation damage, and this combination treatment is more effective against radiation-induced DNA damage than NAC or ALC therapy individually.
Serum Prolidase Enzyme Activity in Obese Subjects and Its Relationship With Oxidative Stress Markers
(Elsevier Science Bv, 2017) Aslan, Mehmet; Duzenli, Ufuk; Esen, Ramazan; Soyoral, Yasemin Usul
Background: The relationship between increased serum enzyme activity of prolidase and increased rate of collagen turnover in the arterial wall has been asserted in previous studies. Collagen reflects much of the strength to the connective tissue involved in the arterial wall. Atherosclerosis is very common vessel disease and oxidative stress plays a pivotal role in the etiopathogenesis. Our objective was to examine the serum enzyme activity of prolidase and its possible relationships with oxidative stress parameters in obese subjects. Methods: Our present study was conducted 27 obese subjects and 26 age-matched healthy control subjects. The serum enzyme activity of prolidase in all study population was evaluated spectrophotometrically. Oxidative stress levels in obese subjects were analyzed with total antioxidant capacity (TAC) and total oxidant status (TOS) as well as oxidative stress index (OSI). Results: Obese subjects have higher serum TOS and OSI indicators as well as prolidase activity than those in control subjects (for all; p < 0.001). Moreover, obese subjects have lower levels of TAC than in those in healthy subjects (p < 0.001). In the Pearson's correlation analysis, enzyme activity of prolidase was positively related with TOS (p < 0.001, r = 0.529) and OSI (p < 0.001, r = 0.519) as well as BMI (p < 0.001, r = 0.692) and inversely related with TAC (p < 0.05, r = 0.405) in obese subjects. Conclusions: Increased serum prolidase activity and decreased antioxidant levels are likely to be a results of increased of oxidative stress levels in obese subjects. The significantly correlation between increased oxidative stress and increased prolidase activity may play a pivotal role in etiopathogenesis of atherosclerotic cardiovascular diseases in obese subjects.
Tonsillotomy Versus Tonsillectomy for Chronic Recurrent Tonsillitis in Children
(Galenos Yayincilik, 2020) Cetin, Yaser Said; Duzenli, Ufuk
Objective: This study was conducted to compare two different surgical methods; partial tonsil resection using the bipolar technique, tonsillotomy (TT), and total tonsillectomy (TE) (blunt dissection) for recurrent tonsillitis in children. The frequency of recurrent throat infections was determined during postoperative follow-up. Methods: A total of 393 patients were included in this study. TT was performed on 174 patients (100 males, 74 females) and TE on 219 patients (112 males, 107 females). Following surgery, an analysis was made of treatment outcomes of patients with upper respiratory tract infections. The patients were followed up for 12-48 months. Their parents were also contacted by telephone to determine the frequency of reinfection and their satisfaction with the surgery. Also, parents of the patients completed a questionnaire pertaining to postoperative satisfaction (scale of 1-10). Results: In the TT group, 14 (8.1%) patients had recurrent tonsillitis postoperatively. In the TE group, 12 (5.4%) patients required antibiotherapy due to recurrent pharyngitis after the surgery. There was no significant difference between the two groups in terms of the one-year infection recurrence rate after surgery (p=0.281). Three patients (1.6%) in the TT group and 12 (5.4%) in the TE group complained of bleeding within the first 24 hours. The rate of bleeding was significantly lower in the TT group than the TE group (p=0.001). There were no fatalities in either group. Conclusion: In both groups, the rate of reinfection accorded with the requirement for postoperative antibiotics. For chronic or recurrent tonsillitis, TT was as effective as TE. However,TT was superior in terms of the risk of bleeding.
Treatment of Multi-Drug Resistant Microorganisms in Chronic Suppurative Otitis Media
(Aves, 2022) Cetin, Yaser Said; Mollamehmetoglu, Serap Oflaz; Duzenli, Ufuk; Turan, Mahfuz; Bozan, Nazim
Objective: The aim of the study was to investigate the bacterial profile of patients who have resistant otorrhea despite the administration of topical antibiotics, antiseptics, and ear cleaning (aural toilet) and to discuss the topical and systemic therapy used for the eradication of treatment-resistant bacteria. Methods: A swab culture was obtained from the external ear canal in 544 patients with resistant otorrhea. All bacterial isolates were identified by conventional microbiological methods. Multidrug-resistant microorganisms were identified, and a systemic or topical antibiotic therapy was initiated based on the culture results. Results: Pseudomonas aeruginosa was the most commonly isolated pathogen (n=128: 24%), followed by Staphylococcus aureus (n=98; 18%). Since otorrhea could not be resolved with outpatient treatment, broad-spectrum antibiotics were applied in 54 (4%) of 1290 patients, 54% of whom were infected with P. oeruginoso. Recovery time was similar in intravenous treatment and topical piperacillin/tazobactam treatment in patients with ear discharge and multidrug-resistant P. aeruginosa infection (P = .82). Conclusion: In medical treatment of chronic suppurative otitis media, obtaining a dry ear can be highly difficult in some patients. Antibiotic resistance was relatively greater in gram-negative bacteria. In particular, multidrug-resistant P. aeruginosa can remain unresponsive to treatment. Data from future prospective studies and clinical trials may provide useful information on the results of topical piperacillin/tazobactam treatment in patients with chronic suppurative otitis media caused by multidrug-resistant P. aeruginosa infections to further improve clinical practice and off-label prescribing decisions.