Browsing by Author "Ebrahimi, Sonia"

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In Vivo Assessment of a Capsaicin-Containing Microemulsion for Neuropathic Pain Management
(Galenos Publ House, 2025) Shayyah, Rumooz; Bolgen, Umay Merve Guven; Alizade, Ares; Kayiran, Serpil Demirci; Ebrahimi, Sonia; Aksu, Fazilet
BACKGROUND/AIMS: Capsaicin (CAP) has been used in clinical applications for the treatment of neuropathic pain (NP). The main disadvantages of CAPare itsshort half-life, lowwatersolubilityand low bioavailability. Thisstudy intended to producea therapeutically effective microemulsion (ME) formulation comprising CAP to decrease NP. MATERIALS AND METHODS: ME was prepared using oleic acid, Tween 80, propylene glycol, ethanol, and water. Neuropathy was induced by partial sciatic nerve ligation (PSL) in mice. Two weeks after, PSL NP was tested using the cold plate (CP) and von Frey (VF) tests. The mice in the treatment group were administered 10 mg/kg CAP by oral gavage. The effects on NP of conventional CAP and ME CAP were compared. RESULTS: The prepared ME formulation of (CAP) was a homogeneous, transparent, thermodynamically stable dispersion of water and oil. The classic CAP was not effective on NP, while ME CAP was effective in the CP. The ME CAP was more effective on mice, than classic CAP using the VF test. CONCLUSION: The developed novel ME formulation at lower doses could reduce side effects and improve the bioavailability of the oral administration of CAP in the treatment of NP, and thus, would achieve good patient compliance.
Investigation of Behavioral Changes and Histopathological Changes in the Brain in Alzheimer's Modeled Mice With Aluminium Chloride (AlCl3)
(Galenos Publ House, 2025) Kanan, Derya Deniz; Aydemir, Isil; Alizade, Ares; Ebrahimi, Sonia; Aksu, Fazilet
BACKGROUND/AIMS: Aluminium (Al) is related with many brain diseases including Alzheimer's disease, however the relation between Al and neurodegenerative diseases is still controversial. In this study behavioral and histopathological changes were investigated in the AlCl3 induced Alzheimer's model in mice. MATERIALS AND METHODS: Male and female mice divided into control (tap water) and test (50 mg/kg/day AlCl3) groups. After ninety days of AlCl3/water intake, rota rod, elevated plus maze, Passive Avoidance tests were performed to assess motor coordination, spatial and emotional learning and memory, respectively. After the behavioural experiments, histopathological examination was made in the brain. RESULTS: No difference was found between the groups and the genders in the rota-rot test. Learning and memory were impaired in both gender. Long term memory impaired female mice in the test group. Neuron loss was observed in both the cerebral cortex and hippocampus CA1 regions in the test group, while an increase in pycnotic nucleated cells was observed. Neurofibrillary tangles were also observed in the hippocampus, with neurons with basophilic nuclei prominently. CONCLUSION: As a result, long-term exposure to low doses of aluminum may cause behavioral changes and histopathological changes in the brain.