Browsing by Author "Ege, Serhat"

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An Analysis on the Roles of Angiogenesis-Related Factors Including Serum Vitamin D, Soluble Endoglin (Seng), Soluble Fms-Like Tyrosine Kinase 1 (Sflt1), and Vascular Endothelial Growth Factor (Vegf) in the Diagnosis and Severity of Late-Onset Preeclampsia
(Taylor & Francis Ltd, 2017) Cim, Numan; Kurdoglu, Mertihan; Ege, Serhat; Yoruk, Ibrahim; Yaman, Gorkem; Yildizhan, Recep
Aim: The aim of this study was to evaluate the roles of proangiogenic factors including serum vitamin D and vascular endothelial growth factor (VEGF) and anti-angiogenic factors including soluble endoglin (sEng) and soluble fms-like tyrosine kinase 1 (sFlt1) in the diagnosis and severity of late-onset preeclampsia. Materials and methods: The study was conducted at Yuzuncu Yil University Research and Education Hospital Department of Gynecology and Obstetrics. The study included a patient group of 40 women with late-onset preeclampsia who were pregnant at >= 32 weeks of gestation according to the last menstrual period (LMP) or ultrasonographic fetal biometric measurement and a control group of 40 healthy pregnant women who presented to our clinic for routine pregnancy examination and were at the same age and gestational period with those in the patient group. The two groups were compared in terms of maternal age, gravida, parity, week of gestation, systolic/diastolic blood pressure, total protein in spot urine sample, 24-h urine protein, white blood cell (WBC), hemoglobin (Hgb), platelet count, urea, creatinine, liver function tests (AST, ALT, LDH), vitamin D-3, 25(OH) vitamin D-3, 1,25(OH) vitamin D-3, sEng, sFlt1, and VEGF levels, mode of delivery, the infant APGAR score at 1 and 5 min after delivery, and infant weight at delivery. Results: The groups were similar in terms of age, gravida, parity, week of gestation, serum vitamin D-3, 25(OH) vitamin D-3, 1,25(OH)(2) vitamin D-3 and VEGF levels, and infant weight at delivery (p > 0.05). Systolic/diastolic blood pressure, total protein in spot urine sample, 24-h urine protein, WBC, Hgb, serum urea, creatine, AST, ALT, and LDH were significantly higher in the preeclamptic group compared to the healthy group (p < 0.05). However, thrombocyte level and the APGAR score at 1 and 5 min after delivery were significantly lower in the preeclamptic group compared to the healthy group (p < 0.05). No significant correlation was found between serum sEng, sFlt1, VEGF, vitamin D-3, 25(OH) vitamin D-3, and 1,25(OH)(2) vitamin D-3 levels. The sEng level was higher in the women with severe preeclampsia compared to the women with mild preeclampsia (p < 0.05) and no significant difference was observed in serum sFlt1, VEGF, vitamin D-3, 25(OH) vitamin D-3, and 1,25(OH)(2) vitamin D-3 levels between the subgroups of preeclampsia (p > 0.05). Conclusion: Both sEng and sFlt1 levels are remarkably high in patients with late-onset preeclampsia; however, only sEng may be a useful tool in the determination of the severity of preeclampsia.
Comparison of Oxidative Stress Markers in Umbilical Cord Blood of Vaginal and Cesarean Babies
(Springer London Ltd, 2025) Aycan, Nur; Akduman, Hasan; Dilli, Dilek; Soysal, Caganay; Akduman, Filiz; Fettah, Nurdan Dinlen; Ege, Serhat
BackgroundOxidative stress is defined as an imbalance between oxidant and antioxidant substances in favor of oxidants. Despite the well-known adverse effects of oxidative stress on the mother, fetus, and newborn, the impact of birth type on oxidative stress experienced by both mother and child remains unclear.AimsOur study aimed to investigate the effects of birth type on the oxidant and antioxidant systems through umbilical cord blood analysis.MethodsBetween 37 and 41 weeks of gestation, cord blood was collected from 92 newborn babies. Participants were divided into two groups according to their mode of birth: Group Cesarean Section (n = 45) and Group Normal Vaginal Delivery (n = 47). The material used in the study was umbilical cord blood samples collected immediately after birth. Total Antioxidant Status, Total Oxidant Status, thiol, catalase, arylesterase, paraoxonase and stimulated paraoxonase, measurements were determined.ResultsNeonatal cord blood thiol levels were significantly lower in both the Cesarean section group (195.60 +/- 4.27) compared to the Normal Vaginal Delivery group (212.06 +/- 6.01,p = 0.025), and in newborns of mothers with a history of urinary tract infection (189.9 +/- 2.8) versus those without (206.26 +/- 4.3,p = 0.041). No significant differences were observed in Total Antioxidant Status, Total Oxidant Status, catalase, stimulated paraoxonase, paraoxonase or arylesterase levels across the studied groups.ConclusionsThe cesarean birth and maternal urinary tract infection history are associated with significantly reduced neonatal cord blood thiol levels while other oxidative stress markers remain unchanged highlighting thiol's potential role as a sensitive biomarker for birth-related oxidative imbalance and supporting its use in early postnatal risk assessment.
Ghrelin Does Not Change in Hyperemesis Gravidarum
(Via Medica, 2019) Ege, Serhat; Kolusari, Ali; Bugdayci, Guler; Cim, Numan; Bademkiran, Muhammet Hanifi; Peker, Nurullah; Yildizhan, Recep
Objectives: Ghrelin levels can play an important role in maintaining the energy balance of pregnant women. Therefore, we investigated the relationship between HG and Ghrelin. Material and methods: 50 female patients admitted to the VAN Yuzuncu Yil University, Gynecology and Obstetrics Department were evaluated. The patients were divided into two groups: Group 1 included 25 pregnant women with HG, Group 2 included 25 healthy pregnant women. Results:The two groups showed similarities in terms of age, gravidity, B-HCG and gestational age.There was no statistically significant difference between the two groups in terms of the Ghrelin levels (p = 0.867). Conclusions: This study shows that there is no difference between Ghrelin levels and HG during pregnancy. Increased Ghrelin in previous studies was attributed to low oral intake. Another study reported lower Ghrelin levels are not the result of, but are rather the cause of, reduced oral intake during. The balancing of these two conditions does not lead to a change in the level of Ghrelin.
Investigation of the Serum Ghrelin Levels in the Serum of Patients With Hyperemesis Gravidarum
(2010) Ege, Serhat; Kolusarı, Ali
Amaç: İlk 10 gebelik haftasındaki Hyperemezis Gravidarum hastalarında serum ghrelin düzeyinin araştırılması.Materyal Metod: Yüzüncü Yıl Üniversitesi Tıp Fakültesi, Sağlık Uygulama ve Araştırma Hastanesi Kadın Hastalıkları ve Doğum Kliniğinde yürütülen çalışmaya Hiperemezis Gravidarum tanısı ile yatırılan 10 ve altındaki gebelik haftalarında 25 gebe ve aynı gebelik haftalarındaki herhangi bir medikal ve obstetrik problemi olmayan 25 sağlıklı gebenin serum ghrelin değerlerinin mikro ELİSA yöntemi ile çalışılması amaçlanmıştır. Biyokimyasal ve hormonal olarak HG tanısı koyduğumuz 25 hasta çalışma grubunu oluştururken, yaptığımız ultrasonografik ve biyokimyasal-hormonal tetkikler sonucu HG düşünmediğimiz 25 hasta da kontrol grubu olarak çalışmaya alınmıştır. Araştırma formları oluşturulup hasta ve kontrol grubu hakkında gerekli bilgiler kaydedildikten sonra hasta ve kontrol grubundan hemogram, biyokimya, tit, tiroid fonksiyon testleri (ST3, ST4, TSH), hormonal parametreler (b HCG, Anti TPO) düzeyleri ölçülmüştür.Bulgular: Her iki grup arasında yaş, gravida, parite, abortus, yaşayan çocuk sayısı, hormon ve biyokimya açısından anlamlı bir fark bulunamamıştır. (p>0.05). Kontrol grubu ile kıyaslandığında Hgb, Htc, kilo kaybı yüksek bulunmuştur. (p<0.05).Sonuç: Daha önce çalışmamızla ilgili çalışma bulunmamaktadır. Çalışmamızda iki gruptada ghrelin düzeyleri arasında anlamlı bir fark bulunamamıştır (p>0.05).