Browsing by Author "Ekinci, Ö."

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The Association of Nlr and Mpv With Treatment Responses, Disease Stages, and International Prognostic Index Scores in Diffuse Large B-Cell Lymphoma
(Yuzuncu Yil Universitesi Tip Fakultesi, 2019) Demircioğlu, S.; Doğan, A.; Ekinci, Ö.; Demir, C.
Diffuse Large B-Cell Lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma. International Prognostic Index (IPI) is the most commonly used scoring system predicting the prognosis. In this study, we aimed to investigate the association of Neutrophil/Lymphocyte Ratio (NLR) and Mean Platelet Volume (MPV) with IPI score, treatment responses, and disease stage. A total of 113 DLBCL patients who received R-CHOP treatment were recruited for this study. Demographic data, disease stages according to the Ann Arbor staging system, IPI scores, treatment methods, treatment responses, complete blood counts, and biochemical tests of the patients were retrospectively evaluated. Elevated NLR had statistically significant correlation with disease stage and IPI score (p=0.001 and p=0.006, respectively). However, the NLR had no statistically significant correlation with the interim-treatment and post-treatment responses (p=0.187, and p=0.96, respectively). MPV showed no significant relationship with disease stages (p=0.56), IPI scores (p=0.188), interim-treatment and post-treatment responses (p=0.122, and p=0.239). In conclusion, NLR was associated with IPI score and disease stage. This suggests that NLR, a cheap and easy investigation, may be used to obtain information about the prognosis. © 2019, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
The Presence of Paroxysmal Nocturnal Hemoglobinuria in Patients With Idiopathic Chronic Renal Failure
(Yuzuncu Yil Universitesi Tip Fakultesi, 2017) Ekinci, Ö.; Doğan, A.; Demir, C.
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal stem cell disease. Chronic renal f ailure (CRF) is defined as progressive deterioration in the regulation of fluid and electrolyte balance of the affected kidney due to a decrease in glomerular filtration rate resulting from various diseases. We also investigated the presence of PNH in foll ow-up patients diagnosed with end-stage renal failure (ESRD) of unknown etiology in this study. This study was carried out at the Yuzuncu Yil University in Van, Turkey. Sixteen patients with end-stage renal failure who had unknown etiology from a total of 143 patients were included in the study. The patients’ age, gender, hemogram, biochemical parameters, and percentage of PNH clone were exami ned. PNH clone was analyzed by the Fluorescein Aerolysin method. Of the patients, 10 (62%) were female, 6 (38%) were male. Hemodialysis was performed in 15 patients (94%) as renal replacement therapy. Fourteen of the patients (88%) had anemia. LDH was elev ated in 6 patients (38%), and those with high LDH also suffered from anemia. PNH clone was negative for all patients as determined by FLAER analysis. A survey of the literature did not result in any study on the presence of paroxysmal nocturnal hemoglobinu ria in idiopathic chronic renal failure. This is the first such study with this focus. Based on review of the cases described in the literature, PNH should be considered in the differential diagnosis of renal failure cases which are unexplained and especia lly those accompanied by hemolysis findings. © 2017, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
The Role of Paroxysmal Nocturnal Hemoglobinuria in Idiopathic Habitual Abortion
(Yuzuncu Yil Universitesi Tip Fakultesi, 2017) Dirik, Y.; Ekinci, Ö.; Kara, O.; Dirik, D.; Doğan, A.; Demir, C.
Paroxysmal nocturnal hemoglobinuria (PNH) which is an acquired clonal hematopoietic stem cell disease, usually presents with intravascular hemolysis, thrombosis and bone marrow failure. Hereditary and acquired thrombophilia are known to play significant role in the etiology of patients with habitual abortion (HA). PNH, which is a cause of acquired thrombophilia, may have a role in the etiology of HA. In the present study, we investigated the presence of PNH clone among the patients with a history of HA. 150 patients were enrolled in the study group, diagnosed with habitual abortus of unknown etiology and 150 healthy women with no history of habitual abortus as a control group. The age range for both groups was 18–55 years. The PNH clone was screened by the FLAER (fluorescein-labeled proaerolysin) method. The PNH clone was positive in five (3.3%) patients in the study group. Four of the PNH clone positive patie nts were found to have a very low clone positivity level (0.05%, 0.24%, 0.12%, 0.21%), while one had a high level (30%). PNH clone positivity results in the study group indicate that PNH should be investigated in cases of idiopathic HA, as one patient required treatment. © 2017, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.