Browsing by Author "Ekinci, O."

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Acquired Von Willebrand Disease in Chronic Myeloproliferative Disorders
(Pergamon-elsevier Science Ltd, 2018) Aslanboga, M.; Ekinci, O.; Demir, C.
A Case of Myasthenia Gravis Developing From Chronic Myeloid Leukemia With Imatinib Use: a Case Report
(Pergamon-elsevier Science Ltd, 2018) Dogan, A.; Ekinci, O.; Demircioglu, S.; Demir, C.
Clinical and Pathological Characteristics of Non-Hodgkin Lymphoma Patients in Eastern Turkey: a Single-Center Study
(Pergamon-elsevier Science Ltd, 2018) Dogan, N. Yildirim; Erkurt, M.; Dogan, A.; Ekinci, O.; Kuku, I.; Kaya, E.
Clinical Features and Responses To Eculizumab of Paroxysmal Nocturnal Hemoglobinuria Patients: a Single-Center Experience
(Pergamon-elsevier Science Ltd, 2018) Ekinci, O.; Dogan, A.; Demircioglu, S.; Sonmez, G.; Demir, C.
The Clinicopathological Features and Survival of Castleman Disease: a Multicenter Turkish Study
(Verduci Editore s.r.l, 2022) Yildiz, J.; Bagci, M.; Sayin, S.; Kaya, A.; Yilmaz, F.; Ekinci, O.; Altuntas, F.
Objective: In this study, we aimed to investigate the clinicopathological features and survival of CD, which is quite rare and has many unknowns. Patients and Methods: This study was conducted by retrospectively evaluating patients diagnosed with CD in six different centers in Turkey. Results: The median age of 33 patients included in the study was 49 and 51.5% (n = 17) of these patients were women. 18 (54.5%) patients were in the hyaline vascular subtype and most of the patients were UCD (n = 20, 60.6%). The most common involvement region was head and neck (n = 19, 57.5%). The UCD group was younger than the MCD group (p=0.027). Visceral lymph node involvement was higher in MCD than in UCD (p=0.001). Similarly, it was observed that there was more hepatomegaly (p=0.035) and splenomegaly (p=0.013) in the MCD group. During the median 19.5 months follow-up period, there were no patients who died. Conclusions: It was observed that UCD and MCD are different clinical entities. Promising survival times can be achieved with surgical and systemic treatments in both subtypes of this extremely rare disease. However, this result should be supported by well-designed prospective comprehensive studies. © 2022 Verduci Editore s.r.l. All rights reserved.
Complement-Mediated Hemolytic Uremic Syndrome: a Case Report
(Pergamon-elsevier Science Ltd, 2018) Dogan, A.; Ekinci, O.; Demircioglu, S.; Aydemir, O.; Gocuncu, S.; Demir, C.
Decreased Bone Mineral Density and Related Parameters in Severe Hemophilia a Patients: a Case-Control Study
(Pergamon-elsevier Science Ltd, 2018) Ekinci, O.; Demircioglu, S.; Dogan, A.; Demir, C.
Disseminated Intravascular Coagulation: a Single Center Experience
(Yuzuncu Yil Universitesi Tip Fakultesi, 2018) Ekinci, O.; Candar, O.; Dogan, A.; Esen, R.; Demir, C.
We aimed to evaluate the clinical and demographic data of adult patients diagnosed with acute disseminated intravascular coagulation (DIC) who had been referred to the hematology unit by other clinics, as well as to evaluate the effect of clinical and laboratory parameters on patient survival. Materials and Methods: The records of 87 adult patients admitted to the Department of Hematology of Yuzuncu Yil University Faculty of Medicine between January 2013 and May 2017 and diagnosed with acute DIC were retrospectively examined. Of the patients participating in the study, 64 (73.6%) were female and 23 (26.4%) were male. Regarding the distribution of etiology in patients with acute DIC, the most common etiology, at 49.3%, was obstectic pathologies. Acute DIC was more frequent in women and younger adults (p = 0.001). Patients with trauma had the highest mortality rate (p = 0.001). Patients diagnosed with acute DIC who died as a result were older, and mortality was higher in males (p < 0.001 for both). Comparing ISTH scores, patients with acute DIC had significantly higher mortality (p = 0.028). In this study, a majority of the patients diagnosed with acute DIC were young and female. De spite their high incidence of acute DIC however, the mortality rate for young female patients was low. The mortality rate was higher in elderly and male patients, although intensive treatment was administered following diagnosis of acute DIC. We believe that early diagnosis and appropriate treatment are of critical importance for patients thought to have acute DIC, regardless of underlying condition. © 2018, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Distribution of Abo and Rh Blood Groups and Seroprevalence of Hbsag, Anti-Hcv, Anti-Hiv and Syphilis in Healthy Donors: a Single Center Experience
(Pergamon-elsevier Science Ltd, 2017) Ekinci, O.; Kara, O.; Dogan, A.; Demircioglu, S.; Demir, C.
Effect of Helicobacter Pylori Infection on the First-Line Treatment Outcomes in Patients With Immune Thrombocytopenic Purpura
(Verduci Editore s.r.l, 2022) Dogan, A.; Ekinci, O.; Ebinc, S.
OBJECTIVE: Helicobacter pylori (H. pylori) eradication therapy is known to increase the platelet count, but in immune thrombocytopenic purpura (ITP), the effect of H. pylori infection on the response to treatment is not clear. This study aims to determine whether the response to the first-line treatment is affected by the states of H. pylori-positivity and -negativity in ITP patients. PATIENTS AND METHODS: Adult newly diagnosed or chronic ITP patients who had not received eradication therapy for H. pylori infection were included. Characteristics of the patients, presence and severity of bleeding, initial platelet count, administered treatments, and treatment response rates were inspected. RESULTS: Of 119 total patients, 66 (55.5%) were female, 32 (26.9%) were H. pylori-positive, 87 (73.1%) were H. pylori-negative. H. pylori-positive and H. pylori- negative groups were not significantly different in terms of age (p=0.127), gender (p=0.078), diagnosis status (p=0.094) and the distribution of bleeding symptoms (p=0.712). The most common treatment was standard-dose steroid in both groups (62.5% vs. 68.9%, p=0.524). Rates of complete response, partial response, no response were comparable for the two groups (respectively, 75% vs. 73.6%, and 18.8% vs. 19.5%, and 6.2% vs. 6.9%), and there was no significant difference between the groups (p=0.283). CONCLUSIONS: It can be stated, according to the present study, that in ITP patients in whom treatment is indicated, the response to the firstline treatment without the administration of H. pylori eradication therapy is similar between H. pylori-positive and H. pylori-negative patients. © 2022 Verduci Editore s.r.l. All rights reserved.
Hemophagocytic Lymphohistiocytosis Associated With Acute Hepatitis a Disease
(Pergamon-elsevier Science Ltd, 2018) Dogan, A.; Demircioglu, S.; Ekinci, O.; Zorlu, D.; Kayran, M.; Kara, O.; Demir, C.
Incidence of Paroxysmal Nocturnal Hemoglobinuria in the Patients With Idiopathic Portal Vein Thrombosis
(Pergamon-elsevier Science Ltd, 2018) Demir, C.; Ebinc, S.; Ekinci, O.
Mucormycosis in a Patient With Acute Lymphoblastic Leukemia: a Case Report
(Pergamon-elsevier Science Ltd, 2018) Demircioglu, S.; Dogan, A.; Ekinci, O.; Duzenli, U.; Baran, A.; Bayram, I.; Demir, C.
The Presence of Paroxysmal Nocturnal Hemoglobinura in Patients With Idiopathic End Stage Chronic Renal Failure
(Pergamon-elsevier Science Ltd, 2017) Ekinci, O.; Dogan, A.; Demir, C.
A Rare Case of Fip1l1-Pdgfr Clonal Hypereosinophilia
(Pergamon-elsevier Science Ltd, 2018) Dogan, A.; Demircioglu, S.; Ekinci, O.; Kaskalan, C.; Gocuncu, S.; Demir, M.; Demir, C.
A Rare Cause of Pancytopenia: Transfusion-Associated Graft Versus Host Disease
(Pergamon-elsevier Science Ltd, 2018) Dogan, A.; Demircioglu, S.; Ekinci, O.; Mamis, Y.; Demir, C.
The Relationship Between 25 Hydroxy Vitamin D3 and Thyroid Antibodies With Thyroid Benign-Malign Neoplasms
(Wolters Kluwer Medknow Publications, 2019) Yildiz, S.; Ekinci, O.; Ucler, R.
Objective: To study the relationship between vitamin D and thyroid antibodies with thyroid benign-malign neoplasms. Materials and Methods: The vitamin D vitamin and thyroid antibodies of 179 patients who underwent thyroidectomy for thyroid nodule were retrospectively reviewed. Results: The mean age of the patients was 44.97 +/- 14.139. Vitamin D levels were 14.473 +/- 4.9999 ng/ml in women and 19.584 +/- 6.1981 ng/ml in men and the mean was 15.016 +/- 5.3579 ng/ml. There was a significant relationship between sex and vitamin D level (P < 0, 05). Antithyroglobulin antibody (anti-TGB) had been detected in 95 patients and Antithyroid peroxidase antibody (anti TPO) in 58 patients. There was no significant relationship between vitamin D levels (P: 0, 65), anti-TPO positivity (P: 0, 86), and anti-TGB (P: 0, 12) with benign-malignant neoplasm of thyroid. There was no relationship between vitamin D and metastatic disease (P: 0, 30) as well. In addition, no association was found between malignancy and metastasis (P = 0.068, P = 0.14, P: 0, P = 0, respectively) with thyroid antibody positivity (anti TPO and/or anti TGB) in severe deficiency (<10 ng/ml) and deficiency (< 20 ng/ml) of vitamin D. Conclusion: Vitamin D deficiency or thyroid autoantibodies did not have any significant effect on thyroid malignancies or metastatic disease separately or together.
The Role of Paroxysmal Nocturnal Hemoglobinuria in Idiopathic Habitual Abortion
(Pergamon-elsevier Science Ltd, 2017) Dirik, Y.; Ekinci, O.; Kara, O.; Dirik, D.; Dogan, A.; Demir, C.
Synchronous Endometrial and Ovarian Cancer With Sigmoid Colon Metastasis One Year After Primary Surgery: a Case Report
(Aras Part Medical International Press, 2015) Guzin, K.; Balci, B.K.; Sandal, K.; Gocmen, A.; Ekinci, O.; Aydin, A.; Yuvruk, M.
Introduction: We describe a patient who had ovarian and endometrial cancer which metastasized to sigmoid colon one year after surgery. Case Presentation: A 53-year-old woman was admitted with the complaints of abdominal pain, abdominal distension and postmenopausal bleeding. Her transvaginal ultrasound scan revealed a cystic mass containing papillary projections with the dimensions of 6.5 × 5 × 4 cm on the right ovary. Level of (carbohydrate antigen) (CA) 125 was 223 IU. Dilation and curettage revealed endometrioid adenocarcinoma. Debulking surgerywas carried out. Histopathological diagnosis was grade 2 adenocarcinoma with squamous differentiation for endometrial cancer and grade 2 endometrioid adenocarcinoma with squamous and mucinous differentiation for ovarian cancer. The stage was 1A for endometrial cancer and 1A for ovarian cancer. 12 months after the operation CA 125 level was 112 IU. Positron emission tomography (PET) scan showed a small lesion (1.5×1.5 cm) in the pelvic cavity with increased fluorodeoxyglucose (FDG) uptake. Five months after the chemotherapy, CA 125 level elevated from 10 to 60 IU and subsequent magnetic resonance imaging (MRI) revealed a tumoral mass with the dimensions of 3×2.2 cm. A second laparotomy was performed and the metastasis was excited. The tumor was endometrioid adenocarcinoma with infiltration in the serosa and muscularis propria of sigmoid colon. Conclusion: It is necessary to consider the presence of double cancer in the diagnosis and treatment of gynecological cancers. © 2015 The Author(s).
Texture Features of Primary Tumor on 18f-Fdg Pet Images in Non-Small Cell Lung Cancer: the Relationship Between Imaging and Histopathological Parameters
(Elsevier Espana Slu, 2021) Aydos, U.; Unal, E. R.; Ozcelik, M.; Akdemir, D.; Ekinci, O.; Tastepe, A., I; Akdemir, U. O.
Objectives: The aims of this study were to evaluate the relationships between textural features of the primary tumor on FDG PET images and clinical-histopathological parameters which are useful in predicting prognosis in newly diagnosed non-small cell lung cancer (NSCLC) patients. Material and methods: PET/CT images of ninety (90) patients with NSCLC prior to surgery were analyzed retrospectively. All patients had resectable tumors. From the images we acquired data related to metabolism (SUVmax, metabolic tumor volume [MTV] and total lesion glycolysis [TLG]) and texture features of primary tumors. Histopathological tumor types and subgroups, degree of Ki-67 expression and necrosis rates of the primary tumor, mediastinal lymph node (MLN) status and nodal stages were recorded. Results: Among the 2 histologic tumor types (adenocarcinoma and squamous cell carcinoma) significant differences were present regarding metabolic parameters, Ki-67 index with higher values and kurtosis with lower values in the latter group. Textural heterogeneity was found to be higher in poorly differentia-ted tumors compared to moderately differentiated tumors in patients with adenocarcinoma. While Ki-67 index had significant correlations with metabolic parameters and kurtosis, tumor necrosis rate was only significantly correlated with textural features. By univariate and multivariate analyses of the imaging and histopathological factors examined, only gradient variance was significant predictive factor for the presence of MLN metastasis. Conclusions: Textural features had significant associations with histologic tumor types, degree of patholo-gical differentiation, tumor proliferation and necrosis rates. Texture analysis has potential to differentiate tumor types and subtypes and to predict MLN metastasis in patients with NSCLC. (c) 2021 Sociedad Espanola de Medicina Nuclear e Imagen Molecular. Published by Elsevier Espana, S.L.U. All rights reserved.