Browsing by Author "Elasan, Sadi"

Now showing 1 - 20 of 32

Biyoistatistik Dersine Yönelik Öğrenci Tutumları: Yüzüncü Yıl Üniversitesi Örneği
(2020) Elasan, Sadi; Keskin, Sıddık
Üniversitelerin lisans ve lisansüstü programlarındaki öğrencilerin istatistik dersine karşıkorku, endişe, sevmeme benzeri önyargıları ve olumsuz tutumları gelecekte bazı akademikeksikliklere yol açabilmektedir. Benzer şekilde biyoistatistik dersi, tüm sağlık alanlarında;araştırma tasarlama, uygulanma, istatistik analizlerin yapılması, bulguların yorumlanmasıve kaliteli bilimsel yayınların üretilmesinde önemli bir yere sahiptir. Bu derse ilişkin görüşve tutumların öğretim elemanı tarafından bilinmesi; bu dersi alan öğrencilerin biyoistatistikdersini daha iyi anlamalarına, dersi severek işlemelerine katkı sunacaktır. Öğrencilerin biyoistatistik dersine yönelik tutumlarının belirlemesi amacıyla, Van Yüzüncü Yıl Üniversitesibünyesindeki Tıp Fakültesi, Eczacılık Fakültesi, Veteriner Fakültesi, Sağlık Yüksek Okuluve Lisansüstü bölümlerinde kayıtlı 420 öğrenciye uygulanan anketlerden elde edilen veriseti kullanılmıştır. Derse yönelik tutumu ölçmek amacıyla 1-5 arası likert puanlar istatistikikarşılaştırma testleri ile incelenmiştir. Biyoistatistik dersine yönelik tutum sorularına verilencevaplara göre tutum puanları hesaplanmış ve bu veriler faktör analizine tabi tutulmuştur(KMO %90.1; p<0.001). Biyoistatistik dersinin genel olarak sevildiği ancak diğer alan derslerine göre zor bir ders olduğu sonucuna ulaşılmıştır. Çalışmada kişisel bilgilere göre; öğrencinin “Anne-Baba Beraberlik Durumu, Haftalık Biyoistatistik Ders Saati ve Okul BitinceHedefine” göre tutum puanları arasında istatistik olarak anlamlı bir farklılık gözlenmiştir.Biyoistatistik dersinin öğrencilere daha fazla sevdirilmesi ve öğretim elemanları tarafındankolay/zevkli şekilde işlenmesi ve öğrencilerin istatistik bulguları kolayca yorumlayabilmesinin sağlanması gerektiği sonucuna ulaşılmıştır. Ayrıca öğrencilerin, biyoistatistiğin üniversitede zorunlu ders olmaması durumunda bile öğrencilerin bu derse girme isteklerininpekiştirilmesi açısından öğretim elemanlarının daha fazla çaba göstermesi önerilmektedir.Çalışmada elde edilen sonuçlar, dersin daha iyi öğretilmesine ve öğrencilerin olumsuz tutumlarının düzeltilmesine ve dolayısıyla üniversitenin genel eğitim kalitesinin de arttırılmasınakatkı sağlayabilecektir.
Cardiothoracic Ratio and Left Ventricular Ejection Fraction Relationship a Meta-Analysis Study
(Saudi Med J, 2023) Elasan, Sadi; Yilmaz, Osman
Objectives: To determine the overall effect size, identify the study with the strongest effect size, and examine the age group with the strongest relationships between the variables.Methods: In this study, a meta-analytical analysis was carried out by bringing together 13 studies from around the world examining the statistical relationships between cardiothoracic ratio (CTR) and left ventricular ejection fraction (LVEF). Thus, it is hoped that the results will contribute to studies on the relationships between CTR and LVEF and bring a holistic view to these relationships. To determine CTR, studies were identified through a review of the literature, and those that reported a correlation between the variables under investigation were included in the analysis process. The date range of this study 01.11.2022-15.01.2023.Results: According to the findings, when all the results were analysed together, the mean effect size for CTR and LVEF correlation was found to be r=-0.12. When all studies were considered separately, generally small negative correlations were observed between CTR and LVEF. It is possible to say that there is no publication bias in the studies.Conclusion: This study is a meta-analytic study combining 13 studies examining the statistical relationships between CTR and LVEF. The results of this study are expected to make a valuable contribution to the field of research on the relationship between CTR and LVEF, providing a more comprehensive understanding of these associations.PROSPERO Reg. No.: 392207
Combined Treatment of Sinapic Acid and Ellagic Acid Attenuates Hyperglycemia in Streptozotocin-Induced Diabetic Rats
(Pergamon-elsevier Science Ltd, 2021) Altindag, Fikret; Ragbetli, Murat Cetin; Ozdek, Ugur; Koyun, Necat; Alhalboosi, Jamal Khalid Ismael; Elasan, Sadi
In the present study, we aimed to investigate the effect of individual and combined treatment of sinapic acid (SA) and ellagic acid (EA) in streptozotocin (STZ)-induced diabetic rats. Rats were divided into eight groups (n = 7): Normal Control, Diabetic Control, Diabetic + Sinapic Acid, Diabetic + Ellagic Acid, Diabetic + Sinapic Acid + Ellagic Acid, Sinapic Acid, Ellagic Acid and Sinapic Acid + Ellagic Acid. Diabetic groups were injected with a single dose of 50 mg/kg STZ intraperitoneally. Rats received 20 mg/kg/day SA and 50 mg/kg/day EA intragastrically for 28 days. The numerical density of immunopositive beta-cells and volume density of pancreatic islets were calculated. Additionally, glucose and insulin levels in serum, MDA, GSH, and CAT levels of pancreatic tissue were measured. While serum glucose levels increased, serum insulin levels decreased in STZ-induced diabetic rats. But these changes in glucose and insulin were restored by individual and combined treatments of SA and EA. Also, individual and combined treatments of SA and EA increased insulin expression of beta-cells in STZ-induced diabetic rats. Moreover, these compounds improved deteriorating oxidative stress parameters in STZ-induced diabetic rats. Our study indicates that SA and EA, especially their combined treatments, can be used as an antihyperglycemic agent in diabetes.
Comparative Effects of Radial and Focused Extracorporeal Shock Wave Therapies in Coccydynia
(Baycinar Medical Publ-baycinar Tibbi Yayincilik, 2023) Sah, Volkan; Elasan, Sadi; Kaplan, Seyhmus
Objectives: This study was conducted to compare the effects of radial and focused extracorporeal shock wave therapy (ESWT) in patients with coccydynia.Patients and methods: In this prospective randomized double-blind study conducted between March 2021 and October 2021, 60 patients with coccydynia (50 males, 10 females; mean age: 35.9 +/- 12.0 years, range 18 to 65 years) were randomized into three groups (n=20) according to different wave types of ESWT: focused, radial, and sham. The Visual Analog Scale (VAS) was used for pain assessment, and the Oswestry Disability Index (ODI) was used for functional assessment in all patients before the treatment (baseline), after the completion of four sessions of treatment (fourth week), one month after the end of the treatment (eighth week), and three months after the end of the treatment (16th week).Results: The mean body mass index of the participants was 26.2 +/- 3.0. Compared to baseline, the VAS scores at four weeks were reduced only in the radial ESWT group (p<0.05). Compared to baseline, the VAS and ODI scores at eight and 16 weeks were significantly reduced in both the focused and radial ESWT groups (p<0.05 for all). The radial ESWT group was significantly superior to the focused ESWT group in the comparisons between the groups at four weeks in the VAS values and at 16 weeks in the ODI scores (p<0.05 for all). Conclusion: Radial and focused ESWT are both effective in treating coccydynia compared to sham ESWT. However, radial ESWT may be more effective in the treatment of coccydynia.
Comparison of the Analgesic Efficacy of Spray and Tablet Flurbiprofen for Pain After Soft Tissue Surgery
(Sociedade Brasileira de Pesquisa Odontologica, 2024) Eroglu, Cennet Neslihan; Yuksek, Mehmet Nuri; Elasan, Sadi; Mizrak, Yusuf Rodi; Karaca, Busra
The aim of this randomized clinical study was to assess the comparative efficacy of flurbiprofen in tablet and spray formulations for postoperative pain management in oral soft tissue wounds undergoing primary closure while investigating the feasibility of achieving optimal analgesia with reduced dosage and risk. Forty patients who underwent epulis fissuratum and frenulum excision for pre-prosthetic surgery were randomly assigned to receive either tablet or spray forms of flurbiprofen. The lesion dimensions were measured preoperatively, followed by excision and primary closure. The tablet group received oral tablets containing 100 mg of flurbiprofen twice daily, whereas the spray group received an oral spray containing 0.25% flurbiprofen, administered as two sprays thrice daily. Postoperative pain was assessed using the Numerical Rating Scale (NRS) until the 7th day. Lesion size, drug consumption, and rescue analgesic use were compared between the groups. There were no statistically significant differences in the lesion size between the groups. However, the mean NRS score in the spray group was significantly lower in the spray group compared to than that in the tablet group at 6th hour postoperatively (p = 0.037). Significant differences favoring the tablet group were observed in the first three doses of the drug (p = 0.001). No patients required rescue analgesics. The spray formulation of flurbiprofen demonstrated effective and safe pain relief in oral soft tissue wounds undergoing primary closure, with no reported adverse effects.
Comprehensive Global Analysis of Future Trends in Artificial Intelligence-Assisted Veterinary Medicine
(Wiley, 2025) Elasan, Sadi; Yilmaz, Osman
Background This study conducts a bibliometric analysis of global trends in 'artificial intelligence studies in veterinary medicine'. The analysis aims to summarise the publications of researchers from various disciplines related to artificial intelligence in veterinary medicine, thereby predicting future trends of AI in this field. The primary objective of the study is to investigate publications pertaining to artificial intelligence in veterinary medicine worldwide and to analyse trends and future developments in this area. Methods This bibliometric study examines artificial intelligence research in veterinary medicine conducted worldwide from 1990 to 2024. To achieve this, a search using the keywords 'artificial intelligence' and 'veterinary medicine' was performed in the Web of Science (WOS) database, resulting in the identification of 1497 studies. After excluding irrelevant publications and those outside the scope of articles, a total of 1400 articles were included in the analysis. The data collection process utilised titles, author names, publication years, journal names, and citation counts. All textual data were analysed using VOSviewer software to ensure accuracy and reliability. In this study, analyses conducted through text mining and data visualisation techniques (e.g., bubble maps) facilitated a clearer understanding of the results. Results This study presents information about 1400 articles obtained from the WOS database and a total of 44,700 citations for these articles. The average number of citations per article is 32, with an H-index of 74. A rapid increase in both the number of articles and citations has been observed since 2019. The majority of the articles (30%) were published in the fields of veterinary sciences, artificial intelligence, and computer sciences. The United States, Taiwan and the United Kingdom are the leading countries, accounting for 84% of the published articles in this field. Additionally, 12% of the articles were published in the area of veterinary sciences, and 85% of the articles fall within the SCI-Expanded category. Conclusions The findings of our study indicate that there are numerous active researchers in the field of artificial intelligence in veterinary medicine and that research in this area is steadily increasing. This bibliometric analysis highlights global trends and significant works in artificial intelligence within veterinary medicine, providing valuable insights into the future directions of research in this field. As the analysis aims solely to identify trends and patterns in the literature, it does not intend to evaluate the applicability of the subject matter.
Derin Sinir Ağlarıve Sağlık Bilimlerinde Bir Uygulama
(2021) Elasan, Sadi
Amaç: Yapay sinir ağları algoritmasında giriş ve çıkış katmanları arasında birden fazla gizli katman bulunduğundan, “Derin Sinir Ağları” (Deep Neural Network) olarak adlandırılır. Klasik bir yapay sinir ağında bulunan nöronların birbirleriyle ilişkileri yoktur ve bilgi ancak giriş katmanından çıkış katmanına doğru aktarılır. Derin sinir ağlarında ise artarda gelen iki katmanda nöronlar birbirlerini çeşitli aktivasyon değerleriyle etkilemektedir. Her katmanın modele etkisi ve dolayısıyla her katmandaki nöronun modele etkisi bulunmaktadır. Çalışmada, Derin Sinir Ağları algoritması; farklı girdi (katman sayısı, döngü, hata oranı) ve uygulamalı modelin performansının değerlendirilmesi amaçlanmaktadır. Gereç ve Yöntem: Derin sinir ağı yöntemini klasik sinir ağlarından ayıran en önemli özellik, karmaşık problemlerde iyi sonuçlar veren katman sayısıdır. Çalışmada veri seti olarak immünoterapi kullanan hastaların siğil tedavisi sonuçları verisi kullanıldı. Bulgular ve Sonuç: Basit katmanlı (bir gizli katman) yapay sinir ağı modelinde %87.5 genel doğruluk ve %29.74 MAPE ile sınıflandırılırken, derin sinir ağı modeli %99.8 genel doğruluk ve %25.19 MAPE oranı ile sınıflandırılmıştır. Çalışma, derin sinir ağları modelinin daha yüksek doğruluk oranına sahip olduğunu göstermiştir.
The Difference Between Clinical Significance and Statistical Significance: an Important Distinction for Clinical Research
(Tubitak Scientific & Technological Research Council Turkey, 2024) Elasan, Sadi
Diş Hekimliği Fakültesindeki Deprem Yaşayan ve Yaşamayan Bireylerde Travma Sonrası Stres Bozukluğu-depresyon Görülme Sıklığı ve Temporomandibular Eklem Hastalıklarıyla İlişkisinin Araştırılması
(2017) Işık, Mesut; Tunç, Serap Keskin; Elasan, Sadi; Eroğlu, Cennet Neslihan
Amaç: Bu çalışmada diş hekimliği fakültesindeki deprem yaşayan ve yaşamayan gönüllüler arasında Travma Sonrası Stres Bozukluğu (TSSB)-depresyon görülme insidansı ve bu bireylerin temporomandibular rahatsızlıklar (TMR) açısından değerlendirilmesi amaçlanmıştır. Gereç ve Yöntem: Çalışmaya fakülte bünyesinde 124 gönüllü katılmıştır. Tüm bireylere Temporomandibular Rahatsızlık/ Araştırma Teşhis Kriterleri (TMR/ATK) anketi (Eksen I-II) ve TSSB anketi uygulanmıştır. İki anket üzerinden elde edilen veriler değerlendirilerek toplumsal örnekleme yüzdeleri sunulmuştur. Verilerin istatistik analizinde Tek Yönlü Varyans Analizi (ANOVA) ve Ki-Kare testleri kullanılmıştır. Hesaplamar için SPSS (ver:12.0) istatistik paket programıkullanılmıştır. Bulgular: Çalışmaya yaş ortalaması 22,76 olan 66'sı kadın, 58'i erkek olmak üzere 62 deprem yaşamış, 62 deprem yaşamamış birey katılmıştır. Tüm gönüllülerin %12.9'unda TSSB, %38.7'sinde depresyon bulgusu tespit edilmiştir. TSSB tespit edilen bireylerde daha çok miyofasiyal ağrı (%60) görülmüştür. Depresyon bulgusu taşıyan gönüllülerin %54,2'sinde eklem şikayeti bulunmuştur ve bu şikayetlerin başlıca sebebinin (%54) osteoartroz olduğu görülmüştür. Gönüllülerin %48'i psikolojik açıdan sağlıklı idi. Bu bireylerin %3,3'ünde eklem şikayeti tespit edilmiştir. Sonuç: TSSB ve depresyon bulgusu gösteren bireylerin TMR bakımından ciddi bir oran oluşturduğu göz ardı edilmemelidir. Gerekli durumlarda multidisipliner tedavi yaklaşımı ile bireylerin sorunlarının çözümüne gidilmesi hasta açısından daha faydalı olabilir.
Effect of Exposure To Fluorine and 7, 12-Dimethyl Benzanthracene on Vascular Responses
(Parlar Scientific Publications (p S P), 2022) Bulduk, Bahattin; Uyar, Hasan; Oto, Gokhan; Ozdemir, Hulya; Gunbatar, Nizamettin; Bulduk, Mehmet; Elasan, Sadi
In this study, the effect of experimental administration of fluorine and DMBA, alone or in combination, on rats on vascular responses was investigated. After adaptation, the rats were randomly selected and divided into 9 groups, 10 male rats in each group. While sodium fluoride was applied daily in drinking water for 12 weeks to the groups to which fluoride will be applied; on the other hand, DMBA was dissolved in sesame oil and applied to the groups that needed it, once a week for a total of 12 weeks. The groups were determined as C, SO, 1NaF, 15NaF, 30NaF, DMBA, 1NaF+DMBA, 15NaF+DMBA and 30NaF+DMBA. Tensions in the thoracic aorta were provided with phenylephrine. Then, relaxation responses were recorded by giving ACh ((10-8'-7'-6'-5)) and SNP ((10-,-9,-8,-7,)(-6)(,)(-5)) at different cumulative concentrations. In the study, it was determined that fluorine caused the vessels to contract and DMBA to relax. Concurrent exposure to high amounts of fluorine and DMBA was observed to cause vasoconstriction.
The Effect of Resveratrol on Toxicity Caused by Cisplatin in Rats With Experimentally Created Diabetes by Streptozotocin
(2022) Bulduk, Bahattin; Oto, Gokhan; Bulduk, Mehmet; Günbatar, Nizamettin; Elasan, Sadi; Koçak, Yılmaz
Aim: In our study, the therapeutic effect of resveratrol against the toxicity of cisplatin in rats with experimental diabetes mellitus with streptozotocin was investigated. Material and Method: 64 rats were used in the study. 8 groups were randomly formed, with 8 rats in each group. Group 1 was determined as the control group. Group 2 (STZ) was injected with 60 mg/kg streptozotocin intraperitoneally (ip) on the first day to induce diabetes. Group 3 (RES) was given 100 mg/kg of resveratrol orally every day. Group 4 (SIS), a single dose of cisplatin 7 mg/kg (ip) was administered 3 days later. Group 5 (STZ+RES), group 6 (STZ+SIS), group 7 (RES+SIS) and group 8 (STZ+SIS+RES) were determined. Results: While there was weight gain in the control and RES groups during the experiment, the STZ and STZ + SIS groups showed a significant decrease in body weights of the rats. In the groups given streptozotocin and cisplatin together with resveratrol, there was no decrease in body weight, but a small increase was observed. In groups with increased blood glucose values with streptozotocin, these values were found to have dropped significantly with resveratrol. The TAS level has increased significantly in groups RES, STZ+RES, SIS+RES and STZ+SIS+RES according to the control group; no significant difference has been found in the other groups compared to the control group. While the AST level was significantly higher in the STZ, SIS and STZ+SIS groups compared to the control group, the ALT level was found to be significantly higher in the STZ and STZ+SIS groups compared to the control group. Creatinine was found to be significantly higher in SIS, STZ+SIS, RES+SIS and STZ+SIS+RES groups compared to the control group. The SIS group and RES+SIS and STZ+SIS+RES groups were compared, the decrease in the RES+SIS and STZ+SIS+RES groups was statistically significant. QT (ms) values increased significantly in the STZ and STZ+SIS groups compared to the control group, but there was no significant difference in the other groups. According to the control group, the heart rate per minute was found to be significantly lower in the STZ and STZ+SIS groups. Conclusion: As a result, it was seen that the use of resveratrol would be effective in reducing the increased glucose levels in the treatment of diabetes and in the treatment of possible complications.
The Effect of Resveratrol Treatment on Heart Rate and Qt Values in Rats With Chronic Fluorosis
(Parlar Scientific Publications (p S P), 2022) Bulduk, Bahattin; Oto, Gokhan; Ozdemir, Hulya; Gunbatar, Nizamettin; Kocak, Yilmaz; Gul, Cihan; Elasan, Sadi
With this study, it was investigated how the impact of sodium fluoride (NaF) exposure on the cardiac conduction system would be treated with resveratrol. A total of 8 rats, 4 female and 4 male, weighing 200-300 grams, were used in each group. The first group was separated as the control group. The second group was determined as the group given 10 melt/day NaF, the third group as the group given 50 mg/It/day resveratrol, and the fourth group as the group given 10 mg/It/day NaF + 50 mg/It/day resveratrol. In the study conducted for 12 weeks, resveratrol and NaF were mixed into the drinking water of rats. When the study was finished after 4 months, the rats were anesthetized. They were placed in the right lateral position for the recording of ECGs. ECG samples were evaluated in II. derivation. Heart rate numbers were found high and QT values were found low in the groups that were administered only NaF. The heart rate and QT values of the groups administered with resveratrol alone or in combination with NaF showed parallelism with the control group.
The Effect of Using a Larger Port on Reducing the Complications of Laparoscopic Cholecystectomy: a Randomized Trial
(derman Medical Publ, 2019) Toktas, Osman; Cikman, Oztekin; Peksen, Caghan; Elasan, Sadi; Yuzkat, Nurettin
Aim: Laparoscopic cholecystectomy (LC) is the gold standard treatment method for cholelithiasis. There are many complications related to LC and many different microinvasive interventions have been performed to decrease the complication rate. In this study, we aimed to demonstrate the surgical results of the LC that was performed with a 15-mm port tool. Material and Method: Two-hundred patients who underwent LC in our clinic were included in this study. These cases were randomized as 10-mm port tool group (n-100) and 15-mm port tool group (n-100) according to the port-tool diameter that was used in LC. The gallbladder extraction time, port site complications, length of hospital stay, postoperative pain and cosmesis scores were compared between two groups.Results: The gallbladder extraction time was 135.3 sec in the 10-mm port tool group and 13.4 sec in the 15-mm port tool group (p<0.05). The complication rate was 53% (53cases) in the 10-mm port tool group and 13% (13cases) in the 15-mm port tool group (p<0.05). The duration of hospitalization was the same in both groups. The port site pain was 5.4 (2-9) in the 10-mm port tool group and 4.3 (1-7) in the 15-mm port tool group (p<0.05). None of the patients in either group had port site hernias or infections, and there was no significant difference between the two groups with regard to the port site incision scarring. Discussion: It was thought that it can reduce the operation time, the need for fascial expansion, gallbladder perforations during removal, and postoperative port site pain. Moreover, it does not increase the risk of a port site infection or a hernia and is not different from wound scarring.
Evaluation of the Differences in the Mri Findings Related To Primary and Secondary Adhesive Capsulitis
(Sage Publications inc, 2023) Gurbuz, Ahmet Faruk; Keven, Ayse; Yetim, Emel Emir; Elasan, Sadi; Karaali, Kamil
Purpose: The aim of this study is to describe the radiological findings of adhesive capsulitis due to different etiological factors and reveal that different clues due to different etiological causes should be considered in the diagnosis of adhesive capsulitis. Methods: The study group comprised 24 primary and 22 supraspinatus tendon rupture-related adhesive capsulitis patients with 24 individuals without adhesive capsulitis and with normal shoulder magnetic resonance imaging. Independent samples t-test and one-way analysis of variance tests were used to compare the measurements between the groups. Paired sample t-test and Cohen's kappa statistic were used to determine inter-observer reliability. The chi-squared test was used to determine the relationships between groups and categorical variables. Study participants were evaluated both qualitatively and quantitatively. Quantitative measurements included the thickness of the humeral and glenoid segment of the joint capsule and the thickness of the anterior joint capsule and the fluid depth within the biceps tendon sheath. The qualitative assessments included the detection of any signal abnormality at the rotator interval, the grading of the humeral and glenoid segment of the joint capsule, and the detection of any signal abnormality in respect of the anterior joint capsule. Results: A statistically significant difference was found between the groups of patients with primary adhesive capsulitis and with supraspinatus tear-related adhesive capsulitis in terms of the thickness of the humeral segment of the joint capsule at the axillary recess level (AUC = .729) (P: .006). Furthermore, setting the cutoff value for the thickness of the humeral segment of the capsule to 4.6 mm allowed the differentiation of primary adhesive capsulitis and supraspinatus tear-related adhesive capsulitis with a sensitivity of 70.8% and a specificity of 87.3%. Conclusion: In conclusion, the humeral segment of the joint capsule thickness at the axillary recess was found to be affected by different degrees depending on whether it is a primary or supraspinatus tear-related adhesive capsulitis.
Evaluation of the Effects of Different Treatment Modalities on Angiogenesis in Heart Failure Patients With Reduced/Midrange Ejection Fraction Via Vegf and Svegfr-1
(Saudi Med J, 2018) Erturk, Ismail; Saglam, Kenan; Elasan, Sadi; Aykan, Musa B.; Acar, Ramazan; Yesildal, Fatih; Ozgurtas, Taner
Objectives: To investigate the clinical significance of VEGF, sVEGFR-1 in heart failure reduced ejection fraction (HFrEF) and heart failure mid-range ejection fraction (HFmrEF) patients. Methods: A total of 104 people consisting of HFrEF and HFmrEF patients (n=54) and healthy (n=50) subjects were included in this comparative cross-sectional study. The study took place in Gulhane Training and Research Hospital, Ankara, Turkey, between 2011 and 2013. Serum VEGF, sVEGFR-1, plasma pro-BNP analysis and transthoracic echocardiography were performed. Results: The average sVEGFR-1 level of the HFrEF and HFmrEF patients was significantly higher than the control group (0.185 +/- 0.122; 0.141 +/- 0.120; p=0.013). The average sVEGFR-1 level of the HFrEF and HFmrEF patients using beta-blocker was significantly higher than the HFrEF and HFmrEF patients not using it (p=0.015). There was a significant and positive correlation between sVEGFR-1 and N-terminal pro-brain natriuretic peptide (pro-BNP) levels in the group with HF (r=0.211, p=0.044). Conclusion: It increases awareness about the role of sVEGFR-1 in HFrEF anf HFmrEF patients and the need for further studies. Beta-blocker may have a negative effect on angiogenesis in HFrEF and HFmrEF via increasing sVEGFR-1 levels. Additionally, Pro-BNP may contribute to inhibiting angiogenesis by increasing sVEGFR-1 levels and sVEGFR-1 may be an important biomarker in HFrEF and HFmrEF.
Evaluation of the Relationship Between Abdominal Fat Distribution and Osteoporotic Vertebral Compression Fracture With Mri
(Springer, 2023) Gurbuz, Ahmet Faruk; Keven, Ayse; Elasan, Sadi; Cevikol, Can
ObjectiveThis study was carried out to investigate the effects of abdominal subcutaneous adiposity and visceral adiposity on osteoporotic compression fractures. Material and methodsThe study group consisted of a total of 152 individuals aged 50-80 years; 76 were included in the vertebral fracture group and 76 in the healthy control group, whose bone mineral density was calculated. In order to determine the distribution of abdominal fat in both groups, four different measurements, i.e., sagittal abdominal diameter (SAD), abdominal diameter (AD), ventral subcutaneous thickness (VST), and dorsal subcutaneous thickness (DST), were made using lumbar magnetic resonance imaging (MRI). The visceral fat ratio (VFR) was also calculated based on these measurements. ResultsThere was a significant difference between the patient and control groups in VST and DST values, both when gender distribution was and was not taken into account (p < 0.006 for all cases). There was no significant difference between the patient and control groups in SAD and AS values, both when only female patients were considered, and gender distribution was not taken into account (p > 0.25 for all cases). On the other hand, in the analysis, when only male patients were considered, the SAD and AD values of the patient group were found to be significantly lower than those of the control group (p = 0.046 and p = 0.048, respectively). ConclusionIn conclusion, the study findings indicated that high SAD values in the male gender and high VST and DST values in both genders were associated with low lumbar vertebral fracture risk.
Global Trends in Studies on the Presence of Demodex Spp. in Patients Diagnosed With Blepharitis
(Iranian Scientific Society Medical Entomology, 2024) Yildiz, Rahmi; Afsar, Milad; Elasan, Sadi
Background: The main objective of this study is to review publications on the presence of Demodex spp. in patients diagnosed with blepharitis worldwide and to analyse the trends and groups in this field. Methods: This bibliometric study was conducted to detect the presence of Demodex spp. in patients diagnosed with blepharitis worldwide between 1984 and 2023. For this purpose, 288 studies were examined as a result of searches using the keywords "Blepharitis and Demodex" in Web of Science (WOS) databases. All text data was analysed using VOSviewer software to ensure accuracy and reliability. In this study, analysis using text mining and data visualization techniques (bubble maps and graphs) helped to make the results more understandable. Results: This study provided information on 288 articles from WOS databases. The average total number of citations is 1305 and the H-index is 41. The majority of articles (63%) were published in the field of ophthalmology. The countries that published the most articles on this topic were the USA (24%), China (13%), and Turkey (11%). Conclusion: This study is the first bibliometric study of patients diagnosed with blepharitis due to Demodex spp. The most used keyword in blepharitis is Demodex. The most studied field of research is ophthalmology and the most studied country is the United States of America. The results of this bibliometric analysis conducted by us reveal global trends in the presence of Demodex spp. in patients diagnosed with blepharitis and provide important information for future directions of research.
Investigation of Different Decision Trees and K-Nearest Neighbor Methods in Data Mining: an Application on Gynecology and Birth Data
(2019) Elasan, Sadi; Keskin, Sıddık
Veri madenciliğinde, sınıflandırma amacıyla kullanılan algoritmalar genel olarak; 'denetimsiz (unsupervised)' ve 'denetimli (supervised)' olmak üzere iki başlık altında incelenebilir. Denetimli veri madenciliğinde 'karar ağaçları (decision trees)' ve 'k-en yakın komşu (k-nearest neighbor | KNN)' algoritmaları; parametrik olmayan yöntemler arasında olup, tahmin edici özelliğe sahiptir. Sınıflandırma amacıyla uygulanan bu algoritmalarla, çalışmadaki cevap değişkeni (bebeklerin doğum ağırlığı) üzerine etkili olan açıklayıcı değişkenler belirlenmiştir. Karar ağaçlarından; 'CART, CHAID, Ayrıntılı CHAID, QUEST, Rastgele Orman ve C4.5' algoritmaları kullanılmıştır. K-en yakın komşu algoritmasında; 'Öklid' ve 'Manhattan (City block)' uzaklık ölçüleri kullanılarak uygulama yapılmıştır. Sınıflandırma performansları göz önüne alınarak, en iyi tahmin değerini veren algoritmalar belirlenmeye çalışılmıştır. Bu sonuçlara göre; Duyarlık (Sensitivity) ölçütü bakımından en yüksek tahmin oranı %88.4 ile 'CART' algoritmasında gözlenmiştir. Özgüllük (Specificity) ölçütü bakımından en yüksek tahmin oranı %98.2 ile 'Rasgele Orman' algoritmasında görülmüştür. Genel doğruluk ölçütü bakımından ise en yüksek tahmin oranı %94.5 ile 'C4.5' algoritmasında gözlenmiştir. Risk (hata) tahmin ölçütü bakımından en düşük algoritma, %5.6 ile 'C4.5' algoritması olmuştur. Genel olarak sonuçlar incelendiğinde; tüm algoritmaların 'iyi sınıflandırma, yüksek tahmin ve düşük hata oranı' ile çalıştığı söylenebilir. Ayrıca bu çalışma, yeni doğacak bebeklerin doğum ağırlığının, düşük doğum ağırlığında olup olmayacağına erken karar verme ve böylece koruyucu tedbirlerin alınması açısından araştırmacılara katkı sağlayabilir. Anahtar kelimeler: Çapraz Geçerlik, Denetimli Yöntemler, Öklid Uzaklığı, Risk Tahmini, Sınıflama
Is Maternal Blood Procalcitonin Level a Reliable Predictor for Early Onset Neonatal Sepsis in Preterm Premature Rupture of Membranes
(Karger, 2017) Cetin, Orkun; Aydin, Zuhal Dilek; Verit, Fatma Ferda; Zebitay, Ali Galip; Karaman, Erbil; Elasan, Sadi; Yucel, Oguz
Background: This study is aimed at comparing the early diagnostic accuracy of maternal blood white blood cell (WBC) count, C-reactive protein (CRP) and procalcitonin in predicting early onset neonatal sepsis (EONS) among early preterm premature rupture of membrane (PPROM) pregnancies. Methods: A total of 57 consecutive pregnancies, complicated with PPROM, between 24 and 34 gestational weeks were recruited to the study at Suleymaniye Maternity Education and Research Hospital, Istanbul, Turkey between January 2012 and January 2013. All patients were hospitalized and followed up with expectant management. Maternal blood WBC count, CRP and procalcitonin levels were measured in the first 12 h of membrane rupture. EONS was diagnosed using clinical and laboratory findings, and obstetric and neonatal outcomes were noted. Results: The cutoff value for maternal blood CRP was >= 9.49 mg/dl. This value predicted EONS with 77.8% sensitivity, 80.0% specificity, 77.8% positive predictive value (PPV) and 80.0% negative predictive value (NPV). The cutoff value for maternal blood procalcitonin was 0.071 ng/ml. This value predicted EONS with 85.2% sensitivity, 86.7% specificity, 85.2% PPV and 86.7% NPV. Conclusion: Maternal blood procalcitonin levels were superior to maternal blood CRP and WBC count in predicting EONS. Consequently, the maternal blood procalcitonin level is a clinically useful, non-invasive and reliable biomarker in antenatal prediction of EONS. (C) 2016 S. Karger AG, Basel
Menstrual Dönemde ve Öncesinde Temporomandibular Eklem, Baş- Boyun, Yüz-kulak Bölgesi Ağrılarının Görülme Sıklığının Araştırılması: Pilot Çalışma
(2018) Eroğlu, Üy C Neslihan; Tunç, Üy Serap Keskin; Elasan, Sadi
Amaç: Kadınlarda menstrual dönemde östrojen seviyesinin düşmesine bağlı olarak ağrı hassasiyetinde değişimler olduğu savunulmaktadır. Bu çalışmada menstrual dönemi ve öncesinde temporomandibular eklem (TME), baş-boyun, yüz-kulak ağrılarının görülme sıklığının araştırılması amaçlanmıştır. Gereç ve Yöntem: Menstrual periotları sorunsuz ve düzenli olan kadın bireyler çalışmaya dahil edildi. Hastalar, menstrual dönemde olan ve olmayan olarak iki gruba ayrıldı. Tüm hastalara TME hastalıkları için TMR/ATK (Temporomandibular Rahatsızlık/ Araştırma Teşhis Kriterleri) muayene anket formu uygulandı. Ek olarak TME, yüz-kulak, baş-boyun bölgesinde ağrı varlığı değerlendirildi. Bulgular: Gruplar arasında istatistiksel olarak anlamlı bir farklılık bulunmadı. Tüm hastaların % 50'si tek bölge ağrısı bildirmişlerdir. Hastaların % 23.5'inde TME ağrısı mevcuttur. TME şikayeti bulunan hastaların % 73.5'i menstrual dönemde değildir. Sonuç: Kadınlar menstruasyon döneminde daha çok baş-boyun ağrılarından, menstrual dönem öncesinde TME ağrılarından etkilenmektedirler