Browsing by Author "Emre, H."

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Amlodipine-Induced Gingival Hyperplasia in Chronic Renal Failure: a Case Report
(Makerere Univ, Fac Med, 2012) Aldemir, N. M.; Begenik, H.; Emre, H.; Erdur, F. M.; Soyoral, Y.
Amlodipine is a dihydropyridine calcium channel blocker that is used in the management of both hypertension and angina. Amlodipine induced side effects are headache, dizziness, edema, flushing, palpitations, and rarely gingival hyperplasia. The exact reason of amlodipine-induced gingival hyperplasia is not known. We presented a case with chronic renal failure (CRF) that developed gingival hyperplasia due to amlodipine use, which improved after ceasing the drug.
The Association Between Serum Dickkopf-1 Levels and Esophageal Squamous Cell Carcinoma
(Sage Publications Ltd, 2014) Begenik, H.; Kemik, A. S.; Emre, H.; Dulger, A. C.; Demirkiran, I.; Ebinc, S.; Kemik, O.
Serum Dickkopf-1 (DKK-1) is elevated in many malignancies and is an important indicator of malignant potential. However, its significance in esophageal squamous cell cancer (ESCC) has not yet been clarified. We hypothesized a role for DKK-1 in patients with ESCC. The study consisted of 90 ESCC patients and 85 healthy controls. After diagnosis, the level of DKK-1 was measured in the serum samples by enzyme-linked immunosorbent assay and the levels of DKK-1 were much higher in the ESCC patients than in the healthy control group (p < 0.0001). For serum DKK-1, the sensitivity and specificity of the assay were 70 and 80%, respectively. The preoperative serum DKK-1 level was elevated in the ESCC patients. Although serum DKK-1 is not a specific biomarker for ESCC, it might be a useful marker for the diagnosis and treatment of ESCC.
Can Renal Infarction Occur After Renal Cyst Aspiration? Case Report
(2011) Emre, H.; Soyoral, Y.U.; Tanik, S.; Gecit, I.; Begenik, H.; Pirincci, N.; Erkoc, R.
Renal infarction (RI) is a rarely seen disorder, and the diagnosis is often missed. The two major causes of RI are thromboemboli originhating from a thrombus in the heart or aorta, and in-situ thrombosis of a renal artery. We report a case of RI that developed due to renal artery and vein thrombosis, as confirmed by pathological evaluation of the nephrectomy material, three weeks after renal cyst aspiration.
Comparison of the Oxidant-Antioxidant Parameters and Sialic Acid Levels in Renal Transplant Patients and Peritoneal Dialysis Patients
(Elsevier Science inc, 2011) Emre, H.; Keles, M.; Yildirim, S.; Uyanik, A.; Kara, F.; Tamer, F.; Aydinli, B.
Objective. Several studies have shown that in end-stage renal failure, increased oxidative stress and reduced antioxidant system functions may play an important role in inflammation, atherosclerosis, and many other complications. Paraoxonase (PON) and arylesterase (ARE) are antioxidant and malondialdehyde (MDA) an oxidant agent. Increased sialic acid (SyA) levels in uremic patients is an acute-phase response showing tissue and organ damage. The aim of this study was to compare PON, ARE, MDA, and SyA among continuous ambulatory peritoneal dialysis (CAPD) and renal transplant patients. Methods. Twenty-six CAPD patients including 7 women and 19 men of overall mean age 40.5 +/- 10.66 years were included in this study. There were 28 preemptive transplant patients, namely 6 women and 22 men of overall mean age 36.5 +/- 10.97 years. CAPD was the initial sole replacement therapy. Serum PON, ATE, MDA, and SyA levels were measured at 13-15 months of treatment. Results. Higher PON (P = .015) and ARE (P = .002) and lower MDA (P = .002) and SyA (P = .000) values were determined among transplanted compared with CAPD patients. Conclusions. In the transplant group, antioxidant parameters were higher and oxidant parameters lower with less activation of SyA than in the CAPD group. We observed that renal transplantation had a constructive effect on the oxidant-antioxidant system and consequent tissue destruction, which were impaired in uremic subjects. This study showed that renal transplantation is a more appropriate replacement treatment than CAPD.
Effect of Kidney Transplantation on Smoking Habits of Kidney Donors
(Elsevier Science inc, 2015) Keles, M.; Avsar, U.; Avsar, Z.; Emre, H.; Cankaya, E.; Cansever, Z.; Aydinli, B.
Introduction. Smoking increases the risk for cardiovascular disease in kidney donors, as is the case with normal individuals; it may also result in the development and progression of chronic renal failure. The present study aimed to investigate the effect of kidney transplant on smoking habits of kidney donors. Method. The study included 98 donors in total (54 female, 44 male). A questionnaire was administered to donors about smoking status. Smoking status was asked about before surgery and 12 months postoperatively, and the preoperative and postoperative values were compared. The Fagerstorm test for nicotine dependence was administered to individuals who were still smokers and those who had smoked but quit. Results. The mean age of the participants was 48.27 +/- 10.8 years. The preoperative smoking status was 47% (n = 46), whereas the postoperative rate decreased to 29% (n = 28). This reduction in smoking rate was significant (P = .001). There was no difference in Fagerstrom levels between donors who continued smoking and those who quit smoking after the surgery (P = .583). Conclusions. A person who becomes a kidney transplant donor has the chance to quit smoking, which is a cardiovascular risk factor. In addition to the psychosocial benefits of being a donor, it should be noted that it might also provide some medical benefits. However, some patients continue smoking after surgery. Smoking should be questioned in the postoperative follow-ups of donors and the support required for smoking cessation should be provided.
Exfoliative Cytology of Oral Mucosa in Kidney Transplant Patients: a Cytomorphometric Study
(Elsevier Science inc, 2011) Keles, M.; Tozoglu, U.; Unal, D.; Caglayan, F.; Uyanik, A.; Emre, H.; Aydinli, B.
Objectives. The aim of this study was to investigate quantitative cytologic changes in oral mucosal smears collected from kidney transplant patients by modern stereologic methods. Methods. Smears were obtained from the clinically healthy buccal mucosa and floor of mouth of transplant patients (n = 21) and healthy volunteers (n = 27). Smears from each individual stained by the Papanicolaou method were analyzed using a stereologic method. Nuclear (NV) and cytoplasmic (CV) volumes were evaluated with Stereo Investigator software. Results. CV values were 123,012.71 +/- 15,840.96 fL in the floor of the mouth and 133,667.10 +/- 26,653.39 fL in the buccal mucosa of the kidney transplant patients. CV values were 133,746.93 +/- 14,210.67 fL in the floor of the mouth and 167,797.78 +/- 21,007.70 fL in the buccal mucosa of the control group. NV values were 945.68 +/- 65.85 fL in the floor of the mouth and 845.15 +/- 81.56 fL in the buccal mucosa of the kidney transplant patients and 485.17 +/- 18.03 fL in the floor of the mouth and 410.25 +/- 52.84 mu m(3) in the buccal mucosa of the control group. Significantly higher NV (P = .000) and NV/CV (P = .000) and lower CS (P = .000) values were found in the patient group compared with the control group. Conclusion. The findings suggest that there were alterations in oral epithelial cells, detectable by microscopy and cytomorphometry in kidney transplant patients.
The Relationship Among Acute-Phase Responce Proteins, Cytokines, and Hormones in Various Gastrointestinal Cancer Types Patients With Cachectic
(Sage Publications Ltd, 2012) Kemik, O.; Kemik, A. S.; Begenik, H.; Erdur, F. M.; Emre, H.; Sumer, A.; Kotan, C.
Background: Acute-phase response proteins (APRPs), cytokines, and hormones have been claimed to be an independent, important factor of cancers. We suggest that in gastrointestinal system cancers, changes in APRP, cytokines, and hormones are associated. Methods: C-reactive protein (CRP), albumin, interleukin I alpha (IL-I alpha), IL-I beta, IL-6, IL-8, IL-10, tumor necrosis factor alpha (TNF-alpha), midkine, vascular endothelial growth factor-A(VEGF-A), VEGF-C, VEGF receptor I (VEGFR I), leptin, adiponectin, and ghrelin serum levels are studied in 148 gastrointestinal system cancer types and 40 healthy controls. Results: We found statistically significant differences and correlations between groups. We found significantly higher serum CRP, IL-I alpha, IL-1 beta, IL-6, IL-8, IL- 10, TNF-alpha, VEGF-A, VEGF-C, VEGFRI, and leptin concentrations in patients with esophageal, gastric, pancreas, colon, and rectum cancers than controls (p < 0.001, p < 0.0001). But, we found lower levels of the serum albumin, midkine, adiponectin, and ghrelin in patients with esophageal, gastric, pancreas, colon, and rectum cancers compared to control subjects (p < 0.05, p < 0.001). Conclusions: Cachexia in gastrointestinal system cancer types is associated with changes in APRP, cytokines, and hormone concentrations. This may be reflected between the outcomes in malignancies and the biomarkers.
Rhabdomyolysis and Acute Renal Failure as a Result of Bentazone Intoxication
(2011) Emre, H.; Keles, M.; Uyanik, A.; Emet, M.; Bilen, Y.; Bayraktutan, D.
Bentazone (Basagran®) is a commonly used and easily available agricultural herbicide. We report a 41- year-old-man who developed rhabdomyolysis with acute renal failure after bentazone toxicity. Four hours later after oral intake of liquid bentazone for suicidal attempt, the patient admitted to emergency service and his initial renal function tests were in normal range. However on the 15th hour of intake, urine output decreased, and blood urine nitrogen, creatinine and creatinine kinase levels were increased. On the fifth day of hospitalization, creatinine and creatinine kinase levels had turned to normal levels. As a result, bentazone intoxication may cause rhabdomyolysis with acute renal failure. Thus, renal functions must be followed up closely.