Browsing by Author "Erbey, Fatih"

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Report of a Non-Hodgkin Lymphoma Case Presenting With Pleural Effusion
(Lippincott Williams & Wilkins, 2011) Akbayram, Sinan; Dogan, Murat; Akgun, Cihangir; Erbey, Fatih; Taskin, Gokmen Alpaslan; Peker, Erdal; Oner, Ahmet Faik
Initial presentation of Non-Hodgkin Lymphoma (NHL) as primary pleural lymphoma is extremely rare. We report a case with NHL, who was initially presented with pleural effusion and pleural thickening. Our patients at first received intensive treatment of broad spectrum antibiotics for 10 days with no change in the clinical status, and then were diagnosed with T-lymphoblastic lymphoma with the examination of pleural fluid by using cytologic and flow cytometric methods, and treated with LMT89 group B treatment protocol. Our case points out the necessity for considering the NHL within the differential diagnosis of any pediatric patient presenting with sterile pleural effusion and pleural thickening who does not respond to antimicrobial therapy.
Retrospective Clinical and Laboratory Evaluation of Children With Brucellosis
(Wiley, 2012) Okur, Mesut; Erbey, Fatih; Bektas, Mehmet Selcuk; Kaya, Avni; Dogan, Murat; Acar, Mehmet Nuri; Uzun, Hakan
Background: Acute brucellosis is a zoonotic disease seen in childhood, with non-specific complaints and clinical findings that can affect the locomotor, gastrointestinal, genitourinary, hematologic, cardiovascular, respiratory, and central nervous systems. Particularly in endemic regions, it occurs as a result of consumption of unpasteurized milk and dairy products. In this study, clinical and laboratory findings of children with acute brucellosis are presented. Methods: Data for 147 patients, aged 2-16 years, were evaluated retrospectively. Results: The most frequent complaints and clinical findings were abdominal pain and fever. Other complaints and clinical findings included arthralgia, myalgia, loss of appetite, weakness, sweating, fatigue, headache, arthritis, hepatomegaly, and splenomegaly. Anemia was the most frequent hematological abnormality detected; other abnormalities included leukopenia, thrombocytopenia, and pancytopenia. Conclusion: Childhood brucellosis can cause non-specific complaints and particularly anemia and leukopenia as hematological abnormalities. It is easily treated, however, with appropriate antibiotics.
Use of Rituximab in Three Children With Relapsed/Refractory Burkitt Lymphoma
(Springer, 2010) Akbayram, Sinan; Dogan, Murat; Akgun, Cihangir; Erbey, Fatih; Caksen, Huseyin; Oner, Ahmet Faik
Monoclonal antibodies have provided new promise for patients with B-cell malignancies. Rituximab is a monoclonal antibody against B-lymphocytes that express CD20; it is used for the treatment of patients with relapsed or refractory B-cell non-Hodgkin lymphoma. Very few data are available regarding the treatment of children with non-Hodgkin lymphoma with rituximab. In this article, we reported three children with primary refractory/relapsed B-cell-non-Hodgkin lymphoma, who were successfully treated with a combination of intensive chemotherapy protocol plus rituximab. In all three of our cases, the patients are still in complete remission. Our aim is to emphasize the importance of use of rituximab in the treatment of childhood B-cell non-Hodgkin lymphoma.