Browsing by Author "Erdogan, S."

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Comparative Clinical Efficiency of Resveratrol, Allopurinol, and Resveratrol Plus Allopurinol in Canine Visceral Leishmaniasis
(American Veterinary Medical Association, 2025) Erdogan, S.; Erdogan, H.; Ural, K.; Pasa, S.; Gultekin, M.; Balikci, C.; Gunal, I.
Objective To assess the clinical and immunological effectiveness of resveratrol alone or combined with allopurinol for treating canine visceral leishmaniasis (CVL). Methods This study included 50 dogs, 30 diagnosed with CVL and 20 healthy controls. Dogs were classified based on their treatment regime (receiving resveratrol [200 mg/dog/d] and/or allopurinol [10 mg/kg/d]). Clinical scores, anti-leishmanial antibody titers, and routine blood parameters were evaluated on days 0, 15, and 30 after treatment. Results Dogs treated with the combination therapy showed the most substantial improvements, with a 75.77% reduction in clinical scores and an 81.25% reduction in antibody titers. Dogs receiving allopurinol exhibited a 56.25% reduction in clinical scores, while those treated with resveratrol showed a 42.82% reduction. Antibody titers were less significantly reduced in the resveratrol group (67.5%) compared to the allopurinol group (45%). Conclusions Combining resveratrol with allopurinol enhances the therapeutic efficacy for CVL, leading to significant clinical improvements and reductions in antibody titers. Resveratrol alone also demonstrates promising anti-leishmanial effects. Clinical Relevance Resveratrol, either alone or in combination with allopurinol, offers a feasible and effective alternative for improving clinical outcomes in CVL. Its incorporation into standard protocols may enhance treatment strategies in veterinary medicine. ©The authors.
Effect of Curcumin Enema Dosage Regimes on the Reduction of Giardia Cyst Among Calves
(Pusat Penelitian Dan Pengembangan Peternakan, 2023) Ural, K.; Erdogan, H.; Ural, Da; Pasa, S.; Erdogan, S.; Ayan, A.; Balikci, C.
Giardiasis is one of the most significant and neglected parasitic infestations among calves, resulting in intestinal infections. This protozoan agent gained diagnostic and therapeutical importance because of its zoonotic potential, in which novel alternative/substitute therapeutical interventions are important, and this is because commonly used anti-parasitic drugs for control and eradication for battling this infection commonly presented side effects. Therefore, the present project evaluated the antiprotozoan activity of curcumin at different dose regimes used via the rectal route, the main constituent of turmeric. Rectal enema groups [Group I: 2 gr/kg, Group II: 80 mg/kg, and Group III: 10 mg/kg] and oral treatment Group IV: 2 gr/calf consisted of curcumin treatment at appropriate dosages showed herein in which the control group V were untreated. All treatment groups showed a statistically significant decrease in cyst counts on day 10, compared to day 10 values of the control group (p<0.005). Among the treatment groups, the highest cyst reduction was evident at 99.86% in curcumin 10 mg/kg rectal enema-administered calves (Group III), which received the lowest dose of the study. Curcumin at all dosages, primarily used in the rectal route at the lowest dosage regimen of 10 mg/kg, could have hastened clinical and parasitological efficacy via probable inhibition of Giardia proliferation and adhesion, as described previously. This treatment modality via the rectal route can change the game, highlighting novel treatment protocols.
The Effects of Different Types of Antioxidants (Se, Vitamin E and Carotenoids) in Broiler Diets on the Growth Performance, Skin Pigmentation and Liver and Plasma Antioxidant Concentrations
(Facta-fundacio Arnco Ciencia Tecnologia Avicolas, 2016) Karadas, F.; Erdogan, S.; Kor, D.; Oto, G.; Uluman, M.
This study investigated the effects of the addition of different antioxidants to broiler diets on their live performance, liver antioxidant composition and concentrations, immune response, and meat and skin color. A total of 945 three-day-old Ross 308 broiler chicks of both genders were randomly allocated to one of nine dietary treatments (n=105), with three replicates 35 chicks per pen, as follows: T1: control (commercially available corn-and soybean-based broiler diet); T2: selenium (control+0.5 mg/kg Sel-PlexTMSe yeast); T3: vitamin E (control+200 mg/kg Kavimix-E-50 a-tocopherol acetate); T4: lutein (control+100 mg/kg 5% Lutein Beads XB); T5: lycopene (control+100 mg/kg 5% Lyco Beads XB); T6: canthaxanthin (control+25 mg/kg 10% Carophyll (R) Red); T7: apoester (control+25 mg/kg 10% Carophyll (R) Yellow); T8: lutein+zeaxanthin (control+25 mg/kg Xamacol (R)); and T9: beta-carotene (control+100 mg/kg 10% Rovimix (R)). Feed (starter, grower, developer and finisher phases) and water were provided ad libitum for 42 days. Body weights, feed intake, feed conversion values and plasma carotene concentrations were recorded weekly, and liver antioxidant concentrations were recorded at the end of the experiment. Newcastle disease (LaSota) vaccination was performed on day 22. HI titers were measured on days 14, 21, 35 and 42 to determine the effects of the antioxidants on the immune system. The addition of selenium, vitamin E, and carotenoid supplements to the commercial broiler diet significantly increased antioxidant accumulation in the liver and the plasma. All antioxidants assessed significantly improved the immune response. Selenium and vitamin E supplementation also significantly improved total carotenoid concentrations in the plasma. The carotenoids enhanced skin and meat color. None of the supplements tested influenced growth (p>0.05).
High Prevalence of Ehrlichia Canis in Dogs in Van, Turkey
(Aloki Applied Ecological Research and Forensic inst Ltd, 2020) Ayan, A.; Kilinc, Orunc O.; Erdogan, S.; Akyildiz, G.; Bia, M. M.; Lee, D.
Tropical and subtropical regions have seen an alarming increase in vector-borne diseases especially tick-borne diseases. Ehrlichiosis is one of the most important vector-borne disease from a zoonotic perspective and it can be even more lethal in dogs and humans a compromised immune system. This study was conducted to determine the prevalence and molecular characterization of E. canis in Van province of Turkey. A total of 387 blood samples were collected from dogs in Van veterinary clinics in 2019. Extracted DNAs were run through Nested PCR using the appropriate primers. A total of 79 samples out of 387 were E. canis positive at 389 bp revealed by Nested PCR. Sanger method was used for DNA sequencing of two selected positive samples. Phylogenetic analysis revealed that relevant amplicon was 100% compatible with 16S RNA gene isolated from E. canis in many geographical regions.
Using of Sunflower Silage Instead of Corn Silage in the Diets of Goat
(Agricultural Research Communication Centre, 2018) Yildiz, S.; Erdogan, S.
The aim of this study was to evaluate the effect of using sunflower silage instead of corn silage for goats in early lactation on rumen and blood parameters and milk yield and composition. Saanen x Hair goat crossbred were used to assess their milk yield and composition with four diets, where corn silage (CS) was substituted with sunflower silage (SS) at amounts of 0, 34, 66 and 100 % of diets, respectively. The concentrations of C18:1 cis-9, C18:2 cis-9, trans-11 (CLA), C18:3n6 and C18:3n:3 fatty acids increased, due to the increase in the content of SS in the diet, and the highest levels of these fatty acids were found in the 100S S group (P<0.05). In conclusion, the roughage source represents an effective strategy for altering the fatty acid composition of goat milk, with evidence that the total mixed ration is an important determinant of ruminal unsaturated fatty acid metabolism in the goat.