Browsing by Author "Ersen Dudu, Tuba"

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Application of Poly (agar-Co Almond Oil) Based Organo-Hydrogels as a Drug Delivery Material
(Springer, 2022) Ersen Dudu, Tuba; Alpaslan, Duygu; Aktas, Nahit
In this study, it was aimed to investigate the synthesis, characterization and drug release behaviors of organo-hydrogels containing pH-sensitive Agar (A), Glycerol (G), Sweet Almond oil (Wu et al. in J Mol Struct 882:107-115, 2008). Organo-hydrogels, which contained Agar, Glycerol and different amounts of Sweet Almond oil, were synthesized via the free-radical polymerization reaction with emulsion technique using glutaraldehyde or methylene bis acrylamide crosslinkers. Then, the degree of swelling, bond structures, blood compatibility and antioxidant properties of the synthesized organo-hydrogels were examined. In addition, Organo-hydrogels which loaded with Ceftriaxone and Oxaliplatin were synthesized with the same polymerization reaction and release kinetics were investigated. In vitro release studies were performed at media similar pH to gastric fluid (pH 2.0), skin surface (pH 5.5), blood fluid (pH 7.4) and intestinal fluid (pH 8.0), at 37 degrees C. The effects on release of crosslinker type and sweet almond oil amount were investigated. Kinetic parameters were determined using release results and these results were applied to zero and first-order equations and Korsmeyer-Peppas and Higuchi equations. Diffusion exponential was calculated for drug diffusion of organo-hydrogels and values consistent with release results were found.
A Garlic Oil-Based Organo-Hydrogel for Use in Ph-Sensitive Drug Release
(Springer int Publ Ag, 2021) Alpaslan, Duygu; Olak, Tulu; Turan, Abdullah; Ersen Dudu, Tuba; Aktas, Nahit
In this study, six different organo-hydrogels containing agar-glycerol (AG)-based garlic oil (GO) were synthesized using two different crosslinkers (N,N, methylenebisacrylamide (MBA), glutaraldehyde (GA)) to ensure the controlled release of ceftriaxone (Ce) and carboplatin (Cp). Synthesized organo-hydrogels were characterized by FT-IR. Afterward, swelling behaviors were investigated in DI, tap water, ethanol, acetone, ethanol/DI water (1:1), acetone/DI water (1:1) and gasoline environments and different pH. As a result of hemolysis, blood clotting and antioxidant analysis, organo-hydrogels have been shown to have blood compatibility and antioxidant properties. Ce and Cp release properties of the prepared organo-hydrogels were also determined. The highest Ce release rate was obtained to be 37.8% for p (AG-g-GO)(3) at pH 8.0 after 7 days. However, the highest Cp release rate was found to be 95.4% for p (AG-g-GO)(3) at pH 7.4 after 1 day.
Novel Dimethylacrylamide/Gelatin Based Smart Hydrogels as a Color Sensor in Food Packaging Materials
(Wiley, 2023) Ersen Dudu, Tuba
New food packaging technologies are developing rapidly in line with the demands of consumers and the trends of the food industry. In the presented study, it was aimed to synthesize a new and smart hydrogel (p (Gelatin-co-DMAAm)/CA-Rh) (GDCa-Rh) from dimethylacrylamide (DMAAm), gelatin, citric acid (CA), and Rosehip (Rh) using the redox polymerization technique and use it as a color sensor in food packaging materials. To impart antimicrobial, antioxidant, and anthocyanin properties to the synthesized smart hydrogel, Rh was added to the reaction mixture. The structure/mechanical properties of GDCa-Rh were elucidated by dynamic mechanical analyzer (DMA), thermogravimetric (TG) analyzer, Fourier transform infrared spectroscopy (FT-IR), and scanning electron microscopy (SEM). The antimicrobial activity of GDCa-Rh was tested against Escherichia coli, Bacillus subtilis, and Staphylococcus aureus. Finally, to determine the effectiveness of synthesized GDCa-Rh on real samples, whole-pasteurized milk/cheese was selected as real samples. The results showed that GDCa-Rh was a good color indicator and exhibited good antimicrobial activity on whole-pasteurized milk/cheese. By means of synthesized smart GDCa-Rh hydrogels, harmful effects such as oxidation reaction, external moisture absorption or loss, physical damage, and biological degradation can be observed in the packaged product, and this new material will be a solution to the deficiencies faced by today's food packaging.
Synthesis and Characterization of Biocompatible Poly(Maleic Acid-Co Acid) Microparticles as a Smart Carrier for Thiamine
(Springer, 2021) Alpaslan, Duygu; Ersen Dudu, Tuba; Kubilay, Senol; Aktas, Nahit
Novel biocompatible homo and co-polymeric microparticles were synthesized from maleic acid (MA) and citric acid (CA) for uptake/release thiamine as a model drug. Surfactant-free self-emulsion polymerization technique was accomplished to synthesize the microparticles in a single step. The antimicrobial, antioxidant properties of those microparticles and their thiamine uptake/release capacities were investigated. Fourier transform infrared spectroscopy (FTIR), thermogravimetric analyzer (TGA), particle-size/zeta-potential (Zeta/DLS) and scanning electron microscopy (SEM) instruments were utilized for the characterizations of microparticles. FTIR revealed the existence of bonding interaction between the carboxylic acid groups of CA and MA. TGA results represented that thermal decomposition of microparticles was gradually continuing up to 1000 degrees C. The hydrodynamic diameters of poly (CA), poly (MA), poly (CA-co-MA) microparticles were found to be in the range of 681 nm, 1273 nm, 1604 nm, respectively. The zeta potential of those microparticles was in the range of - 5.69 mV, - 16.90 mV and - 7.73 mV, respectively. The studies demonstrated that all microparticles have superior properties to absorb and release thiamine compared with similar candidates. Furthermore, controlled release behavior of thiamine was examined using zero sequence, first-order, Higuchi and Korsmeyer-Peppas models in PBS solutions at pH 7.4. Thiamine release from all microparticles exhibits a very high correlation with the Korsmeyer-Peppas semiempirical model and could be interpreted by the superposition of both Fickian diffusion and non-Fickian diffusion based on Peppas' semiempirical equation. Superior capacities of microparticles, synthesized in one step without formation of toxic by-products, to absorb and release thiamine, aside from their biocompatible, antioxidant and antimicrobial properties make them valuable materials in nanotechnology and biomedical applications.
Synthesis of Smart Food Packaging From Poly (gelatin-Co Acrylamide) / Citric Acid-Red Apple Peel Extract
(Taylor & Francis inc, 2021) Alpaslan, Duygu; Ersen Dudu, Tuba; Aktas, Nahit
A novel and smart hydrogel was synthesized from N, N dimethyl acrylamide (DMAAm), gelatin, and citric acid (CA) red apple peel extract (RApE) to be utilized as a multi-functional food packaging material. The p(Gelatin-co-DMAAm)/CA-RApE was prepared through a redox polymerization technique in film form in petri dishes. Mechanical and water resistance of the p(Gelatin-co-DMAAm)/CA-RApE was improved by the addition of citric acid and N, N, methylenebisacrylamide (MBA) as cross linker. The characterization of p(Gelatin-co-DMAAm)/CA-RApE was carried out by Fourier transform infrared spectroscopy (FT-IR), thermo gravimetric analyzer (TGA), scanning electron microscopy (SEM), and dynamic and mechanical analyzer (DMA). FT-IR revealed the existence of bonding interactions between the functional group of RApE and gelatin, carbonyl groups of DMAAm, and carboxylic acid groups of CA. TGA results found that p(Gelatin-co-DMAAm)/CA-RApE was stable up to 565 degrees C. It was observed that RApE improved thermal stability and decreased the elasticity of the p(Gelatin-co-DMAAm)/CA-RApE. When tested against Escherichia coli, Bacillus subtilis and Staphylococcus aureus, p(Gelatin-co-DMAAm)/CA-RApE was observed to have antimicrobial activity. Total antioxidant and anthocyanin effect of p(Gelatin-co-DMAAm)/CA-RApE was analyzed. Additionally, to monitor the color changes of p(Gelatin-co-DMAAm)/CA-RApE, it was studied at different pH values. Furthermore, p(Gelatin-co-DMAAm)/CA-RApE was applied to real samples such as whole pasteurized milk and cheese. It was found to have a good color indicator and antimicrobial activity for pasteurized whole milk and cheese. It was concluded that p(Gelatin-co-DMAAm)/CA-RApE is a very good candidate to be used in food packaging and biomedical materials, along with other potential applications.
Use of Coconut Oil-Based Organo-Hydrogels in Pharmaceutical Applications
(Springer, 2022) Alpaslan, Duygu; Olak, Tulu; Turan, Abdullah; Ersen Dudu, Tuba; Aktas, Nahit
In this study, six different organo-hydrogel containing Agar-Glycerol (AG) based Coconut Oil (CnO) were synthesized using different crosslinkers to ensure the controlled release of D-3 Vitamine and 5-Fluorouracil (5-Flu). Synthesized organo-hydrogels were characterized by FT-IR, Afterwards, swelling behaviors were investigated in ethanol, acetone, ethanol/ID water (1:1), acetone /ID water (1:1) and gasoline environments and different pH. As a result of hemolysis, blood clotting and antioxidant analysis, organo-hydrogels have been shown to have blood compatibility and antioxidant properties. The effects of the initial pH of the solution on the drug release process were investigated. It was observed that the most release occurred at pH 2 and glutaraldehyde crosslinker. Release kinetics models were applied to understand the mechanism of the release system of D-3 Vitamine and 5-Flu (anti-cancer) with poly(Agar-co-Glycerol-co-Coconut Oil) (p(AG-co-CnO)) organo-hydrogel. The value of the correlation coefficient (R-2) was used as the best model fit indicator of different models and it was determined that the balance data fit the Korsmeyer-Peppas with large R(2)s and the Higuchi kinetic model. The results showed that the p(AG-co-CnO) organo-hydrogel can be used as a suitable carrier for the controlled release of D-3 Vitamin and 5-Flu.