Browsing by Author "Ertekin, A"

Now showing 1 - 3 of 3

The Effects of Carbon Tetrachloride (Ccl4) Induced Experimental Acute and Chronic Intoxication on Histological Structure of Liver and Some Hematological Values and Electrocardiogram in Rabbits
(Scientific Technical Research Council Turkey, 1999) Çinar, A; Yörük, M; Meral, I; Kiliçalp, D; Koç, A; Ertekin, A
This paper reports an investigation of the effects of acute and chronic carbon tetrachloride intoxications on the histologic structure of the liver and hematological values and electrocardiograms in rabbits. The rabbits were divided into 3 groups of 7. The first group was the control group, the second group was acutely intoxicated and the third group was chronically intoxicated. In the acutely intoxicated group, caryorexsis, along with necrosis was observed in the hepatocyte of the centrolobular area of the liver. In the chronically intoxicated group, connective tissue mass around the V. centralis increased. This increase of connective tissue caused chirrosis. Hematological values of the groups were as follows: red blood cells 5.86+/-0.6, 5.95+/-1.5, 4.26+/-0.7 billion/mm(3); white blood cell: 6.9+/-1.35, 5.90+/-0.8, 4.0+/-2.44 thousand/mm(3); hemoglobin concentration: 12.7+/-0.9, 13.6+/-1.5, 11.8+/-1.2 gr/dl; hematocrit value: 41.8+/-3.3, 44.6+/-4.9, 33.0+/-4.4%; sedimentation: 5.2+/-1.6, 8.0+/-2.8, 10.2+/-1.3 45 degrees/1 hours respectively. The formula leukocyte was as follows: in the control group: neutrophil 34+/-5.3%, eosinophil 0.6+/-0.8%, basophil 0.2+/-0.4%, lymphocyte 62+/-5.02%, monocyte 3.2+/-0.97%. In the acutely intoxicated group: neutrophil 7.75+/-1.1%; eosinophil 1+/-0%; basophil 0+/-0%; lymphocyte 88.5+/-1.3%; monocyte 3.5+/-1.8%. In the chronically intoxicated group: neutrophil 60+/-8.51%; eosinophil 1+/-0.71%; basophil 0+0%: lymphocyte 35.75+/-7.33%; monocyte 3.2+/-0.83%. The extremity leads and 2 vertical and 1 horizontal chest leads were used in the electrocardiograph of the rabbits, All waves were observed in all derivations. The P and T waves were negative in the III and aR leads and positive in the other leads, The amplitudes of waves decreased (hypo voltage) as a result of intoxication. In the groups, the heart rates were 219+/-21 in the control. 215+/-17 in the acutaly intoxicated, 201+/-35 per minute in the chronically intoxicated and the mean electrical axes of the heart rate were 45 degrees+/-20, 50 degrees+/-27. 35 degrees+/-20 respectively. Statistical comparisons were carried out using analysis of variance and Q test.
Investigation of the Lipid Peroxidation, Antioxidant Substances, Antioxidant Vitamins and Some Hematologic-Biochemical Parameter Levels in Gentamycine Induced Nephrotoxicosis in Dogs
(Tubitak Scientific & Technological Research Council Turkey, 2003) Ertekin, A; Karaca, M; Akkan, HA; Cemek, M; Ormanci, N
In our study, malondialdehyde, antioxidant vitamins, antioxidant substances and some hematologic-biochemical parameter levels in nephrotoxicosis were investigated. Six dogs were used in the study. Blood samples taken before the experiment were used as the control. Blood samples were taken on days 2, 5, 7 and 10 during the experiment. During analysis, we found that the statistical changes were not significant in the retinol and Vitamin C levels of the experiment group when compared to those of the control group. beta-carotene (P < 0.05) and Vitamin E (P < 0.001) levels were significantly decreased. Increases in the levels of malondialdehyde, seruloplasmin and urine gamma-glutamyl transferase (GGT) enzyme were P < 0.001, while decreases in the amounts of glutathione were P < 0.001. We also found that changes in erythrocyte and hemotocrit levels were not significant. On the other hand, increases in the levels of leucocyte (P < 0.01), creatinin and blood urea nitrogen (BUN) P < 0.001 were significant. In conclusion, oxidative damage can occur in cells in nephrotoxicosis, the use of antioxidants could be of benefit during treatment with chemotherapeutics.
An Investigation on Blood Gases and Some Haematological-Biochemical Parameters in Experimentally Induced Liver Cirrhosis of Dogs
(indian veterinary Journal, 2003) Ertekin, A; Mert, N; Akgul, Y; Karaca, M; Akkan, HA; Keles, I