Browsing by Author "Erten, Remzi"

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Apparent Vaccine-Thimerosal Induced Hypersensitivity, Myelodysplastic Syndrome and Pancytopenia
(J infection developing Countries, 2007) Karsen, Hasan; Akdeniz, Hayrettin; Karahocagil, Mustafa K.; Baran, Ali I.; Erten, Remzi
A case of hypersensitivity reaction, myelodysplastic syndrome and pancytopenia, which developed after an administration of thimerosal-containing tetanus vaccine, is presented and discussed.
A Case of Linear Syringocystadenoma Papilliferum of the Axilla: A Rare Location
(deri Zuhrevi Hastaliklar dernegi, 2019) Bilgili, Serap Gunes; Yavuz, Ibrahim Halil; Yavuz, Goknur Ozaydin; Ozturk, Murat; Erten, Remzi
Clinical and Histological Evaluation of the Efficacy of Antimicrobial Photodynamic Therapy Used in Addition To Antibiotic Therapy in Pericoronitis Treatment
(Elsevier Science Bv, 2018) Eroglu, Cennet Neslihan; Tunc, Serap Keskin; Erten, Remzi; Usumez, Ashhan
Background: Although antimicrobial efficacy of photodynamic therapy has been studied several times, there is no study investigating its efficacy on pericoronitis. This study aimed to determine whether antimicrobial photodynamic therapy combined with antibiotic therapy is clinically and histologically superior to antibiotic therapy alone in pericoronitis treatment. Methods: Patients (n = 40) with pericoronitis were divided into two groups (20 patients for each) to receive either antibiotic + indocyanine green + 810 nm wavelength diode laser (antimicrobial photodynamic therapy group) or antibiotic alone. Initial biopsy samples were obtained from the affected tissue of the patients at their first presentation to the clinic before any intervention. The second biopsy samples were obtained on the 3rd day of treatment in both groups from the tissue part not biopsied before; tooth extraction was then performed. All tissue samples were histologically examined to assess inflammatory cell response. Patients' pain (using Visual Analogue Scale) and lymphadenopathy (presence or absence) were clinically evaluated in the first 3 days and on the 7th day of treatment. Results: In the antimicrobial photodynamic therapy group, 100% improvement was achieved regarding pain and lymphadenopathy at the end of the 7th day. Comparison of the inflammatory cell scores of the 2nd biopsy samples between the antibiotic alone and antimicrobial photodynamic therapy groups revealed a significant difference in favor of antimicrobial photodynamic therapy group. Conclusions: Antimicrobial photodynamic therapy combined with antibiotic therapy for pericoronitis treatment was found to be more successful as compared with the antibiotic therapy alone regarding clinical and histological outcomes.
Comparative Nephroprotective Effects of Silymarin, N-Acetylcysteine, and Thymoquinone Against Carbon Tetrachloride-Induced Nephrotoxicity in Rats
(Kowsar Publ, 2017) Ustyol, Lokman; Demiroren, Kaan; Kandemir, Ibrahim; Erten, Remzi; Bulan, Kezban; Kaba, Sultan; Basunlu, Mehmet Turan
Background: Many pharmacological agents may lead to kidney damage. Preventing nephrotoxicity reduces the risk of morbidity and mortality, as well as decreasing hospitalization costs. Objectives: In this study, we investigated the comparative nephroprotective effects of silymarin, N-acetylcysteine (NAC), and thymoquinone (TQ) in animal models (rats) in which we induced nephrotoxicity using carbon tetrachloride (CCl4). Methods: This animal experimental study was conducted at the experimental animals center of Yuzuncu Yil University, Turkey, in 2015. Thirty-eight adult male Wistar rats were used in this study. We defined five experimental groups and treated them for four weeks. The first group (n = 8) was given no medicine. The second group (n = 8) was given only CCl4 (1.5 ml/kg, intraperitoneally (IP), in olive oil, twice a week). The third group (n = 6) was given TQ (10 mg/kg, IP, in dimethyl sulfoxide (DMSO), daily) and CCl4 (1.5 mL/kg). The fourth group (n = 8) was given silymarin (100 mg/kg, IP, in DMSO, daily) and CCl4 (1.5 mL/kg), while the fifth group (n = 8) was given NAC (10 mg/kg, IP, daily) and CCl4 (1.5 mL/kg). The kidneys of all the rats in every group were evaluated histologically using light microscopic methods at the end of the fourth week. A grading scheme was used to score the histological alterations related to tubular injury: absent (-), mild (+), moderate (++), severe (+++), and quite severe (++++). Results: In terms of the mean values of tubular damage, the first group had a mean of 0.0, the second group had 3.88 +/- 0.35, the third group had 1.00 +/- 0.89, the fourth group had 2.13 +/- 1.13, and the fifth group had 2.75 +/- 1.04. The results showed that, histopathologically, CCl4 had quite a severe toxic effect on the tubules when compared to the control group, although the glomeruli were intact. Silymarin, TQ, and NAC all showed statistically significant nephroprotective effects (P < 0.01). However, of the three, TQ was the most powerful nephroprotective agent (P < 0.01). Conclusions: In conclusion, we suggest that TQ may be used as a prophylactic agent against nephrotoxicity, especially in instances of tubular injury. However, human-based studies are still needed.
Comparison of Effects of High and Low Dose Paracetamol Treatment and Toxicity on Brain and Liver in Rats
(Kare Publ, 2020) Oksuz, Ersoy; Yasar, Semih; Erten, Remzi; Arihan, Okan; Oto, Gokhan
OBJECTIVE: Paracetamol is thought that it acts by inhibiting the central cyclooxygenase (COX) enzyme; its mechanism of action is still not fully explained. Although its most important side effect is hepatoxicity, it is thought to cause toxicity on the brain in recent years. The present study aims to investigate the treatment and toxic effects of low and high doses of paracetamol on the liver and brain. METHODS: Wistar-albino rats were used in this study. At doses of 20-500 mg/kg, paracetamol was administered intraperitoneally once a day for one and three days. The brain and liver were used for immunohistochemical evaluation using COX-3, prostaglandin E-2 (PGE(2)) and caspase 3 antibodies and for total antioxidant (TAS), total oxidant ( TOS) and oxidative stress index (OSI) measurements. Results were evaluated using the Kruskal Wallis test (SPSS ver.24). RESULTS: The liver COX-3 levels were significantly lower in both groups with higher doses (p<0.05). In the brain, there was no statistically significant difference in COX-3 levels between the groups. There was no statistically significant difference in PGE(2) levels in the liver and brain between the groups (p>0.05). The caspase 3 level in the liver was statistically significantly higher in the low dose group compared to the other groups (p<0.05). In both liver and brain, OSI values were significantly higher in the 3-day high-dose group compared to others (p<0.05). There was no statistically significant difference between the groups in ALT and AST values (p>0.05). CONCLUSION: The results of our study show that paracetamol inhibits the COX-3 enzyme in the liver but has no effect in the brain, and COX-3 does not have an effect on PGE(2). Paracetamol causes apoptosis in the liver only in low doses; higher doses may cause toxicity by increasing oxidative stress, especially in the brain.
Comparison of Enalapril, Candesartan and Intralesional Triamcinolone in Reducing Hypertrophic Scar Development: an Experimental Study
(Springer, 2018) Demir, Canser Yilmaz; Ersoz, Muhammet Eren; Erten, Remzi; Kocak, Omer Faruk; Sultanoglu, Yilmaz; Basbugan, Yildiray
The purpose of this study was to compare the effects of oral enalapril, an angiotensin-converting enzyme inhibitor (ACE-I), oral candesartan, an angiotensin receptor blocker (ARB), and intralesional corticosteroid treatments in reducing scar formation. Twenty male rabbits were divided into five study groups: A (sham), B (control), C (ACE-I), D (ARB) and E (intralesional corticosteroid). The rabbit ear hypertrophic scar model was used. The hypertrophic scars were photographed and analyzed with the program ImageJ quantitatively to determine the degree of collagen fibers. The scar elevation index (SEI) was calculated at the end of the 40th day. Tissue samples were stained with hematoxylin and eosin and Masson's trichrome and examined under light microscopy for the determination of fibroblast number, epithelization, vascularization, inflammation and fibrosis. The SEI was the highest in the control group with the highest number of fibroblasts under the epithelium. In the steroid group, the SEI was significantly lower than both the ACE-I (p: 0.02) and ARB (p: 0.001) groups. The density of type 1 collagen fibers was the lowest in the control group, whereas type 3 collagen fibers were highest in that group. The ACE-I and ARB groups were similar regarding densities of type 1 and type 3 collagen fibers. The density of type 1 collagen fibers was the highest in the steroid group, whereas the density of type 3 collagen fibers was the lowest in that group. Enalapril, candesartan and intralesional steroid therapies were all effective in reducing scar tissue development; however, enalapril and steroid groups revealed better results. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
Comparison of the Effectiveness of Thymoquinone, St. John Wort Oil and Silver Sulfadiazine in Experimental Burn Wounds
(Oxford Univ Press, 2024) Canbaz, Yasin; Karakol, Percin; Erten, Remzi; Mercantepe, Tolga; Alp, Hamit Hakan; Canbaz, Esra Turan; Yuce, Serdar
We aimed to compare the effectiveness of thymoquinone (TQ), the most important bioactive component of black cumin, St. John wort (SJW) oil, a traditional medicinal plant used in burns, and silver sulfadiazine (AgSD), a well-known antiinflammatory agent used in modern medicine, in an experimental burn rat-model. Sixty-three Wistar-Albino rats were randomly divided into 9 groups (n = 7). TQ and SJW were administered topically and systemically but AgSD was applied topically. Epithelialization, inflammatory cell response, granulation tissue, vascularization, and fibrosis were evaluated. Malondialdehyde (MDA), total antioxidant status (TAS), total oxidant status (TOS), vitamin E, 8-hydroxy-deoxyguanosine (8-OHdG), coenzyme Q10 (CoQ10) were analyzed in serum. Topical TQ accelerated the epithelialization, enabled granulation, vascularization, and fibrosis in wounds (P = .001). Topical and systemic TQ increased Vitamin E levels (P = .003) but reduced TOS and 8-OHdG levels (P = .001). Topical SJW reduced granulation and vascularization. Topical and systemic SJW decreased TOS, MDA, and 8-OHdG levels (P = .001) but increased TAS (P = .001) and Vitamin E levels (P = .003). Topical AgSD reduced TOS, 8-OHdG, and MDA levels (P = .001). Topical and systemic TQ demonstrated significant advantages in accelerating the wound healing process while also enhancing antioxidant defenses and reducing oxidative damage. SJW oil, particularly in topical application, improved epithelialization, and antioxidant status but showed less efficacy in systemic use. AgSD, while effective in reducing oxidative stress, was less successful in promoting wound healing and appeared to delay granulation and fibrosis. Thymoquinone offers superior protective and healing benefits, SJW is effective locally but less so systemically, and AgSD should be used cautiously, potentially combined with antioxidants to mitigate its negative impact on wound healing.
A Comparison of the Effects of Thymoquinone, Silymarin and N-Acetylcysteine in an Experimental Hepatotoxicity
(Elsevier France-editions Scientifiques Medicales Elsevier, 2018) Demiroren, Kaan; Basunlu, Mehmet Turan; Erten, Remzi; Cokluk, Erdem
This study investigated the effects of thymoquinone, silymarin, and N-acetylcysteine in a rat model with carbon tetrachloride (CCl4)-induced hepatotoxicity. Although numerous similar studies are available, we aimed to compare the efficacy of these agents by considering N-acetylcysteine as a reference compound. A total of 50 male Wistar albino rats were randomly designated as 5 groups: Group I, CCl4; group II, thymoquinone and CCl4; group III, silymarin and CCl4; group IV, N-acetylcysteine and CCl4; group V, control group. CCl4 was administered intraperitoneally at a dose of 1.5 mL/kg (a mixture of CCl4: olive oil, 1:2) twice a week. Thymoquinone was administered at a dose of 10 mg/kg, silymarin was administered at a dose of 100 mg/kg, and N-acetylcysteine was administered at a dose of 100 mg/kg by daily intraperitoneal injection. At the end of four weeks, blood and liver tests were analyzed. The results were evaluated statistically via the one-way ANOVA test. A p-value < 0.05 was considered statistically significant. Thymoquinone, silymarin, and N-acetylcysteine improved the levels of alanine aminotransferase, tumor necrosis factor-alpha, platelet-derived growth factor-BB, and interleukin-6, which were increased by CCl4. Thymoquinone and silymarin showed the positive increase in liver glutathione levels. Thymoquinone, silymarin, and N-acetylcysteine improved blood total oxidant status. In the histological examinations of liver tissue, thymoquinone decreased necrosis, and inflammation. The most positive decrease in the alpha-smooth muscle actin-stained hepatic stellate cell count was only observed with thymoquinone. These findings suggest that thymoquinone, silymarin, and N-acetylcysteine have potential for the treatment of diseases causing liver injury. Among these agents, thymoquinone showed the best results on most of the parameters. Since TQ appears to be at least as effective as SM and NAC in our in-vitro study, we propose that it is time for clinical studies with thymoquinone on hepatotoxicity.
Comparison of the Expression of Tumor Necrosis Factor Α Induced Protein 8 in Cervical Cancer and Precancerous Lesions of the Cervix, Its Relationship With P16, in Situ Hybridization of Low High-Risk Human Papillomavirus Types, and Its Ki-67 Cellular Proliferation
(2017) Şenköy, Funda Çalışkan; Erten, Remzi
Amaç: Serviks kanseri günümüzde dünyada kadınlar arasında dördüncü sıklıkta görülen ve gelişmekte olan ülkelerde kadınlarda kansere bağlı ölümlerin önemli bir nedeni olmasıyla önemini korumaktadır. Günümüzde serviks kanseri için en önemli risk faktörünün Human papillomavirüs (HPV) olduğu bilinmekte olup hastaların %99,7'sinde izlenmektedir. HPV serviks kanserinin gelişiminde, premalign lezyonlarının oluşumunda ve bunların kansere dönüşümünde en önemli etkendir. Tümör nekroz faktörü α'nın indüklediği protein 8 (TNFAIP8), sitozolik bir protein olup bağışıklık, karsinogenezis ve tümör progresyonu süreçlerinde rol alan, TNF- α ve transkripsiyon faktörü Nükleer faktör κB ile indüklenebilen antiapoptotik ve onkojenik moleküldür. Bizim çalışmamızda ise yeni keşfedilmiş prognostik ve karsinojen belirteç olan TNFAIP8'in serviks uterinin prekanseröz lezyonlarında servikal kansere progresyonunu, serviks kanserlerindeki agresiviteyi, düşük/yüksek risk HPV (LR/HR HPV) ile servikal kanser oluşum riski ile karşılaştırmayı, p16 ekspresyonu ve Ki-67 proliferasyon indeksi ile ilişkisinin olup olmadığını araştırmayı amaçladık. Gereç ve Yöntem: 22 adet Servikal intraepitelyal neoplazi (CIN) I, 21 adet CIN II, 19 adet CIN III, 10 adet iyi diferansiye SHK, 14 adet orta derecede diferansiye SHK, 11 adet az diferansiye SHK ve 19 adet ise nonneoplastik serviks uteriden oluşan toplam 116 vaka seçildi. TNFAIP8, p16 ve Ki-67 immünhistokimyasal boyama ve in situ hibridizasyonla düşük/yüksek risk HPV yapıldı. Bulgular: TNFAIP8 116 vakanın 48'inde yüksek boyanma gösterip boyanma oranı %41,4 olarak izlendi. TNFAIP8, CIN I'de %18,2, CIN II'de %14,3, CIN III'de %52,6, iyi diferansiye SHK'da %90,0, orta derecede diferansiye SHK'da %85,7, az diferansiye SHK'da %81,8 ve nonneoplastik serviks uteride %5,6 oranında boyanma izlendi. Tüm vakalar arasında p16 %74,1, Ki-67 %79,3, HR HPV %85,7, LR HPV %18,9 oranında boyanma izlendi. Sonuç: Çalışmamız TNFAIP8'in SHK'larında premalign lezyonlarına göre daha fazla boyanması nedeniyle karsinogenezde rol oynayan prognostik bir belirteç olduğunu göstermektedir. Premalign lezyonların arasında en fazla CIN III'te boyanma oranıyla hastaların tanı ve prognozuyla ilişkili olabileceği düşündürmektedir. HR HPV ve LR HPV ile TNFAIP8'in aralarında malignite gelişimi açısından korele bir ilişki saptanmadı. Ayrıca TNFAIP8'in, p16 ve Ki-67 boyanma oranları ile korele olmadığı görülmekle birlikte p16 ve Ki-67 gibi rutinde kullanılabilecek bir belirteç olmadığı düşündürmektedir. Anahtar kelimeler: Serviks uterinin skuamöz hücreli karsinomu, serviks uterinin premalign lezyonları, TNFAIP8, p16, Ki-67, düşük/yüksek risk Human papillomavirüs.
Diffüz Büyük B Hücreli Lenfoma ve Kronik Lenfositer Lösemili Hastalarda Pd-1 / Pd-l1 Ekspresyonlarının Değerlendirilmesi
(2024) Akkuş, Çiğdem; Erten, Remzi; Dağlı, Sinemis Çetin; Doğan, Ali; Demircioğlu, Sinan
Amaç: Programlanmış ölüm 1 (PD-1) / PD-ligandı (PDL) yolu, T hücresi aracılı immün yanıtlarının düzenlenmesi için önemli bir kontrol noktasıdır. Kanserler ne yazık ki PD-1/ PD-L1 yolunun immünsüpresif etkilerinden de yararlanmaktadır. Yaygın Büyük B Hücreli Lenfoma ( YBBHL) ve Kronik Lenfositer Lösemi (KLL)'de PD-1/ PD-L1’in önemi ile ilgili yeterli kanıt yoktur. Çalışmamızda YBBHL ve KLL’de PD-1/ PD-L1 ekspresyonun varlığını ve prognostik önemini değerlendirmeyi amaçladık. Gereçler ve Yöntem: Hematoloji Kliniğinde Ocak 2010 ile Eylül 2018 tarihleri arasında takip edilen 18-80 yaş arası 26 YBBHL hastası ve 27 KLL hastası çalışmaya dahil edildi. İmmunhistokimyasal boyama için Tıbbi Patoloji Anabilim Dalı arşivinde bulunan hastalara ait parafin blokları kullanıldı. YBBHL hastalarının lenf bezi biyopsi materyalleri ve KLL hastalarının kemik iliği biyopsi materyalleri değerlendirildi. PD-1 neoplastik olmayan dokularda boyandı ve PD-L1 neoplastik hücrelerde boyandı. Boyanma yüzdesi %5'in üzerinde olanlar pozitif kabul edildi. Bulgular: PD-1; YBBHL olgularının %65,4’ünde (n=17) pozitif, KLL olgularının %14,8’inde (n=4) pozitif saptandı. PD-L1; YBBHL olgularının %69,2’sinde (n=18) pozitif, KLL olgularının PD-L1 %3,7’sinde (n=1) pozitif saptandı. PD-1 ve PD-L1 ekspresyon ve boyanma sıklığı istatistiksel olarak anlamlı şekilde YBBHL’da daha yüksek bulundu (p=<0.001). PD-L1’de YBBHL tanılı olgularda evreler arasında ekspresyon açısında anlamlı fark bulundu (P=0,004). Sonuç: Çalışmamızda YBBHL’de literatürden daha yüksek oranda PD-1/ PD-L1 ekspresyonu tespit edildi. KLL’de diğer çalışmalara göre daha düşük oranda PD-1/PD-L1ekspresyonu saptandı. PD-1/ PD-L1 ekspresyonun YBBHL’de KLL’den daha fazla olduğu gösterildi.
A Dilemma in Staging of Esophageal Cancer: How Should We Stage Ypt0 N2 M0 Esophageal Cancer After Neoadjuvant Therapy
(Hindawi Ltd, 2015) Celik, Sebahattin; Erten, Remzi; Batur, Abdulsamed; Suvak, Burak
Background. Since neoadjuvant treatment in esophageal cancer began to become popular, a complete pathological response at the primary tumour site has been commonly reported. An issue of conflict is whether complete response in the esophageal lumen means that the esophagus is completely tumour-free. Another important issue is whether lymph nodes that are retrieved from pathologically complete response cases are also tumour-free or not. There is a gap in the esophageal cancer staging system for ypT0 N2 M0 tumours that have received neoadjuvant therapy. Here, we will discuss the problem about staging of esophageal cancer associated with neoadjuvant therapy. Case. A female aged 40 years complaining of dysphagia was diagnosed as having locally advanced thoracic esophageal cancer. Neoadjuvant therapy decision was taken by oncology committee. Six weeks after neoadjuvant therapy, with a curative intention, minimal invasive surgery was performed. The pathology report was as follows. "There were no neoplastic cells in the suspected area of the esophageal mucosa upon examination with all staining. There was no cancer at resection margins. Four metastatic lymph nodes were infiltrated with squamous cell cancer." Conclusion. Despite the growing use of neoadjuvant treatment in locally advanced esophageal cancer in world, we do not have a protocol for the evaluation of these patients' pathology reports. We believe that new studies and new ideas are needed to resolve this dilemma associated with neoadjuvant therapy.
The Effect of Fucoidan on The Gentamicin Induced Nephrotoxicity in Rats
(Parlar Scientific Publications (p S P), 2018) Yilmaz, Mesut; Mert, Handan; Irak, Kivanc; Erten, Remzi; Mert, Nihat
Possible preventive or therapuetic effects of fuciodan, which has antioxidant properties and was administered together with gentamicin (GM) made up nephrotoxicity through giving GM to the rats, have been searched. The rats used in this study were randomly grouped in three: control, GM (80 mg/kg/day/i.p GM was administered for 8 days), GM+fucoidan (80 mg/kg/day/i.p GM for 8 days + fucoidan 100 mg/kg/day/ for 8 days were administered with intra-gastric gavage) groups. Blood and tissue samples were taken 24 hours after the 8 days trial period. Besides determining plasma creatinine, BUN, sodium, potassium, chloride levels in auto-analyser, whole blood glutathione, plasma MDA and AOPP levels were analyzed spectrophotometrically. The highest plasma creatinine, BUN, potassium, AOPP and MDA levels were found in the GM group. It was determined that while the levels of creatinin (p<0.01), BUN (p<0.05), potassium (p<0.05), AOPP (p<0.01), MDA (p<0.01) in GM+fucoidan group were decreasing with regard to those in GM group, chloride levels were rising (p<0.05). The study revealed the nephroprotective effect of fucoidan. These findings suggest that fucoidan administration together with GM may attenuate renal dysfunction and structural damage through the reduction of oxidative stress in the kidney.
Effects of Jnk Inhibitor on Inflammation and Fibrosis in the Ovary Tissue of a Rat Model of Polycystic Ovary Syndrome
(E-century Publishing Corp, 2015) Bulut, Gulay; Kurdoglu, Zehra; Donmez, Yeliz Bozdemir; Kurdoglu, Mertihan; Erten, Remzi
Objective: In our study, we aimed to investigate the effects of Jun N-terminal kinase inhibitor (SP600125) on fibrosis and inflammation in rats with polycystic ovary syndrome (PCOS). Method: 50 Wistar-albino rats were divided into five groups (n=10 each): control group, sham group, PCOS group, SP600125+ PCOS group and SP600125 group. In the estradiol valerate (EV)-treated group in which PCOS was injected with a single 4 mg/kg i.p. of EV in 0.2 ml sesame oil and the rats were sacrificed on day 60. The estradiol valerate (EV)-treated + SP600125-treated group was injected with a single 4 mg/kg i.p. of EV in 0.2 ml sesame oil. As of day 60, the treatment group was additionally given 15 mg/kg i.p. of SP600125 once daily for 4 consecutive days and the rats were sacrificed on day 65. Histopathological findings (ovarian morphology, edema, inflammatory cell infiltration, vascular congestion and hyperemia) and collagen type IV immunoexpression were assessed. Results: The SP600125+ PCOS group showed a significant level of improvement in ovarian follicle morphology, edema, inflammatory infiltrate, vascular congestion and hyperemia as compared with the PCOS group. Furthermore, collagen type IV immunoexpression showed a significant reduction in staining intensity on the theca cell layer and ovary stroma as compared to the PCOS group. Conclusion: This study demonstrates the therapeutic effect of SP600125 in the prevention of PCOS in an experimental model.
Effects of Leontice Leontopetalum and Bongardia Chrysogonum on Oxidative Stress and Neuroprotection in Ptz Kindling Epilepsy in Rats
(C M B Assoc, 2018) Erkec, Ozlem Ergul; Arihan, Okan; Kara, Mehmet; Karatas, Ersin; Erten, Remzi; Demir, Halit; Ozgokce, Fevzi
We investigated the effects of Leontice leontopetalum and Bongardia chrysogonum on apoptosis, gamma-aminobutyric acid (GABA(A)) receptor positive cell number. cyclin-B1 and bcl-2 levels and oxidative stress in pentylenetetrazol (PTZ.) kindling in rats. Kindling was produced by subconvulsant doses of PTZ treatments in rats. Wistar albino rats were divided into 4 groups; Control, PTZ treated (PTZ), PTZ ;L. leontopetalum extract treated (PTZ FILE) and PTZ ;B. chrysogonum extract treated (PTZ+BCE) groups. Extracts were given a dose (200 mg/kg) 2h before each PTZ, injection. PTZ treatment significantly decreased the glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) activities and bc1-2 levels and increased the total oxidant status (TOS), malondialdehyde (MDA), cyclin B1, oxidative stress index (OSI) and number of neurons that expressed GABA(A) receptors when compared to the control. LLE and BCE possessed antioxidant activity in the brain and ameliorated PTZ induced oxidative stress, decreased cyclin-B1, increased bcl-2 levels, and kept the GABA(A) receptor number similar to that of the control despite the PTZ application.
Endobronchial Aspergilloma: a Case Report
(Elsevier Science Bv, 2016) Sunnetcioglu, Aysel; Ekin, Selami; Erten, Remzi; Parlak, Mehmet; Esen, Ramazan
A 28-year-old male with B-cell acute lymphoblastic leukemia presented to our pulmonary clinic with progressive dyspnea, cough, hemoptysis, and fever. Diagnostic bronchoscopy revealed white masses at the entrance of the right middle lobe bronchus and distal to the right main bronchus. Histopathological examination of the biopsy specimen showed those masses to be hyphae of Aspergillus. (C) 2016 The Authors. Published by Elsevier Ltd.
Esophageal Squamous Papillomatosis
(Springer Wien, 2016) Olmez, Sehmus; Aslan, Mehmet; Guducuoglu, Huseyin; Erten, Remzi; Tas, Adnan; Saritas, Bunyamin
Evaluation of Meibomian Glands in Obstructive Sleep Apnea-Hypopnea Syndrome
(Lippincott Williams & Wilkins, 2020) Muhafiz, Ersin; Olcen, Merhamet; Erten, Remzi; Bozkurt, Erdinc
Purpose: To evaluate the effect of obstructive sleep apnea-hypopnea syndrome (OSAHS) on the meibomian glands, ocular surface, and tear parameters. Methods: The study included 59 individuals (32 subjects with OSAHS, 27 control subjects) who underwent polysomnography in the Chest Diseases Clinic. The right eyes of all individuals were evaluated in the Ophthalmology Clinic. The first noninvasive tear break-up time (f-NTBUT) and the average noninvasive tear break-up time were measured, and Schirmer test was applied. Meibography was taken (Sirius; CSO, Florence, Italy), and meiboscore was used for indexing meibography. Finally, a sample was taken for conjunctival impression cytology. Results: In the study and control groups, the median of f-NTBUT was 2.1 seconds [interquartile range (IQR); 1.5-5.0] and 5.7 seconds (IQR; 2.9-8.8) and the median of average noninvasive tear break-up time was 5.6 seconds (IQR; 3.6-9.5) and 7.2 seconds (IQR; 4.2-10.7), respectively (P= 0.007 andP= 0.487, respectively). The mean Schirmer value was 16.3 +/- 5.9 mm (range; 5-25) and 17.3 +/- 6.6 mm (range; 5-30) in the study and control groups (P= 0.604). In upper eyelid meibography, the median of loss in the meibomian glands was 20.10% (IQR; 11.60%-40.80%) in the study group and 14.70% (IQR; 10.40%-21.30%) in the control group (P= 0.043). In lower eyelid meibography, the median of loss in the meibomian glands was 19.00% (IQR; 13.60%-35.30%) in the study group and 12.40% (IQR; 9.10%-16.40%) in the control group (P= 0.002). The median of the Nelson grade in conjunctival impression cytology was 1 (IQR; 0-1) in the study group and 1 (IQR; 0-1) in the control group (P= 0.445). Conclusions: The loss in the meibomian glands together with the shortened f-NTBUT shows that there could be a predisposition in OSAHS for evaporative dry eye originating from meibomian gland damage.
Evaluation of Tissue Levels of Glutathione S-Transferases (Gst) Isoenzymes in Patients With Discoid Lupus Erythematosus
(2019) Karadağ, Ayşe Serap; Yavuz, Göknur Özaydın; Erten, Remzi; Yavuz, İbrahim Halil; Oğuztüzün, Serpil; Bilgili, Serap Güneş
Aim: Cutaneous lupus erythematosus (CLE) has a multifactorial pathogenesis involving genetic and environmental triggers and congenital and acquired immune response. The aim of this study was to investigate the effects of Glutathione S-Transferases (GST) isoenzymes including GSTT1, GSTM1, and GSTP1 in the CLE patients with an etiology of solar radiation exposure.Material and Methods: Paraffin-embedded skin biopsy sections from the patients were stained by immunohistochemical methods. The results were evaluated under a light microscope by a pathologist. The pattern, localization, and distribution of the immunohistochemical staining were recorded for each patient. Staining of the nucleus or cytoplasm was considered as positive staining. The accuracy of staining was determined based on the intensity and percentage of staining.Results: No significant difference was found between the patient and control groups regarding staining intensity. In terms of staining percentage, the prevalence of GSTP1-3 genotype was significantly lower in the patient group compared to the control group (25% vs. 63.33%) (p=0.002).Conclusion: No significant difference was observed in the staining intensity of GSTP1, GSTT1, and GSTM1 between the patient and control groups and the staining percentage in some genotypes was even higher in the control group compared to the patient group.
Ewing's Sarcoma of the Lung: a Rare Case
(Turkish Assoc Tuberculosis & Thorax, 2019) Ekin, Selami; Cobanoglu, Ufuk; Goya, Cemil; Erten, Remzi; Yildiz, Hanifi
The Ewing's sarcoma family of tumors (ESFT) incorporates both the well-recognized primary bone and the extraskeletal soft tissue sarcomas. Primitive neuroectodermal tumors (PNET) and ESFT have a similar neural phenotype and can be considered in the same entity. Here, we will present 28 years old patient with Ewing Sarcoma. Patient was admited chest pain. Chest radiograph showed a suspicious lesion in the left paracardiac area. Computed tomography (CT) scan and positron emission tomography (PET)/CT result were compatible with malignant tumor. The patient was underwent surgical resection as the bronchoscopic result couldn't a malignant finding and pathological finding was detected as Ewing's sarcoma. Ewing's sarcoma should be considered in patients who are very fast growing in the lungs, are properly confined and suspected of malignancy in FDG-PET/CT.
Ewings Sarcoma of the Finger
(Medknow Publications & Media Pvt Ltd, 2014) Gokalp, Mehmet Ata; Kaplanoglu, Veysel; Unsal, Seyyid Serif; Erten, Remzi
Ewings sarcoma is a mesenchymal cell tumor usually seen in long bones but very rarely seen in the bones of a finger. Swelling and pain are the most common complaints of the affected finger. In radiological imaging, it may be seen as permeative bone destruction accompanied by a soft tissue component or an expansile bone lesion. A 27-year-old right-hand dominant female patient presented with a swelling on the proximal phalanx of her right 3 (rd) finger that had existed for 3 years. However, the mass started to gradually increase in size and the pain worsened over a period of 5 weeks. The mass was excised under regional intravenous anesthesia and Ewings sarcoma was confirmed following a histopathological evaluation. No local recurrence or metastasis was detected 1 year after surgery. Since Ewings sarcoma is rarely seen in the finger, we present this case with its radiological and clinical findings.