Browsing by Author "Eryilmaz, Recep"

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Comparative Evaluation of Bilateral Pudendal Nerve Blockade and Periprostatic Nerve Block in Transrectal Ultrasound Guided Prostate Biopsy: a Prospective Randomised Trial
(Polish Urological Assoc, 2020) Aslan, Rahmi; Erbin, Akif; Eryilmaz, Recep; Taken, Kerem
Introduction Although the periprostatic nerve block (PNB) is accepted as the standard method for local anesthesia prior to transrectal ultrasound (TRUS)-guided prostate biopsy, it is not the most ideal method. We aimed to analyze the effectiveness and safety of bilateral pudendal nerve blockage (PuNB) by comparing with PNB. Material and methods Between June 2019 and October 2019, a total of 108 patients with elevated serum prostate specific antigen values (PSA >= 4 ng/ml) and/or abnormal digital rectal examination findings were included in the study. After exclusion criteria, the remaining 91 patients were randomly divided into two groups as PuNB (n = 46) and PNB (n = 45). Pain during local anesthesia application was recorded as a visual analog scale (VAS) 1, pain during placement of the rectal probe and manipulation was recorded as VAS 2 and pain during needle penetration into prostate tissue and sampling was recorded as VAS 3. Results No significant difference was found between the two groups with regard to age, body mass index, serum PSA, prostate volume and prostate cancer rates. Mean VAS-2 score was significantly lower in the PuNB group when compared with the PNB group. There was no significant difference in terms of VAS-1 and VAS-3 scores. There was no significant difference between the groups in terms of mild and severe complications. Conclusions Both techniques are safe for TRUS-guided prostate biopsy; however, PuNB provided more effective pain control compared to PNB especially during placement of rectal probe and manipulation.
Comparison of Ceftriaxone and Cefazolin Sodium Antibiotic Prophylaxis in Terms of Sirs/Urosepsis Rates in Patients Undergoing Percutaneous Nephrolithotomy
(Galenos Yayincilik, 2019) Taken, Kerem; Asik, Alper; Eryilmaz, Recep; Aslan, Rahmi; Donmez, Muhammet Irfan; Gunes, Mustafa
Objective: The aim of this study is to compare ceftriaxone and cefazoline sodium antibiotic prophylaxis in terms of development of Systemic Inflammatory Response syndrome (SIRS)/urosepsis in patients undergoing percutaneous nephrolithotomy (PCNL). Materials and Methods: Patients who underwent PCNL between June 2015 and October 2015 in our hospital were prospectively randomized to ceftriaxone (n=30) and cefazoline sodium (n=32) antibiotic prophylaxis groups. Patients with predisposing conditions to SIRS were excluded. Intraoperative urine cultures from renal pelvis and stone cultures were obtained from all patients. Clinical and laboratory findings of the patients who developed postoperative fever were evaluated. SIRS and urosepsis rates were compared between two groups. Results: There were 7 patients in ceftriaxone group (23.3%) and 4 patients in cefazoline sodium group (12.5%) who developed SIRS (p=0.264). Sepsis was observed in 2 patients in both groups (p=0.826). Prolonged duration of surgery in ceftriaxone group and renal pelvis urine culture positivity in cefazoline group were found to be statistically significant in patients who developed SIRS (p=0.02, p=0.015, respectively). Conclusion: There was no significant difference between two groups in terms of SIRS and sepsis following PCNL. Therefore, cefazoline, which has a narrower antimicrobial spectrum, may be preferred for prophylaxis.
Comparison of Complications Following Laparoscopic Radical and Simple Nephreoctomy Using the Clavien-Dindo Clasification
(Galenos Yayincilik, 2019) Eryilmaz, Recep; Aslan, Rahmi; Taken, Kerem; Gunes, Mustafa
Aim: In this article, we aimed to compare the complications occurring after laparoscopic radical (LRN) and simple nephrectomy (LSN). Methods: After obtaining local ethics committee approval, we analyzed the records of a total of 98 patients, who underwent transperitoneal laparoscopic nephrectomy. LSN and LRN were performed in 64 and 34 patients, respectively. The Clavien-Dindo classification was used for evaluating complications. Pneumoperitoneum was created using a Veress needle. Intraabdominal carbon dioxide pressure was 18 mmHg while three 10 mm trocars were inserted and then one 5 mm trocar was inserted if needed. Results: The mean age of the LSN and LRN patients was 38.8 +/- 18.43 and 55.7 +/- 14.75 years, respectively. Five patients who underwent LSN developed postoperative minor complications (fever in one patient, nausea and vomiting in four patient). In addition, one patient who underwent LSN died postoperatively (vascular injury). Minor complications (fever in two patients, nausea and vomiting two, and ileus in one patient) developed postoperatively in five of 34 patients in LRN group. Conclusion: The rate of complication after LRN was found to be statistically significantly higher than that after LSN.
Comparison of Retrograde Intrarenal Surgery, Mini Percutaneous and Super Mini Percutaneous in the Treatment of <2cm Renal Lower Pole Stones
(2020) Taken, Kerem; Duran, Mehmet Arif; Md, Kasim Ertas; Eryilmaz, Recep; Aslan, Rahmi
Renal lower pole stones are a common disorder in the community. In this study, we aimed to compare Retrograde intrarenal surgery (RIRS), Mini PCNL(percutaneous nephrolithotomy) and Super Mini PCNL treatments in the treatment of lower pole stones. Patients who had lower pol renal stones with <20 mm stone sizes were en-rolled in the study. Preoperatively, renal stone and kidney characteristics were evaluated renal ultrasonography, intravenous pyelography and/or non-contrast abdominal computed tomography (CT). RIRS, Mini PCNL and Super Mini PCNL surgery methods were performed. Holmium laser and pneumatic lithotriptor were used for stone lithotripsy. The mean age of the patients in the RIRS group was 35 ± 5.23 years, the mean age in the Mini PCNL group was 38.3 ± 6.47 years and the mean age in the Super Mini PCNL group was 34.12 ± 3.56 years. RIRS were performed in 43 patients, Mini PCNL 37 patients and Supper Mini PCNL 35 patients.Stone free in RIRS was 74.3% Mini PCNL was 93.3% Super Mini PCNL was 94.6 %. According to clavien dindo classification postop grade2-3 complication , in RIRS was 4,6%Mini PCNL was 8,1% .But no grade2-3 complication was seen in Super Mini PCNL group. Hospital stay of RIRS was 1.59± 2.03 mini pnl was 3.73±1.76 and Super Mini PCNL was 2.3±1.55.Cost analysis respectively ,RIRS group, $801.52 ± 25.32; Mini PCNL group, $698.33 ± 22.37; Super Mini PCNL group,$703.13±62. In lower pole stones, RIRS is minimally invasive and have less hospital stay.Stone free rates were higher in Mini PCNL and Super Mini PCNL than RIRS. Super Mini PCNL has short hospital stay and less postoperative complication rate than Mini PCNL. RIRS is more expensive than Mini PCNL and SMP.
Comparison of Supine-Prone Percutaneous Nephrolithotomy Methods in the Treatment of Kidney Stones in Pediatric Patients: Prospective Randomized Study
(Springer, 2024) Eryilmaz, Recep; Ertas, Kasim; Aslan, Rahmi; Sevim, Mehmet; Keles, Muhammed Fatih; Taken, Kerem
Mini-PCNL is one of the most effective surgical methods in the treatment of kidney stones in pediatric patients. In this study, we aimed to compare PCNL in the supine-prone position in pediatric patients (especially operation time, postop complications, hospital stay and stone-free rates).We conducted our study in a randomized and prospective manner. Patients with lower pole stones larger than 1 cm, stones larger than 1.5 cm in the pelvis, upper pole, midpole or multiple locations, and patients who did not respond to ESWL or whose family that preferred mini-PCNL to be the primary treatment were included in the study. Patients with any previous kidney stone surgery, patients with coagulation disorders and patients with retrorenal colon were excluded from the study. Between 2021 and 2023, a total of 144 patients underwent PCNL. 68 of these patients had supine PCNL and 76 prone PCNL. Postoperative Clavien grade1 complication occurred in a total of 7 patients in the prone position; Clavien grade1 complication occurred in 1 patient in the supine position. The mean operation time for prone PCNL was 119.88 +/- 28.32 min, and the mean operative time for supine PCNL was 98.12 +/- 14.97 the mean hospitalization time in prone PCNL was 3.56 +/- 1.12 days, and 3.00 +/- 0.85 days in supine PCNL. In conclusion, supine PCNL is a safe and effective method in the treatment of pediatric kidney stones and postoperative complications were observed to be less; the operation time and hospital stay were shorter in supine PCNL.
Cutaneous Ewing's Sarcoma Secondary To Chemotherapy Given for Testis Tumor: Case Report
(Elsevier Sci Ltd, 2014) Tanik, Serhat; Zengin, Kursad; Albayrak, Sebahattin; Eryilmaz, Recep; Yilmaz, Deniz; Pirincci, Necip
INTRODUCTION: Testicular cancer has high cure rates, especially after the adjuvant use of chemotherapy. Secondary tumors may develop months and years after the primary tumor. We aimed to report a case of cutaneous Ewing's sarcoma at the site of surgery 3 years after BEP chemotherapy. PRESENTATION OF CASE: 21 year old male underwent radical orchiectomy in 2008. After one year surgical site complaints brought him to same hospital. A limited surgical resection was made. As his complaints continued he applied to our clinic. We resected the lesion with a 5 cm safety margin with the light of previous medical history. Pathology revealed cutaneous Ewing's sarcoma, and patient received VACD-IE chemotherapy. He is free of recurrence till now. DISCUSSION: Chemotherapy may cause secondary cancer especially in long term. In this case secondary tumor is diagnosed three years after surgery. Patient underwent therapeutic surgery and received chemotherapy (VACD-IE) for secondary Ewing's sarcoma. Early diagnosis and definitive treatment provide recurrence free survival in the patient. CONCLUSION: Secondary tumors can emerge months or years after primary tumor therapies, and are not related with the primary tumors. Any lesion or sign should be investigated carefully. Early diagnosis and correct treatment could prevent dramatic results. (C) 2014 The Authors. Published by Elsevier Ltd. on behalf of Surgical Associates Ltd. This is an open access article under the CC BY-NC-ND license
Determination of Oxidative Stress Levels and Some Antioxidant Enzyme Activities in Prostate Cancer
(Taylor & Francis Ltd, 2019) Amar, Safa Ali Ahmed; Eryilmaz, Recep; Demir, Halit; Aykan, Serdar; Demir, Canan
In this study, the antioxidant enzyme activities such as (SOD, GSH, and CAT) and malondialdehyde (MDA) level which is the end product of lipid peroxidation, were determined from the serum samples taken from patients diagnosed with prostate cancer Van Yuzuncu Yl University Medical Faculty of Educational Research and Training Hospital and stanbul Bagcilar Education Research Hospital. The SOD, GSH, and CAT activity of patient groups was found significantly lower than the healthy control group in patients with prostate cancer (p<.05). Serum MDA level is found significantly high when compared to control groups. MDA levels increased in patients that suffer prostate cancer disorder. Whereas, firstly antioxidant enzymes activity of SOD, GSH and CAT have been decreased in control groups. Thus, we concluded that the cause of development of prostate cancer may be the result of an imbalance between the antioxidants and oxidative stress. As a result, SOD, CAT, GSH, and MDA may play an important role in the etiopathogenesis of prostate cancer.
The Diagnostic Value of Ischemia-Modified Albumin in Prostate Cancer
(Galenos Yayincilik, 2020) Aslan, Rahmi; Eryilmaz, Recep; Sevim, Mehmet; Demir, Murat; Taken, Kerem
Aim: The aim of this study was to investigate whether serum ischemia-modified albumin (IMA) levels have a diagnostic value in prostate cancer (Pca). Methods: Thirty primary Pca patients and 30 age-matched healthy male subjects were included in this prospective case-control study. The patients were selected from the urology clinic of a tertiary university hospital. Healthy men included in the control group were selected from hospital staff and patient relatives. Patients with severe chronic diseases and other malignancies were excluded. Serum IMA level was measured using the colorimetric method. The results were reported in absorbance unit (ABSU). Results: Serum IMA levels were significantly higher in the study group when compared to the control group (0.843 +/- 0.76 and 0.443 +/- 0.49 ABSU, respectively; p=0.002). The mean IMA value in patients with a Gleason score >= 7 (1.08 +/- 0.053 ABSU) was significantly higher than in patients with Gleason score <= 6 (IMA 0.418 +/- 0.64 ABSU). According to the receiving operating characteristic (ROC) analysis, when the cut-off value was ABSU=0.57, the sensitivity and specificity were 80% and 56.7%, respectively. Conclusion: Serum concentrations of IMA are significantly elevated especially in clinically significant Pca patients. Its high sensitivity (80%) in ROC analysis suggests that IMA can be used an ancillary biomarker in diagnosis.
Does Tamsulosin Use Before Ureteroscopy Increase the Success of the Operation
(Coll Physicians & Surgeons Pakistan, 2022) Demir, Murat; Ertas, Kasim; Aslan, Rahmi; Eryilmaz, Recep; Sevim, Mehmet; Taken, Kerem
Objective: To investigate the effect of preoperative tamsulosin use on the success and complications rates of ureteroscopy for ureteral stone removal. Study Design: A randomised clinical trial. Place and Duration of Study: Department of Urology, Dursun Odabas Medical Center, Van Yuzuncu Yil University, Turkey, from December 2020 to June 2021. Methodology: Patients were scheduled for ureteroscopy due to ureteral stones, and were randomly divided into two groups; 67 patients preoperatively were given 0.4 mg tamsulosin for 7 days and 70 patients were not given tamsulosin. Each patient's intraoperative surgical complications, preoperative and postoperative pain, postoperative fever, need for analgesia, stone-free rate, and double J ureteral stent (DJ) insertion rates were recorded and evaluated. Results: A total of 137 patients, 103 (75.1%) males, and 34 (24.8%) females, were included. In 70 (51.1%) of these patients, the stone was on the right side, while in 67 (48.9%) the stone was on the left side. The stone was in the distal ureter in 47 (34.3%) patients, in the middle in 38 (27.7%) patients, and the proximal in 52 (37.9%) patients. The patients who were given tamsulosin had lower preoperative visual analog scale (p=0.02), operation time (p=0.003), post-ureteroscopic lesion scale (p=0.01), postoperative 24th-hour visual analog scale (p=0.03), fever (p=0.02), and analgesic need (p=0.04), while their rate of accessing the stone (p=0.02); and their stone-free rates (p=0.02) was higher. Conclusion: Preoperative tamsulosin use increases the success of the operation and reduces complications.
Effect of Combined Use of Tolterodine and Continuous Positive Airway Pressure Vs Continuous Positive Airway Pressure Only Treatment on Overactive Bladder Symptoms in Women With Moderate-To Obstructive Sleep Apnea Syndrome: a Randomized Clinical Trial
(Springer London Ltd, 2022) Ertas, Kasim; Yildiz, Hanifi; Demir, Murat; Aslan, Rahmi; Eryilmaz, Recep; Kirmizitoprak, Sevder; Taken, Kerem
Introduction and hypothesis Obstructive sleep apnea syndrome is associated with urological symptoms, including overactive bladder (OAB). This study aims to determine whether combined tolterodine and CPAP therapies are more effective for patients with OSAS than CPAP treatment only. Methods Women who underwent polysomnography test and were diagnosed with moderate-to-severe OSAS with apnea-hypopnea index (AHI) were included in the study. Data were collected on AHI, OAB awareness-8-item tool (OAB-V8), incontinence questionnaire-urinary incontinence short form (ICIQ-UI-SF), total daily urine volume (DUV), and the Benefit, satisfaction with treatment and willingness (BSW) tool. Eligible patients were randomized to receive either CPAP treatment only or combined CPAP and tolterodine treatment for 3 months. Results Among 103 participants, a total of 60 were included. Patients in both treatment arms showed significant improvements in OAB-V8, ICIQ-UI-SF, and total DUV compared to their baseline. The mean OAB-V8 was 15.7 at baseline and 5.6 at 3 months for the combined treatment arm and 16.6 and 7.6 at 3 months for the CPAP group only (mean baseline-adjusted between-group difference -1.1 [95% CI, -12.3 to -7.4]; p < 0.001). The improvement in the mean ICIQ-UI-SF was also statistically more significant in the combined therapy group than in the CPAP only arm (mean baseline-adjusted between-group difference -3.27 [95% CI, -4.6 to -1.59]; p < 0.001). No statistical significance was found in the improvement of total DUV between the groups. Conclusions In this study, combined use of tolterodine with CPAP provides beneficial effects to CPAP treatment only regarding OAB symptoms. Further research is required to confirm these findings in a large cohort.
The Effect of Plasma Rich Platelet Graft on Post-Operative Complications in Mid-Penile Hypospadias
(Wiley, 2020) Eryilmaz, Recep; Simsek, Metin; Aslan, Rahmi; Beger, Burhan; Ertas, Kasim; Taken, Kerem
Hypospadias is one of the most common penile congenital anomalies, which often requires a surgical approach. After the hypospadias is repaired, urethral fistula can occur in around 20% of patients. In this study, we used platelet-rich plasma (PRP) to reduce the urethral fistula and other post-operative complications after hypospadias repair. Only patients with primary mid-penile hypospadias were included study. Patients with forms other than mid-penile hypospadias and cases with previous hypospadias surgery were excluded from the study. A total of 40 hypospadias patients were included in this study. These patients were divided into groups A and B with 20 patients in each group. Hypospadias repair was performed with the Snodgrass TIPU technique on both groups. PRP was used with group A, and PRP was not use with group B. These two groups were compared in terms of early and long-term post-operative complications. Both early and long-term post-operative UCF, urethral stenosis and post-operative infection rates were lower in the group using PRP, group A. PRP has the potential to prevent post-operative complications occurring after hypospadias repair, particularly post-operative infection.
Examining Changes on Testicular Structure and Sperm Analysis of Covid-19 Patients
(Wiley, 2022) Ertas, Kasim; Eryilmaz, Recep; Yokus, Adem; Korpe, Kadir; Geduk, Nurullah; Ozkan, Mazlum; Aslan, Rahmi
This study aimed to examine the testicular functions with sperm analysis of patients with COVID-19. The study was carried out with male patients aged between 18 and 50 years with positive RT-PCR test and SARS-CoV-2 virus between December 2020 and April 2021. A total of 103 participants were included in the study. The mean age was 31.24 +/- 5.67 (19-45) years and the mean body mass index of the participants was 28.41 +/- 4.68 kg/m(2). The patients were divided into two groups, group-1 was patients who had COVID-19, group-2 was healthy men. A semen analysis of both groups was performed, and the serum total testosterone, FSH, LH, anti-mullerian hormone and Inhibin-B tests were analysed and recorded. The testicular dimensions and testicular densities were examined by ultrasound and elastography for both groups. Comparing the patient and control groups results, this study found that the sperm count per 1 cc (p = 0.01) and total motility (p = 0.01) in group-1 was lower than in the control group, the testicular dimensions decreased (for right testis group-2 was 15.39 +/- 4.78 ml versus group-1 was 12.11 +/- 4.62 cm(3) p < 0.01, for left testis group-2 was 16.01 +/- 5.12 versus group-1 was 11.92 +/- 4.78 cm(3); p < 0.01), and the shear wave velocities were significantly higher in group-1 patients. In conclusion, sperm parameters deteriorate in men who have symptomatic disease with SARS-CoV-2 infection. The fact that the cause of this deterioration is characterized by changes at the cellular level in the testis raises doubts about the persistence of this condition.
Fournier's Gangrene: Causes, Presentation and Survival of Sixty-Five Patients
(Professional Medical Publications, 2016) Taken, Kerem; Oncu, Mehmet Resit; Ergun, Muslum; Eryilmaz, Recep; Demir, Canser Yilmaz; Demir, Murat; Gunes, Mustafa
Objective: To report our experience with Fournier's Gangrene (FG) over the past eight years and evaluate the predisposing factors which affect the mortality. Methods: Sixty-five patients who were admitted to emergency surgical unit of our institution presenting with FG between January 2006 and August 2014 were included. The anatomical site of infective gangrene, predisposing factors, etiological factors, and outcomes were retrospectively reviewed. Results: Our cases included 8 women and 57 men. The average age of men was 51 +/- 13.9 (range 19-75) and the average age of women was 63 +/- 10.5 (range 52-76). Average hospitalization time was 9.2 +/- 6.6 days (range 5-25) days. The most frequent comorbid disease was diabetes mellitus and the most frequent etiology was perianal abscess. Colostomy was performed in 11 patients, orchidectomy in two patients, cystostomy in two patients. Notably, all of the 8 (12.3%) patients who died from FG had diabetes and low socioeconomic status. A total of six patients who died required more than one surgical debridement. Conclusions: Fournier's gangrene is a severe surgical emergency, with a high mortality rate. Low socioeconomic status, diabetes and more than one debridement play a major role in mortality and morbidity.
Isolated Renal Pelvis Rupture Secondary To Blunt Trauma: Case Report
(Elsevier Sci Ltd, 2015) Taken, Kerem; Oncu, Mehmet Resit; Ergun, Muslum; Eryilmaz, Recep; Gunes, Mustafa
Introduction: Isolated rupture of the renal pelvis is a very rare condition and thus causes delays in the diagnosis of the rupture. It is most commonly seen in the setting of obstructive ureteric calculus. Other rare causes include neoplasms, trauma, and iatrogenic procedures. Diagnosis is usually established on computed tomography (CT) which demonstrates the extravasation of the contrast in the peripelvic, perinephric, or retroperitoneal collections. PRESENTATION OF CASE: A 27-year-old male patient was admitted to our hospital due to multiple traumas associated with motor vehicle accidents. The patient had clear urine output. A large pelvic rupture was detected by abdominal contrast-enhanced CT and after consulting with other departments, emergency repair of the renal pelvis was performed and a ureteral stent was implanted. DISCUSSION: Only a few isolated cases of pelvis rupture with resultant extravasation have been reported in the literature. The treatment of pelvic rupture should be preceded by the removal of underlying causes, followed by conservative management. However, surgical intervention should be warranted in the emergency cases presenting with the symptoms that may impede the decision-making process and in the cases whose diagnosis cannot be clarified by radiological techniques. CONCLUSION: Renal pelvic injury must be considered in the differential diagnosis of blunt trauma. Surgical intervention may be necessary in some cases. We present a case who underwent surgery due to isolated renal pelvis rupture caused by blunt abdominal trauma. (C) 2015 The Authors. Published by Elsevier Ltd. on behalf of Surgical Associates Ltd.
Levels of Serum Trace Elements in Patients With Peyronie
(Taylor & Francis Ltd, 2020) Gunes, Mustafa; Aslan, Rahmi; Eryilmaz, Recep; Demir, Halit; Taken, Kerem
Aim: The etiology of the disease of Peyronie is not certainly known. However, penile micro traumas are thought to be important in the pathogenesis of Peyronie's disease (PD) in genetically predisposed individuals. In this study, we aimed to determine the relationship of some trace element and heavy metals with PD. Material and methods: Thirty Peyronie patients and 26 healthy volunteers were included in the study. In individuals in both groups, levels of serum trace elements (Manganese [Mn], Cu, Cobalt (Co), zinc [Zn], Cd, and iron [Fe]) were determined separately by Atomic Absorption Spectrophotometer method in Yuzuncu Yil University Central Research Laboratory. Results: Mn, Cu, Zn, and Fe levels in Peyronie patients were statistically significantly lower when compared to the healthy control group (p < .05). Cd and Co levels were similar for both groups but not statistically significant (p > .05). Conclusions: The changes in trace element levels are related to the etiopathogenesis of PD. We think that our study is the first from this aspect.
Oxidant-Antioxidant Levels in Patients With Bladder Tumours
(Taylor & Francis Ltd, 2020) Gunes, Mustafa; Eryilmaz, Recep; Aslan, Rahmi; Taken, Kerem; Demir, Halit; Demir, Canan
Purpose: We have aimed to determine whether oxidants-antioxidants play a role in the etiopathogenesis of bladder tumour by measuring their levels in the serums of patients with bladder tumour. Material method: Thirty patients with bladder tumour with superficial bladder tumour and 27 normal healthy volunteers were included in the study. Four cc of venous blood was taken from these patients and volunteers in the control group and centrifuged at 5000 rpm for 10 minutes and divided into serum and plasma. The activities of xanthine oxidase, glutathione reductase, glutathione-s transferase, reduced glutathione and superoxide dismutase enzymes in serum were then measured spectrophotometrically. Findings: Antioxidant parameters (glutathione-s-transferase, reduced glutathione, superoxide dismutase and glutathione reductase) in the serum of patients with bladder tumours were found statistically significantly lower than control group (p < .05). On the other hand, xanthine oxidase which is an oxidant indicator, was found significantly higher in patients with bladder cancer than control group (p < .05). Conclusion: Oxidative stress is effective in the etiopathogenesis of bladder tumour. We, therefore, believe that antioxidants are protective against bladder tumours and will be effective in the treatment of bladder tumours.
Oxidative Dna Damage To Sperm Cells and Peripheral Blood Leukocytes in Infertile Men
(int Scientific Literature, inc, 2016) Taken, Kerem; Alp, Hamit Hakan; Eryilmaz, Recep; Donmez, Muhammet Irfan; Demir, Murat; Gunes, Mustafa; Sekeroglu, Mehmet Ramazan
Background: Oxidative DNA damage is associated with male infertility. The aim of this study was to evaluate the oxidative DNA damage of sperm cells and blood leukocytes and to determine the levels of MDA and NO levels in seminal and blood plasma of idiopathic infertile men. Material/Methods: The study enrolled 52 patients, including 30 infertile and 22 fertile men. MDA, NO, and 8-OHdG/10(6)dG were estimated using spectrophotometry and high-pressure liquid chromatography ( HPLC)-based methods in seminal and blood plasma. The association with the sperm parameters was assessed, particularly sperm counts and motility. Results: The mean sperm concentration and sperm motility of the fertile men were significantly higher than that of the infertile men. The mean MDA and NO concentration in the seminal and blood samples of the infertile men were higher than that of fertile men. Also, the mean numbers of sperm cells and leukocytes 8-OHdG/10(6)dG of the infertile men were significantly higher than that of fertile men (p=0.04 and p<0.001, respectively). Sperm motility and sperm count were negatively correlated with leukocyte and sperm cell 8-OHdG/10(6)dG ratio. However, progressive motility was significantly negatively correlated with sperm cell and leukocyte 8-OHdG/10(6)dG ratio (R=-0.357, p=0.026; R=-0.388, p=0.024, respectively). Conclusions: Oxidative stress is an important factor in male infertility. Therefore, biochemical detection of 8-OHdG/10(6)dG in sperm cells and blood leukocytes may be an additional tool in the diagnosis of male infertility.
Periprostatic Nerve Block Alone Versus Combined With Perineal Pudendal Nerve Block or Intrarectal Local Anesthesia During Transrectal Ultrasound-Guided Prostate Biopsy: a Prospective Randomized Controlled Trial
(Wiley, 2019) Aslan, Rahmi; Erbin, Akif; Celik, Sebahattin; Ucpinar, Burak; Eryilmaz, Recep; Taken, Kerem
Objectives To compare the efficacy, safety and cost of combinations of perineal pudendal nerve block + periprostatic nerve block and intrarectal local anesthesia + periprostatic nerve block with the standard technique (periprostatic nerve block). Methods The study was designed as a randomized prospective controlled trial. Patients with elevated serum prostate-specific antigen values (prostate-specific antigen >= 4 ng/mL) and/or abnormal digital rectal examination findings were included in the study. Patients with anorectal diseases, chronic prostatitis, previous history of prostate biopsy and anorectal surgery were excluded from the study. A total of 148 patients (group 1 [periprostatic nerve block], n = 48; group 2 [intrarectal local anesthesia + periprostatic nerve block], n = 51; group 3 [perineal pudendal nerve block + periprostatic nerve block], n = 49) were included in the final analysis. Pain during insertion and manipulation of the transrectal ultrasound probe was recorded as visual analog scale 1, pain during penetration of the biopsy needle into the prostate and sampling was recorded as visual analog scale 2, and pain during the entire procedure recorded as visual analog scale 3. Results The mean visual analog scale 1 score was significantly lower in group 3, when compared with group 1 and group 2 (P < 0.001). There was no significant difference between the groups in terms of the mean visual analog scale 2 score. The mean visual analog scale 3 score was significantly lower in group 3 when compared with other groups (P < 0.001). The total cost for transrectal ultrasound-guided biopsy in the intrarectal local anesthesia + periprostatic nerve block group was significantly higher than the other two groups. Conclusions The combination of perineal pudendal nerve block and periprostatic nerve block provides more effective pain control than intrarectal local anesthesia plus periprostatic nerve block and periprostatic nerve block alone, with similar complication rates and without increasing cost.
Pregnancy and Renal Cyst Hydatid Disease: Case Report
(Academic Journals, 2012) Gecit, Ilhan; Pirincci, Necip; Taken, Kerem; Eryilmaz, Recep; Ozveren, Huseyin; Deveci, Serkan
Hydatid cyst disease is an important health problem in many countries, including Turkey. While it can impact any organ, it is most often found in the lung and liver. Renal involvement is relatively rare. A diagnosis of renal cystic hydatidosis was established with ultrasound and magnetic resonance in a 22 year old patient who was 25 weeks pregnant after she presented with severe right flank pain. Albendazol was administered at a dose of 10 mg/kg/day. She was closely followed during her pregnancy. At 38 weeks, she gave birth to a healthy baby via vaginal delivery. Following her delivery, the cyst was resected. Post-operatively, she completed an 8 week course of albendazol at a dose of 10 mg/kg/day. 1 year later, the patient has done well with no complications. We presented this case to highlight the lack of consensus in regards to the treatment of renal hydatid cyst disease in pregnancy.
Preoperative Levels of Matrix Metalloproteinase-7 And-9 and Tissue Inhibitor of Matrix Metalloproteinase-1 Relation To Pathologic Parameters in Bladder Carcinoma Patients
(Asian Pacific Organization Cancer Prevention, 2013) Gunes, Mustafa; Kemik, Ahu Serap; Pirincci, Necip; Gecit, Ilhan; Taken, Kerem; Yuksel, Mehmet Bilgehan; Eryilmaz, Recep
Our aim was to test the hypothesis that preoperative serum levels of matrix metalloproteinase-7 (MMP-7) and -9 (MMP-9) and tissue inhibitor of matrix metalloproteinase (TIMP-1) levels correlate with pathological features. Serum levels of MMP-7, and MMP-9 and TIMP-1 were determined in 90 bladder cancer patients and 40 healthy controls using an enzyme linked immunosorbent assay. Preoperative serum MMP-7 and MMP-9 levels were significantly higher in cancer patients than control groups (p<0.001). In contast, serum TIMP-1 levels were lower (p<0.001). Alteration in MMP-7, and MMP-9, and TIMP-1 production may contribute to tumor angiogenesis and be associated with clinic-pathological features.