Browsing by Author "Eryonucu, B."

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Comparison of Heart Rate Variability and Treadmill Exercise Score in Patients With Stable Coronary Artery Disease
(2001) Eryonucu, B.; Bilge, M.; Güler, N.
Depressed heart rate variability (HRV) is associated with increased mortality and morbidity with various forms of heart disease, and the Duke treadmill score (DTS) provides diagnostic and prognostic information for the evaluation of patients with coronary artery disease (CAD). Our study was aimed at assessing any possible correlation between HRV and DTS in stable CAD. We evaluated the correlation between the HRV assessed by using 24 hour ambulatory ECG monitoring, and treadmill exercise score in 37 patients with angiographically proven and clinically stable CAD. In univariate analysis, DTS showed a significant negative correlation with age (r = -0.89, p < 0.01) and a significant positive correlation with the square root of the mean of the sum of the squares of differences between adjacent R-R intervals (RMSSD) (r = 0.67, P < 0.05), percent difference between adjacent normal R-R intervals >50 ms (PNN50) (r = 0.69, P < 0.05), and mean of the standard deviation of all R-R intervals in all the 5-minute intervals (HRVM) (r = 0.63, P < 0.05). There is no significant correlation between DTS and standard deviation of all R-R intervals (SDNN), standard deviation of the averages of R-R intervals in all 5-minute segments of the entire recordings (SDANN) and standard deviation of the SDNN in all the 5-minute intervals (HRVSD). In multiple regression analysis, age was the only independent significant predictor of DTS (p < 0.01). DTS decreased with advancing age. SDNN, SDANN, RMSSD, HRVM and HRVSD were not appearent predictors for detecting of DTS. Age was an independent predictor of DTS. Although DTS was correlated with RMSSD, PNN50 and HRVM in patients with stable CAD, time domain parameters of HRV were not appearent predictor for DTS.
The Effect of Perindopril and Amlodipine on Brachial Artery Pulse Wave Velocities in Patients With Essential Hypertension
(1999) Guler, N.; Bilge, M.; Eryonucu, B.; Ipeksoy, U.
It is known that the brachial artery flow velocity as assessed by duplex Doppler ultrasound is changed in hypertension. The main purpose of this study was to assess the effects of perindopril and amlodipine on the brachial artery pulse wave velocity in essential hypertension. Blood flow profile and velocity of the brachial artery were determined noninvasively by pulsed Doppler ultrasound technique under the guidance of a B-mode ultrasound image. Thirty-two untreated hypertensive patients and 11 control subjects matched for age and sex were included in the study. Hypertensive patients were classified into two groups which were treated either with amlodipine 5 mg or perindopril 4 mg and re-evaluated after 15 days. Patients with essential hypertension had significantly larger peak systolic velocity than those without it (71(18 cm/sec vs. 45(16 cm/sec, P<0.001). After antihypertensive treatment, significant decrease was found in the mean blood pressures of both groups (P<0.001). After treatment with perindopril, peak systolic velocity decreased (73±19 vs 58±14 cm/sec, P<0.05) and duration of systolic flow prolonged (269±18ms vs 291±17ms, P<0.05). Also, after treatment with amlodipine, peak systolic wave decreased (68±15ms vs 55±13ms, P<0.05) and duration of systolic flow prolonged (266±17ms vs 288±18ms, P<0.01). In conclusion, as assessed by duplex Doppler ultrasound, peak systolic wave was increased and systolic flow duration not changed in essential hypertension. Both perindopril and amlodipine treatments decreased peak systolic velocity and prolonged systolic flow duration. Further study is needed to clarify the exact mechanisms of the flow velocity alterations with antihypertensive therapy.
The Effects of Volatile Anaesthetic Agents in Myocardial Repolarization During Induction of Anaesthesia
(1999) Guler, N.; Bilge, M.; Eryonucu, B.; Demirel, C.B.; Kati, I.; Sayarlioglu, M.
QT dispersion may serve as a measure of variability in ventricular repolarization time and may be a means of identifying patients at risk of arrhythmias and sudden death after different clinical settings. The acute responses of QTc dispersion were assessed in 47 American Society of Anesthesiology (ASA) class 1 or 2 patients receiving volatile anaesthetic agents. Anaesthesia was induced with sevoflurane (n=16), halothane (n=17), or isoflurane (n=14), and the inspired concentration increased to reach an end- tidal concentration of 1% to 6%. Recordings of ECG, heart rate, blood pressures were obtained at the following times: prior to induction of anaesthesia, 1 min and 3 min after stable end-tidal concentration, 1 min and 3 min later vecuronium administration, and 1 min and 3 min after tracheal intubation. All the patients studied had normal values of QTc interval and QTc dispersion at rest. All anaesthetic agents significantly increased QTc dispersion compared with baseline values. Both isoflurane and sevoflurane increased QTc interval compared with baseline in contrast to halothane which did not change it significantly. Thus, anaesthetic agents cause myocardial repolarization abnormalities in man in terms of increased QTc dispersion. This may be relevant in the aetiology of arrhythmias in patients receiving anaesthesia without cardiovascular disease.
Impaired Heart Rate Variability as a Marker of Cardiovascular Autonomic Dysfunction in Multiple Sclerosis
(Blackwell Publishing, 2004) Tombul, T.; Anlar, O.; Tuncer, M.; Huseyinoglu, N.; Eryonucu, B.
The Psychometric Properties of the Clark-Beck Obsessive-Compulsive Inventory in a Turkish Population
(2007) Beşiroǧlu, L.; Aǧargün, M.Y.; Boysan, M.; Güleç, M.; Eryonucu, B.
Objective: We examined the psychometric properties of the Clark-Beck Obsessions and Compulsions Inventory eveloped to assess the frequency and severity of obsessive compulsive symptoms. Methods: The sample consisted of 52 OCD patients, 32 non-OCD patients with other anxiety disorders, 36 nonobsessional depressed patients, 75 healthy adults, and 278 undergraduate students. We investigated internal consistency, test-retest reliability, concurrent and discriminant validity of the instrument. Results: Cronbach's α coefficients for the CBOCI Obsessions, Compulsions and Total scale were found as 0.86, 0.83 and 0.91 in all samples respectively. The CBOCI obsessions (r=0.81, p<0.001), compulsions (r=0.85, p<0.001) and total score (r=0.85, p<0.001) showed a significant level of temporal stability. OCD patients scored significantly higher on CBOCI obsessions, compulsions and total scale than non-obsessional anxious, depressed patients, healthy control subjects. Obsession, compulsion and total scores of both OCD and nonclinical sample were significantly correlated with other scales assessing obsessive compulsive symptoms. Discussion: The Turkish version of the CBOCI has appropriate reliability and validity for assessing the frequency and severity of obsessive-compulsive symptoms.
Vasorelaxant Effect of Sildenafil on Aorta and Pulmonary Artery in Rabbits
(2006) Güler, N.; Özbek, H.; Eryonucu, B.
This in vitro study was designed to determine the direct vasorelaxant effect of the sildenafil on isolated rabbit pulmonary artery and compare it with the response of isolated rabbit aorta. Endothelium intact aortic and pulmonary artery rings from seven domestic rabbits were suspended in organ chambers containing 15 mL Krebs solution aerated with 95% O2, 5% CO2. In both phenylephrine and potassium chloride (KCl) precontracted vessels, relaxant responses of sildenafil were recorded by strain gauge transducers connected to a polygraph. Sildenafil (10-9 to 3×10-5 M) induced a dose-dependent vasodilation of phenylephrine precontracted aorta and pulmonary artery; 55 and 95% relaxations were obtained, respectively, at a concentration of 3×10-5 M. Sildenafil also caused a dose-dependent vasodilation of KCl-precontracted aorta and pulmonary artery, but this vasodilation was significantly lesser. Sildenafil-induced relaxations were higher in pulmonary arteries when compared to aortic rings precontracted with either phenylephrine or KCl. We concluded that sildenafil induces a dose-dependent vasodilation on phenylephrine and KCl-precontracted rabbit aorta and pulmonary artery. This vasodilatory effect is more potent in pulmonary arteries than in aortic rings. © 2006 Asian Network for Scientific Information.
Vasorelaxant Effects of Sildenafil and Verapamil on Isolated Rat Aorta With and Without Intact Endothelium
(2006) Özbek, H.; Güler, N.; Eryonucu, B.
This study was designed to compare vasorelaxant effects of the sildenafil and verapamil on isolated rat aorta. Endothelium intact and denuded aortic rings were suspended in organ chambers. Sildenafil (10-10 to 10-4 M) induced a dose-dependent vasodilation of phenylephrine precontracted aortic rings. Relaxation of endothelium intact and denuded aortic rings caused by 10-4 M sildenafil was about 96 and 79%, respectively. Verapamil (10-10 to 10-4 M) induced a dose-dependent vasodilation of phenylephrine precontracted aortic rings. Relaxation of endothelium intact and denuded aortic rings caused by 10-4 M verapamil was about 99 and 98%, respectively. In the phenylephrine precontracted aortic rings, pD2 values for sildenafil were 4.93±0.59 and 4.11±0.62 in the presence and absence of endothelium, respectively. The pD2 values for verapamil were not different in the presence and absence of endothelium (5.15±1.05 vs 4.96±1.14). Verapamil and sildenafil showed a similar degree of vasorelaxant effect in the intact aortic rings, although there was a significant difference in the degree of relaxation in the absence of endothelium (98 vs 79%). Sildenafil induced both endothelium-dependent and independent vasorelaxation on the aortic rings. Although, there was no significant difference in the degree of relaxation induced by verapamil and sildenafil in aortic rings with intact endothelium, verapamil has more relaxing effect in the denuded aortic rings. © 2006 Asian Network for Scientific Information.