Browsing by Author "Eser, Gizem"

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Bir Güvercinin (Oriental Roller) Göz Kapağında Tüberküloz Olgusu
(2021) Eser, Gizem; Saglam, Yavuz Selım; Yildirim, Serkan; Alkan, Ismaıl
Kanatlı tüberkülozu Mycobacterium avium spp. tarafından oluşturulan pek çok evcil ve yabani kanatlılarda rastlanılan kronik seyirli bir hastalıktır. Bu çalışmanın materyalini Van Yüzüncü Yıl Üniversitesi Cerrahi kliniğine getirilen gözkapağında bir kitle (1,5 x 1,5 x 0,5 cm. ölçülerinde ve 0,88 gr ağırlığında) bulunan üç yaşında Oriental Roller ırkı bir güvercin oluşturdu. Göz kapağı ve çevresinde bulunan bu kitle anestezi altında cerrahi operasyonla total olarak alındı. Alınan kitle sitolojik ve histopatolojik olarak incelendi. Sitolojik incelemede çok sayıda langhans dev hücresi gözlendi. Histopatolojik muayenede ise; merkezinde nekroz, çevresinde çok çekirdekli langhans dev hücreleri, mononükleer hücre infiltrasyonları ve en dıştan fibröz kapsül ile çevrili tüberküllerin varlığı gözlendi. Alınan kesitlerin Ziehl-Neelsen boyama ile boyanmasında, nekrotik kitle içerisinde yoğun asit-fast basili tespit edilerek tüberküloz tanısı konuldu. Tanı sonucu hayvan sahibinin isteği üzerine ötenazi yapıldı. Nekropside iç organlarda herhangi bir patolojik bulguya rastlanmadı. Bu olgu Van yöresinde güvercinlerde bildirilen ilk avian tüberküloz vakasıdır. Van ili göçmen kuşların önemli göç yolları ve uğrak bölgelerinden biri olduğu için bölgede hastalığın görülmesi evcil ve yabani hayvanlar arasında hastalığın yayılmasında önemli bir risk faktörüdür. Bu nedenle konuyla ilgili daha fazla çalışmaların yapılması önerilmektedir.
Evaluation of the Protective Effect of Chlorogenic Acid and Rhabdosciadium Anatolyi Against Cyclophosphamide-Induced Ovarian Toxicity in the Rat With Histopathological and Immunohistochemical Findings
(Kafkas Univ, veteriner Fakultesi dergisi, 2020) Alkis, Ismet; Ekin, Suat; Yildirim, Serkan; Bakir, Ahmet; Eser, Gizem; Firat, Mehmet
Cyclophosphamide (CD) has a range of adverse effects on ovarian tissue in humans. It is widely an anticancer drug and used in autoimmune disorders. Also, CD produces reactive oxygen species. In the current study, we evaluated possible protective roles of Rhabdosciadium anatolyi (RA) and chlorogenic acid (CA) on histopathological alterations and immunohistochemical assessment of 8-OHdG in the ovarian tissues of female rats given cyclophosphamide. Female Wistar albino rats were divided into six experimental groups, each consisted of eight rats: control group, CD (200 mg/kg) with i.p. for the first day as single dose, CA (100 mg/kg), RA (300 mg/kg) for each day, RA (300 mg/kg) + CD (200 mg/kg) and CA(100 mg/kg) + CD (200 mg/kg) groups. The rats were administered treatments lasted 7 days for all groups. CA and RA treatment is associated with positive the ovary action CD-induced ovotoxicity in rats. CA and RA could ameliorate the histopathological and immunohistochemical finding restoring which may show moderate levels of primordial follicle, primary, secondary, tertiary and graafian follicles were observed degeneration in germinative cells.Therefore, our results suggest that chlorogenic acid and Rhabdosciadium anatolyi might be a protective effect for CD-induced ovotoxicity.
Investigation of Protective Effects of Lithium Borate on Spermatogenesis and Testes Histopathology Against Cadmium-Induced Acute Toxicity in Rats
(Tubitak Scientific & Technological Research Council Turkey, 2020) Yildirim, Serkan; Celikezen, Fatih Caglar; Belhan, Saadet; Oto, Gokhan; Eser, Gizem; Sengul, Emin; Cinar, Dursunali
In this study, protective effects of lithium borate (LTB) on spermatogenesis as well as histopathological and immunohistochemical findings of testes in experimentally induced acute Cadmium (Cd) toxicity in rats were determined. Twenty-eight male Wistar albino rats, were used, weighing 200-220 g. Rats were randomly divided into 4 groups: Control, Cd, LTB, and LTB + Cd. Rats were anesthetized with ketamine at the end of the sixth day, blood was taken from their hearts, and the rats were decapitated. Typically, the control and LTB groups exhibited similar values. Compared with those observed for the control group, the sperm morphology (i.e. abnormal sperm count) increased for the Cd group, while the FSH, LH, total testosterone levels, sperm motility, and density decreased in a statistically significant manner. Clearly, no adverse effects of LTB on the sperm motility, density, and sperm morphology (i.e. abnormal sperm count) were observed, but LTB decreased the negative effects of Cd toxicity. Abnormal disturbances in the head and tail areas of the sperms increased; thus, the total abnormal sperm rate increases, leading to the decreased fertilization capacity. The histopathological examination of testicular tissues revealed severe haemorrhage and hyperaemia in intertubular intervals, tubule atrophy, severe degenerative and necrotic changes in spermatocytes, tubule wall thinning, and necrosis in basal germ cells. In immunohistochemically Caspase-3, 8-OHdG, and COX-2 staining, changes in the control and LTB groups were not detected, while the Cd toxicity group exhibited severe expression in the testis tissue. Histopathological and immunohistochemical changes were significantly decreased in the LTB + Cd group compared to the Cd group. In conclusion, in this study it was determined that LTB has protective effects on Cd-induced testicular toxicity in rats.