Browsing by Author "Esmer, Oktay"

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Bilateral Lower Eyelid Basosquamous Cell Carcinoma: a Rare Case
(Pakistan Medical Assoc, 2014) Esmer, Oktay; Karadag, Remzi; Bayramlar, Huseyin; Soylu, Erkan; Kosem, Mustafa
Basosquamous cell carcinoma is a subtype of basal cell cancer. It is known to be more aggressive than basal cell cancer. A 70-year-old male patient was admitted to our clinic for evaluation of cosmetic problems caused by masses on both lower eyelids for at least two years. The mass excision from and reconstruction of lower eyelids were performed. Histopathological examination of the resected masses was consistent with basosquamous cell carcinoma. We present a case of basosquamous cell carcinoma involving bilateral lower eyelids with a different clinical appearance. To the best of our knowledge, this is the first report of bilateral basosquamous cell carcinoma in a patient.
Causes of Visual Impairment in the Van City Area According To the Health Committee's Reports
(Turkish Ophthalmological Soc, 2012) Ceyhan, Dogan; Yasar, Tekin; Demirok, Ahmet; Cinal, Adnan; Esmer, Oktay; Batur, Muhammed
Purpose: In this study, disability reports of the Health Committee of the Hospital of the Yiiziincii Yil University School of Medicine will be evaluated. The demographic characteristics, causes and degree of visual loss, visual system impairment rating and whole body impairment rating of the people with visual impairment will be determined. Material and Method: Health committee disability reports of our hospital, between September 2006 and August 2010, were evaluated. Relevant variables of each patient were recorded and evaluated. Results: 415 health committee reports for visual impairment were found to be prepared during the period of the study. One hundred fifty three (36,9%) of the cases were female and 262 (63.1%) were male and the mean age was 41.8 +/- 22.4 years. The most frequent causes of visual impairment were macular diseases, evisceration and phitisis, amblyopia, optic nerve diseases, degenerative myopia, acquired corneal and hereditary retinal diseases. The patients who had a disability report had a mean of 41.69 +/- 25.92% visual system impairment rating and 60,76 +/- 24,67% whole body impairment rating. Discussion: This research was planned for contributing to the epidemiologic information about visual impairment in our country. This data may serve to compute the cost of visual disability reports. The information is also expected to contribute to determine the causes and measures for the prevention of diseases and conditions leading to visual disability.
Effects of Different Doses of Systemic Isotretinoin on Eyes: a Histopathological and Immunohistochemical Study in Rats
(Lippincott Williams & Wilkins, 2020) Karadag, Remzi; Karadag, Ayse Serap; Ozlu, Emin; Oguztuzun, Serpil; Simsek, Gulcin Guler; Esmer, Oktay; Bilgili, Serap Gunes
Purpose: To evaluate ocular side effects associated with systemic isotretinoin histopathologically. Methods: In this multicenter study, a total of 15 male and 15 female rats were randomly divided into 3 equal groups according to the oral dose of isotretinoin they were administered: 0 mg/kg/d (group A), 7.5 mg/kg/d (group B), and 15 mg/kg/d (group C). Biopsy specimens were taken from the globe conjunctiva, cornea, and eyelid conjunctiva. Expression levels of human beta-defensin-1, human beta-defensin-2, toll-like receptor (TLR)-2, and TLR-4 were evaluated by immunohistochemical methods. Results: The number of goblet cells in eyelid conjunctiva was significantly lower in group B than that in group A and group C (P = 0.002). The sizes of meibomian gland acini were significantly smaller in group B and group C than those in group A (P < 0.001). Fibrosis of eyelid conjunctiva was significantly higher in group C and group B than that in group A (P = 0.002). The levels of staining of TLR-4 in the cornea with group B were significantly lower compared with group C (P = 0.035). Conclusions: Our study suggests that isotretinoin in the early period affects eyelid conjunctiva and meibomian glands without affecting the globe conjunctiva and cornea. Occurrence of the initial symptoms of isotretinoin on the eyelids, especially on the meibomian glands, suggests that the symptoms of patients occur because of evaporative dry eye.
Endophthalmitis Rate After Open-Globe Injuries in He Area of the City of Van
(Turkish Ophthalmological Soc, 2010) Gul, Adem; Yasar, Tekin; Caglar, Cagatay; Esmer, Oktay
Purpose: Endophthalmitis is an inflammation of the intraocular structures and is mostly associated with open-globe injuries and various surgical eye interventions. In this study, we investigated the endophthalmitis rate in patients who underwent primary repair of open-globe injury. Material and Method: We retrospectively reviewed the records of patients with open-globe injuries who had attended YOzUncti Yil University, Department of Ophthalmology between 1993 and 2009. We analyzed the data of 810 patients who had undergone primary repair; of those, 64 patients had developed endophthalmitis. Results: Endophthalmitis rate was 7,9% (64 patients). Perforating eye injury was commonly seen between 2 and 6 years of age; 56 cases (.1:0/0) were with corneal, 2 (3%-with scleral, and 6 cases (9%) were with corneoscleral perforation. Regarding the time between the onset of endophthalmitis and trauma, 11 (17%) patients developed endophthalmitis in the first 12 hours, 15 (23%)-between 12-24 hours, 13(20%)-on the second day, 13 (20%)-on the third day, and the remaining 12 patients-between the fourth and 30th day. The range of the follow-up period was 2 days-96 months. The most common agents in patients who developed posttraumatic endophthalmitis were metal objects such as fork, knife, needle, injector (39%), wood and thorn (23%) and the remaining were stone, glass, and animal-related factors like horn. Discussion: It was seen that 64 out of 810 patients (7,9%) in our clinic developed endophthalmitis after primary repair of penetrating eye injury.
Epidemiology of Adult Open Globe Injury
(Lippincott Williams & Wilkins, 2016) Batur, Muhammed; Seven, Erbil; Esmer, Oktay; Akaltun, Mahmut Nedim; Yasar, Tekin; Cinal, Adnan
Objective:The aim of this study was to evaluate the epidemiology and outcomes of adult open globe injuries (OGI) in the eastern part of Turkey.Methods:The retrospective study included all the patients who were diagnosed with OGI (436 eyes in 425 patients) at our clinic between 1997 and 2015. The OGI patients aged over 16 years were included into the study. Open globe injuries were classified according to the Ocular Trauma Classification. Age, gender, medical history, time between trauma and hospital admission, and mechanism of injury were recorded for each patient.Results:The incidence of OGI in adults was found to be 3.40/100,000, with 5.00/100,000 in males and 1.67/100,000 in females. Open globe injuries were mostly seen in the age group of 17 to 29 years and in October and November. The patients included 79.5% males and 20.5% females. Intraocular foreign body was detected in 99 (22.7%) eyes. A strong, linear, negative correlation was found between the Ocular Trauma Classification values and final visual LogMAR (r(p) = -0.602, P = 0.0001). The most common mechanism of injury was occupational accident (38.4%).Conclusion:Open globe injuries remain a serious public health problem, resulting in significant vision loss. Open globe injuries are mostly seen in the young, middle-aged, and male working population. Additional preventive measures should be taken for the individuals in these groups.
Evaluation of Ocular Findings in Patients With Vitiligo
(Wiley, 2016) Karadag, Remzi; Esmer, Oktay; Karadag, Ayse S.; Bilgili, Serap Gunes; Cakici, Ozgur; Demircan, Yuhanize Tas; Bayramlar, Huseyin
In this study, we aimed to investigate ocular manifestations in patients with vitiligo. Sixty-one patients with vitiligo were included in the study. From the patients who referred for examination to the dermatology and ophthalmology clinic, 57 patients without any systemic disease were taken as the control group. In both groups, otorefractometry, keratometry, visual acuity test, intraocular pressure measurement, anterior segment, and fundus examinations of the eye with slit lamp, Schirmer test, and perimetry were carried out. The mean age was 24.54 +/- 11.90years and 23.03 +/- 8.72years in the patients and control group, respectively. The mean Schirmer test results were as follows: 16.74 +/- 9.11mm and 17.64 +/- 9.41mm for the right and left eyes of the patients, and 21.96 +/- 12.51mm and 23.42 +/- 12.51mm for the right and left eyes of controls, respectively. Of the patients, 36 eyes showed lenticular findings. However, only 12 eyes of the controls have some lenticular findings. Twenty-nine eyes in the vitiligo group and four in the controls showed some fundus findings. When the two groups were compared with each other, there was a statistically significant difference between them in terms of Schirmer test results, lens, and fundus findings (P<0.05 for all). However, there was no significant difference in terms of age, gender, visual acuity, refraction, keratometry, intraocular pressure, perimetry, and corneal findings (P>0.05 for all). Patients with vitiligo may have more lenticular and retinal findings than normal. They can be more prone to dry eye syndrome as well.
Nasolacrimal System Obstruction, Ptosis and Esotropia Due To Chemotherapy in Acute Lymphoblastic Leukemia
(informa Healthcare, 2013) Esmer, Oktay; Karadag, Remzi; Soylu, Erkan; Oner, Ahmet Faik; Burakgazi-Dalkilic, Evren
Eight-year-old girl was admitted to our clinic with the complaint of constant epiphora in the right eye. It was reported that this complaint began after the start of chemotherapy with a diagnosis of Acute Lymphoblastic Leukemia (ALL) about 5 years ago. In addition, eyelid ptosis associated with esotropia also occurred during that period. We found that nasolacrimal duct obstruction did not improve with medical treatment but ptosis and esotropia improved with pyridoxine and pyridostigmine treatment during that period. Examination of the eye on admission revealed nasolacrimal duct obstruction on the right side. Other ocular findings were normal. Nasolacrimal system obstruction, ptosis and esotropia combination has not been reported previously in patients using systemic drugs or receiving chemotherapy due to ALL.
Ocular Findings in Patients With Alopecia Areata
(Wiley, 2016) Esmer, Oktay; Karadag, Remzi; Cakici, Ozgur; Bilgili, Serap Gunes; Demircan, Yuhanize Tas; Bayramlar, Huseyin; Karadag, Ayse S.
Objectives This study investigated ocular findings in patients with alopecia. Methods A total of 42 patients with alopecia (31 male, 11 female; 84 eyes) and 45 healthy individuals (28 male, 17 female; 90 eyes) were enrolled in the study. Of the patients with alopecia, 34 had alopecia areata, seven had alopecia universalis, and one had ophiasis alopecia. Seven patients had eyebrow involvement and seven had eyelash involvement. Autorefractometry, keratometry, visual acuity, central corneal thickness and intraocular pressure (IOP) measurements, bilateral anterior and posterior segment examinations, Schirmer's tests, and visual field examinations were performed in both groups. Results The mean +/- standard deviation age of the subjects was 25.21 +/- 10.88 years in the alopecia group and 28.24 +/- 9.31 years in the control group. Lens abnormalities were observed in 35 eyes in the alopecia group and in 11 eyes in the control group (P < 0.05). Posterior segment abnormalities were seen in 29 eyes in the alopecia group and four eyes in the control group (P < 0.05). There were no statistically significant differences in age, sex, visual acuity, refractive error, keratometric findings, IOP, central corneal thickness, perimetry, or Schirmer's test results between the alopecia and control groups (P > 0.05). Conclusions Patients with alopecia may have more lenticular and retinal findings than normal individuals, but those findings do not interfere with visual acuity. Close surveillance for the early onset of cataract formation is important in patients with alopecia.
Three Eyelid Localized Cutaneous Anthrax Cases
(Taylor & Francis Ltd, 2014) Esmer, Oktay; Karadag, Remzi; Bilgili, Serap Gunes; Gultepe, Bilge; Bayramlar, Huseyin; Karadag, Ayse Serap
Anthrax is primarily seen in the developing countries, but it can be a worldwide medical concern due to bioterrorism threats. Palpebral anthrax is a rare form of cutaneous anthrax. Untreated cutaneous anthrax can be lethal. Patients with palpebral anthrax can develop complications including cicatrisation and ectropion. Thus, anthrax should be considered in differential diagnosis for patients presenting with preseptal cellulitis in high-risk regions. Herein, we report three anthrax cases (with different age) involving eyelids that were cured without any complications due to early diagnosis and treatment.
Topikal ve Sistemik Steroidlere Bağlı Glokomların İncelenmesi
(2016) Batur, Muhammed; Yaşar, Tekin; Çağlar, İsmail Çağatay; Seven, Erbil; Esmer, Oktay
Amaç: Steroide bağlı glokomları ve tıbbi ya da cerrahi tedavilerini değerlendirmek. Gereç ve Yöntem: Yüzüncü Yıl Üniversitesi Göz Hastalıkları Ana Bilim Dalında, 1996-2009 arasında steroide bağlı glokomu bulunan 14 hastanın 23 gözü geriye dönük olarak incelendi. Tüm hastalar artmış göz içi basıncı (GİB), glokomatöz cup-disk hasarı ve glokomatöz görme alanı kaybına sahiplerdi. Bulgular: Hastaların ortalama yaşı 32.09±15.58 idi. Glokom için en sık sebep topikal steroid kullanımıydı (%71.4). On üç gözde deksametazon (%0.1) damla kullanılmıştı. Steroid kullanımın en sık sebebi vernal keratokonjunktivitti (5 hasta). Tedavi öncesi GİB 39±13.5, tedavi sonrası 12.9±3.4 mm Hg idi. Vertikal cup-disk oranı 0.69±2.2 idi. Dokuz hastada (%73.5) medikal tedavi ile GİB kontrol altına alınırken, 5 hastada (%26.5) cerrahi tedavi gerekti. Sonuç: Steroidin indüklediği glokom topikal ya da sistemik yolla olabilir. Bizim çalışmamızda GİB, tüm hastalarda medikal ya da cerrahi tedaviyle kontrol altına alınabilmiştir. Güçlü etkiye sahip topikal veya sistemik steroid tedavisi verilen hastalar GİB yüksekliği ve glokom açısından potansiyel bir riske sahiptir. Glokom riski olan hastalar için dikkatli takip esastır
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(Lippincott Williams & Wilkins, 2013) Karadag, Remzi; Esmer, Oktay; Totan, Yuksel
Van ve Yöresinde Delici Göz Yaralanmaları Sonrası Endoftalmi Görülme Sıklığı
(2010) Gül, Adem; Yaşar, Tekin; Çağlar, İsmail Çağatay; Esmer, Oktay
Amaç: Göz içi dokularının enfeksiyonuna endoftalmi denir. Çoğunlukla delici göz yaralanmaları ve çeşitli göz müdahaleleri sonucu gelişir. Bu çalışmada kliniğimizde delici yaralanma sonrası primer onarım yapılan hastalarda endoftalmi sıklığı araştırılmıştır. Gereç ve Yöntem: Bu çalışma Yüzüncü Yıl Üniversitesi Tıp Fakültesi Hastanesi Göz Kliniğine 1993 ile 2009 yılları arasında göz travması nedeni ile başvuran hastaların, hasta kartlarının retrospektif olarak taranması ile oluşturulmuştur. Primer onarım yapılan 810 hasta incelenmiştir. Bu hastalardan endoftalmi olan 64 hastaya ait analizler yapılmıştır. Sonuçlar: Delici göz yaralanmalarının 64’ünde (%7,9) endoftalmi gelişmiştir. Travmaya maruz kalma zamanı en sık olarak 2 ile 6 yaş arası görülmektedir. 56 (%88) hastada korneal, 2 (%3) hastada skleral, 6 (%9) hastada korneoskleral perforasyon mevcuttur. Travmaya maruz kalma zamanı ile endoftalmi gelişmesi arasında geçen süre açısından bakıldığında; ilk 12 saatte endoftalmi gelişen hasta sayısı 11 (%17) iken, 12-24 saat içerisindeki hasta sayısı 15 (%23), ikinci gündeki hasta sayısı 13(%20), üçüncü gündeki 13(%20) kişidir, geri kalan 12 hasta dördüncü ve otuzuncu günler arasında başvurmuşlardır. Hastaların takip süresi 2 gün ile 96 ay arasında değişmektedir. Travma sonrası endoftalmi gelişen hastalarda en sık etken olarak çatal, bıçak, iğne, enjektör gibi metal etkenler ilk sırada yer alırken (%39), ikinci sırada ağaç ve diken yer almaktadır (%23). Bu etkenleri sırasıyla taş, cam ve hayvanlara bağlı yaralanmalar takip etmektedir. Tartışma: Kliniğimizde primer onarım yapılmış 810 hastanın 64’ünde (%7,9) endoftalmi geliştiği görüldü.