Browsing by Author "Evirgen, Ö"

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The Effect of Levamisole Combined With the Classical Treatment in Chronic Brucellosis
(Tohoku Univ Medical Press, 2003) Irmak, H; Buzgan, T; Karahocagil, MK; Evirgen, Ö; Akdeniz, H; Demiröz, AP
Levamisole is an immunopotenciator drug which is used as an antihelmintic drug as well as very effective remedy on cellular immunity compared with humoral immunity. A total 71 patients (37 men, 34 women) who referred to our department between March 1997 and December 2001, with a history of the disease for about I year, were diagnosed as having chronic brucellosis through those tests brucella serum agglutination test (SAT), SAT with Coombs and SAT with 2-mercaptoethanol. The patients were randomly divided into levamisole group (36 patients) and control group (35 patients). All patients were given rifampicin 600 mg/day + doxycycline 200 mg/day for 6 weeks as a standard classical combined therapy for brucellosis. In the levamisole group, oral levamisole 80 mg every other day for 6 weeks was added to the treatment. There was a statistically significant difference between two groups, in complaints of arthralgia, fatigue and sweats before and 6 months after treatment, as well as in erythrocyte sedimentation rate and C-reactive protein elevations and lymphomonocytosis finding. While it was provided both clinical and serological improvement in all patients in the levamisole group; 11 patients in the control group did not improve both clinically and in view of specific and nonspecific laboratory findings and a recurrence occurred in one case, in this group. In conclusion, levamisole added to classical antibiotic therapy in treatment of chronic brucellosis was found quite efficient in all patients in providing adequate clinical and laboratory response in comparison to classical antibiotic therapy alone. -chronic brucellosis; levamisole; treatment (C) 2003 Tohoku University Medical Press.
Mr Findings in Pericardial Hydatid Cyst
(Tohoku Univ Medical Press, 2003) Sakarya, ME; Irmak, H; Etlik, Ö; Evirgen, Ö; Temizöz, O; Sakarya, N
Pericardial hydatid cyst is rare. We present a 32-year-old man with a pericardial. hydatid cyst. Chest x-ray film showed a spherical mass located left mediastinum. A pericardial cyst with low signal intensity was noted on T1 weighted magnetic resonance (MR) images. The cyst had high signal intensity, but signal intensity of folded parasitic membranes in the cyst were seen lower intensity on T2 weighted MR images. Based on these MR findings, pericardial hydatid cyst was diagnosed. The patient underwent surgical removal of the cyst. Histologic study of the cyst confirmed hydatid cyst diagnosis. (C) 2003 Tohoku University Medical Press.
Use of the Brucella Igm and Igg Flow Assays in the Serodiagnosis of Human Brucellosis in an Area Endemic for Brucellosis
(Amer Soc Trop Med & Hygiene, 2004) Irmak, H; Buzgan, T; Evirgen, Ö; Akdeniz, H; Demiroz, AP; Abdoel, TH; Smits, HL
The clinical utility of two complementary tests for brucellosis, the Brucella IgM and IgG flow assays, was evaluated in a hospital in eastern Turkey. The results show that the flow assays are convenient diagnostic tests for use in endemic areas. A positive result in the flow assays was obtained in 91% and 97% of the admission sera from adult and pediatric patients with brucellosis, respectively, and the sensitivity at admission was 100% for culture-confirmed brucellosis. The assay system performed equally well in diagnosing patients at different stages of illness including patients with acute, subacute, or chronic disease and with relapse. The results of the flow assays correlated well with those of a serum agglutination test at a cut-off greater than or equal to1:160. The agreement was 92%. Application of the flow assays on serum samples collected during a village survey for brucellosis after an outbreak demonstrated their diagnostic potential as field tests.