Browsing by Author "Evyapan, G."

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Effect of Education and Regular Examination on the Prevalence of Head Louse Infestations in Adana
(Galenos Publishing House, 2022) Kavur, H.; Özkurt, H.; Büyükkatran, F.; Evyapan, G.; Kalkan, S.; Çelik, Z.; Alptekin, D.
Objective: The current study provides training to parents and teachers about pediculosis in schools in three villages in Adana to measure their knowledge level by conducting surveys and to determine the prevalence of pediculosis in these foci. Methods: Pre-and post-questionnaires including 30 questions about pediculosis were handed to parents and teachers. The answers were analyzed with the Pearson correlation analysis. Overall, 418 school pupils s were examined for lice. The results of the head louse control were analyzed by the chi-square test and t-test. Results: We observed that the level of awareness increased in parents and teachers. Additionally, the gender of both teachers and parents was determined as the most important factor in increasing this awareness. Because of interventions for the control of head and lice, the prevalence of pediculosis decreased from 15.22% to 1.71%. Conclusion: It is very important that parents and teachers are aware of the health problems related to pediculosis, while regular combing of school children may be essential for the control of this common infestation. © 2022 Turkish Society for Parasitology.
Metformin Induces Mitochondria-Mediated and Endoplasmic Reticulum Stress-Mediated Apoptosis and Inhibits Angiogenesis-Related Gene Expression in Breast Cancer Cells Via Targeting Vegf-a/Vegfr2
(2025) Alizade, A.; Evyapan, G.; Celik, I.S.; Ozdem, B.
AIM: To investigate the apoptotic and anti-angiogenic effects of metformin in human MCF7 breast cancer cells. METHODS: The effect of metformin on cell viability was assessed by MTS and crystal violet assays, and its effect on cell migration was evaluated by the wound healing assay. The gene expression and protein levels of angiogenesis- and apoptosis-related genes were determined by real-time polymerase chain reaction, Western blot, and flow cytometry. RESULTS: Metformin reduced the viability and migration of breast cancer cells compared with the control group. Furthermore, metformin (10 μM) increased the apoptosis-related gene and protein expression of caspase-3, Bax, AIF, CHOP and GRP78 48 hours after treatment compared with the control group. In contrast, it significantly decreased Bcl-2 and Wee1 gene and protein expression and suppressed angiogenesis-related genes VEGFA, VEGFR2, and NRP1. CONCLUSIONS: Our results suggest that metformin treatment activates apoptosis pathways and inactivates the angiogenesis pathway. Although this study was conducted in vitro and did not directly evaluate blood vessel formation, the observed downregulation of angiogenesis-related genes suggests potential anti-angiogenic activity of metformin at the gene expression level.