Browsing by Author "Firat, M."

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Activity, Acute and Sub-Acute Toxicity and Safety Assesment of the Hydroalcholic Root Extract of Diplotaenia Turcica
(Agricultural Research Communication Centre, 2018) Ozdek, U.; Basbugan, Y.; Yildirim, S.; Boga, M.; Firat, M.; Deger, Y.
Diplotaenia turcica is widely utilized in conventional treatment in the east of Turkey. Due to the insufficient data on the safety profile, the acute and sub acute toxicity of Diplotaenia turcica was determined. Furthermore, total phenolic content, flavonoid content and antioxidant activity of the extract were determined. The acute toxicity of hydroalcoholic root extract of Diplotaenia turcica (HREDT) was evaluated in mice after administration of single oral dose at the 5000 mg/kg (acute model) and rat after 28 days orally administration at the dose range of 250, 500 and 1000 mg/kg (subacute model). According to result, the LD50 value of HREDT was found to be greater than 5000 ing/kg. In sub acute toxicity study, no statistically significant differences were observed in the values of hematological and pathological parameters in comparison with control group. It was determined that the glucose, triglyceride, cholesterol and LDL levels exerted a significant effect depending on the HREDT doses. The results from the present study found out that HREDT did not produce any toxic effects or deaths in animals for both single and chronic administration. Additionally, HREDT showed moderate antioxidant activities and exhibited relatively notable total phenolic content.
An Addition To the Flora of Turkey: Salvia Reuteriana (Lamiaceae), With Contributions To Its Taxonomy
(Research Institute of Forests and Rangelands of Iran, 2020) Firat, M.
Salvia reuteriana Boiss. (Lamiaceae), a new record for the flora of Turkey, is described. It is collected in Şırnak province, southeastern Anatolia. Salvia reuteriana was previously known from Iraq and Iran, with the type specimen of the species from Iran. Morphological description, photographs and distribution map of the new record are presented. © 2020, Research Institute of Forests and Rangelands of Iran. All rights reserved.
Allium Pervariensis, Sect. Allium (Amaryllidaceae), a New Species From Siirt Turkey
(Taylor & Francis Ltd, 2018) Firat, M.; Koyuncu, M.; Eksi, G.
Allium pervariensis, a new species of sect. Allium, is described and illustrated from southeastern Anatolia, Turkey. It is a narrowly distributed geophyte in Siirt Province and its closest relatives are A. pustulosum Boiss. & Hausskn, A. karyeteini Post, but it is clearly differentiated due to outer tunic, perigon, pedicel, leaf and filament, and bracteoles characteristics. In this study, a comprehensive description, detailed illustration of A. pervariensis and distribution map, identification key are provided for A. pervariensis and related taxa.
Essential Oil Contents and Biological Activities of Thymus Canoviridis Jalas and Thymus Sipyleus Boiss
(University of Ankara, 2024) Yi̇Ği̇Tkan, S.; Firat, M.
Objective: Members of the Lamiaceae family are considered to be major sources of bioactive therapeutic agents. Many of them are important medicinal and aromatic plants used in traditional and modern medicine and in the food, cosmetic and pharmaceutical industries. The aim of this study was to investigate in detail the biological activities and chemical composition of the essential oils of Thymus canoviridis Jalas and Thymus sipyleus Boiss. species belonging to the genus Thymus, one of the most important genera of the Lamiaceae family. Material and Method: The essential oil content of the species was determined by GC-MS. Antioxidant activities of the essential oils were determined using lipid peroxidation, DPPH free radical, ABTS cation radical and CUPRAC methods. In addition, cytotoxic activities against breast cancer (MCF-7) and colon cancer (HT-29) cell lines and anticholinesterase (against AChE and BChE enzymes), urease, tyrosinase, elastase, collagenase and angiotensin converting enzyme inhibition activities were determined. Result and Discussion: When the essential oil composition of T. sipyleus was analyzed, the major compounds were 1,8-cineole (eucalyptol) (18.16%), camphor (15.08%) and endo-borneol (11.63%), while T. canoviridis was found to be rich in carvacrol (72.88%). T. canoviridis showed high antioxidant activity in lipid peroxidation (IC50: 45.72±0.12 μg/ml), ABTS (IC50: 6.12±0.03 μg/ml) and CUPRAC (IC50: 5.31±0.01 μg/ml) methods. The selectivities of T. canoviridis and T. sipyleus species against MCF-7 cell line were 4.39 and 6.81, respectively. In the enzyme inhibition studies, both Thymus species showed moderate inhibition activity against BChE enzyme (Inhibition%: 57.88±1.14, 39.21±0.89, respectively). In addition, T. sipyleus showed moderate inhibition of elastase enzyme (Inhibition%: 25.33±0.79). When the results are evaluated in general, it can be said that T. canoviridis essential oil with its rich carvacrol content and high cytotoxic and antioxidant activity can be preferred as a safer and natural option instead of synthetic preservatives in food, pharmaceutical and cosmetic industries to extend shelf life and ensure food safety. © 2024 University of Ankara. All rights reserved.
Essential Oil Contents of Hypericum Linarioides , H. Helianthemoides, and H. Lydium With Their Biological Activities: Importance of Hypericum Genus in the Cosmeceutical and Pharmaceutical Industries
(Springer, 2023) Akdeniz, M.; Yener, I.; Ertas, A.; Dincel, D.; Firat, M.; Kocakaya, S.O.; Kolak, U.
In the literature, more than 3000 studies have been carried out on species in the Hypericum genus in the last ten years, especially for H. perforatum. The importance of Hypericum species in traditional medicine and modern medicine is increasing day by day. From this point of view, the chemical composition of H. linarioides, H. helianthemoides, and H. lydium essential oils was analyzed by GC-MS/FID. In addition, their antioxidant, cytotoxic and antimicrobial activities along with their enzyme inhibitory potentials (cholinesterase, urease, tyrosinase, elastase and, collagenase) were defined. Also, in vitro and in silico studies of the major components of the species have been carried out on the studied enzymes. H. linarioides and H. helianthemoides were found to be rich in monoterpene hydrocarbons (63.96% and 43.86%, respectively), and H. lydium in sesquiterpene hydrocarbons (48.41%). The major components were indicated as α-pinene for H. linarioides (50.39%) and for H. helianthemoides (36.84%), and β-selinene for H. lydium (10.12%). H. lydium essential oil exhibited very high cytotoxic activity on breast cancer (MCF-7) (selectivity indices SI: 12) and colon cancer (HT-29) (SI: 2) cell lines. In particular, the selectivity indice value in MCF-7 cell lines of H. lydium could have natural therapeutic potential for breast cancer. H. lydium possessed neuropharmacological potential due to its high anticholinesterase activity. Since H. linarioides indicated high anti-aging potential (tyrosinase, elastase, and collagenase enzyme inhibitory activities), it could be used in the cosmetic industry. © 2024, Springer Science+Business Media, LLC, part of Springer Nature.
Essential Oil of Cyclotrichium Longiflorum Leblebici
(Springer New York, 2007) Aslan, S.; Firat, M.; Konuklugil, B.
Exploration of Effects of Bleeding Water of Grapevine on in Vitro Germination of Single-Point Endemic Lophanthus Turcicus Seeds
(Scibulcom Ltd, 2017) Turkoglu, N.; Ozudogru, A.; Firat, M.; Keskin, N.; Tuncer, B.
Turkey is highly rich in endemic plant species. Natural spreads of these species are subjected to the risk of extinction through pressures exerted by various factors, especially by anthropogenic factors. Current traditional propagation and conservation methods are rarely sufficient to protect them, thus exploitation of the biotechnological approaches is required, as well. Lophanthus turcicus Dirmenci, Yildiz and Hedge, is a single-point endemic species of Turkey, found in a very narrow area of Van region. Present study explored the efficiency of in vitro germination for this valuable delicate species, and highlighted the promising effects of the artificial medium composed of agarised bleeding water (BW) of grapevine in vivo conditions. In addition to BW medium, also Murashige and Skoog (MS), Gamborg B5, Shenk and Hildebrandt (SH) and White (WH) media were tested for their efficiency. In vitro germination trials were performed both under 16 h photoperiod and in darkness. 90% of germination was achieved when decontaminated seeds were cultured on BW medium, providing a germination rate of 3.5 days and emergence rate of 8.12 days in 16 h photoperiod.
Hirtellina Kurdica (Asteraceae); a Species New To the Flora of Turkey, With Contributions To Its Taxonomy
(Research Institute of Forests and Rangelands of Iran, 2019) Firat, M.
Hirtellina kurdica (Merxm. & Rech. f.) Dittrich, (Asteraceae) is described as a new record for the Flora of Turkey (C9 Şırnak, Siirt). A detailed morphological description, photographs, distribution map, pollen and achen morphology of this new record are given. © 2019, Research Institute of Forests and Rangelands of Iran. All rights reserved.
Morphology and Utilization of Allium L. Species Used as Herbs in Cheese Around Van Province in Turkey
(int Soc Horticultural Science, 2016) Tuncer, B.; Firat, M.; Yarali, F.; Sarikamis, G.
Allium L. species used in the present study are obtained during floristic field studies in Van province and surrounding regions between 1999-2014 as a result of field observations and investigation of herbarium samples. According to information from the locals of Van district and uplands, 11 Allium species are determined in well known herb cheese of Van province. These species are Allium aucheri Boiss, Allium kharputense Freyn & Sint., Allium pseudoampeloprasum Miscz. ex Grossh., Allium schoenoprasum L., Allium shatakiense Rech. f., Allium szovitsii Regel, Allium vineale L., Allium cardiostemon Fisch. & C.A.Mey., Allium dictyoprasum C.A.Mey. ex Kunth, Allium stipitatum Regel., Allium scorodoprasum L. subsp. rotundum (L.) Stearn. In this study, the entire process from the collection of leaves from their natural habitat till the incorporation of these into herb cheese will be described with original photographs. In addition, detailed and descriptive information about bulbs (shape, diameter, outertunics colour and structure), stem (lenght), leaf (number, width, shape) and floral characteristics (flowering time, umbel shape and diameter, spathe colour and structure, pedicel lenght, flower shape and colour, filament and anther colour) together with general photographs will be provided. Additionally, brief information about the habitat, endemism, phytogeographical regions of these species and map based distribution in Turkey will be presented.