Browsing by Author "Güler, O"

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Comparison of the Analgesic Effect of Betamethasone and Diclofenac Potassium in the Management of Postoperative Haemorrhoidectomy Pain
(Taylor & Francis Ltd, 2005) Kisli, E; Baser, M; Güler, O; Aydin, M; Kati, I
Background: Outpatient postoperative haemorrhoidectomy pain remains a difficult problem. The purpose of this study is to compare the results of the use of betamethasone with diclofenac potassium in postoperative pain following haemorrhoidectomy. Material and methods : Closed haemorrhoidectomy was performed on 40 patients who were diagnosed grade III, grade IV haemorrhoid on physical examination. Patients were divided equally randomized into two groups, prospectively (betamethasone was used for 20 patients and diclofenac potassium was given for 20 patients). A verbal categorical scale was used to evaluate postoperative pain (for pain intensity, none = 0, mild = 1, moderate = 2 and severe = 3). Results : The amount of narcotics required on postoperative first, second and third day were significantly less in the betamethasone group than in the diclofenac potassium group (P < 0.001) (Pearson Chi-Square test). Conclusion : Results indicate that use of betamethasone provides more effective analgesia than diclofenac potassium for postoperative pain management in the haemorrhoidectomy patient.
The Effect of Lymphatic Blockage on the Amount of Endotoxin in Portal Circulation, Nitric Oxide Synthesis, and the Liver in Dogs With Peritonitis
(Springer verlag, 1999) Güler, O; Ugras, S; Aydin, M; Dilek, FH; Dilek, ON; Karaayvaz, M
This study was performed to investigate the effect of lymphatic blockage on the amount of endotoxin in portal venous blood, nitric oxide synthesis, the release of aspartate aminotransferase (AST) from the liver, hepatic damage, and survival in an experimental model of dogs with peritonitis, The dogs were divided into a control group (group 1), an unligated thoracic duct peritonitis group (group 2), and a ligated thoracic duct peritonitis group (group 3), Peritoneal fluid and blood from the portal vein and femoral artery were taken for peritoneal culture, endotoxin, and AST assay, respectively, and liver biopsies were performed to assess for hepatic damage and for nitric oxide assay, There was a higher bacteria count in the peritoneal fluid from group 3 than in that from group 2 (P < 0.0001), Bacteria grew in all of the blood cultures from the group 2 animals, but growth was seen only in blood cultures from four of the group 3 animals. The levels of endotoxin, nitrite, and AST levels in group 3 were significantly increased in comparison with those in group 2 (P < 0.0001), Extensive hepatocellular necrosis,vith hemorrhage was observed in the livers of the group 3 animals, and all of them died,within 48 h, The results of this study suggest that the blockage of lymph flow has a negative effect on liver and survival in dogs with peritonitis, and that hepatic damage is directly related to the amount of endotoxin to which the liver is exposed,
Malignant Pheochromocytoma With Peritonitis Carcinomatosa
(Lippincott Williams & Wilkins, 2005) Algün, E; Kösem, M; Alici, S; Harman, M; Güler, O; Kotan, E
Pheochromocytomas and functioning paragangliomas are rare tumors arising from the primitive neural crest. Approximately 10% of adrenal pheochromocytomas are malignant. Malignant pheochromocytomas usually recur in the retroperitoneum or appear as metastatic deposits in bone, lung, or liver. Here, we report a 51-year-old woman with malignant pheochromocytoma with a peritoneal metastasis, which is a very unusual metastatic site. She was referred to the hospital with headache, abdominal pain, and ileus. A right adrenal mass was surgically removed in May 1997. Pathologic examination revealed pheochromocytoma and capsular with adjacent muscle invasion. During the next 3 years, the patient remained well. The disease recurred in 2001, with hypertensive episodes and peritonitis carcinomatosa. Further investigation revealed no other metastatic sites. Peritoneal metastasis is very rare in malignant pheochromocytoma and generally is attributed to direct peritoneal seeding during surgery.