Browsing by Author "Gültepe, B."

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Epidemiology of the Hepatitis C Infection in Van's Region
(2013) Gültepe, B.; Dülger, A.C.; Aytemiz, E.
Hepatitis C virus (HCV) is an enveloped positive-strand RNA virus of the genus hepacivirus in the family of Flaviviridae. HCV causes chronic infection in more than 80% of cases. It is responsible for more than 50% of liver transplantation among adults in the developed countries. Approximately 200 million people are infected with HCV entire of the world. Africa and many parts of Asia are the major endemic areas for HCV infection. Although HCV is one of the most common cause of chronic liver disease in middle-east, its epidemiology remains unclear around the Lake Van region. Therefore, we assessed the prevalence of HCV infection in individuals who live in rural areas of eastern part of Turkey. We retrospectively analyzed 1062 (405 male, 657 female) patients who admitted to Gastroenterology clinic of Yuzuncu Yil University Faculty of Medicine between January-October in 2011. Patients with prior HCV infection and with acute HCV infection were excluded. Presence of HCV infection was assessed by the routine ELISA method. Anti-HCV antibodies were screened by ELISA method using ADVIA Centaur ® XP Immunoassay System (Siemens, Ireland). Samples with positive HCV RNA real-time PCR was used as the correction method. Isolation reaction processes were analyzed by QIAGEN (Düsseldorf, Germany) brand in the QIAsymphony SP/AS instrument. Real Time PCR analysis was studied by Rotor Gene Q instrument and Artus HCV Virus-1 QS-RGQ kits (QIAGEN, Düsseldorf, Germany). All data was recorded on SPSS and was analyzed by simple statistical methods. The mean age was 46.1±17.9 years in males and was 42.5±17 years in females. 3 men and 6 women had anti-HCV antibody. Total Anti-HCV seropositivity was 0.8%. Interestingly, HCV infection is not a serious health problem in eastern part of Turkey. It may be due to low prevalence of intravenous drug users and homosexuals as well as to strict traditional rules. Further analyses may be required to establish this phenomenon particularly in eastern part of Turkey which is located on the main crossroad of the world narcotic trade.
Helicobacter Pylori Seroprevalance in Patients With Obstructive Sleep Apnea Syndrome
(Yuzuncu Yil Universitesi Tip Fakultesi, 2014) Gültepe, B.; Günbatar, H.; Cumhur Dülger, A.
Hypoxemia related conditions are associated with an increased risk of gastric damage. Helicobacter pylori (H.pylori) infection also causes gastric damage and affects approximately 40 million individuals in Turkey. Obstructive sleep apnea syndrome (OSAS) is a sleep disorder and is characterized by episodic upper airway obstruction during sleep. It is associated with oxyhemoglobin desaturations, hypoxemia and discontinuation of sleep. However, there are a few data in the field of H.pylori prevalence among the patients with OSAS which is linked to tissue hypoxemia. The aim of the current study was to investigate the link between H.pylori infection and OSAS. Between February 2011 and February 2012, faeces was collected from OSAS patients (n=24; 12 female) and healthy individuals (n=100, 50 female) and analysed using the H. pylori Stool Antigen Test. OSAS was detected with polysomnography in connection with disease symptoms and findings. All data was recorded on SPSS and analyzed with chi-square test. Among 24 patients with OSAS, 12 (50%) of them had a positive result for H.pylori fecal test. In control group (100 subjects), H.pylori fecoprevalance was only 15%. H.pylori antibody seropositivity was significantly higher in patients with OSAS compared to control patients (p<0.001). Consistent with recent epidemiologic studies to date, seroprevalence of H.pylori was found higher than normal subjects. Seroprevalance of H.pylori detected with fecal test were significantly higher in patients with OSAS. OSAS is related to presence of H.pylori. A positive correlation between the H.pylori infection and OSAS might be hypothesized. This may be due to gastric damage due to OSAS-related hypoxemia.