Browsing by Author "Günbatar, N."

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Effect of Exercise on Erythrocyte Osmotic Fragility in High Fat Diet Fed Rats During Intermittent Fasting
(Yuzuncu Yil Universitesi Tip Fakultesi, 2017) Yaşar, S.; Günbatar, N.; Yüksek, S.; Arıhan, O.; Oto, G.
Exercise is an important component of a healthy lifestyle. High fat diets are blamed for various health problems such as cardiovascular diseases. Intermittent fasting is a way of increasing longevity and decreasing certain adverse health conditions. In this study effect of exercise, intermittent fasting and high fat diet on erythrocyte osmotic fragility which is an important marker of erythrocyte integrity was investigated. 42 Wistar albino male rats were used in this study. Rats were divided into 7 groups in which each were composed of 6 animals. Exercise was administered 3 times a week. Intermittent fasting was administered 2 times a week (24 without any food in those two days). High fat was given in a high fat diet. Combination of applications was also administered in different groups. Results state an increase in erythrocyte osmotic fragility due to exercise. High fat or intermittent fasting did not cause in increase in fragility however they did not alleviate increased fragility due to exercise where they are concomitantly administered with exercise. Intermittent fasting administered solely or with high fat did not change erythrocyte osmotic fragility therefore stating no negative impact of intermittent fasting on this studied parameter. However no protective effect was observed in IF+Exe group. This result can also be interpreted with high impact of Exe in this study on the rats. Studies including molecular mechanism focusing on erythrocyte membrane lipid alterations should be performed to clarify current findings. © 2017, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Examination of the Relationship Between Intermittent Fasting and Irisine Levels in Rats Fed a High-Fat Diet
(Yuzuncu Yil Universitesi Tip Fakultesi, 2023) Günbatar, N.; Bulduk, B.
In this study, the relationship between intermittent fasting and irisin levels has been examined in rats fed on a high-fat diet. Eighteen Wistar albino rats were randomly divided into three groups as control, high-fat diet (HFD) and, high-fat diet+intermittent fasting (HFD+IF) (n=6). After 8 weeks of study irisin level were measured in serum. Irisin levels in the HFD group were lower (8.24 ng/ml) than the control (10.50 ng/ml) but in the HFD+IF group was higher (12.25 ng/ml) compared to the HFD group (8.24 ng/ml) (P<0.05). It was observed that body weight in the HFD group was higher (385.92 g) than the control group (270.50 g) and was lower (297.71 g) in the HFD+IF group compared to the HFD group (385.92 g) (P<0.05). As a result, it has been seen that intermittent fasting increases the level of irisin and causes weight loss, and it is conclu ded that it can be evaluated among the methods to be used in the treatment and prevention of obesity. © 2023, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.