Browsing by Author "Garca, M. Fatih"

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Effects of Extracorporeal Shock-Wave Lithotripsy Directed at the Parotid Gland on Oxidative Stress Parameters and Some Trace Element Levels in Facial Nerve of Rats
(Wiley, 2012) Kavak, Servet; Garca, M. Fatih; Gecit, Ilhan; Meral, Ismail; Cengiz, Nurettin; Demir, Halit
Introduction: This study was designed to assess the effect of extracorporeal shock-wave lithotripsy (ESWL) exposure of the parotid gland on oxidative stress and some trace element levels in the facial nerves of rats. Methods: Twelve male Wistar albino rats were divided into two groups, each consisting of 6 animals. The rats in the first group served as controls. The left parotid glands of animals in the second group were treated with 1000 18-kV shock waves while anesthetized with ketamine. The animals in both groups were euthanized 72 h after the ESWL treatment, and the right facial nerve was harvested for determination of oxidant/antioxidant status and trace element levels. Results: Lipid peroxidation product malondialdehyde (MDA) and antioxidant glutathione (GSH) levels increased, and the activities of antioxidant enzymes, such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), decreased in the facial nerves of ESWL-treated rats. The levels of iron, lead, manganese, and cobalt increased, and magnesium, cadmium, and copper levels decreased. Conclusions: ESWL treatment of the parotid gland may increase lipid peroxidation and decrease antioxidant enzyme activity in adjacent tissues such as the facial nerve. It also causes a decrease or increase in many mineral levels of the facial nerve, which is an undesirable condition for normal physiological function. Muscle Nerve, 2012
Effects of Shock Waves on Oxidative Stress in Parotid Gland of Rat
(Sage Publications inc, 2014) Garca, M. Fatih; Kavak, Servet; Gecit, Ilhan; Meral, Ismail; Demir, Halit; Turan, Mahfuz; Cankaya, Hakan
This study was designed to investigate whether extracorporeal shock wave lithotripsy (ESWL) exposure to parotid gland produces an oxidative stress in parotid glands of rats. Twelve male Wistar-albino rats, 6 months of age with an average body weight of 250-300 g, were divided randomly into two groups, each consisting of six rats. The animals in the first group did not receive any treatment and served as control. The left parotid glands of animals in group 2 (ESWL treated) received a thousand 18 kV shock waves after anesthetizing the rats with 50 mg/kg of ketamine. The animals in both groups were killed 72 hours after the ESWL treatment, and the parotid glands were harvested for the determination of lipid peroxidation product malondialdehyde (MDA), antioxidant glutathione (GSH) levels and the activities of antioxidant enzymes such as superoxide dismutase (SOD), GSH-Px and catalase (CAT). It was found that MDA level increased in parotid glands of rats after the ESWL treatment. The SOD, GSH-Px and CAT enzyme activities, and the level of antioxidant GSH decreased in parotid gland of rats after the ESWL treatment. It was concluded that short-term ESWL treatment caused an increase in the free radical production and a decrease in the antioxidant enzyme activity in parotid glands of ESWL-treated rats.
The Forehead Flap With Subdermal Pedicle
(Medknow Publications & Media Pvt Ltd, 2012) Isik, Daghan; Sarici, Murat; Garca, M. Fatih; Canbaz, Yasin; Atik, Bekir
Objective: Although the forehead flap is an axial flap, in contrary to the other axial flaps, its use as an island flap is not popular. The aim of this study is to present the patients in whom the forehead flaps with subdermal pedicle were used. Methods: The forehead flap with subdermal pedicle was used for 7 patients aged between 45 and 65 years. All patients were operated with the diagnosis of skin cancer. Four and two of the lesions were in the nasal and medial canthal regions, respectively. The lesion was involved nasal dorsum and medial chantal region together in one patient. The forehead flap was used with subdermal pedicle in all patients. The second session in which the flap was divided was performed 3 weeks after the first session. Results: Flap loss was not observed in any patients and basal cell skin cancer was diagnosed in the histopathological examination of all lesions. In five patients, within 3 months, reduced or completely dissolved depression was noted in the donor area of the flaps. Conclusion: The use of forehead flap as an island flap does not affect flap vascularity and provide less scar formation in the donor area.
Oxidative Stress in the State of Tissue and Evaluation of Patients With Chronic Otitis
(2013) Avşar, Barış; Garca, M. Fatih
Kronik otitis media ve kolesteatomanın etiyopatogenezi halen tam olarak aydınlatılmamıştır. Bununla ilgili olarak osteoklastik aktivite, sitokinler, kronik inflamasyon, endotoksin ve lipid peroksidasyon ürünlerinin toksik etkileri gibi pek çok neden suçlanmaktadır. Çalışmamızda otit tablosunda kronikleşme sürecinde ve kolesteatom formunda organizmanın oksidatif stres durumunun etkin olup olmadığını ve kronik otit formları arasında oksidatif ürünler ve antioksidan savunma sistemi arasındaki dengesizliğin yol açtığı oksidatif streste farklılığı vurgulamak amaçlandı. Oksidatif ürünler ve antioksidan savunma sistemi arasındaki dengesizliğin yol açtığı oksidatif stresi gösterebilmek amacıyla oksidatif markırlar olan MDA ile antioksidan GSHPx,SOD,CAT'ı serumda ve dokuda araştırdık.
Peripheral Osteoma of Mandible: Case Report
(Galenos Yayincilik, 2012) Garca, M. Fatih; Micoogullari, E. Deniz; Bozan, Nazim; Cankaya, Hakan
Osteoma is a benign tumor of bone. Although most commonly occurs in the craniofacial region, the mandible is the rare site of involvement. The mass causes symptoms according to localization and size. Panoramic radiography and computed tomography are the preferred methods used for the diagnosis of osteoma. In this case report, we present a case of mandibular osteoma that despite had reached a very large size, did not produce any signs or symptoms except for the presence of a mass.
Presence of Accompanying Head Injury in Patients With Maxillofacial Trauma
(Turkish Assoc Trauma Emergency Surgery, 2012) Isik, Daghan; Gonullu, Hayriye; Karadas, Sevdegul; Kocak, O. Faruk; Keskin, Siddik; Garca, M. Fatih; Eseoglu, Metehan
BACKGROUND Patients with maxillofacial fractures are at high risk of accompanying traumatic cranial injuries. Prompt determination of head injury in these patients is crucial for improving patient survival and recovery. METHODS The records of 246 patients with maxillofacial fractures referred to the emergency department of our hospital between January 2006 and September 2009 were reviewed in this retrospective study. The patients' age and gender, cause, type and location of the maxillofacial fracture, and the cranial injuries were analyzed. RESULTS The mean age of the patients was 23.61 +/- 16.75 years (83.3% males and 16.7% females). Cranial injury was observed in 38 patients with maxillofacial trauma. While the risk of head injury was found to be 3.44-fold lower among patients with single facial bone fracture (p<0.001), the risk of experiencing head injury significantly increased in patients with multiple facial bone fractures (p<0.001). The risk of head trauma significantly increased in patients with fractures of the nasal bone, maxillary bone, mandibular bone, and with frontal region fractures (p<0.05 in each group). CONCLUSION The patients with multiple facial bone fractures should be investigated with regard to head injury even if they do not have clinical findings.
Reconstruction of Lower Lip With Myomucosal Advancement Flap
(Wiley-blackwell, 2012) Isik, Daghan; Garca, M. Fatih; Durucu, Cengiz; Goktas, Ugur; Atik, Bekir
Background In this article, a new surgical procedure that can be used for reconstruction of lower lip defects of any size is described. Methods In this prospective study, the surgical procedure was applied in 16 patients. In this procedure, the mucosa and the orbicularis oris muscle of the lower lip are repaired with a composite flap, and the skin defect is closed using local skin flaps. The patients were assessed in terms of complications, mouth opening, sphincter function of the mouth, and sensation in the lower lip. Results The aesthetic results obtained in all patients were satisfactory. Sufficient oral sphincter function was achieved in all patients. Conclusion Reconstruction of lower lip defects using the procedure described here can be performed in patients with lower lip defects of any size as long as the mucosal and skin repair lines are not superimposed. This procedure yielded good sphincter function and aesthetic results. (C) 2011 Wiley Periodicals, Inc. Head Neck, 2011