Browsing by Author "Garipardic, Mesut"

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Association of Attention Deficit Hyperactivity Disorder and Autism Spectrum Disorders With Mean Platelet Volume and Vitamin D
(int Scientific information, inc, 2017) Garipardic, Mesut; Dogan, Murat; Bala, Keziban Asli; Mutluer, Tuba; Kaba, Sultan; Aslan, Oktay; Ustyol, Lokman
Background: The purpose of this study was to assess the values of the mean platelet volume (MPV) in children with attention deficit hyperactivity disorder (ADHD) and with autism spectrum disorders (ASDs) to determine the risk of cardiovascular disease in these 2 disorder groups. Material/Methods: The study included a total of 79 patients with ADHD or ASDs and controls in the Van region of Turkey. The control group included subjects of matching age and sex with no ADHD, ASDs, or chronic disease and taking no vitamins. The hematological parameters of the patients, including MPV, vitamin B12, and vitamin D, were assessed. Results: The study included a total of 79 children and adolescents aged 2-18 years (32 females and 47 males). Of the patients, 36 were in the ADHD group, 18 in the ASDs group, and 25 in the control group. There was no statistically significant difference in hematological parameters between the groups, but there were significant differences in terms of vitamin D and vitamin B12. The patient groups showed lower levels of vitamin B12 and vitamin D. In the ADHD group, there was a negative correlation between both vitamins and MPV (p<0.05). Partial correlation analysis of the ADHD group showed that MPV in particular was negatively correlated to vitamin D, and not to vitamin B12 (p: 0.03). Conclusions: Both ADHD and ASDs may accompany increased risk for cardiovascular disease due to the presence of vitamin B12 and D deficiency and their own characteristics. Therefore, these disorders should be closely followed up.
A Case of Atypical Brucellosis Presented With Isolated Lymphadenopathy
(Aves Yayincilik, Ibrahim Kara, 2017) Karaman, Kamuran; Akbayram, Hatice Tuba; Akbayram, Sinan; Garipardic, Mesut; Oner, Ahmet Fayik
Brucellosis is transmitted via animal or animal products. The transmission of infection from animal to human occurs by the ways of; generally the direct contact of secretions of infected animals through the human skin which of broken integrity, consumption of unpasteurized milk and milk products, inhalation and contact with conjunctiva with infected aerosols. The infection can be presented with variable manifestations and involment of cardiovascular, central nervous system, skeletal system, skin and gastrointestinal system. It is generally a disease with good prognosis; but the complicated involvement like of bone, cardiovascular and menegial site leads to significant morbidity and mortality. Here, we presents a case of brucella lymphadenitis of 9 years old patiens in whom admitted with isolated lmphadenopathy and recovered clinically and laboratory upon starting the treatment for brucellosis.
Circumcision in Patients With Congenital Factor X Deficiency
(Springer india, 2014) Akbayram, Sinan; Garipardic, Mesut; Karaman, Kamuran; Bilici, Salim; Oner, Ahmet Faik
Diagnostic Evaluation of Our Patients With Hemophilia A: 17-Year Experience
(Turkish Pediatrics Assoc, 2015) Karaman, Kamuran; Akbayram, Sinan; Garipardic, Mesut; Oner, Ahmet Fayik
Aim: Hemophilia A is a rare inherited bleeding disorder resulting from factor VIII deficiency and is a group of diseases characterized by intra-articular and intramuscular bleeding. In this study, we aimed to retrospectively evaluate the treatment outcomes, demographic and clinical characteristics of our patients who were treated and followed up for last 17 years in our pediatric hematology unit with a diagnosis of Hemophilia A. Material and Methods: The medical records of 83 patients who were diagnosed with Hemophilia A and followed up between 1997 and 2014 in our hospital's pediatric hematology clinic were reviewed retrospectively. The demographic data, prophylaxis state, development of inhibitors and clinical characteristics of the patients were evaluated. Results: When the complaints at presentation were examined, it was found that 27 (32%) patients had hemarthrosis, 24 (29%) patients had ecchymosis and hematoma, 13 (16%) patients had prolonged bleeding after trauma or cut, 10 (12%) patients had gingival, mouth or nose bleeding, 4 (5%) patients had prolonged bleeding after circumcision, 4 (5%) patients had gastrointestinal bleeding, 1 (1%) patient had hematuria. Fifty (60%) patients were considered severe hemophilia A, 20 (24%) patients were considered moderate hemophilia A and 13 (16%) patients were considered mild hemophilia A according to factor activity. Among severe hemophilia A patients, primary prophylaxis was being administered in 2 (2%) patients and secondary prophylaxis was being administered in 40 (48%) patients. Inhibitor positivity was found in 8 (10%) of these patients. It is found that hemophilic artropathy developed in 17 patients and 8 of these 17 patients had undergone radioisotope synovectomy. Conclusions: Treatment of severe bleeding in hemophilia A patients should be performed in hospital and the presence of inhibitor must be investigated in cases of uncontrolled bleeding where adequate doses of factor concentrates have been administered for treatment. In order to decrease the development of inhibitor, prophlaxis should be suggested to patients rather than repetetive treatment when bleeding occurs. The radioactive synovectomy should not be overlooked in countries like ours in which factors can not be used adequately.
Eosinophilic Leukemoid Reaction in a Male Adolescent With Loeffler Syndrome
(Wolters Kluwer Medknow Publications, 2015) Iclal, Bayhan Gulsum; Garipardic, Mesut; Karaman, Kamuran; Akbayram, Sinan
The Loeffler syndrome is characterized by pulmonary infiltrates on a chest x-ray accompanied with peripheral eosinophilia. In this article, we have highlighted the Loeffler syndrome complicated with a eosinophilic leukemoid reaction in a previously healthy boy. The patient was treated with albendazole for five days, with a successful result. In countries where parasitic diseases are endemic, the Loeffler syndrome must always be considered in patients who present with a eosinophilic leukemoid reaction.
Initial Lymphocyte Count as Prognostic Indicator for Childhood Immune Thrombocytopenia
(Springer india, 2017) Akbayram, Sinan; Karaman, Kamuran; Dogan, Murat; Ustyol, Lokman; Garipardic, Mesut; Oner, Ahmet Faik
Acute ITP is a benign, self-limiting disease. Chronic ITP is diagnosed when thrombocytopenia persists beyond 12 months. The main objective of the present study was to examine whether absolute lymphocyte counts at diagnosis has predictive value with chronic ITP. A total of 601 patients diagnosed as ITP between 1995 and 2014 were retrospectively evaluated. CBCs with differential counts were performed at presentation for 601 patients. Absolute lymphocyte counts at presentation were independently predictive of disease duration. The male to female ratio was almost 1:1 and 25.9 % (156/601) of the patients had chronic ITP. We determined that age >6.75 year, platelet counts >6.950/mm(3) and absolute lymphocyte counts <= 2.050/mm(3) was associated with a significant risk for developing chronic ITP. Absolute lymphocyte counts at the time of diagnosis were predictive variables for the development of chronic ITP. Further researches are needed to confirm the current finding and to assess the underlying pathophysiology with the course of the ITP in observational studies.
Mean Platelet Volume and Vitamin D Deficiency
(Galenos Yayincilik, 2016) Bala, Keziban Asli; Dogan, Murat; Kaba, Sultan; Garipardic, Mesut; Aslan, Oktay; Dogan, Sekibe Zehra; Kocaman, Selami
Aim: To evaluate whether vitamin D deficiency has an effect on mean platelet volume (MPV). Materials and Methods: This was a retrospective study. The children followed-up at the pediatrics endocrinology polyclinic and diagnosed as nutritional rickets were included in this study. The patient group was created, and by screening the files of 478 case files, those compatible with the patient group for age and gender, were taken as the control group. Results: A total of 684 children and adolescents cases between the ages 0.1-18 years were included in the study. The cases were divided into 3 groups according to the vitamin D levels. Those with vitamin D levels of less than 15 ng/mL were classified as the vitamin D deficiency group, those between 15-20 ng/mL were classified as the insufficiency group, and those between 20-100 ng/mL were classified as the normal Vitamin D level group. There was no statistically significant difference between the groups in terms of age and gender. There was no significant difference observed between the groups in terms of the MPV levels. There was no statistically significant correlation determined in the correlation analysis between the vitamin D level and the MPV (p>0.05). In the multiple regression analysis, it was observed that vitamin D had no statistically significant effect on MPV. In the performed partial correlation analysis, when hemoglobin, hematocrit, calcium, phosphorus and parathyroid hormone were selected as controlling factors, again, there was no statistically significant correlation observed between the MPV and the vitamin D (r=-0.19, p>0.05). Conclusion: In the pathophysiology of the cardiac dysfunctions appearing as a result of vitamin D deficiency, we wished to emphasize that the hypothesis of the probable effect of vitamin D on MPV should be questioned in more detail.
Retinal Fiber Layer Thickness in Children With Thalessemia Major and Iron Deficiency Anemia
(Taylor & Francis inc, 2014) Aksoy, Adnan; Aslan, Lokman; Aslankurt, Murat; Eser, Ozlem; Garipardic, Mesut; Okumus, Seydi; Kaya, Gul
Purpose: We aimed to measure peripapillary retinal nerve fiber layer (RNFL) thickness in children with thalassemia major (tha-major), children with iron deficiency anemia (IDA), and children in a healthy control group. Materials and Methods: A total of 47 children with tha-major and 22 children with IDA were selected from two pediatric hematology outpatient clinics as our experimental groups, while 35 healthy children were randomly selected from a primary school to act as a control group. After a complete eye examination was conducted and intraocular pressure measurements were obtained, RNFL measurements were performed using optical coherence tomography, and the information was recorded for statistical analysis. Results: The mean age of the participants was 9.65 +/- 4.13 years in the tha-major group, 9.14 +/- 2.53 years in the IDA group, and 9.13 +/- 3.29 years in the control group, respectively, with no statistically significant difference among the three groups (p>0.05). Mean peripapillary RNFL thickness was 119.38 +/- 35.49 microns in the tha-major group, 184.00 +/- 31.14 microns in the IDA group, and 187.73 +/- 27.36 microns in the control group. It was significantly thinner in all quadrants in the tha-major group vs. the other two groups (p<0.01), and in only the inferior quadrant in the IDA group (p<0.05). Average RNLF thickness correlated positively with mean hemoglobin value (r = 0.488; p<0.001) and negatively with mean ferritin level (r = -0.544; p<0.001), but no correlations with mean number of transfusions and mean visual acuity were observed (p>0.05). Conclusion: The study revealed that peripapillary RNFL is thinner in tha-major in all quadrants and in only the inferior quadrant in IDA. Thinning of the RNLF correlated with hemoglobin value and ferritin level, but not with number of transfusions and visual acuity.
Successful Treatment of Vincristine Induced Unilateral Ptosis With Pyridoxine and Pyridostigmine in a Child With Langerhans Cell Histiocytosis (Lch)
(Modestum Ltd, 2016) Karaman, Kamuran; Akbayram, Sinan; Garipardic, Mesut; Oner, Ahmet Fayik
We report the case of a 2-year-old boy with langerhans cell histiocytosis who developed vincristine (VCR)-induced unilateral ptosis and recovered on treatment with pyridoxine and pyridostigmine. He was treated with LCH TRAIL (Initial treatment) chemotherapy regimen. Two days after the fifth dose of VCR, he presented with unilateral ptosis. VCR as an antineoplastic drug causes neurotoxicity frequently. Neurological examination revealed unilateral ptosis, without pupillary or other oculomotor dysfunction. The other cranial nerves and peripheral nerves examinations were normal. Cranial magnetic resonance imaging and cerebrospinal fluid examination were normal. The unilateral ptosis markedly improved after two weeks of pyridoxine and pyridostigmine treatment and completely resolved after 3 weeks and there was no further recurrence of ptosis on follow up.
The Use of Ankaferd Blood Stopper in a Child With Glanzmann Thrombasthenia With Gingival Bleeding
(Lippincott Williams & Wilkins, 2015) Karaman, Kamuran; Aydin, Ilyas; Akbayram, Sinan; Garipardic, Mesut
Voriconazole-Associated Visual Disturbances and Hallucinations
(Taylor & Francis Ltd, 2016) Bayhan, Gulsum Iclal; Garipardic, Mesut; Karaman, Kamuran; Akbayram, Sinan
Voriconazole is a second-generation azole widely used for the prevention and treatment of fungal infection in leukemia patients. Voriconazole is considered the primary antifungal agent for invasive aspergillosis. We report a case of 16-year-old girl who developed visual disturbance and visual and auditory hallucinations after intravenous voriconazole treatment for invasive pulmonary aspergillosis. Due to the visual hallucinations and visual disturbance began acutely and shortly after the initiation of voriconazole, and no other cause could be determined, the symptoms were considered to be the side effects of voriconazole. Simultaneous development of visual side effects and hallucinations rarely have been reported before.
When Should Transient Myeloproliferative Disorder of the Newborn With Down Syndrome Be Treated? Case Report
(Dr Behcet Uz Cocuk Hastaliklari ve Cerrahisi, 2013) Gul, Ozlem; Goksugur, Yalcin; Davutoglu, Mehmet; Garipardic, Mesut
Transient Myeloproliferative Disorder (TMD), is an important hematological disorder which is seen in newborns with Down syndrome. It is often self- limiting and spontaneous remissions occur within 3 months. Leukocytosis, thrombocytopenia, anemia, hepatosplenomegaly, the presence of cutaneous nodules and blasts in the peripheral blood are characteristic findings. We present a TMD case of newborn with Down syndrome and aimed to emphasize the importance of early diagnosis and therapy of these patients.