Browsing by Author "Gonullu, Hayriye"

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Acute Toxic Fulminant Myocarditis After a Black Widow Spider Envenomation: Case Report and Literature Review
(Taylor & Francis Ltd, 2013) Golcuk, Yalcin; Velibey, Yalcin; Gonullu, Hayriye; Sahin, Musa; Kocabas, Engin
An Adult Form of Gaucher Disease Associated With Portal Hypertension: a Case
(derman Medical Publ, 2013) Dulger, Ahmet Cumhur; Karadas, Sevdegl; Gonullu, Hayriye; Gultepe, Bilge; Tasdemir, Mehmet
Gaucher disease (GD) is an inborn error of metabolism that affects the recycling of cellular glycolipids. Glucosylceramide (also called glucocerebroside) accumulate within the lysosomes of cells. Gaucher's disease is most common lysosomal storage disease and its incidence is 1/75.000. Three types of this disease have been defined. During the course of disease, it was reported that hepatosplenomegaly, portal hypertension, hyperferritinemia, splenic infarcts and splenic nodules might develop. Therefore, as in our case; Gaucher's disease must be remembered in the setting of hepatosplenomegaly, portal hypertension, hyperferritinemia, splenic infarcts and splenic nodules of unknown etiology.
The Analysis of the Cases of Aspired Fuel Oil and Gasoline Through Siphonage Method
(Pakistan Medical Assoc, 2013) Gonullu, Hayriye; Karadas, Sevdegul; Oncu, Mehmet Resit; Dulger, A. Cumhur; Keskin, Siddik
Accidental aspiration of petroleum products in children can also be witnessed in adults working with petroleum products by siphonage or swallowing fire for demonstration purposes. Ten cases admitted to Yuzuncu Yil University Emergency Service due to fuel oil and gasoline aspiration in a three-year period were retrospectively analysed. All cases were males and their average age was determined as 32,4 +/- 7.83 years. Three of the patients aspirated gasoline and 7 fuel oil. Blood gas values in all patients were at normal levels and their average white blood cell values were 16590. The most frequent symptom for referral to our service was shortness of breath. Infiltration was confirmed in the chest X-ray of 2 patients with aspirated fuel oil and all cases of gasoline aspiration. All patients received methylprednisolone and IV proton-pump inhibitors for treatment. Eight patients were given antibiotics. All victims were discharged from the hospital after recovery. Aspiration of petroleum products which is normally rarely seen is witnessed more frequently in under developed countries. Since the findings determined by screening methods are often nonspecific, history is important for making a diagnosis.
Bone Marrow Biopsy Findings in Brucellosis Patients With Hematologic Abnormalities
(Lippincott Williams & Wilkins, 2012) Demir, Cengiz; Karahocagil, Mustafa Kasim; Esen, Ramazan; Atmaca, Murat; Gonullu, Hayriye; Akdeniz, Hayrettin
Background Brucellosis can mimic various multisytem diseases, showing wide clinical polymorphism that frequently leads to misdiagnosis and treatment delay, further increasing the complication rates. In this study, we aimed to examine bone marrow biopsy findings in brucellosis cases presenting with hematologic abnormalities. Methods Forty-eight brucellosis cases were prospectively investigated. Complaints and physical examination findings of patients were recorded. Patients' complete blood count, routine biochemical tests, erythrocyte sedimentation rate, C-reactive protein and serological screenings were performed. Bone marrow biopsy and aspiration was performed in patients with cytopenia, for bone marrow examination and brucella culture, in accordance with the standard procedures from spina iliaca posterior superior region of pelvic bone. Results Of the 48 patients, 35 (73%) were female and 13 (27%) were male. Mean age was (34.8 15.4) years (age range: 15-70 years). Anemia, leukopenia, thrombocytopenia and pancytopenia were found in 39 (81%), 28 (58%), 22 (46%) and 10 patients (21%), respectively. In the examination of bone marrow, hypercellularity was found in 35 (73%) patients. Increased megacariocytic, erythroid and granulocytic series were found in 28 (58%), 15 (31%) and 5 (10%) patients, respectively. In addition, hemophagocytosis was observed in 15 (31%) patients, granuloma observed in 12 (25%) and increased eosinophil and plasma cells observed in 9 (19%) patients. Conclusion According to the results of our series, hemophagocytosis, microgranuloma formation and hypersplenism may be responsible for hematologic complications of brucellosis. Chin Med J 2012;125(11):1871-1876
Brucellosis-Related Acute Pancreatitis: a Rare Complication of a Universal Disease
(Sage Publications Ltd, 2016) Suvak, Burak; Dulger, Ahmet Cumhur; Karadas, Sevdegul; Gonullu, Hayriye; Bayram, Yasemin; Gonullu, Edip; Guducuoglu, Huseyin
Objectives To determine the prevalence and determinants of acute pancreatitis in patients with acute brucellosis. Methods Adult patients with brucellosis were retrospectively recruited. Brucellosis and acute pancreatitis were diagnosed according to standard criteria. Laboratory analyses included Wright agglutination titre, serum biochemical parameters and blood count. Results Patients with acute pancreatitis (n=21) had significantly higher Wright agglutination titres, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, -glutamyl transpeptidase, amylase, lipase and serum glucose concentrations, and significantly lower haemoglobin concentrations and haematocrit than patients with brucellosis alone (n=326). Conclusions Hyperglycaemia, anaemia, and liver transaminase and cholestatic enzyme concentrations may represent new approaches for assessing disease severity in patients with brucellosis and acute pancreatitis.
Can D-Dimer Levels Predict the Treatment Outcome in a Patient With Tuberculosis
(Pakistan Medical Assoc, 2014) Dulger, Ahmet Cumhur; Karadas, Sevdegul; Gonullu, Hayriye; Beyazal, Mehmet; Bulut, Gulay; Gultepe, Bilge
Tuberculous peritonitis is a leading cause of mortality and morbidity particularly in the developing world. Delay in initiation of treatment distinctively increases mortality. Treatment response to anti-tuberculosis drugs is usually observed by regression of symptoms and clearance of ascites. With initiation of treatment, laboratory values including CA-125 levels generally return to normal levels in 3 months. However, there is still no consensus about treatment response during the follow-up period. Serum D-dimer level is used as an inflammation marker in some cases. A case with Tuberculous peritonitis successfully monitorised by serum D-dimer levels is presented.
Cerebral Venous Sinus Thrombosis Presentation in Emergency Department in Van, Turkey
(Pakistan Medical Assoc, 2014) Karadas, Sevdegul; Milanlioglu, Aysel; Gonullu, Hayriye; Sayin, Refah; Aydin, Mehmet Nuri
Objective: To exmaine the distribution of age, gender, time between onset and presentation, clinical findings, predisposing factors, platelet distribution width, mean platelet volume values and neuroimaging findings, together with the treatment regime and the outcome for patients of cerebral venous sinus thrombosis. Methods: The retrospective, descriptive cross-sectional study was conducted at Yuzuncu Yil University, Medical Faculty Hospital in Van, Turkey, comprising 51 cases diagnosed with cerebral venous sinus thrombosis between January 2008 and September 2011. The diagnosis was based on the results of clinical evaluation, cranial magnetic resonance imaging and venography. SPSS 16 was used for statistical analysis. Results: Overall, 43 (84.3%) of the cases were female, and 8(15.7%) were male. The average age was 32 +/- 11.13 years. The most frequent symptom was headache in 41 (80.4%) cases. The postpartum period was one of the most observed predisposing factors in 17 (33.3%) patients. The magnetic resonance imaging was normal in 35 (68.6%) cases, but in all of the cases, magnetic resonance venography was abnormal. Topographically, the most frequent involvement was transverse sinus in 40 (78.4%) cases. Besides, 50 (98%) patients were discharged following full recovery or mild sequela and only 1 (2%) case had severe sequela. Conclusion: Patients presenting with headache should be examined carefully in the emergency department. Early diagnosis and treatment with clinical and neuroimaging techniques for such patients is recommended.
Chemical Cardioversion of Atrial Fibrillation With Calcium Gluconate
(Kowsar Publ, 2012) Serhat, A.; Gonullu, Hayriye; Huriye, A.
Background: Calcium infusion is used as a pre-treatment before calcium channel blockers to prevent hypotension. Occasional cardioversion with calcium gluconate infusion is seen in patients with paroxysmal supraventricular tachycardia. Several mechanisms have been suggested for mechanism. Herein we report a case presenting with atrial fibrillation but cardioverted with calcium gluconate infusion, which is unreported in the literature before.
Coexistence of Hepatocelluler Carcinoma and Cyst Hydatid Disease of the Liver
(Pakistan Medical Assoc, 2014) Karadas, Sevdegul; Dulger, Ahmet Cumhur; Gonullu, Hayriye; Bulut, Gulay; Beyazal, Mehmet
The evidence suggests that both delta hepatitis-related hepatocellular carcinoma (HCC) and cyst hydatid disease (CHD) are frequently seen separately in people who live in the rural areas of Asia. However, there are still a few case reports about coexistence of these different diseases in the same liver. The current case illustrates a number of clinical problems that physicians face in the diagnosis of patients with basically different liver masses.
Contact Dermatitis Due To Alternative Treatment Methods: Four Case Reports
(Emergency Medicine Physicians Assoc Turkey, 2012) Karadas, Sevdegul; Gonullu, Hayriye; Aydin, Irfan; Oncu, Mehmet Resit
Herbal medicines are commonly used in the eastern regions of Turkey, especially in the treatment of rheumatic complaints. In addition, the use of various foods and drinks for cosmetic purposes is increasing among Turkish people. Despite this extensive use of alternative treatment methods for medical and cosmetic purposes, comprehensive research is still required due to the severe local and systemic adverse effects of these treatments. Here, cases of phyto contact dermatitis due to "Ranunculus kotchy boiss" and "Urtica" and irritant contact dermatitis associated with butter are presented.
Delayed Traumatic Intracerebral Hemorrhage: for How Many Hours Should Patients With Mild Head Trauma Be Observed
(derman Medical Publ, 2015) Karadas, Sevdegul; Gonullu, Hayriye; Gulsen, Ismail; Baltacioglu, Huseyin
Delayed traumatic intracerebral hematoma is a rare complication of head injury. The etiopatogenesis of DTIH is not precisely known. We herein report a case of delayed traumatic intracerebral hematoma, with mild HT. This 25-year-old male fell down while playing in a footbal match. He had headache and vertigo. He was kept under observation for about 12 hours at the emergency department. At the 26th hour after the HT incident, he presented to our hospital again with the complaints of nausea, vomiting and headache. A control brain computed tomography was performed and a traumatic intracerebral hematoma was determined in the frontal region. As a result, DTIH may be fatal. Close observation and repeat CBT scanning may reduce complications and mortality.
Delta Hepatitis-Related Thyroid Disease: a Unique Phenomenon
(Termedia Publishing House Ltd, 2015) Suvak, Burak; Dulger, Ahmet Cumhur; Aykac, Mehmet Coskun; Gonullu, Hayriye; Gonullu, Edip
Introduction: Hepatitis delta virus (HDV) infection is a serious health problem worldwide. Thyroid disturbances represent a major limitation to the efficacy of interferon treatment targeting chronic HDV (C-HDV) infection. Moreover, pre-treatment thyroid diseases may be influenced by interferon therapy. Despite this, the characteristic features of the thyroid diseases in C-HDV patients remain poorly characterised. Aim: To determine the prevalence of thyroid diseases and evaluate the impact of delta hepatitis on thyroid function tests. Material and methods: We retrospectively reviewed the charts of 127 hepatitis C virus (HCV)-negative adults, treatment-naive outpatients with C-HDV, between July 2013 and July 2014. Thyroid-stimulating hormone (TSH) and thyroid antibodies (TAbs) including anti-thyroid peroxidase antibodies (anti-TPO), liver transaminases, and other routine laboratory tests were conducted during the study period. Results: A total of 127 C-HDV patients (female 52.9%, mean age 54.5 +/- 8.01 years) were enrolled. The rate of hypothyroidism, defined as a TSH level above 10 IU/l, was 4.7%. No patient had hyperthyroidism. Both elevated levels of liver transaminases and HDV ribonucleic acid (HDV-RNA) were positively correlated with high levels of thyroid autoantibodies. Conclusions: The rate of hypothyroidism is higher than the rate of hyperthyroidism at baseline. Most remarkably, for the first time we discovered a correlation between disturbed thyroid autoantibodies and elevated liver transaminases as well as high HDV-RNA levels even in euthyroid delta hepatitis patients. But in order to have an adequate understanding of such correlations, further studies are needed.
Does Heated Erythrocyte Suspension Transfusion With Medical Devices Containing Phthalates Increase Dehp and Mehp Levels
(Wiley, 2021) Gonullu, Edip; Bilvanisi, Sevdegul; Tasdogen, Aydin; Gonullu, Hayriye; Erkin, Yuksel; Kume, Tuncay; Aykac, Mehmet Coskun
Aims It is commonly known that stored blood and blood products are heated before transfusion to prevent hypothermia, which leads to increased di-(2-ethylhexyl) phthalate (DEHP) content leaching into the blood and blood products and thereby causes greater conversion of DEHP to mono (2-ethylhexyl) phthalate (MEHP). However, there has been no study in the literature reporting on the amount of toxic phthalates in blood following the erythrocyte suspension (ES) transfused via warming. In this study, we aimed to investigate the DEHP and MEHP content in blood following the heated ES transfusions administered by DEHP-containing and DEHP-free infusion sets. Methods The study included 30 patients that were randomly divided into two groups with 15 patients each: group I underwent ES transfusion via DEHP-containing infusion sets warmed with blood-fluid warmers, and group II underwent ES transfusion via DEHP-free infusion sets warmed with blood-fluid warmers. DEHP and MEHP levels were measured both before and after transfusion. Results DEHP-free infusion sets led to no increase in the phthalate content, whereas DEHP-containing infusion sets significantly increased the DEHP and MEHP, where the DEHP level increased almost four times (P = .001). Conclusion DEHP-containing products lead to toxicity. Therefore, using DEHP-free medical devices may prevent toxicity in patients undergoing ES transfusion.
The Effects on Complications and Myopathy of Different Voltages in Electrical Injuries
(Turkish Assoc Trauma Emergency Surgery, 2011) Karadas, Sevdegul; Gonullu, Hayriye; Oncu, Mehmet Resit; Isik, Daghan; Canbaz, Yasin
BACKGROUND The purpose of this study was to investigate the demographic and clinical characteristics of electrical injuries, laboratory findings, complications, and mortality and morbidity rates of these injuries. METHODS Patients with electrical injuries admitted to the emergency department between January 2006-2010 were retrospectively analyzed. The cases were evaluated by age, gender, source of electrical power (low-high voltage), seasonal distribution, ECG changes, laboratory findings, clinical care units, complications, and mortality rate. RESULTS Eighty-four (57.1%) of the cases were exposed to low-voltage electricity (Group I), while 63 (42.9%) of the cases were exposed to high-voltage electricity (Group II). The majority of cases with electrical injuries were aged 26-45 years. Thirty of the women (85.7%) were wounded by low-voltage while 58 of the men (51.8%) were wounded by high-voltage electricity. Alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, creatine kinase, and CK-MB levels were higher and the level of calcium was lower in Group II. Complications (pathologies due to fall from high levels, cardiac dysrhythmias, compartment syndrome) and the mortality rate were higher in Group II. CONCLUSION In cases with high-voltage electrical injuries, cardiac complications, complications due to fall from high levels and the mortality rate increase in conjunction with the degree of the muscle damage.
Epidemiological Analysis of Poisoning Cases in Van, Turkey
(Pakistan Medical Assoc, 2014) Aydin, Irfan; Karadas, Sevdegul; Gonullu, Hayriye; Dulger, Ahmet Cumhur
Objective: To investigate the etiological and demographical characteristics of acute adult poisoning cases in eastern Turkey. Methods: The retrospective study was conducted at the Emergency Department of Yuzuncu Yil University, School of Medicine, and comprised data related to the period between 2007 and 2009. The data obtained included age, gender, referrals, manner of poisoning, manner of application, the department which followed up on the patients, duration of hospital stay. All data was noted on proforma. SPSS 15 was used for statistical analysis. Results: Of the total cases visiting the Emergency Department, 1207 (1.1%) related to poisoning. Of them, 880 (72.9%) had attempted suicide; 858 (71.1%) were female; 349 (29%) were male. The average age of the females was 25.4 +/- 8.5 years, and that of the males 28.3 +/- 14.3 years. Single-medicine was noted in poisoning 544(45.1%) patients. Other poisoning types were multidrugs 373 (30.9%); rat poisoning, insecticide and pesticides, 145 (12%); corrosives 38 (3.1%); and weed, mushroomang; food 47 (3.8%). Oral poisoning was noted in 1141(94.5%) cases. A total of 1019 (84.4%) patients received treatment and were followed up in the Emergency Department. Six (0.6%) patients died. Conclusion: There is a need to generate more awareness about the hazards of domestic cleaning products and to keep it away at some distinct place to minimised chances of confusion.
Evaluation of Oculocutaneous Anthrax. a Series of 20 Cases
(Carbone Editore, 2015) Gonullu, Hayriye; Karads, Sevdegul; Batur, Muhammed; Baran, Ali Irfan; Sunnetcioglu, Mahmut
Introduction: Cutaneous anthrax is the most common clinical presentation of human anthrax. This study presents an evaluation of cases of ocular lesions from cutaneous anthrax. Methods: A total of 20 patients who attended the emergency department of Yuzuncu Yil University, School of Medicine between 2007 and 2013 were enrolled in the study. Results: 65% of the cases were female and 35% were male. The mean age was 29.16+/-14.80. In 60% there were periorbital lesions in the right eye. 90% of the patients had a history of contact with animals or had eaten animal meat. The mean starting time of lesion was 3.2+/-1.2 days before admittance. In 75% of the cases the diagnosis was based on the characteristic appearance of the lesion and the patient's history. All the patients spent 9.9+/-4.3 days in hospital. Upper eyelid scar tissue and ectropion were found respectively in 20 % and 10 % of the cases. Conclusions: Early diagnosis and appropriate antibiotic treatment can facilitate recovery and prevent the development of eyelid complications.
Gastrointestinal Foreign Body Complementing 83 Days Its Passage: Case Report
(derman Medical Publ, 2013) Karadas, Sevdegul; Gonullu, Hayriye; Oncu, Mehmet Resit; Ebinc, Senar
Foreign body ingestion is an important health problem for children but it can also occur in all age groups. Ingestion or aspiration of foreign bodies such as turban pin and sewing needle more frequently occur in adults. A case of sewing needle ingestion which was removed from the body through defecation in a long time after passing through the small intestine without any complication is presented in this study.
Hepatotoxicity Associated With the Ingestion of Papaver Rhoease
(Pakistan Medical Assoc, 2014) Gonullu, Hayriye; Karadas, Sevdegul; Dulger, Ahmet Cumhur; Ebinc, Senar
Liver injury appears to be associated with the use of herbal products and wild plants. This paper presents what is to our knowledge the first case report in the world of acute liver toxicity caused by Papaver Rhoease. A 17-year-old woman from eastern Turkey ingested Papaver Rhoease which is known as "poppy flower" among the local inhabitants. Her liver function tests were initially 1015 fold higher than normal. She was hospitalised in intensive care unit and on day 2 of hospitalisation, the results of her liver function tests showed about a hundred-fold increase compared to the normal level. Her general status deteriorated and she was transferred to another medical centre for liver transplantation.
High Prevalence of Chronic Hepatitis D Virus Infection in Eastern Turkey: Urbanization of the Disease
(Termedia Publishing House Ltd, 2016) Dulger, Ahmet Cumhur; Suvak, Burak; Gonullu, Hayriye; Gonullu, Edip; Gultepe, Bilge; Aydin, Ibrahim; Olmezi, Sehmus
Introduction: Both hepatitis B virus (HBV) and hepatitis D virus (HDV) infection play an increasingly important role in liver diseases. The main objective of this study was to investigate the socio-epidemiological, laboratory and radiological aspects of both HBV and HDV infection near the Iranian border of Turkey. Material and methods: The study included 3352 patients with HBV and HDV infection. Socioepidemiological, laboratory and radiological aspects of the study subjects were retrospectively examined. Comorbid metabolic diseases were not assessed due to the retrospective design of the study. Results: Most of the study subjects were HBe antigen negative. No significant difference in terms of HBV-DNA levels or HBe antigen seropositivity was detected between the city centre and rural areas (p > 0.005). The mean HBV-DNA level in the anti-HDV-positive group was significantly lower than in the anti-HDV-negative group (p < 0.001). The rate of HDV-RNA positivity in women was higher than in their male counterparts (p = 0.017). Anti-HDV-IgG was detected in 18.4% of tested subjects who came from an urban area. In contrast, 12.5% of subjects of the rural group had a positive result for anti-HDV-IgG. Among 134 ultrasonographically evaluated delta hepatitis patients, 37.3% had liver cirrhosis. On the other hand, in 1244 patients with hepatitis B monoinfection, there were 90 patients with liver cirrhosis. Radiologically, the rate of hepatic steatosis in delta hepatitis patients was lower than in those with HBV monoinfection. Conclusions: Hepatitis D virus infection was particularly prevalent among the urban population as well as in female subjects. More broadly, the current observations are the first to suggest an inverse correlation between delta hepatitis and ultrasonography-proven hepatic steatosis.
The Levels of Trace Elements and Heavy Metals in Patients With Acute Migraine Headache
(Pakistan Medical Assoc, 2015) Gonullu, Hayriye; Gonullu, Edip; Karadas, Sevdegul; Arslan, Mehmet; Kalemci, Orhan; Aycan, Abdurrahman; Demir, Halit
Objective: To compare the levels of trace elements and heavy metal in patients with acute migraine and healthy controls. Methods: The prospective study was conducted at Yuzuncu Yil University, Turkey, from May to July 2013, and comprised migraine patients and an equal number of healthy controls. International Headache Society classification was used for diagnosing migraine. Serum copper, zinc, lead, iron, cadmium, cobalt, manganese, and magnesium levels were measured in both groups. Metal concentrations were assessed by atomic absorption spectrophotometry. SPSS 13 was used for statistical analysis. Results: There were 25 migraine patients with an average age of 36.4+/-8.9 years and 25 healthy controls with a mean age of 42.4+/-9.5 years. Cadmium, iron, manganese and lead levels were significantly elevated in the patients compared to the controls (p<0.05 each), while copper, magnesium and zinc were decreased and cobalt demonstrated no change. Conclusions: Trace elements and heavy metals may have a role in the genesis of considerable oxidative stress in patients with acute migraine headache.