Browsing by Author "Gorken, Gokhan"

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Epilepsia Partialis Continua in a Patient With Progressive Multiple Sclerosis
(Turkish Neurological Soc, 2021) Gorken, Gokhan; Yilgor, Abdullah
Multiple sclerosis (MS) is a chronic autoimmune neurologic disease with demyelination. Epileptic seizures can be seen during episodes or out of the episodes in the course of MS. Although epileptic seizures are rare in patients with MS, they are more common than the normal population. We present a patient with MS who presented with epilepsia partialis continua, which could not be stopped with antiepileptics in the classic status epilepticus protocol but was limited with pulse steroid therapy.
Investigation of Oxidative Stress Level and Antioxidant Enzyme Activities in Operated and Nonoperated Patients With Spontaneous Intracerebral Hematoma
(Thieme Medical Publ inc, 2024) Akyol, Mehmet Edip; Demir, Canan; Gorken, Gokhan
Background Complex underlying mechanisms consisting of cytotoxic, excitotoxic, and inflammatory effects of intraparenchymal hemorrhage (ICH) are responsible for the highly detrimental effects on brain tissue. Oxidative stress also plays a significant role in brain damage after ICH; however, it is less important than other factors. In this study, we aimed to evaluate the oxidative stress parameters malondialdehyde (MDA) and antioxidant-reduced glutathione (GSH), superoxide dismutase (SOD), and catalase (CT) activities in operated and nonoperated patients with spontaneous ICH. Methods One hundred patients with spontaneous ICH and 100 healthy controls were included in this study. Within the indication, 50 of the 100 patients underwent decompressive surgery. MDA, GSH, SOD, and CT activities were measured in the serum obtained from the patients. Results SOD and CT levels were lower in the nonoperated group than in the operated and control groups. GSH was similar in the operated and nonoperated groups, but it was lower in the control group. However, MDA was higher in those who did not undergo surgery than in the other groups. Conclusions In our study, MDA, an indicator of oxidative stress, was found to be lower, and CT and SOD activities were found to be higher in ICH patients who underwent decompression than in those who did not. This is the first study to present the correlations of MDA, SOD, CT, and GSH in operated and nonoperated patients with spontaneous ICH.