Browsing by Author "Gul, Ahmet"

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Comparison of Argon Laser Photocoagulation-Induced Cutaneous Inflammation and Skin Pathergy Test in Behcet's Disease
(Springer, 2010) Sayarlioglu, Mehmet; Calka, Omer; Cinal, Adnan; Sayarlioglu, Hayriye; Akdeniz, Necmeddin; Topcu, Nazan; Gul, Ahmet
Nonspecific increased inflammatory response is an important feature of Behcet's disease (BD). The skin pathergy reaction (SPR) which tests this hyperreactivity in the skin is frequently used as a diagnostic tool. This study aims to investigate the argon laser photocoagulation (ALP)-induced cutaneous inflammation in BD patients and controls and also to compare the results with the skin pathergy test (SPT). The study group consisted of 35 patients with BD and 28 healthy volunteers. The ALP was applied to the left forearms of all cases from 20-cm distance (2,000 mW, 100 A mu m) with exposure times ranging from 0.2 to 0.7 s with 0.1-s increments. Also, a SPT with three prics was performed to both forearms of all cases. The ALP-induced cutaneous inflammation and SPT were evaluated and scored with the same method at 48 h, and the SPR scores of 2+ and above was accepted as positive. Positive results as defined above were found in eight cases (23%) with the ALP and in nine (26%) with the SPT in patients with BD. There was no clear correlation between the ALP and SPT results and also between the exposure time to laser beam and SPR scores. The preliminary results of this study reveal that ALP can induce a skin hyperreactivity similar to the needle prick-induced SPR in patients with BD. We, herein, showed that ALP can induce skin inflammation with its thermal effect and without any inoculation of antigen in BD. This method would help to develop another experimental method to investigate the cutaneous inflammation in BD.
Synthesis and Electrochemical Characterization of Biphenyl-Malonic Ester Substituted Cobalt, Copper, and Palladium Phthalocyanines
(Pergamon-elsevier Science Ltd, 2007) Sener, M. Kasim; Koca, Atif; Gul, Ahmet; Kocak, Makbule Burkut
Phthalocyanines with four biphenyl-malonic ester groups on the periphery were synthesized by cyclotetramerization of 4-(1,1-dicarbethoxy-2-(4-biphenyl)-ethyl)-phthalonitrile. The new compounds were characterized by elemental analyses, FT-IR, H-1 NMR, C-13 NMR, UV-Vis, and MASS spectral data. Electrochemical behaviors of novel Co(II), Cu(II), and Pd(II) phthalocyanines were investigated by cyclic voltammetry, potential differential pulse voltammetry, and applied potential chronocoulometry techniques. While Cu(II) and Pd(II) phthalocyanines give up to four common phthalocyanine ring reductions, Co(II) phthalocyanine gave two ligand-centered and two metal-centered redox processes. HOMO-LUMO gap of the complexes are comparable with the reported MPc papers. (c) 2006 Elsevier Ltd. All rights reserved.