Browsing by Author "Gul, Asli San Dagli"

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Behavior, Antioxidant, and Metabolomics Effects of Allium Tuncelianum
(Wiley, 2024) Abbak, Nigar; Nemutlu, Emirhan; Recber, Tuba; Gul, Asli San Dagli; Akkoyun, H. Turan; Akkoyun, Mahire Bayramoglu; Arihan, Okan
Allium species are consumed extensively as folkloric medicine and dietary elements, but limited studies have been conducted on them. In this study, the effects of an ethanol-water extract obtained from the underground bulb of Allium tuncelianum (Kollmann) ozhatay, B. Mathew & Siraneci (AT) on the behavioral, antioxidant, and metabolite parameters in rats were evaluated. AT was administered orally once a day at doses of 100 and 400 mg/kg to male Wistar albino rats for 10 consecutive days. The elevated plus maze, rotarod, and hotplate tests were used to examine anxiety-like behaviors, locomotor activities, and pain perception in the rats, respectively. Additionally, untargeted metabolomic analyses were performed on plasma samples and AT extracts using two orthogonal analytical platforms. The phenolic components, mainly fumaric acid, malic acid, vanillic acid, quercetin-3-arabinoside, hydrocinnamic acid, and gallocatechin, were determined in the extract. In addition, arbutin, salicylic acid, trehalose, and nicotinic acid were analyzed in the extract for the first time. The AT extract did not decrease the catalase, glutathione peroxidase, or superoxide dismutase levels; however, diazepam decreased some of those parameters significantly in the brain, liver, and kidney. Although both the AT and diazepam treatments resulted in an increase in anxiolytic-like effects compared to the control group, no significant differences were observed (p > .05). In the metabolomic analysis, significant changes were observed in the rats treated with AT and diazepam, and they caused significant changes in some metabolic pathways, including amino acid and fatty acid metabolism, compared to the control.
Evaluation of the Effect of Allium Tuncelianum (Tunceli Mountain Garlic) Plant Extract on Behavioral, Antioxidant and Metabolomic Parameters in Rats
(Wiley, 2025) Abbak, Nigar; Nemutlu, Emirhan; Recber, Tuba; Gul, Asli San Dagli; Akkoyun, Hurrem Turan; Akkoyun, Mahire Bayramoglu; Arihan, Okan
Example of Digital Exhibition in Anthropology and Medical Education
(Taylor & Francis Ltd, 2023) Gul, Asli San Dagli; Arihan, Seda Karaoz; Arihan, Okan
Technology brings new opportunities in terms of education and research, and global pandemics such as the recent COVID-19 pandemic require online education-style approaches. Visualisation is of great importance in digitised education. In this study, materials that are of interest to the disciplines of anthropology, dentistry and medicine were selected from the skeletal materials and presented in a virtual exhibition. The mandible samples were digitised by photogrammetric method, and the exhibition was made navigable by using the Unity game engine program. In the exhibition, information on dental and bone physiology and palaeopathology, as well as the mandibles of the skeletons obtained from the excavation area, and information on individuals are presented on informative boards. The exhibition can be visited online with the link provided. In this study, the opinions of 30 students, who visited the exhibition from Faculty of Medicine 3(rd)-5(th) classes, were asked to complete an online questionnaire. Results of this questionnaire show that students would like to see more of such digital education methods. Digitising educational presentations enables these exhibitions to transcend physical boundaries and reach a global audience. In addition, the images can be easily examined by anyone who visits and can be evaluated for educational purposes.