Browsing by Author "Gulsen, I."

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Evaluation of Blood Neutrophil To Lymphocyte and Platelet To Lymphocyte Ratios According To Plasma Glucose Status and Serum Insulin-Like Growth Factor 1 Levels in Patients With Acromegaly
(Sage Publications Ltd, 2016) Ucler, R.; Aslan, M.; Atmaca, M.; Alay, M.; Ademoglu, E. N.; Gulsen, I.
Introduction: Cardiovascular, respiratory, and cerebrovascular diseases and malignancies are responsible for morbidity and mortality in acromegaly. Also these diseases are associated with chronic inflammation. The neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) are currently gaining interest as new markers of inflammation. Moreover, increased morbidity and mortality are positively correlated with the presence of diabetes and levels of insulin-like growth factor 1 (IGF-1) in acromegaly. The objective of the present study was to investigate the relationship between these markers and acromegaly according to plasma glucose status and serum IGF-1 levels. Materials and Methods: We retrospectively analyzed data from 61 acromegaly patients who were in a newly diagnosed period (35 male, 26 female; mean age 38.13 +/- 13.98). Patients with normal plasma glucose (n = 27), impaired fasting glucose (n = 18), and diabetes mellitus (n = 16) were categorized into three different groups. NLR and PLR were compared between the study groups and were evaluated according to IGF-1 levels. Results: There were no statistically significant differences inNLR and PLR measurements among the study groups (p > 0.05). However, there were significant positive correlations between NLR and IGF-1 levels and between PLR and IGF-1 levels when all patients were evaluated (r = 0.334, p = 0.011 and r = 0.277, p = 0.035, respectively). Conclusions: This is the first report studying the relationship of NLR and PLR with glucose status and IGF-1 levels in acromegaly patients. Our study results suggest that subclinical inflammation may play a role in increased incidence of mortality and morbidity, which depends on uncontrolled IGF-1 levels in patients with acromegaly.
Management of Haemangiopericytoma Located in the Spinal Cord Diagnosed During Pregnancy
(Taylor & Francis inc, 2015) Kurdoglu, Z.; Cetin, O.; Bulut, G.; Erten, R.; Gulsen, I.; Sahin, H. Guler
Megalencephaly, Polymicrogyria, Polydactyly and Hydrocephalus (Mpph) Syndrome: a New Case With Occipital Encephalocele and Cleft Palate
(Medecine Et Hygiene, 2015) Demir, N.; Peker, E.; Gulsen, I.; Kaba, S.; Tuncer, O.
Megalencephaly, polymicrogyria, polydactyly and hydrocephalus (MPPH) syndrome: a new case with occipital encephalocele and cleft palate: The megalencephaly, polymicrogyria, polydactyly, and hydrocephalus (MPPH) syndrome is quite rarely seen. The four main findings in this syndrome may be accompanied by severe psychomotor retardation, blindness, hypotonia, convulsions, and facial dysmorphism. In this paper, we present a female newborn at 39 weeks gestational age born to parents who are first degree cousins. Beside the facial dysmorphism and four main features of the MPPH syndrome, the findings on the physical examination of the patient were, hypertonicity, occipital encephalocele, cleft palate, and multiple polyps in the tongue. The presence of occipital encephalocele, cleft palate, and polyps in the tongue in this patient was not reported previously in the literature.
Powder Topical Rifampicin on Reducing Infections After Neural Tube Defect (Ntd) Surgery in Infants
(Springer, 2016) Demir, N.; Peker, E.; Gulsen, I.; Kocaman, S.; Tuncer, O.; Kirimi, E.
Prognostic Factors in Oligodendrogliomas: a Clinical Study of Twenty-Five Consecutive Patients
(Asian Pacific Organization for Cancer Prevention, 2015) Atalay, T.; Ak, H.; Celik, B.; Gulsen, I.; Seckin, H.; Tanik, N.; Bavbek, M.
Background: The purpose of this study was to evaluate the prognostic significance of Ki-67 and subjective microvascular density (SMVD) indexes together with other factors in patients with oligodendroglioma. Materials and Methods: In this retrospective study, oligodendroglioma specimens obtained from twenty-five consecutive patients were evaluated for Ki-67 and SMVD indices to help determine histological grading and investigate the fidelity of these markers in clinical prognosis. Other potentially prognostic factors were Karnofsky performance scale, tumor histological grade, and adjuvant radiotherapy. Results: The Ki-67 proliferation index appeared to have a strong correlation with the grade of the tumor and the survival. Age, gender, adjuvant radiotherapy, surgical resection type (complete versus incomplete) did not have any influence on recurrence. The SMVD index correlated significantly with the 3 to 5-year survival. Conclusions: Ki-67 and MVD indexes are important and useful markers in estimating the prognosis of oligodendrogliomas.
A Single Center Experience of Cns Anomalies or Neural Tube Defects in Patients With Jarcho Levin Syndrome
(Springer, 2016) Demir, N.; Peker, E.; Gulsen, I.; Agengin, K.; Kaba, S.; Tuncer, O.