Browsing by Author "Gumrukcuoglu, H. A."

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Anomaly of Left Main Coronary Artery Arising From the Right Sinus of Valsalva
(Elsevier Ireland Ltd, 2011) Simsek, H.; Sahin, M.; Islek, M.; Paker, S.; Gumrukcuoglu, H. A.
Comparison of Effects of Nebivolol and Atenolol on P-Wave Dispersion in Patients With Hypertension
(Russian Heart Failure Soc, 2008) Tuncer, M.; Fettser, D.; Gunes, Y.; Batyraliev, T. A.; Guntekin, U.; Gumrukcuoglu, H. A.; Sidorenko, B. A.
Background. P-wave dispersion has been shown to be a noninvasive electrocardiographic predictor for development of atrial fibrillation. Thus it may be possible to attenuate atrial fibrillation risk through normalization of P-wave variables and improvement in P-wave dispersion may be an important goal in treatment of hypertension. Objective. To compare the effects of nebivolol, a new P-blocker that have additional vasodilating activity via acting on endothelium and nitric oxide release, and atenolol on P-wave duration and dispersion in patients with mild-to-moderate hypertension. Methods. A total of 34 newly-diagnosed hypertensive patients were enrolled in the study. The patients were randomly assigned to receive treatment with either nebivolol (5 mg) or atenolol (50 mg). P-wave durations (Pmin and Pmax) and P-wave dispersion were measured before and one month after treatment. Results. While Pmin increased (50,6 +/- 11,2 ms to 54,7 +/- 9,1 ms, p=0,05), Pmax decreased (111,9 +/- 9,1 ms to 104,0 +/- 12,4 ms, p=0,003) and P-wave dispersion decreased (62,5 +/- 10,6 ms to 51,3 +/- 8,9 ms, p<0,001) with nebivolol, Pmin increased (44,4 +/- 9,8 ms to 58,0 +/- 15,5 ms, p=0,02), Pmax didn't change (106,1 +/- 13,8 ms to 107,0 +/- 11,6 ms, p=NS) and P-wave dispersion decreased (61,7 +/- 15,0 ms to 49,0 +/- 13,7 ms, p<0.001) with atenolol. However, there was no statistical difference between pre- and post-treatment values of two groups. Conclusions. Both nebivolol and atenolol are effective in improvement of P-wave dispersion in patients with hypertension and there's no significant difference between them.
The Effect of Low Sodium Dialysate on Ambulatory Blood Pressure Measurement Parameters in Patients Undergoing Hemodialysis
(Oxford Univ Press, 2015) Akdag, S.; Akyol, A.; Cakmak, H. A.; Tosu, A. R.; Asker, M.; Yaman, M.; Gumrukcuoglu, H. A.
Effects of Illness Activity on Electrocardiographic Parameters in Patients With Multiple Sclerosis
(Elsevier Ireland Ltd, 2011) Gumrukcuoglu, H. A.; Tuncer, M.; Simsek, H.; Sahin, M.; Akdag, S.; Gunes, Y.; Tombul, T.
Effects of Lowered Dialysate Sodium on Left Ventricle Function and Brain Natriuretic Peptide in Maintenance of Hemodialysis Patients
(Sage Publications Ltd, 2017) Akyol, A.; Akdag, S.; Asker, M.; Gumrukcuoglu, H. A.; Duz, R.; Demirel, K. C.; Begenik, H.
Introduction: Impaired diastolic flow is characterized by decreased left ventricular (LV) filling diastole, abnormal LV distensibility, or delayed relaxation. B-Type natriuretic peptide (BNP) is an indicator of various cardiovascular diseases and body volume status. The aim of this study was to determine whether the lowering of dialysate sodium (Na) levels is effective on LV systolic and diastolic parameters and BNP in the maintenance of hemodialysis patients. Materials and Methods: The study included 49 chronic hemodialysis patients. Left atrium (LA) diameter and LV ejection fraction, LV systolic and diastolic diameter, deceleration time (DT), pulmonary artery pressure (PAP), inferior vena cava diameter (IVCD), early diastolic transmitral flow (E) and late diastolic transmitral flow (A) velocities, E/A ratio, isovolumic relaxation time, peak early diastolic velocity (E), late diastolic velocity (A) of tissue Doppler mitral annulus, and flow propagation velocity of mitral inflow (V-p) were measured before and 6 months after hemodialysis with low Na dialysate. Results: Six months after low Na hemodialysis, a decrease was observed in echocardiographic parameters such as PAP and IVCD (p < 0.05, p < 0.001, and p < 0.001, respectively). However, a significant difference was not observed in LA diameter. In LV diastolic measurement of E and A waves, E/A ratio, DT, V-p, septal E and A, and lateral E and A exhibited significant improvement by low Na HD. BNP level was significantly reduced (p < 0.001). Conclusions: Lowered dialysate Na concentration improves PAP, IVCD, and LV diastolic properties assessed by mitral inflow filling, tissue Doppler velocity, and mitral inflow velocity propagation.
Maternal, Fetal Outcome, and Anticoagulant Management in Pregnant Women With Prosthetic Heart Valves
(Imr Press, 2018) Akyol, A.; Yuman, M.; Sabin, M.; Simsek, H.; Akdag, S.; Gumrukcuoglu, H. A.; Tuncer, M.
Introduction: Cardiac disease in maternity is a great problem particularly in developing countries. Pregnant patients with prosthetic heart valves (PHV) may suffer therapeutic difficulty, as the need for anticoagulation is fraught with risk of hemorrhagic or thromboembolic complications and structural valve deterioration. The present study aimed to evaluate the maternal, fetal outcome, and anticoagulant management in pregnant women with PHV. Materials and Methods: This study is prospective observational research. The medical archives of pregnant patients with PHV from September 2010 to January 2015 were scanned. Data collected from Yuzuncu Yil University Hospital Cardiology clinics archives included demographic characteristics, anticoagulant, presence or absence of obstructive or non-obstructive thrombus, and maternal-fetal outcome. Results: The authors evaluated the outcomes of 56 pregnant patients with PHV. The age at the time of pregnancy ranged between 19 and 37 (mean 28.7 +/- 8.4) years. Most common preferred anticoagulation therapy was heparin during the first trimester, followed by oral anticoagulation up to the 36th week, with subsequent replacement by heparin until delivery. Most common encountered complication was preterm birth. Death occurred in one patient due to obstructive valve thrombosis. Conclusion: Ideal PHV is not accessible for women during childbearing age. The risk of adverse event during pregnancy depends on valve position, symptoms, valve type, cardiac function, and functional capacity in patients with PHV. The active collaboration among an obstetrician, a cardiologist, and a cardiothoracic surgeon is required for optimal outcome patient with PHV.
Movable Thrombus Attached on Mitral Anterior Leaflet
(Elsevier Ireland Ltd, 2011) Gumrukcuoglu, H. A.; Odabasi, D.; Ekim, H.; Akdag, S.; Ozdemir, M.
A New Echocardiographic Parameter of Arterial Stiffness in End-Stage Renal Disease
(Urban & Vogel, 2014) Sahin, M.; Simsek, H.; Akyol, A.; Akdag, S.; Yaman, M.; Aydin, C.; Gumrukcuoglu, H. A.
Background. Cardiovascular disease is the leading cause of death among patients with end-stage renal disease (ESRD). Arterial stiffness is an independent predictive parameter of overall and cardiovascular mortality in these patients. However, the defined procedures for the measurement of arterial stiffness are time consuming and not practical in daily practice. Methods. The study population included 50 patients with ESRD who were treated with hemodialysis (HD; n=23) or peritoneal dialysis (PD; n=27) and 70 age-and sex-matched control subjects. Aortofemoral pulse wave velocity (PWV), carotid intima-media thickness (CIMT), and color M-mode propagation velocity of the descending aorta (aortic propagation velocity, APV) were measured. Results. Compared to the control group, the patients with ESRD had significantly lower APV (46.4 +/- 12.4 vs. 58.5 +/- 8.5, p<0.01) and higher PWV (10.5 +/- 2.5 vs. 9.2 +/- 1.2, p<0.01) and CIMT (0.66 +/- 0.15 vs. 0.43 +/- 0.06, p<0.01) measurements. There were significant correlations between APV and CIMT (r=-0.769, p<0.001), APV and PWV (r=-0.682, p<0.001), and PWV and CIMT (r=0.564, p<0.001). There were no significant differences in APV and PWV between the PD and HD patients. Conclusion. Arterial stiffness is an important indicator of atherosclerosis and arterial aging in patients with ESRD. The measurement of APV is an easy and practical new echocardiographic method and may be used to identify arterial stiffness in these patients.
A Novel Echocardiographic Method for Assessing Arterial Stiffness in Obstructive Sleep Apnea Syndrome
(Oxford Univ Press, 2015) Akdag, S.; Akyol, A.; Cakmak, H. A.; Gunbatar, H.; Asker, M.; Babat, N.; Gumrukcuoglu, H. A.
P Wave Dispersion in Hypertensive Urgency
(Russian Heart Failure Soc, 2008) Tuncer, M.; Fettser, D.; Gunes, Y.; Batyraliev, T.; Guntekin, U.; Gumrukcuoglu, H. A.; Guler, N.
Background and purpose: P wave dispersion (PWD) has been accepted as a predictor for atrial fibrillation (AF) in hypertension and some other cardiac diseases. The aim of this study was to compare the P wave parameters between patients with mild-moderate hypertension and those with hypertensive crises. Methods: A total of 48 patients, 24 of who presented to the emergency department with hypertensive urgency and 24 patients who were followed in the cardiology clinic with mild-moderate essential hypertension were included in this study. P wave durations were measured manually by two investigators blinded to data of patients. Results: The maximal duration of P wave (P-max) and the PWD were found to be significantly different between groups, being longer in patients with hypertensive urgency (p=0,05 and 0,02; respectively). Conclusions: PWD increases in hypertensive urgency states. Clinical implication of this finding should be addressed with further, prospective studies conducted on larger samples.
Resolution of Atrial Thrombus With Adjusted Dose Warfarin Therapy in Patient With Nonvalvular Atrial Fibrillation
(Elsevier Ireland Ltd, 2011) Simsek, H.; Dogan, A.; Sahin, M.; Gumrukcuoglu, H. A.; Akdag, S.
Role of Echocardiography in the Evaluation of Atrial Function and Diseases
(Edizioni Minerva Medica, 2010) Gunes, Y.; Gumrukcuoglu, H. A.; Tuncer, M.
This article describes four essential components (hemodynamic, bioelectrical, hormonal and metabolic) of atrial function. And then discusses the traditional and more recent echocardiographic measures that have been employed to evaluate atrial function. Conventional parameters include the study of the various phases of atrial activity using atrial volume measurements, the peak A wave velocity, its velocity time integral (VTI), fraction of atrial contribution and atrial ejection force. Newer parameters for atrial function assessment include Doppler tissue imaging (DTI) including segmental atrial contractility using color Doppler tissue imaging (CDTI) and estimates of atrial strain and strain rate. Furthermore, the authors relate various particular types of atrial function in physiological and in selected pathological conditions.
Severe Mitral and Aorta Insufficiency in Patient With Acute Rheumatismal Fever
(Elsevier Ireland Ltd, 2011) Akdag, S.; Sahin, M.; Simsek, H.; Gumrukcuoglu, H. A.; Tuncer, M.
Short-Term Levosimendan Treatment Protects Rat Testes Against Oxidative Stress
(Assoc Bras Divulg Cientifica, 2012) Yuksel, M. B.; Kavak, S.; Gecit, I.; Basel, H.; Gumrukcuoglu, H. A.; Demir, H.; Meral, I.
The objective of this study was to evaluate the effect of short-term levosimendan exposure on oxidant/antioxidant status and trace element levels in the testes of rats under physiological conditions. Twenty male Wistar albino rats were randomly divided into two groups of 10 animals each. Group 1 was not exposed to levosimendan and served as control. Levosimendan (12 mu g/kg) diluted in 10 mL 0.9% NaCl was administered intraperitoneally to group 2. Animals of both groups were sacrificed after 3 days and their testes were harvested for the determination of changes in tissue oxidant/antioxidant status and trace element levels. Tissue malondialdehyde (MDA) was significantly lower in the levosimendan group (P < 0.001) than in the untreated control group and superoxide dismutase and glutathione peroxidase (GSH-Px) levels were significantly higher in the levosimendan group (P < 0.001). Carbonic anhydrase, catalase and GSH levels were not significantly different from controls. Mg and Zn levels of testes were significantly higher (P < 0.001) and Co, Pb, Cd, Mn, and Cu were significantly lower (P < 0.001) in group 2 compared to group 1. Fe levels were similar for the two groups (P = 0.94). These results suggest that 3-day exposure to levosimendan induced a significant decrease in tissue MDA level, which is a lipid peroxidation product and an indicator of oxidative stress, and a significant increase in the activity of an important number of the enzymes that protect against oxidative stress in rat testes.
Treatment of Gigantic Left Ventricular Thrombus: Case Report
(Elsevier Ireland Ltd, 2011) Sahin, M.; Simsek, H.; Gumrukcuoglu, H. A.; Akdag, S.; Ekici, B.
Vascular Endothelial Function in Patients With Coronary Slow Flow and the Effects of Nebivolol
(Elsevier Ireland Ltd, 2011) Gunes, Y.; Gumrukcuoglu, H. A.; Akdag, S.; Simsek, H.; Sahin, M.; Tuncer, M.