Browsing by Author "Gunbatar, H."

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Assessment of Palliative Care in Lung Cancer in Turkey
(Karger, 2017) Bulbul, Y.; Ozlu, T.; Arinc, S.; Ozyurek, B. A.; Gunbatar, H.; Senturk, A.; Talay, F.
Objective: To investigate the symptoms of lung cancer in Turkey and to evaluate approaches to alleviate these symptoms. Subjects and Methods: This study included 1,245 lung cancer patients from 26 centers in Turkey. Demographic characteristics as well as information regarding the disease and treatments were obtained from medical records and patient interviews. Symptoms were evaluated using the Edmonton Symptom Assessment Scale (ESAS) and were graded on a scale between 0 and 10 points. Data were compared using the. 2, Student t, and Mann-Whitney U tests. Potential predictors of symptoms were analyzed using logistic regression analysis. Results: The most common symptom was tiredness (n = 1,002; 82.1%), followed by dyspnea (n = 845; 69.3%), appetite loss (n = 801; 65.7%), pain (n = 798; 65.4%), drowsiness (n = 742; 60.8%), anxiety (n = 704; 57.7%), depression (n = 623; 51.1%), and nausea (n = 557; 45.5%). Of the 1,245 patients, 590 (48.4%) had difficulty in initiating or maintaining sleep. The symptoms were more severe in stages III and IV. Logistic regression analysis indicated a clear association between demographic characteristics and symptom distress, as well as between symptom distress (except nausea) and well-being. Overall, 804 (65.4%) patients used analgesics, 630 (51.5%) received treatment for dyspnea, 242 (19.8%) used enteral/parenteral nutrition, 132 (10.8%) used appetite stimulants, and 129 (10.6%) used anxiolytics/antidepressants. Of the 799 patients who received analgesics, 173 (21.7%) reported that their symptoms were under control, and also those on other various treatment modalities (dyspnea: 78/627 [12.4%], appetite stimulant: 25/132 [18.9%], and anxiolytics/antidepressants: 25/129 [19.4%]) reported that their symptoms were controlled. Conclusion: In this study, the symptoms progressed and became more severe in the advanced stages of lung cancer, and palliative treatment was insufficient in most of the patients in Turkey. (C) 2016 S. Karger AG, Basel
The Association Between Platelet-Derived Growth Factor Receptor-Β Polymorphisms and Idiopathic Pulmonary Fibrosis
(Yuzuncu Yil Universitesi Tip Fakultesi, 2023) Kaya, Z.; Duran, S.; Gunbatar, H.; Sahin, E.S.; Karan, B.M.
Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease with a dismal prognosis. Platelet-derived growth factor (PDGF) receptor-β (PDGFR-β) are a receptor tyrosine kinase that PDGFs activate. It has been reported that inhibiting PDGFR-β in IPF patients can slow and improve disease progression. However, the effects of PDGFR-β on IPF remain unknown, and no studies on PDGFR-β polymorphisms for IPF have been conducted. The purpose of this study is to look into the relationship between PDGFR-β gene polymorphisms (rs246395, rs2302273, rs3828610, rs138008832) and IPF disease. The study included eleven patients with IPF and twelve healthy controls. DNA was isolated from blood samples taken from all participants, and genotyping was performed using a StepOne plus real time PCR device. There was no statistically significant difference between the variables (age, gender, smoking, alcohol, and gastroesophageal reflux [GER]). There was no statistically significant difference between the patient and control groups in the allele and genotype frequencies of these polymorphisms. Furthermore, no statistically significant difference was found between patients' smoking, forced vital capacity (FVC) (normal, low), and GER data, as well as PDGFR-β variants (rs246395, rs2302273, rs3828610 and rs138008832). In order to determine the relationship between PDGFR-β gene polymorphisms and the risk of IPF, larger studies with more participants are required. © 2023, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Brucella Related Mediastinal Lymph Nodes Enlargement
(Amer Thoracic Soc, 2015) Sertogullarindan, B.; Ekin, S.; Gunbatar, H.; Olmez, S.
Circulating Betatrophin Levels Are Associated With the Apnea-Hypopnea Index and Lipid Profile in Subjects With Obstructive Sleep Apnea
(Wiley-blackwell, 2016) Sertogullarindan, B.; Komuroglu, A. U.; Ucler, R.; Gunbatar, H.; Sunnetcioglu, A.; Bozan, N.; Dalli, A.
The Correlation Between Red Blood Cell Distribution Width Levels With the Severity of Obstructive Sleep Apnea and Carotid Intima Media Thickness
(International Scientific Literature Inc., 2014) Gunbatar, H.; Sertogullarindan, B.; Ekin, S.; Akdag, S.; Arisoy, A.; Sayhan, H.
Background: Obstructive sleep apnea syndrome (OSAS) is characterized by repetitive collapse of the upper airway during sleep. Red blood cell distribution width (RDW) increases platelet activation and has been reported as an independent predictor of adverse outcomes in the general population and is believed to be associated with cardiovascular morbidity and mortality. We evaluated RDW, mean platelet volume (MPV), and platelet distribution width (PDW) as a severity index in OSAS and the relationship between carotid intima media thickness and pulmonary hypertension.; Material/Methods: The study population consisted of 99 patients who were admitted to the sleep laboratory. Based on the apneahypopnea index, patients were grouped into 3 OSAS severity categories. Morning blood samples were withdrawn from patients after a 12-hour fasting period. MPV, PDW, and RDW were measured in a blood sample. Bilateral common carotid arteries of the patients were scanned.; Results: Ninety-nine patients – 73 with OSAS and 26 simple snoring control cases – were included. Mean values of MPV, PDW, and RDW were similar in patients compared to simple snoring subjects in the control group (p=0.162, p=0.656, p=0.091). RDW showed an inverse correlation with mean desaturation and lowest desaturation (p<0.01). Body mass index, apnea-hypopnea index, pulmonary artery pressure, and desaturation time under 90% were positively correlated with RDW (p<0.05). MPV, PDW, and carotid intima media thickness had no correlation with any other parameters.; Conclusions: The study showed a positive relationship between RDW and the apnea-hypopnea index and systolic pulmonary hypertension in patients with OSAS. © Med Sci Monit, 2014.
Does Hypoxia Only Importan for Fatty Liver in Osa Patients
(Amer Thoracic Soc, 2016) Sertogullarindan, B.; Bulut, D.; Gunbatar, H.; Sunnetcioglu, A.; Ekin, S.; Arisoy, A.
Is İt İn Our Genes That We're Going To Have Pulmonary Embolism
(Yuzuncu Yil Universitesi Tip Fakultesi, 2024) Uney, İ.H.; Arisoy, A.; Sunnetcioglu, A.; Mermit Çilingir, B.; Yıldız, H.; Gunbatar, H.; Asker, S.
Pulmonary thromboembolism is a disease with high mortality and morbidity, which can be recurrent, difficult to diagnose, yet preventable and treatable. In this study, our aim was to evaluate comorbidities, risk factors, laboratory results, and clinical scoring in patients diagnosed with pulmonary embolis m. Our primary goal was to detect genetic mutations in cases of pulmonary embolism with acquired risk factors. Our study is a prospective study that includes clinical information, laboratory tests, Wells scoring, admission, and the prospective history of 60 patients with no previous history of venous thromboembolism (VTE) and no history of anticoagulation use. These patients were admitted to the chest diseases outpatient clinic, emergency department, or hospitalized for another reason and diagnosed with pul monary thromboembolism. The mean age of the patients was 59.9 ± 18.7 years. The most common presenting complaints were shortness of b reath and sharp chest pain. Nearly half of the patients had at least one comorbid disease. There was at least one genetic/congenital risk factor in all cases, and at least two risk factors were present in more than half of the cases. The most common mutati ons were plasminogen activator inhibitor type 1 (PAI-1) and Methylenetetrahydrofolate Reductase (MTHFR) heterozygote mutations. Pulmonary embolism continues to be a more prevalent disease with increasing age and associated risk factors. Since there is at least one acquired risk factor in all of our cases, we believe that almost every patient may have an acquired risk factor if the history is thoroughly investigated. We also believe that genetic or thrombophilic conditions may be detected in almost all cases diagnosed with pulmonary embolism. It has been concluded that immobilization and obesity are the most common preventable risk factors associated with VTE. © 2024, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Is There a Correlation Between Obstructive Sleep-Apnea Syndrome Severity and Prolidase Activity as an Oxidative Stress Marker
(Wolters Kluwer Medknow Publications, 2020) Gunbatar, H.; Kaplan, H. S.; Yildiz, S.
Objective: Obstructive sleep apnea syndrome (OSAS) is a highly prevalent breathing disorder in sleep. The aim of this study was to evaluate the relationship between OSAS and prolidase activity, the oxidative stress index (OSI), total antioxidative capacity (TAC), total oxidative capacity (TOC) and the carotid intima media thickness (CIMT). Method: After night polysomnography, 74 people were diagnosed with OSAS and simple snoring. Plasma prolidase activities, TAC and TOC were measured in blood samples taken in the morning after the sleep study. The patients' bilateral common carotid arteries were scanned. Results: In total, 56 patients were in OSAS group [13 subjects 23.2% mild, 19 subjects 33.9% moderate, 24 subjects 42.8% severe] and 18 in simple snoring control group. The mean Prolidase, TOC, TAC and OSI levels were 744.7 +/- 156.8, 59.2 +/- 19.2, 2.12 +/- 0.41, 3.12 +/- 1.03, in the mild OSAS group, 761.6 +/- 114.4, 57.9 +/- 18.3, 2.03 +/- 0.37, 3.15 +/- 0.8, in the moderate OSAS group, 754.08 +/- 133.9, 51.15 +/- 12.1, 1.97 +/- 0.27, 2.8 +/- 0.82, in the severe OSAS group, and 711.9 +/- 139, 52.3 +/- 15.1, 1.83 +/- 0.32, 3.06 +/- 0.92 in the control group, respectively. Mean CIMT measurements were 0.71(+/- 0,13) in the OSAS group and 0.76(+/- 0.07) in the control group. Conclusion: There was no difference between the control and OSAS groups in terms of the parameters studied. Further studies should be undertaken in order to clarify the relation.
A Novel Echocardiographic Method for Assessing Arterial Stiffness in Obstructive Sleep Apnea Syndrome
(Oxford Univ Press, 2015) Akdag, S.; Akyol, A.; Cakmak, H. A.; Gunbatar, H.; Asker, M.; Babat, N.; Gumrukcuoglu, H. A.
Presented With Central Nervous System Involvement, Extra- Pulmonary and Intra-Pulmonary Tuberculosis Combined Infection in a Dialysis Patient
(Yuzuncu Yil Universitesi Tip Fakultesi, 2015) Gunbatar, H.; Bulut, G.; Soyoral, Y.; Sertogullarindan, B.; Ebinc, S.
The clinical appearance of Mycobacterium tuberculosis (TB) in patients on dialysis are substantially non-specific that makes diagnosis difficult. We report a case of extrapulmonary and intrapulmonary TB in end stage renal disease (ESRD). A 58- year-old female with ESRD was admitted to emergency with the complaints of intermittent fever, weakness, impairment of consciousness for last three days. Because of mental confusion she was entubated, transferred to the intensive care unit. Thorax CT showed widespreadcentryasinarnodules in both lungs. The empirically anti-TB therapy was initiated. There was in size of 4x5 cm palpable lymphadenopaty on left supraclavicular region, excisional biopsy revealed caseating granulomatous lymphadenitis. Lumbar puncture was performed and analysis was consistent with TB meningitis. The patient was diagnosed as miliary TB, TB meningitis and TB lymphadenitis and died on the tenth day on admission. Increased awareness of TB in the ESRD population, early diagnosis and treatment are very important. © 2015, Yuzuncu Yil Universitesi Tip Fakultesi, Universitas Indonesia. All rights reserved.
Pulmonary Langerhans Cell Histiocytosis: Two Cases With Varied Radiologic Findings
(Yuzuncu Yil Universitesi Tip Fakultesi, 2016) Gunbatar, H.; Yavuz, A.; Sertogullarindan, B.; Ekin, S.; Asker, S.; Sayır, F.; Bayram, I.
Pulmonary Langerhans Cell Histiocytosis (PLCH) is an idiopathic interstitial lung disease with Langerhans cell infiltration in the lung. PLCH X has non-spesific symptoms, and most patients have smoking history. A combination of stellate nodules, reticular and nodular opacities, upper zone cysts or honeycombing, preservation of lung volume and costophrenic angle sparing are highly specific for PLCH. To contribute to the literature, two cases are presented. First case is 30 years old man with 10 pack/years smoking history was admitted with cough and persevering interstitial opacities. Second case is 34 years old man with 15 pack/years smoking history was admitted with persistant cough. On thorax CT the first case had reticulonodular opacities at the perifery of the upper and middle zones, second case had multiple parenchymal cystic nodular lesions. Open lung biopsy performed, immunohistochemical examination CD1a, CD68, S100 detecting antigenpositive and histologically and radiologically confirmed diagnosed of PLCH. © 2016, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Using Propofol for Flexible Bronchoscopy
(Yuzuncu Yil Universitesi Tip Fakultesi, 2015) Arısoy, A.; Demirkiran, H.; Ekin, S.; Gunbatar, H.; Asker, S.; Sertogullarindan, B.
Propofol is a sedative-hypnotic drug with rapid onset and recovery time. There are limited number of studies in which propofol was used for bronchoscopy. In this current study, we evaluated our patients who received propofol sedation for bronchoscopy in our clinic and investigated the usefulness of the procedure for both patients and physicians We prospectively evaluated patients who had bronchoscopy in our clinic between 2012 January and 2013 January. We recorded demographic features, indications for bronchoscopy, procedures of bronchoscopy, duration of the procedures, minor and major adverse events and hemodynamic parameters of the patients. All patients were monitored until they were discharged from the bronchoscopy unit. In total, 97 patients were included in the study. The mean age of the participants was 65 years, 60 of them were male (61%) and 37 were women (39%). Major indications were lung lesions that were suspected to be central or peripheral lung cancer. Other indications were mediastinal-hilar lymph nodes, hemoptysis, tuberculosis, atelectasis, chronic cough and tracheomalacia. Mean propofol dose was 90 mg in patients who had biopsy and 70 mg for those who did not have biopsy. Mean duration of the procedure was 14 minutes in those who had biopsy and 10 minutes in those who did not have biopsy. One patient had epistaxis after receiving topical lidocaine and two patients had respiratory arrest that required ambulation with a mask. Thirty-five patients (36%) had desaturation, which was reversed by providing adequate oxygenation. Propofol is a useful and applicable sedative-hypnotic for patients and physicians for fiberoptic bronchoscopy. © 2015, Yuzuncu Yil Universitesi Tip Fakultesi, Universitas Indonesia. All rights reserved.
Utility of Computed Tomography in Assessment of Pulmonary Hypertension Secondary To Biomass Smoke Exposure
(International Scientific Literature Inc., 2014) Sertogullarindan, B.; Bora, A.; Yavuz, A.; Ekin, S.; Gunbatar, H.; Arisoy, A.; Ozbay, B.
Background: The aim of this study was to investigate the feasibility of main pulmonary artery diameter quantification by thoracic computerized tomography (CT) in the diagnosis of pulmonary hypertension seconder to biomass smoke exposure. Material/Methods: One hundred and four women subjects with biomass smoke exposure and 20 healthy women subjects were enrolled in the prospective study. The correlation between echocardiographic estimation of systolic pulmonary artery pressure and the main pulmonary artery diameter of the cases were studied. Results: The main pulmonary artery diameter was 26.9±5.1 in the control subjects and 37.1±6.4 in subjects with biomass smoke exposure. This difference was statistically significant (p<0.001). The systolic pulmonary artery pressure was 22.7±12.4 in the control subjects and 57.3±22 in subjects with biomass smoke exposure. This difference was statistically significant (p<0.001). Systolic pulmonary artery pressure was significantly correlated with the main pulmonary artery diameter (r=0.614, p<0.01). A receiver operating characteristic (ROC) curve analysis showed that a value of 29 mm of the main pulmonary artery diameter differentiated between pulmonary hypertension and non-pulmonary hypertension patients. The sensitivity of the measurement to diagnose pulmonary hypertension was 91% and specificity was 80%. Conclusions: Our results indicate that main pulmonary artery diameter measurements by SCT may suggest presence of pulmonary hypertension in biomass smoke exposed women. © Med Sci Monit.