Browsing by Author "Gunbatar, Nizamettin"

Now showing 1 - 9 of 9

The Effect of a Highly Saturated Fat Diet and Intermittent Fasting Diet on Adiponectin and Lipid Metabolism
(Wiley-blackwell, 2015) Gunbatar, Nizamettin; Bayiroglu, Fahri; Bulduk, Bahttin; Karaaslan, Selver
The Effect of Boric Acid and Borax on Blood Pressure in the Benzo(A)pyrene (B and 3-Methylcholanthrene (3-Mc) Applied Rats
(Wiley-blackwell, 2015) Bulduk, Bahattin; Oto, Gokhan; Ozdemir, Hulya; Gunbatar, Nizamettin; Uyar, Hasan; Bulduk, Mehmet; Elaslan, Sadi
Effect of Boric Acid and Borax on Heart Rate in Rats Treated With Benzo(A)pyrene and 3-Methylcholanthrene
(Parlar Scientific Publications (p S P), 2021) Bulduk, Bahattin; Oto, Gokhan; Ozdemir, Hulya; Gunbatar, Nizamettin; Bulduk, Mehmet; Kocak, Yilmaz; Keskin, Siddik
In this study, the effects of boric acid (BA) and borax (BX) on the heart rate of rats treated with benzo(a)pyrene (B(a)P) and 3-methylcholanthrene (3-MC) were investigated. This research was conducted with the permission of Van Ytiztincti Yil University Animal Experiments Local Ethics Committee. Wistar albino rats weighing 250 +/- 50 g were used in the study and divided into nine groups, six in each group. Group 1 was assigned as the control group. B(a)P (100 mg/kg) was administered intraperitoneally to Group 2 and 3-MC (100 mg/kg) to Group 3. BA only was administered to Group 4 at 300 mg/L in drinking water and to Group 5, BX only at 300 mg/L. Group 6 received B(a)P (100 mg/kg) + BA (300 mg/L) and Group 7 3-MC (100 mg/kg) + BA (300 mg/L). B(a)P (100 mg/kg) + BX (300 mg/L) was administered to Group 8 and 3 -MC (100 mg/kg) BX (300 mg/L) to Group 9. At the end of the 150th day, the rats were anaesthetised and their ECGs recorded. The heart rate (beats/min) was found to be statistically significant in B(a)P, 3 -MC and groups compared to the control group. It was found that the heart rate increased by 3 -MC and B(a)P in the groups was regulated by BA and BX.
Effect of Exposure To Fluorine and 7, 12-Dimethyl Benzanthracene on Vascular Responses
(Parlar Scientific Publications (p S P), 2022) Bulduk, Bahattin; Uyar, Hasan; Oto, Gokhan; Ozdemir, Hulya; Gunbatar, Nizamettin; Bulduk, Mehmet; Elasan, Sadi
In this study, the effect of experimental administration of fluorine and DMBA, alone or in combination, on rats on vascular responses was investigated. After adaptation, the rats were randomly selected and divided into 9 groups, 10 male rats in each group. While sodium fluoride was applied daily in drinking water for 12 weeks to the groups to which fluoride will be applied; on the other hand, DMBA was dissolved in sesame oil and applied to the groups that needed it, once a week for a total of 12 weeks. The groups were determined as C, SO, 1NaF, 15NaF, 30NaF, DMBA, 1NaF+DMBA, 15NaF+DMBA and 30NaF+DMBA. Tensions in the thoracic aorta were provided with phenylephrine. Then, relaxation responses were recorded by giving ACh ((10-8'-7'-6'-5)) and SNP ((10-,-9,-8,-7,)(-6)(,)(-5)) at different cumulative concentrations. In the study, it was determined that fluorine caused the vessels to contract and DMBA to relax. Concurrent exposure to high amounts of fluorine and DMBA was observed to cause vasoconstriction.
The Effect of Moderate-Intensity Physical Exercise on Some Serum Inflammation Markers and the Immune System in Rats Fed Intermittent Fasting With a High-Fat Diet
(Mdpi, 2023) Gunbatar, Nizamettin; Bulduk, Bahattin; Bezgin, Selver; Oto, Gokhan; Bayiroglu, Fahri; Bulduk, Mehmet
Background and Objectives: This study aimed to investigate the impact of moderate-intensity physical exercise on serum inflammation markers and the immune system in rats that were fed a high-fat diet (HFD) with intermittent fasting. Materials and Methods: A total of 48 Wistar albino male rats were included in the study and divided into eight groups, each consisting of six rats. Group 1 served as the control group (CG), receiving a standard diet. Group 2 followed the standard nutrition program with intermittent fasting (CG + IF). Group 3 underwent exercise with a standard diet (CG + E). Group 4 underwent both a standard diet with intermittent fasting and exercise (CG + IF + E). Group 5 was fed a high-fat diet (HFD). Group 6 received a high-fat diet with intermittent fasting (HFD + IF). Group 7 followed a high-fat diet with exercise (HFD + E). Group 8 underwent both a high-fat diet with intermittent fasting and exercise (HFD + IF + E). The study lasted for 8 weeks. Results: The results of the analysis show that lymphocyte cell levels in groups HFD + IF, HFD + IF, and HFD + IF + E were higher compared to groups CG-HFD (p < 0.05). Additionally, B lymphocyte and monocyte cell levels were higher in group HFD + IF + E compared to groups CG, CG + IF, and CG + IF + E, as well as CG, CG + IF, and CG + E, respectively. TNF-alpha levels were significantly higher in group HFD compared to the other groups. Furthermore, IL 10 levels were higher in group HFD + IF + E compared to the other groups. Conclusions: These findings indicate that moderate exercise and intermittent fasting, particularly in groups fed a high-fat diet, increased anti-inflammatory cytokine levels, and certain immune system cell counts, while decreasing pro-inflammatory cytokine levels.
The Effect of Resveratrol Treatment on Ecg Values of Cronical Flourozis Induced Rats
(Wiley-blackwell, 2015) Bulduk, Bahattin; Oto, Gokhan; Ozdemir, Hulya; Gunbatar, Nizamettin; Bulduk, Mehmet; Elaslan, Sadi
The Effect of Resveratrol Treatment on Heart Rate and Qt Values in Rats With Chronic Fluorosis
(Parlar Scientific Publications (p S P), 2022) Bulduk, Bahattin; Oto, Gokhan; Ozdemir, Hulya; Gunbatar, Nizamettin; Kocak, Yilmaz; Gul, Cihan; Elasan, Sadi
With this study, it was investigated how the impact of sodium fluoride (NaF) exposure on the cardiac conduction system would be treated with resveratrol. A total of 8 rats, 4 female and 4 male, weighing 200-300 grams, were used in each group. The first group was separated as the control group. The second group was determined as the group given 10 melt/day NaF, the third group as the group given 50 mg/It/day resveratrol, and the fourth group as the group given 10 mg/It/day NaF + 50 mg/It/day resveratrol. In the study conducted for 12 weeks, resveratrol and NaF were mixed into the drinking water of rats. When the study was finished after 4 months, the rats were anesthetized. They were placed in the right lateral position for the recording of ECGs. ECG samples were evaluated in II. derivation. Heart rate numbers were found high and QT values were found low in the groups that were administered only NaF. The heart rate and QT values of the groups administered with resveratrol alone or in combination with NaF showed parallelism with the control group.
High Fat Diet Induces Anti-Inflammatory Effect in Experimental Colitis
(Natl inst Science Communication-niscair, 2023) Emlik, Huseyin; Bayiroglu, Fahri; Mis, Leyla; Kaya, Mehmet Salih; Gunbatar, Nizamettin
The prevalence of ulcerative colitis, one of the inflammatory bowel diseases, has been increasing worldwide. Though fatty diet leads to development of colitis, only little is known about the separate and combined effects of different fat compositions and intermittent fasting, and the effects of preventative dietary changes on experimental colitis. In this study, we investigated the effect of feeding type and frequency on the inflammation ulcerative colitis. Five groups, each comprising 7 male Wistar albino rats, were formed viz. Colitis (as a control), High sucrose diet + Colitis, High sucrose diet + Intermittent fasting + Colitis, High fat diet + Colitis, High fat diet + Intermittent fasting + Colitis. The intermittent fasting group (experimental group) was not fed for 2 days (non-consecutive) in a week (except water), otherwise fed with ad libitum. Following the 7-wk feeding application, the rats were treated with intrarectal administration of 4% acetic acid (pH 2.4). After the rats were sacrificed, the levels of interleukin-10, insulin, C-reactive protein, leptin, tumor necrosis factor-alpha, interleukin-6, insulin-like growth factor-1 and adiponectin were analyzed from the blood samples. Analyzes of results revealed a statistically significant decrease in interleukin-10, C-reactive protein, tumor necrosis factor-alpha, interleukin-6 and adiponectin levels in High sucrose diet + Intermittent fasting + Colitis and High fat diet + Intermittent fasting + Colitis groups (P<0.05). According to these findings, the amount of fat and fatty acid composition in the fatty diet may have a protective effect against the development of colitis. Intermittent fasting further enhances this protective effect by lowering proinflammatory cytokine levels and reducing systemic inflammation in the body.
The Prevalence and The Determinants of Contraceptive Use Among Men and Women in Eastern Turkey
(Parlar Scientific Publications (p S P), 2017) Karaaslan, Selver; Sahin, Hanim Guler; Yesilova, Abdullah; Gunbatar, Nizamettin; Keskin, Siddik; Orhun, Reyhan; Akyigit, Elif
A variety of individual and community level determinants affect contraceptive usage. Traditionally the researches focus on women. The aim of this study was to investigate the prevalence and factors that are related to the use of contraception and the choice of contraceptive method among men and women in eastern Turkey which has a high fertility rate. The randomly selected study respondents were privately interviewed face-to-faces. A total of 3292 (676 men and 2616 women) respondents between 15 and 50 years of age were interviewed. The prevalence of the use of any form of family planning was 74%. Male condoms were used by 22.9% of the respondents, followed by intrauterine devices (16.7%), oral contraceptives (13.7%) and withdrawal (13%). Lower education level, maternal age at first birth, belief that lactation protects against getting pregnant, incorrect knowledge about contraceptive methods and efficacy were significantly associated with a preference for using less effective traditional methods (p < 0.05). Governments should focus on increasing the education level of men and women, creating greater awareness of family planning methods and their side effects, and increasing male involvement, which can decrease male opposition and thus increase rates of contraceptive use.