Browsing by Author "Gunduz, Huseyin"

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Changes in Serum Natriuretic Peptide Levels After Percutaneous Closure of Small To Moderate Ventricular Septal Defects
(Hindawi Publishing Corporation, 2012) Kaya, Yuksel; Akdemir, Ramazan; Gunduz, Huseyin; Murat, Sani; Bulut, Orhan; Kocayigit, Ibrahim; Acar, Zeydin
Background. B-type natriuretic peptide has been shown to be a very sensitive and specific marker of heart failure. In this study, we aimed to investigate the effect of percutaneous closure of ventricular septal defects with Amplatzer septal occluders on brain natriuretic peptide levels. Methods. Between 2008 and 2011, 23 patients underwent successfully percutaneous ventricular septal defect closure in 4 cardiology centers. Brain natriuretic peptide levels were measured in nine patients (4 male, mean ages were 25.3 +/- 14.3) who underwent percutaneous closure with Amplatzer occluders for membranous or muscular ventricular septal defects were enrolled in the study. Brain natriuretic peptide levels were measured one day before and one month after the closure. Patients were evaluated clinically and by echocardiography one month after the procedure. Results. Percutaneous closures of ventricular septal defects were successfully performed in all patients. There was not any significant adverse event in patients group during followup. Decrease in brain natriuretic peptide levels after closure were statistically significant (97.3 +/- 78.6 versus 26.8 +/- 15.6, P = 0.013). Conclusion. Brain Natriuretic Peptide levels are elevated in patients with ventricular septal defects as compared to controls. Percutaneous closure of Ventricular Septal Defect with Amplatzer occluders decreases the BNP levels.
Dentinal Tubule Penetration and Dislocation Resistance of a New Bioactive Root Canal Sealer Following Root Canal Medicament Removal Using Sonic Agitation or Laser-Activated Irrigation
(Aves Press Ltd, 2020) Ozlek, Esin; Neelakantan, Prasanna; Akkol, Elif; Gunduz, Huseyin; Ucar, Yagmur Arzu; Belli, Sema
Objective: To investigate the influence of sonic agitation or laser-activated irrigation techniques on the removal chlorhexidine (CHX) and modified triple antibiotic paste (mTAP) on the sealer penetration depth and dislocation resistance of Guttaflow Bioseal. Methods: Single-rooted mandibular premolars (n=96) were prepared with rotary nickel titanium instruments and randomly divided into two groups (n=48) based on the intracanal medicaments used: Group 1, mTAP; Group 2, CHX gel. After 7 days, the specimens in each group were divided into three subgroups (n=16) based on the supplementary irrigation technique used to remove the medicaments: laser activated irrigation (Er, Cr: YSGG laser, Waterlase MD, Biolase Technology Inc., San Clemente, CA, USA), sonic agitation (EndoActivator, Dentslpy Sirona Endodontics, PA, USA) and syringe-and-needle irrigation (control) techniques. Canals were filled with single matched-taper gutta-percha cone and a calcium silicate-based sealer (GuttaFlow (R) Bioseal, Coltene/Whaledent, Langenau, Germany). At the end of three weeks, sealer penetration was investigated using confocal microscopy (n=6), and dislocation resistance was calculated by measuring the push-out bond strength (n=10). Statistical analysis was performed using three-way analysis of variance (ANOVA) and Tukey post-hoc test (P=0.05). Results: Laser activated irrigation resulted in significantly higher depth of sealer penetration compared to sonic agitation and syringe irrigation (P<0.01). The average sealer penetration depths were recorded as 846.6 mu m, 786.5 mu m and 505 mu m in the Er,Cr:YSGG laser, EndoActivator and control groups, respectively. The mean bond strength obtained in group 3 (syringe-and-needle irrigation) was significantly less than the other groups (P<0.05). The mean values were 9.08 in the Er,Cr:YSGG laser group, 8.44 in the EndoActivator group and 5.08 in the needle group. Conclusion: Er,Cr;YSGG laser irrigation to remove the medicaments was advantageous to other irrigation techniques in sealer penetration and dislocation resistance of the sealer.
The Effect of Using Different Kinematics Single File Systems With Coronal Preflaring Instruments on Postoperative Pain With Symptomatic Irreversible Pulpitis: a Randomized Clinical Trial
(Elsevier Science inc, 2023) Ozlek, Esin; Gunduz, Huseyin
Introduction: The aim of this study was to investigate the effect of using coronal preflaring file (One Flare; OF) with rotational (One Curve; OC) and reciprocal (WaveOne Gold; WOG) single file systems on postoperative pain in mandibular premolar teeth with symptomatic irreversible pulpitis.Methods: Eighty patients were included in this prospective, superiority, parallel, and randomized controlled clinical trial. The patients were randomly divided into four groups (n 5 20) based on the use of coronal preflaring and the kinematics of the shaping instrument: WOG (without coronal preflaring), WOG with coronal preflaring (OF), OC (without coronal preflaring), and OC with coronal preflaring (OF). Patients recorded their postoperative pain intensity at 6, 24, 48, and 72 hours using a 10-cm visual analog scale. Friedman and Wil-coxon's tests were used for intragroup comparisons, and Kruskal-Wallis test was used for intergroup comparisons. The post hoc analysis was performed using Dunn's test. The Chi-square test was used to compare gender and tooth localization according to the groups, and Kruskal-Wallis test was used to compare age and preoperative pain (P < .05).Results: At 6 and 24 hours, WOG and OC with coronal preflaring groups showed statistically significantly lower pain scores than WOG and OC groups without coronal preflaring (P < .05). No significant difference was found between the groups in terms of analgesic medication intake. Conclusions: The use of coronal preflaring with both rotational and reciprocal single file systems in root canal preparation resulted in less postoperative pain in mandibular premolar teeth diagnosed with symptomatic irreversible pulpitis.
The Effects of Laser and Ultrasonic Irrigation Activation Methods on Smear and Debris Removal in Traditional and Conservative Endodontic Access Cavities
(Springer London Ltd, 2023) Gunduz, Huseyin; Ozlek, Esin
In this study, it was aimed to evaluate the smear and debris removal efficiency of laser and ultrasonic irrigation activation methods in traditional and conservative endodontic access cavity preparations. 60 freshly extracted human mandibular molar teeth were randomly divided into 2 groups according to the access cavity preparation (n = 30): Traditional endodontic access cavities (TEC) and Conservative endodontic access cavity (CEC). After the access cavity preparation, the mesiobuccal root canals were prepared to 35/0.4 with the VDW Rotate file system. Teeth with completed root canal preparation were randomly divided into 3 subgroups according to the final irrigation activation protocol (n = 30): Conventional needle irrigation, passive ultrasonic activation and laser activation. The crowns of the teeth were removed and the mesiobuccal roots were divided longitudinally into two halves, mesial and distal. Samples were scanned with scanning electron microscopy. Photomicrographs in the coronal, middle, and apical thirds of each specimen were taken at a magnification of 200 for debris and 1000 for evaluation of the smear layer. Data were analysed using the three-way Robust Anova test and Bonferroni test.The effect of access cavity design on remaining smear (p = 0.057) and debris (p = 0.5) was not statistically significant. The effect of the interaction of access cavity and irrigation activation on the remaining smear and debris was not statistically significant (p = 0.556, p = 0.333). Significantly fewer smears were detected in the laser activation group than in the ultrasonic activation and control groups. Conservative access cavities did not differ from conventional access cavities in terms of debris and smear.
Evaluation of Preoperative Apical Periodontitis, Treatment Indications, and Methods in Endodontically Treated Teeth: a Retrospective Study
(BMC, 2025) Gunduz, Huseyin; Bas, Zuleyha; Kilic, Asli Zeynep Kapoglu; Apari, Beyda Sevgul; Sahin, Pelinsu
Background This study evaluated the presence of preoperative apical periodontitis (AP) in endodontically treated teeth within a Turkish population, along with its causes, treatment methods, and the effectiveness of preventive and early intervention practices. Methods A retrospective analysis was conducted on 1,440 teeth from 1,055 patients treated at Van Y & uuml;z & uuml;nc & uuml; Y & imath;l University between 2021 and 2023. Preoperative panoramic and periapical radiographs and postoperative periapical radiographs were examined. Data recorded included patient demographics, treated tooth location, presence of preoperative AP, coronal restorations, reasons for treatment, treatment methods, and number of missing and endodontically treated teeth. Statistical analyses were performed using Chi-Square, Mann-Whitney U, Kruskal-Wallis, and Spearman correlation tests. Results The overall incidence of AP was reported as 28.7%. It was more frequently observed in the mandible than in the maxilla and in incisors compared to other tooth groups (p < 0.001). Caries was the primary reason for treatment in molars (81.5%), while periodontal disease was more common in incisors (p < 0.001). As age increased, the number of endodontically treated and missing teeth also rose (p = 0.019; p < 0.001). Teeth with crowns had a lower AP rate, while retreatments due to periodontal disease or previous root canal failures showed higher AP rates (p < 0.001). Conclusions The high AP rate and the predominance of caries and periodontal disease as treatment causes indicate insufficient application of preventive and early treatments. AP prevalence varied by jaw location, tooth group, coronal restoration and treatment method. This study provides epidemiological data on endodontically treated teeth and their association with AP. These findings emphasize the importance of early diagnosis, preventive measures, and effective treatment planning in preserving tooth survival.
Native Aortic Coarctation Stenting in Adults and Adolescents: Early and Mid-Term Results of an Adult Interventional Cardiology Team
(Termedia Publishing House Ltd, 2012) Akdemir, Ramazan; Gunduz, Huseyin; Murat, Sani; Kilic, Harun; Yeter, Ekrem; Agac, Mustafa Tarik; Erdem, Ali Fuat
Background: Stent implantation has evolved as an important therapeutic strategy for aortic coarctation. Aim: This study aimed to present the experience of aortic coarctation stenting using the Cheatham-Platinum stent by an Adult Interventional Cardiology Team. Material and methods: The data of 11 patients (ages were between 15 to 58 years) who underwent aortic coarctation stent implantation between 2008 and 2011 for moderate to severe native aortic coarctation were retrospectively collected. Results: Average systolic blood pressure was 175 +/- 35 mm Hg, and mean diastolic blood pressure was 115 +/- 15 mm Hg. Pressure gradient proximal and distal to aortic coarctation was 55.5 +/- 17.7 before the stenting. The invasive gradient decreased below 10 mm Hg in all patients. There were no complications except in one patient whose subclavian artery was occluded without any clinical finding. One patient had a totally occluded lesion, needing perforation for acquired interruption using a 0.35 inch hydrophilic wire under the supporting balloon. There was no aneurysm or restenosis at follow-up. Left ventricular functions completely recovered within 1 month in all patients. Conclusions: Stenting using the Cheatham-Platinum stent, either covered or bare, is safe in moderate to severe native aortic coarctation and provides an excellent transcoarctation gradient and clinical hypertension and left ventricular functional relief in adult patients.