Browsing by Author "Gunebakmaz, Ozgur"

Now showing 1 - 2 of 2

Association of Resting Heart Rate and Arterial Stiffness in Healthy Adults
(Pera Yayincilik Hizmetleri, 2016) Altiparmak, Ibrahim Halil; Erkus, Muslihittin Emre; Kocaarslan, Aydemir; Gunebakmaz, Ozgur; Kaya, Zekeriya; Sezen, Yusuf; Demirbag, Recep
Introduction: The arterial stiffness and resting heart rate (HR) are independent predictors of cardiovascular diseases. There are a few data about the association of HR with arterial stiffness in healthy men subjects. We aimed to evaluate this relationship in healthy male adults in the present study. Materials and Methods: A total of 50 volunteer healthy-nonsmoking male individuals (mean age: 40 +/- 12 years) enrolled in this observational study. According to the HR, the individuals were classified as group I, who have HR 50-70 beats/min (n=25) and group II, who have HR 71100 beats/min (n=25). History of the enrolled adults was recorded and they were physically examined. Blood pressure, body mass index and waist/hip ratio were measured in accordance with standard protocol. Arterial age and aortic pulse wave velocity (aPWV)indicating direct measurement of arterial stiffness were calculated by TensioMed (TM) Arteriograph. Results: There were no statistically significant differences between two groups with regard to age, body mass index, waist/hip ratio, systolic and diastolic blood pressure (for all p>0.05). The arterial age and aPWV were significantly higher in group II than group I (both; p<0.001). HR shows significant positive correlation with systolic blood pressure, body mass index, arterial age and aPWV (for all p<0.001). Conclusion: We conclude a relation between the HR and the increased arterial age and aortic pulse wave velocity levels in healthy male individuals. However, further studies are needed to clarify the pathophysiologic mechanisms responsible for the association between high HR and arterial stifness.
Relation Between Mean Platelet Volume and Severity of Atherosclerosis in Patients With Acute Coronary Syndromes
(Sage Publications inc, 2013) Murat, Sani Namik; Duran, Mustafa; Kalay, Nihat; Gunebakmaz, Ozgur; Akpek, Mahmut; Doger, Cihan; Kaya, Mehmet Gungor
Platelets play a central role in the pathophysiology of coronary artery disease (CAD). Increased mean platelet volume (MPV) is an indicator of platelet function and associated with poor clinical outcome in patients with acute coronary syndrome (ACS). We evaluated the relationship between MPV and severity of CAD in patients with ACS. A total of 395 patients with ACS were included. Severity of CAD was assessed with the Gensini and Syntax scores. High levels of MPV were associated with the Gensini and Syntax scores, number of diseased vessels (> 50%), number of critical lesions (> 50% and > 70%), and noncritical lesions. After multivariate analysis, high levels of MPV were independent predictors of multivessel CAD together with age. In patients with ACS, high MPV levels were associated with severity of CAD. It is possible that MPV can be a helpful marker in patients with CAD for the severity of coronary atherosclerosis.