Browsing by Author "Gunes, Mustafa"

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Beneficial Influence of Topical Extra Virgin Olive Oil Application on an Experimental Model of Penile Fracture in Rats
(Sage Publications inc, 2015) Gunes, Mustafa; Ozkol, Halil; Pirincci, Necip; Gecit, Ilhan; Bilici, Salim; Yildirim, Serkan
Penile fracture (PF) is known as a traumatic rupture of the tunica albuginea of corpus cavernosum. In this study, we aimed to investigate the healing influence of topical extra virgin olive oil (EVOO) on PF through evaluating levels of some oxidative stress biomarkers for the first time. Histopathological evaluation was also realized. A total of 18 male Sprague-Dawley albino rats were divided into three groups of six rats each as control group, in PF (alone) group, and PF + EVOO group. Experimental PF was formed via incising from the proximal dorsal side of the penis in the rats of all groups except control. While in PF (alone) group, fracture was formed and the incision was primarily closed, in PF + EVOO group in addition to foregoing processes, EVOO was also administrated topically twice a day for 3 weeks. At the end of the experiment, all rats were killed and penectomy was carried out. While malondialdehyde, myeloperoxidase, lipid hyroperoxide, and total oxidant status significantly (p < 0.05) increased, reduced glutathione and total free sulfhydryl groups markedly (p < 0.05) decreased in PF (alone) group when compared with PF + EVOO group. Levels of these parameters were reversed to nearly normal values by topical EVOO application. Protection by EVOO is further substantiated via the improved histological findings in PF + EVOO group as against degenerative changes in the rats of PF (alone) group. Our data revealed that EVOO has protective effect in penile cavernosal tissue through probably its antioxidant, free radical defusing, anti-inflammatory, and antimicrobial effects.
Comparison of Ceftriaxone and Cefazolin Sodium Antibiotic Prophylaxis in Terms of Sirs/Urosepsis Rates in Patients Undergoing Percutaneous Nephrolithotomy
(Galenos Yayincilik, 2019) Taken, Kerem; Asik, Alper; Eryilmaz, Recep; Aslan, Rahmi; Donmez, Muhammet Irfan; Gunes, Mustafa
Objective: The aim of this study is to compare ceftriaxone and cefazoline sodium antibiotic prophylaxis in terms of development of Systemic Inflammatory Response syndrome (SIRS)/urosepsis in patients undergoing percutaneous nephrolithotomy (PCNL). Materials and Methods: Patients who underwent PCNL between June 2015 and October 2015 in our hospital were prospectively randomized to ceftriaxone (n=30) and cefazoline sodium (n=32) antibiotic prophylaxis groups. Patients with predisposing conditions to SIRS were excluded. Intraoperative urine cultures from renal pelvis and stone cultures were obtained from all patients. Clinical and laboratory findings of the patients who developed postoperative fever were evaluated. SIRS and urosepsis rates were compared between two groups. Results: There were 7 patients in ceftriaxone group (23.3%) and 4 patients in cefazoline sodium group (12.5%) who developed SIRS (p=0.264). Sepsis was observed in 2 patients in both groups (p=0.826). Prolonged duration of surgery in ceftriaxone group and renal pelvis urine culture positivity in cefazoline group were found to be statistically significant in patients who developed SIRS (p=0.02, p=0.015, respectively). Conclusion: There was no significant difference between two groups in terms of SIRS and sepsis following PCNL. Therefore, cefazoline, which has a narrower antimicrobial spectrum, may be preferred for prophylaxis.
Comparison of Complications Following Laparoscopic Radical and Simple Nephreoctomy Using the Clavien-Dindo Clasification
(Galenos Yayincilik, 2019) Eryilmaz, Recep; Aslan, Rahmi; Taken, Kerem; Gunes, Mustafa
Aim: In this article, we aimed to compare the complications occurring after laparoscopic radical (LRN) and simple nephrectomy (LSN). Methods: After obtaining local ethics committee approval, we analyzed the records of a total of 98 patients, who underwent transperitoneal laparoscopic nephrectomy. LSN and LRN were performed in 64 and 34 patients, respectively. The Clavien-Dindo classification was used for evaluating complications. Pneumoperitoneum was created using a Veress needle. Intraabdominal carbon dioxide pressure was 18 mmHg while three 10 mm trocars were inserted and then one 5 mm trocar was inserted if needed. Results: The mean age of the LSN and LRN patients was 38.8 +/- 18.43 and 55.7 +/- 14.75 years, respectively. Five patients who underwent LSN developed postoperative minor complications (fever in one patient, nausea and vomiting in four patient). In addition, one patient who underwent LSN died postoperatively (vascular injury). Minor complications (fever in two patients, nausea and vomiting two, and ileus in one patient) developed postoperatively in five of 34 patients in LRN group. Conclusion: The rate of complication after LRN was found to be statistically significantly higher than that after LSN.
Comparison of Cystoscopy With Diffusion-Weighted Magnetic Resonance Images Used in the Diagnosis and Follow-Up of Patients With Bladder Tumors
(Asian Pacific Organization Cancer Prevention, 2010) Ceylan, Kadir; Taken, Kerem; Gecit, Ilhan; Pirincci, Necip; Gunes, Mustafa; Tanik, Serhat; Karaman, Ihsan
Purpose: To compare diffusion-weighted magnetic resonance imaging (DW-MRI) with cystoscopy in the diagnosis and follow-up of patients with bladder tumor and to investigate any histopathological correlation. Materials and Methods: Totally 59 patients, between 31-85 years (mean age 60 +/- 13) referred to our clinic due to a hematuria complaint were enrolled and evaluated by upper urinary system pathology and then DW-MRI (average 7 days) and cystoscopy. Apparent diffusion coefficients (ADCs) of images were calculated. Results: While a mass in bladder was determined with cystoscopy in 43 out of 59 patients, the mass was not deternined in 16 of the patients(n=34 malign, n=9 benign). While a mass was determined in 40 out of 59 patients with DW-MRI, the mass was not determined in 19 of the patients(n=40 malign, n=19 benign). Regarding ADC values, mean ADC values of 34 patients who were diagnosed with a bladder tumor (1.05 +/- 0.22 x 10(-3)mm(2)/s), were significantly lower than the mean ADC values obtained from the normal bladder wall (1.830 +/- 0.18 x 10(-3)mm(2)/s) whereas a statistically significant difference was found (p<0.001). ADC values in 9 patients with a benign lesion (1,73 +/- 0.12 x 10(-3)mm(2)/s), were not found statistically different from the mean ADC values obtained from the normal bladder wall (1.78 +/- 0.2x10(-3)mm(2)/s) (p>0.05). A significant difference was determined between ADC values of benign lesions and the ADC values of malign lesions (p<0.001). Conclusions: According to cystoscopy, values of DW-MRI's related with sensitivity, specificity and accuracy were found, respectively 90%, 93% and 91%. As the DW-MRI is a non-invasive and a rapid technique, and does not contain ionized radiation and because it is accepted as an important marker of tumor cellularity, it may be used as an alternative in future diagnosis and follow-up of bladder tumors.
Comparison of Dartos Flap and Dartos Flap Plus Spongioplasty To Prevent the Formation of Fistulae in the Snodgrass Technique
(Springer, 2011) Bilici, Salim; Sekmenli, Tamer; Gunes, Mustafa; Gecit, Ilhan; Bakan, Vedat; Isik, Daghan
The aim of our study was to evaluate the role of paraurethral spongial tissue plus dartos flap using an additional urethral cover to prevent fistula formation in patients who underwent surgery with the Snodgrass technique. A retrospective study was performed on 161 patients aged 10 months to 15 years who underwent midpenile and distal hypospadias repair using the Snodgrass technique. The patients were assigned to one of two groups. In Group I (75 patients), the neourethra was covered with the dartos flap, and in Group II (86 patients), the neourethra was covered with the dartos flap plus spongioplasty. Urethral fistulae were encountered in six cases (8%) in Group I, and no fistulae were encountered in Group II. The use of corpus spongiosum as an intermediate layer in urethral coverage, combined with the dartos flap, reduces the likelihood of fistula formation. This procedure can be applied easily and effectively to prevent the formation of fistulae.
Complete Duplication of the Bladder and Urethra in the Coronal Plane: Case Report With Review of the Literature
(Karger, 2013) Pirincci, Necip; Gecit, Ilhan; Gunes, Mustafa; Tanik, Serhat; Ceylan, Kadir
Complete duplication of the bladder and urethra without other congenital anomalies is a very rare congenital anomaly. We report the case of an 8-year-old boy with complete duplication of the bladder and urethra in the coronal plane, without any other associated congenital anomalies and without complaint associated with the urinary tract. Copyright (C) 2012 S. Karger AG, Basel
Conservative Approach in the Treatment of Renal Trauma in Children
(Karger, 2014) Pirincci, Necip; Kaba, Mehmet; Gecit, Ilhan; Gunes, Mustafa; Tanik, Serhat; Ceylan, Kadir
Objective: Our aim was to evaluate the role of a conservative approach in the treatment of renal trauma in the pediatric age group. Materials and Methods: A total of 31 pediatric patients with renal trauma (male = 25, female = 6) in whom we used a conservative approach in our clinic between the years 2002 and 2010 were included in the study. Patients were assessed according to the type of trauma, type of treatment, findings of radiological imaging, concomitant other organ injuries and complications occurring during follow-up. Results: Surgery was required in just 4 of 31 pediatric patients who were treated with the conservative approach. Of the patients who underwent surgery, only one child needed nephrectomy. No complications were detected in the clinical and radiological follow-up of the patients who received the conservative approach. Conclusions: The main objective in the treatment of renal trauma occurring in childhood is to protect the kidneys. If the hemodynannic findings are stable, a conservative approach should be the first preferred method of treatment in every grade of renal trauma that can occur in childhood. Copyright (C) 2013 S. Karger AG, Basel
Dickkopf-1 Levels in Turkish Patients With Bladder Cancer and Its Association With Clinicopathological Features
(Asian Pacific Organization Cancer Prevention, 2014) Kaba, Mehmet; Pirincci, Necip; Benli, Erdal; Gecit, Ilhan; Gunes, Mustafa; Yuksel, Mehmet Bilgehan; Kemik, Ahu Sarbay
Background: Evidence indicates that Dickkopf-1 (DKK-1) levels may be a biomarker for cancer risk. The aim of this study was to assess DKK-1 and its correlation with clinic-pathological features in patients with bladder cancer. Materials and Methods: DKK-1 levels were determined in serum samples from 90 patients with bladder cancer before transurethral tumor resection. The concentrations of DKK-1 were determined by using enzyme linked immune-sorbent assay (ELISA). Results: Elevated preoperative DKK-1 levels were associated with tumor stage (p<0.001), grade (p<0.001) and histological grade (p<0.001). Conclusions: The results of our study demonstrated that the level of serum DKK-1 is correlated with both disease progression and increase in the tumor grade. Preoperative serum DKK-1 elevation may thus represent a novel marker for the determination of bladder cancer and the detection of patients with a likely poor clinical outcome.
Distal Hipospadias Onarım Deneyimlerimiz
(2003) Gunes, Mustafa; Ceylan, Kadir; Can, Şaban
Amaç: Hipospadias external meanın penisin ventraline açıldığı bir patolojidir. En sık distal yerleşim gösteren ve 300 erkek doğumda bir görülen bu konjenital anomalinin tedavisi cerrahidir. Bu amaçla pek çok cerrahi yöntem tanımlanmıştır. Bu çalışmada kendi sonuçlarımız sunulmuştur. Gereç ve Yöntem: Distal hipospadias onarımı yapılan 74 hasta retrospektif olarak değerlendirildi. 11 MAGPI, 18 Mathieu, 44 TIPU ve 3 hastada Onlay ada flebi teknikleri uygulandı. Bu çalışmada olgularımızdaki komplikasyon ve başarı oranları değerlendirildi. Bulgular: MAGPI tekniği uygulanan 1 hastada darlık gelişti. Mathieu tekniği uygulanan 2 vakada tüp kaybı, 5 vakada fistül ve 1 olguda darlık gelişti. TIPU uygulanlarda ise sadece 3 olguda meatal darlık ve 1 olguda fistül gözlendi. Sonuç: Distal hipospadias onarımında pek çok değişik teknik uygulanmaktadır. Bunlar içerisinde TIPU yönteminin uygulaması kolay, daha anatomik bir yaklaşım sağlaması ve daha az komplikasyonları olması nedeni ile diğer yöntemlere tercih edilebileceğini düşünüyoruz.
Effects of Shock Waves on Oxidative Stress and Some Trace Element Levels of Rat Liver and Diaphragm Muscles
(Wiley, 2012) Gecit, Ilhan; Kavak, Servet; Meral, Ismail; Gunes, Mustafa; Pirincci, Necip; Sayir, Fuat; Ceylan, Kadir
This study was designed to investigate whether the short-term extracorporeal shockwave lithotripsy (ESWL) exposure to kidney produces an oxidative stress and a change in some trace element levels in liver and diaphragm muscles of rats. Twelve male Wistar albino rats were divided randomly into two groups, each consisting of six rats. The animals in the first group did not receive any treatment and served as control group. The right-side kidneys of animals in group 2 were treated with two-thousand 18?kV shock waves while anesthetized with 50?mg kg-1 ketamine. The localization of the right kidney was achieved after contrast medium injection through a tail vein under fluoroscopy control. The animals were killed 72 h after the ESWL treatment, and liver and diaphragm muscles were harvested for the determination of tissue oxidative stress and trace element levels. Although the malondialdehyde level increased, superoxide dismutase and glutathione peroxidase enzyme activities decreased in the livers and diaphragm muscles of ESWL-treated rats. Although glutathione level increased in liver, it decreased in diaphragm muscles of ESWL-treated animals. Fe, Mg and Mn levels decreased, and Cu and Pb levels increased in the livers of ESWL-treated animals. Fe and Cu levels increased, and Mg, Pb, Mn and Zn levels decreased in the diaphragm muscles of ESWL-treated animals. It also causes a decrease or increase in many mineral levels in liver and diaphragm muscles, which is an undesirable condition for the normal physiological function of tissues. Copyright (c) 2012 John Wiley & Sons, Ltd.
Effects of Shock Waves on Oxidative Stress, Antioxidant Enzyme and Element Levels in Kidney of Rats
(Springernature, 2011) Gecit, Ilhan; Kavak, Servet; Meral, Ismail; Pirincci, Necip; Gunes, Mustafa; Demir, Halit; Ceylan, Kadir
The aim of this study was to investigate the effect of extracorporeal shock wave lithotripsy (ESWL) on kidney oxidative stress and trace element levels of adult rats. Twelve male Wistar albino rats were divided equally into two groups. First group was used as control. The right-side kidneys of animals in second group were treated with 2,000 18-kV shock waves under anesthesia. Localization of the right kidney was achieved following contrast medium injection through a tail vein under flouroscopy control. The animals were sacrificed 72 h after the ESWL treatment, and the kidneys were taken. Malondialdehyde level was higher in the ESWL group than in the control. Reduced glutathione levels, superoxide dismutase, and glutathione peroxidase activities were lower in the ESWL group than those of the control. Fe, Cu, Pb, Mn, Cd, and Ni levels were lower in the ESWL group than in the control, although Mg level was higher in the ESWL group than in the control. In conclusion, the result of the present study indicated that ESWL treatment produced oxidative stress in the kidney and caused impairments on the antioxidant and trace element levels in the kidneys of rats.
Erectile Dysfunction Is a Marker for Obstructive Sleep Apnea
(Taylor & Francis Ltd, 2016) Taken, Kerem; Ekin, Selami; Arisoy, Ahmet; Gunes, Mustafa; Donmez, Muhammet Irfan
Purpose: To investigate the prevalence of erectile dysfunction (ED) in patients with obstructive sleep apnea (OSA) with and without any other comorbidities. Methods: The patient group was newly diagnosed as having OSA (apnea-hypopnea index [AHI]>5/h) using a polysomnographic examination. A group of subjects with simple snoring were included into the control group. Clinically relevant comorbidities were systematically assessed in face-to-face interviews. All patients were asked to complete the 15-item International Index of Erectile Function (IIEF-15) questionnaire for the evaluation of ED. The patients with OSA and ED were evaluated according to these comorbidities. Results: Of the 94 patients, 39 patients were excluded because of severe diseases. OSA was observed in 38 (69.1%) of the 55 patients. ED was seen in 24 (63.2%) patients with OSA, and in 8 (47.1%) patients without OSA (p>0.05). There were no statistical differences between the groups' ages, IIEF scores, and body mass index (BMI) scores. There were statistically significant differences between the groups' AHI scores (p<0.05). There was a significant correlation between the groups' AHI scores, BMI, and age (p<0.05). There was no statistically significant difference in patients with OSA, with and without comorbidity in terms of ED. Conclusion: The rate of ED was higher in patients with OSA who had no other comorbidities. Therefore, ED can be a sensitive marker of OSA.
Fournier's Gangrene: Causes, Presentation and Survival of Sixty-Five Patients
(Professional Medical Publications, 2016) Taken, Kerem; Oncu, Mehmet Resit; Ergun, Muslum; Eryilmaz, Recep; Demir, Canser Yilmaz; Demir, Murat; Gunes, Mustafa
Objective: To report our experience with Fournier's Gangrene (FG) over the past eight years and evaluate the predisposing factors which affect the mortality. Methods: Sixty-five patients who were admitted to emergency surgical unit of our institution presenting with FG between January 2006 and August 2014 were included. The anatomical site of infective gangrene, predisposing factors, etiological factors, and outcomes were retrospectively reviewed. Results: Our cases included 8 women and 57 men. The average age of men was 51 +/- 13.9 (range 19-75) and the average age of women was 63 +/- 10.5 (range 52-76). Average hospitalization time was 9.2 +/- 6.6 days (range 5-25) days. The most frequent comorbid disease was diabetes mellitus and the most frequent etiology was perianal abscess. Colostomy was performed in 11 patients, orchidectomy in two patients, cystostomy in two patients. Notably, all of the 8 (12.3%) patients who died from FG had diabetes and low socioeconomic status. A total of six patients who died required more than one surgical debridement. Conclusions: Fournier's gangrene is a severe surgical emergency, with a high mortality rate. Low socioeconomic status, diabetes and more than one debridement play a major role in mortality and morbidity.
Guillain-Barre Syndrome Following Spinal Anaesthesia
(Coll Physicians & Surgeons Pakistan, 2013) Sayin, Refah; Kati, Ismail; Isik, Yasemin; Gunes, Mustafa
Guillain-Barre Syndrome (GBS) is the most common disease resulting in acute diffuse flaccid paralysis. It is an autoimmune disease that can occur at any age. The clinical course is characterized by weakness in the arms and legs, areflexia and the progression of muscle weakness from the lower limbs to the upper limbs. The most common causes of GBS include infections, vaccinations, surgery and some medicines. We present the case of a 48 years old male patient, who developed GBS after undergoing surgery for renal calculus, under spinal anaesthesia. In this case report, we presented a rather rare case of GBS occurring following spinal anaesthesia.
Haptoglobin Levels in Turkish Patients With Bladder Cancer and Its Association With Clinicopathological Features
(Asian Pacific Organization Cancer Prevention, 2012) Pirinicci, Necip; Gecit, Ilhan; Gunes, Mustafa; Kemik, Ahu Sarbay; Yuksel, Mehmet Bilgehan; Kaba, Mehmet; Aslan, Mehmet
Although alteration in the haptoglobin phenotype has been reported in patients with bladder cancer, serum haptoglobin levels have not been evaluated. We hypothesized that serum haptoglobin can be used as a biomarker. The aim of this study was to evaluate the expression of haptoglobin in bladder cancer and to determine the relationship with clinicopathological features. A total of 68 serum specimens obtained before surgery were used to investigate haptoglobin expression using the sandwich ELISA technique. Serum haptoglobin levels were higher in the patients with bladder cancer compared to healthy controls (p<0.0001). Additionally, the levels of haptoglobin protein increased with increasing tumor grades (p<0.001) and were significantly higher in patients with metastatic disease and the presence of lymphovascular involvement, lymph node metastases and increasing tumor burden (p<0.0001). This study suggests that elevated haptoglobin levels are associated with a higher stage, grade, and extent of distant metastasis and larger tumor size. Haptoglobin may therefore provide a useful diagnostic and treatment biomarker for patients with bladder cancer.
Hospital Readmissions Due To Subcapsular Renal Hematoma After Flexible and Rigid Ureterorenoscopy
(Galenos Yayincilik, 2018) Taken, Kerem; Gunes, Mustafa; Ergun, Muslum; Donmez, Muhammet Irfan
Objective: The aim of this study is to compare the rates of hospitalization due to subcapsular renal hematoma (SRH) following flexible ureterorenoscopy (FURS) and semirigid ureterorenoscopy (RURS) for the treatment of ureteral and renal stones. Materials and Methods: Patients who have been treated with FURS and RURS at two different institutions between March 2009 and February 2014 were enrolled in the study. Patient files and hospital records were reviewed. Pneumatic lithotriptor was used in RURS while holmium:yttrium aluminium garnet laser was used for FURS. Subcapsular hematoma diagnosis was based on clinical and radiological findings. Comparative analysis of patients with SRH in terms of age, sex, stone size/position, degree of preoperative hydronephrosis, duration of surgery and size of hematoma was done. Results: A total of 1187 patients were found to have undergone ureteroscopic intervention due to ureteal or renal stones. RURS was performed in 992 (83.6%) patients and FURS was performed in 195 patients (16.4%). Of the 992 patients who underwent RURS, postoperative SRH occurred in 6 patients (0.6%). Postoperative SRH occurred in 3 patients (1.5%) who underwent FURS. Of the 9 patients who developed SRH, blood transfusions were needed in three patients and one patient was treated with percutaneous drainage catheter insertion. No patient underwent open surgery. There was no statistically significant difference between the two types of surgeries with regard to age, stone size/localization, degree of preoperative hydronephrosis, duration of surgery and size of SRH (p>0.05). Conclusion: SRH is a rare complication following RURS and FURS. There is no statistically significant difference in the risk for this specific complication between FURS and RURS.
Isolated Renal Pelvis Rupture Secondary To Blunt Trauma: Case Report
(Elsevier Sci Ltd, 2015) Taken, Kerem; Oncu, Mehmet Resit; Ergun, Muslum; Eryilmaz, Recep; Gunes, Mustafa
Introduction: Isolated rupture of the renal pelvis is a very rare condition and thus causes delays in the diagnosis of the rupture. It is most commonly seen in the setting of obstructive ureteric calculus. Other rare causes include neoplasms, trauma, and iatrogenic procedures. Diagnosis is usually established on computed tomography (CT) which demonstrates the extravasation of the contrast in the peripelvic, perinephric, or retroperitoneal collections. PRESENTATION OF CASE: A 27-year-old male patient was admitted to our hospital due to multiple traumas associated with motor vehicle accidents. The patient had clear urine output. A large pelvic rupture was detected by abdominal contrast-enhanced CT and after consulting with other departments, emergency repair of the renal pelvis was performed and a ureteral stent was implanted. DISCUSSION: Only a few isolated cases of pelvis rupture with resultant extravasation have been reported in the literature. The treatment of pelvic rupture should be preceded by the removal of underlying causes, followed by conservative management. However, surgical intervention should be warranted in the emergency cases presenting with the symptoms that may impede the decision-making process and in the cases whose diagnosis cannot be clarified by radiological techniques. CONCLUSION: Renal pelvic injury must be considered in the differential diagnosis of blunt trauma. Surgical intervention may be necessary in some cases. We present a case who underwent surgery due to isolated renal pelvis rupture caused by blunt abdominal trauma. (C) 2015 The Authors. Published by Elsevier Ltd. on behalf of Surgical Associates Ltd.
Kutlay Technique for Hypospadias Repair
(Springer, 2012) Gecit, Ilhan; Isik, Daghan; Pirincci, Necip; Bilici, Salim; Gunes, Mustafa; Canbaz, Yasin; Kocak, O. Faruk
Although many techniques have been described, new techniques with a wide range of therapeutic options are needed. The Kutlay technique is a novel technique that is based on the reconstruction of the neourethra with two horizontal meatal-based skin flaps. In the present study, the data of 31 patients who underwent surgery with the Kutlay technique are presented. Thirty-one patients with hypospadias with an average age of 5.6 years who did not have previous hypospadias repair were operated on with the Kutlay technique. Ten patients had chordee. Among those patients, three patients were circumcised. The patients were followed up for 4-13 months (average, 9.3 months). During the follow-up period, a fistula was observed in only one patient. None of the patients developed neourethral dehiscence, meatal stenosis, urethral stricture, wound infection, penile torsion, hematoma, or persistent or recurrent chordee. On uroflowmetry studies, the maximum flow rate of the patients was approximately 10.5 ml/s (range, 6-17 ml/s). The patients were observed to void with a single straight urinary stream in a forward direction. The Kutlay technique is a technique that is easily applied in patients with chordee and that provides a low risk of fistulas and acceptable functional and esthetic results. The factors that reduce the risk of fistula are the lack of the superposition of the suture lines of the skin and the urethra, the reconstruction of the urethra with well-vascularized flaps, and the replacement of the neourethra in its appropriate location through the tunnel created in the glans.
Levels of Serum Trace Elements in Patients With Peyronie
(Taylor & Francis Ltd, 2020) Gunes, Mustafa; Aslan, Rahmi; Eryilmaz, Recep; Demir, Halit; Taken, Kerem
Aim: The etiology of the disease of Peyronie is not certainly known. However, penile micro traumas are thought to be important in the pathogenesis of Peyronie's disease (PD) in genetically predisposed individuals. In this study, we aimed to determine the relationship of some trace element and heavy metals with PD. Material and methods: Thirty Peyronie patients and 26 healthy volunteers were included in the study. In individuals in both groups, levels of serum trace elements (Manganese [Mn], Cu, Cobalt (Co), zinc [Zn], Cd, and iron [Fe]) were determined separately by Atomic Absorption Spectrophotometer method in Yuzuncu Yil University Central Research Laboratory. Results: Mn, Cu, Zn, and Fe levels in Peyronie patients were statistically significantly lower when compared to the healthy control group (p < .05). Cd and Co levels were similar for both groups but not statistically significant (p > .05). Conclusions: The changes in trace element levels are related to the etiopathogenesis of PD. We think that our study is the first from this aspect.
Levels of Serum Trace Elements in Renal Cell Carcinoma Cases
(Asian Pacific Organization Cancer Prevention, 2013) Pirincci, Necip; Gecit, Ilhan; Gunes, Mustafa; Kaba, Mehmet; Tanik, Serhat; Yuksel, Mehmet Bilgehan; Demir, Halit
Trace elements which are essential components of biological structures may also be toxic when present at levels above the amounts required for biological function. In our study, trace element levels were measured with furnace atomic absorption spectrophotometry in 33 newly diagnosed renal cell carcinoma cases (preoperative) and 32 healthy controls. When compared with the control group, it was found that the levels of cadmium (Cd), lead (Pb) were higher and the levels of zinc (Zn), iron (Fe) and manganese (Mn) were lower in the patient group. These changes may be important in the formation of renal cell carcinoma, a question which should be explored with postoperative comparative studies.