Browsing by Author "Gunes Bilgili, Serap"

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Assessment of Hla-A, Hla-Dr, and Hla-Dq Alleles in Patients With Pemphigus Vulgaris From Eastern of Turkey
(Wiley, 2020) Dere, Gokturk; Yavuz, Ibrahim Halil; Ozaydin Yavuz, Goknur; Bayram, Yasemin; Gunes Bilgili, Serap; Ozturk, Murat
Background Pemphigus vulgaris (PV) is a chronic progressive autoimmune bullous disease caused by the interaction of pathogenic factors, genetic, and environmental factors. HLA alleles, which are considered as protective factors against disease or predisposing factors, may be different in various populations and ethnic groups. Aims The purpose of this study is to examine the HLA-A, HLA-DR, and HLA-DQ alleles in patients that are diagnosed with PV in and around eastern of Turkey and to determine the alleles that create predisposition to disease or protect against the disease. Patients/Methods Thirty patients diagnosed as PV with clinical, histopathological, and immunofluorescence findings and 30 healthy subjects were included in this study. The HLA-A, HLA-DR, and HLA-DQ typology in the DNA samples that were obtained from the blood samples of the groups was performed by using the PCR-SSP low-resolution gene panels. Results The HLA-A*03 allele was found to be significantly higher in patient group than the control group (P-value: .020). HLA-DRB1*04 and HLA-DRB1*14 alleles in PV patients were found to be significantly higher than the control group (P-value = .000). Conclusion It was concluded that the HLA-DRB1*03, HLADQB1*02, and HLA-DQB1*06 alleles in and around eastern of Turkey showed protective effects against pemphigus vulgaris. It was also concluded that the HLA-A*03, HLA-DRB1*04, HLA-DRB1*14, HLA-DRB4, HLA-DQB1*03, and HLA-DQB1*05 alleles could cause predisposition to the disease.
Evaluation of Brainstem Auditory Evoked Potentials and Their Relationship With Levels of Thyroid Autoantibodies in Patients With Vitiligo
(Tubitak Scientific & Technological Research Council Turkey, 2016) Cecen, Ilhan; Karadag, Ayse Serap; Tombul, Temel; Gunes Bilgili, Serap; Calka, Omer; Burakgazi, Ahmet Zubeyir
Background/aim: Vitiligo is a common depigmenting disorder. The damage can also occur in similar ways to melanocytes within other organs. We evaluated the brainstem and auditory pathway functions by evaluating brainstem auditory evoked potentials (BAEPs) and whether there is any relationship between auditory functions and autoimmunity. Materials and methods: Forty patients with vitiligo and 20 healthy volunteers were enrolled. Thyroid functions and autoantibodies were examined and BAEP tests were assessed by a neurologist. Results: Antithyroid peroxidase (anti-TPO) and antithyroglobulin (anti-TGA) antibody positivity was higher in the patient group (P < 0.05). A negative correlation was detected between anti-TPO and lead III, IV, and V latency and I-III interpeak latency (IPL) of the right ear together with lead IV latency and I-V IPL of the left ear in the patient group. When each BAEP parameter was compared between the two groups, more abnormalities were detected in the V latency and III-V IPL of the left ear together with IV and V latency of the right ear. Conclusion: In this study the presence of a correlation between increased anti-TGA and anti-TPO levels and BAEP parameters may be related to an autoimmune-mediated mechanism. However, further studies are needed to be performed in a large patient series.
Evaluation of Hirsutism and Hormonal Parameters in Acne Vulgaris Patients Treated With Isotretinoin
(Wiley-hindawi, 2021) Aktar, Rojda; Gunes Bilgili, Serap; Yavuz, Ibrahim Halil; Ozaydin Yavuz, Goknur; Aktar, Sirac; Ozturk, Murat; Karadag, Ayse Serap
Background Although the effect of isotretinoin use on hormonal changes in acne pathogenesis is not fully known, there are limited studies on its effects on the development of hirsutism. In this study, it was aimed to evaluate the effect of isotretinoin use on hirsutism and hormonal parameters in patients with acne vulgaris. Methods In this study, 30 female acne patients and 30 healthy females were evaluated prospectively. Menstrual irregularity, LH, FSH, prolactin, progesterone, 17-OH progesterone, oestradiol, total testosterone, DHEA-S, insulin, glucose, TSH levels, Ferriman-Gallwey (FG) score and ultrasonography (USG) findings of control group and patient group were recorded. Results Pre-treatment progesterone (P = .007) and oestradiol (P = .001) levels of the patients were statistically lower than the control group. In the patient group, menstrual irregularity (P < 001) and FG hirsutism score at the third month of treatment were significantly higher than before treatment. In 10% of the patients, there were abnormal findings on pelvic USG in the third month of treatment. Conclusion In our study, it could not be revealed that isotretinoin has a significant effect on pituitary, adrenal hormones and insulin resistance. We found that 3 months of isotretinoin treatment caused an increase in menstrual irregularity and FG hirsutism score.
Retrospective Evaluation of 104 Tinea Capitis Cases
(Tubitak Scientific & Technological Research Council Turkey, 2013) Calka, Omer; Gunes Bilgili, Serap; Karadag, Ayse Serap; Onder, Sevda
Aim: Tinea capitis is a superficial scalp dermatophyte infection. Tinea capitis is particularly seen during childhood and is not usually seen after puberty. In untreated cases, it can be contagious and can progress to cicatricial alopecia. This study aimed to retrospectively evaluate cases of tinea capitis. Materials and methods: We evaluated 104 tinea capitis patients presenting to our dermatology clinic between 2007 and 2011. Results: Of these patients, 38 (36.5%) were female and 66 (63.5%) were male. The median age was 6.41 +/- 3.4 years (range: 1-18 years old). The clinical types appearing in descending order were tinea capitis profunda (88.5%), tinea capitis superficial (10.6%), and tinea capitis favosa (1.9%). The most frequently seen transmission route was human-to-human transmission in 23.5% of the patients, followed by animal-to-human transmission in 19.2% of the patients. Conclusion: Tinea capitis is a commonly seen dermatosis in our region. Patients with tinea capitis usually seek a physician when inflammatory lesions develop. Cases are usually misdiagnosed as eczema or psoriasis by primary care physicians, causing a delay in proper treatment. Tinea capitis can cause hair loss and scar formation, and so early diagnosis and treatment is very important. For the accurate diagnosis and treatment of tinea capitis, required health education programs should be implemented.