Browsing by Author "Guven, Ahmet Sami"

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Alstrom Syndrome Associated With Cerebral Involvement: an Unusual Presentation
(Modestum Ltd, 2006) Yilmaz, Cahide; Caksen, Huseyin; Yilmaz, Nebi; Guven, Ahmet Sami; Arslan, Derya; Cesur, Yasar
Alstrom syndrome (AS) is a rare autosomal recessive disorder, characterized by retinal degeneration, progressive hearing impairment, truncal obesity and non-insulin dependent diabetes mellitus. A 6-year-old girl was admitted with aphasia, deafness, strabismus, abdominal distention, and weakness on the right body side. The physical and laboratory examination revealed psychomotor retardation, right hemiparesis, sensorioneural hearing loss, aphasia, eye and teeth abnormalities, hyperpigmentation, truncal obesity, hepatosplenomegaly, severe iron deficiency anemia, delayed bone age, and cerebral hemiatrophy. Based on these abnormal findings she was diagnosed as AS. According to our knowledge this is the first case of AS with cerebral involvement. This last finding may be a component of the syndrome.
A Child With Incomplete Kluver-Bucy Syndrome Developed During Acute Encephalitis
(Elsevier Science inc, 2008) Yilmaz, Cahide; Cemak, Fatma; Guven, Ahmet Sami; Caksen, Hueseyin; Atas, Buelent; Tuncer, Oguz
Clinical Outcome and Magnetic Resonance Imaging Findings in Infants With Hypoglycemia
(Sage Publications inc, 2011) Caksen, Huseyin; Guven, Ahmet Sami; Yilmaz, Cahide; Unal, Ozkan; Basaranoglu, Murat; Sal, Ertan; Kaya, Avni
The authors examined clinical outcome and cranial magnetic resonance imaging (MRI) findings in infants with hypoglycemia to determine the effects of hypoglycemia on the developing brain. A total of 110 infants with hypoglycemia were included in the study. Of the patients, 36 were females and 74 were males. The age of the infants was between 1 day and 22 months. Of the 110 infants, 47 were preterm neonates, 40 were term neonates, and 23 were older than 28 days. No difference in serum glucose level was noted between symptomatic and asymptomatic infants. The most common observed abnormal findings were hyperintense lesions, encephalomalacia, and cerebral atrophy. Abnormal MRI findings were found in 4% of preterm infants, in 32.5% of term infants, and in 43.5% of older infants. Abnormal MRI findings were statistically significantly more common in symptomatic infants than in asymptomatic infants. Of the infants, 45.5% of hypoglycemic infants had cerebral palsy and/or cerebral palsy plus epilepsy.
Effect of Antiepilepsy Drug Therapy on Ventricular Function in Children With Epilepsy: a Tissue Doppler Imaging Study
(Springer, 2014) Kibar, Ayse Esin; Unver, Olcay; Oflaz, Mehmet Burhan; Guven, Ahmet Sami; Balli, Sevket; Ece, Ibrahim; Icagasioglu, Fusun Dilara
Impaired cardiac myocardial function may contribute to the risk for sudden unexpected death of a patient with epilepsy. This study aimed to investigate the effect of antiepilepsy drugs (AEDs) on cardiac function in pediatric epileptic patients using standard and tissue Doppler imaging (TDI) echocardiography. This hospital-based, prospective cross-sectional study investigated 52 epileptic children (mean age 9.3 +/- A 3.1 years) treated with AEDs (duration 2.4-10.0 years) and 36 healthy children (mean age 9.5 +/- A 4.0 years). In the epilepsy group, standard echocardiography showed increased left ventricular (LV) end-diastolic and end-systolic diameters, an increased LV mass index, and preserved ejection fraction. The patients also exhibited increased mitral peak A-wave velocity and mitral E-wave deceleration time as well as a decreased mitral E/A ratio. The E/Em ratio was significantly higher in the epilepsy group (5.6 +/- A 1.2) than in the control group (5.2 +/- A 1.1) (p = 0.016). In the epilepsy group, TDI showed an increased isovolumetric relaxation time and myocardial performance index (MPI). It also exhibited decreased early diastolic velocity (Em) and a decreased mitral annular displacement index in these patients. There were positive correlations between the LV lateral wall MPI (r = 0.231), septal MPI (r = 0.223), and LV mass index (p < 0.05) but no correlation with the duration of AED treatment. The authors detected subclinical ventricular dysfunction associated with AEDs at a preclinical stage. They suggest that TDI can be useful for determining the short- and long-term cardiac effects of AEDs.
Evaluation of Auditory Brainstem Potentials in Children With Acute Herpes Simplex Encephalitis
(Taylor & Francis Ltd, 2009) Caksen, Hueseyin; Yilmaz, Cahide; Tombul, Temel; Guven, Ahmet Sami; Ozen, Ozlem
Objective: In this study, auditory brainstem potentials (ABPs) were studied in children with Herpes simplex encephalitis (HSE) to determine the ABP abnormalities in HSE during childhood. We also wished to determine whether or not to use ABP in early diagnosis of HSE. Method: The study includes 28 children; eight children with acute HSE, nine with nonspecific encephalitis, and 11 healthy age-matched control subjects. The diagnosis of HSE was confirmed by the demonstration of Herpes simplex virus type 1 in CSF by polymerase chain reaction. Recordings of ABPs were performed by using Nihon Kohden Neuropack 2 device. Results: The study includes eight children (four females and four males) with acute HSE, nine children (five males and four females) with nonspecific encephalitis, and 11 healthy age-matched control subjects (six males and five females). Age ranges of the patients and controls were between six months and 12 years. There was not statistically significant difference between the groups for age and gender (p>.05). There were significant differences in the mean latencies of the wave IV on the right ear and in the mean interpeak latencies (IPLs) of the waves III-V on the right and left ears between the nonspecific encephalitis group and the control group (p<.05). However, there were no statistically significant differences between the HSV and control groups (p>.05). In addition, there was no significant difference between HSV and nonspecific groups (p>.05). Conclusions: Our findings revealed that there were mild ABP abnormalities in children with nonspecific encephalitis, but no ABP abnormality in patients with HSV encephalitis. However, we think that more extensive and detailed studies should be performed to determine whether or not there were ABP abnormalities in childhood HSV encephalitis.
Is Atrial Electromechanical Coupling Delayed in Patients With Secundum Atrial Septal Defect
(Wiley-blackwell, 2013) Oflaz, Mehmet Burhan; Karapinar, Hekim; Kucukdurmaz, Zekeriya; Guven, Ahmet Sami; Gumrukcuoglu, Hasan Ali; Sarikaya, Savas; Yilmaz, Ahmet
Background: There is no available published information about the atrial electromechanical coupling time (AEMCT) in patients with atrial septal defect (ASD). The aim of this study was to investigate the relationship between ASD and AEMCT obtained by tissue Doppler imaging (TDI). Methods: A total of 35 patients with ASD and 22 healthy controls were included in the study. The time intervals from the onset of the P-wave on the surface electrocardiogram to the beginning of the late diastolic A-wave (PA) representing AEMCT were obtained from the lateral mitral annulus, septal mitral annulus, and right ventricular (RV) tricuspid annulus, and named PA-lateral, PA-septal, and PA-tricuspid, respectively. The difference between PA-septal and PA-tricuspid, PA-lateral and PA-septal, and PA-lateral and PA-tricuspid were defined as intra-right AEMCT, intra-left AEMCT, and inter-AEMCT, respectively. Results: PA-tricuspid, PA-septal, and PA-lateral values were longer in patients with ASD when compared with the controls, but did not reach statistical significance (39.9 +/- 19.1 vs. 37.2 +/- 15.5, P = 0.952; 49.6 +/- 14.0 vs. 45.4 +/- 11.1, P = 0.826 and 60.3 +/- 16.3 vs. 59.7 +/- 12.5, P = 0.437, respectively). There were no significant differences between the ASD and control groups in terms of inter-atrial, intra-right atrial, and intra-left AEMCT (21.3 +/- 2.3 vs. 20.8 +/- 4.6, P = 0.957; 9.7 +/- 3.3 vs. 6.9 +/- 1.3, P = 0.723 and 13.6 +/- 4.7 vs. 10.9 +/- 4.5, P = 0.518, respectively). Furthermore, ASD diameter and total septum length did not correlate with AEMCT. Conclusion: Both intra-and inter-AEMCT were not increased in patients with ASD than control subjects. In addition, we found no association between the ASD diameter and indices of AEMCT in patients with ASD.
Noninvasive Evaluation of Cardiac Autonomic Modulation in Children With Primary Raynaud's Phenomenon: a Controlled Study
(Springer London Ltd, 2014) Oflaz, Mehmet Burhan; Ece, Ibrahim; Kibar, Ayse Esin; Balli, Sevket; Alaygut, Demet; Guven, Ahmet Sami; Cevit, Omer
This study aimed to objectively evaluate autonomic nervous function in children with primary Raynaud's phenomenon (PRP). Thirty-two children with PRP and 30 healthy subjects were included in the study. We analyzed heart rate variability (HRV) in the time domain by the following six standard time-domain measures: standard deviation of all normal R-R intervals during 24 h (SDNN), standard deviation of all normal R-R intervals for all 5-min segments (SDNNi), standard deviation of the average normal R-R intervals for all 5-min segments (SDANN), root mean square of the successive normal R-R interval difference, percentage of successive normal R-R intervals longer than 50 ms, and triangular index (integral of the density distribution of NN intervals divided by the maximum of the density distribution). The mean heart rate throughout 24 h was significantly higher in the PRP group than in the control group (p = 0.001). Although heart rate during the activity period was not significantly different from that during the night period, it was higher in the PRP group than in the control group (p = 0.002). In children with PRP, HRV analysis showed significantly lower values of SDNN (p = 0.01), SDNNi (p = 0.005), SDANN (p = 0.02), and HRV triangular index (p = 0.02) compared with the control group. HRV analysis for sympathovagal balance demonstrated a preponderance for the sympathetic component in patients with PRP. We conclude that all time-domain parameters evaluated in HRV analysis are significantly lower in children with PRP than in healthy subjects.
Paroxysmal Supraventricular Tachycardia Following Dtp and Poliomyelitis Immunization
(Georg Thieme verlag Kg, 2006) Yilmaz, Cahide; Uner, Abdurrahman; Erol, Mehmet; Guven, Ahmet Sami; Caksen, Huseyin