Browsing by Author "Guzel Ozdemir, Pinar"

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Comparison of Paraoxonase, Prolidase Activities and Hs-Crp, Bdnf Levels in Patients With Autogenous and Reactive Subtypes of Obsessive Compulsive Disorder
(Cumhuriyet Univ Tip Fak Psikiyatri Anabilim Dali, 2019) Guzel Ozdemir, Pinar; Yilmaz, Ekrem; Yilmaz, Emine
Objective: Obsessions have been categorized as autogenous obsessions and reactive obsessions on the original of the cognitive theory and this study aimed to evaluate whether differences are found between obsessive compulsive disorder (OCD) subgroups in terms of biochemical markers. Methods: Thirty patients with obsessions defined as autogenous, 30 patients with obsessions defined as reactive group and 30 healthy volunteers were consisted the sample of the study. Sociodemographic Data Form, Yale-Brown Obsessive Compulsive Scale (Y-BOCS), Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI) were filled to the participants. The activity of paraoxanase, prolidase and Hs-CRP and brain-derived neurotrophic factor (BDNF) levels were detected. Results: There was no any statistically significant difference between autogenous and reactive obsession groups in terms of total mean score of Y-BOCS, BDI and BAI. Paraoxanase activity did not statistically significant difference between all groups. Prolidase activity showed significantly higher in reactive group than autogenous obsession and control groups. Serum Hs-CRP levels were not statistically different among participants of autogenous group, reactive group and control groups. Serum BDNF levels were significantly lower in autogenous obsession group rather than reactive obsession and control groups. Conclusion: This finding indicates that neurobiological processes have important role in the pathophysiology of autogenous obsessions.
The Effect of Alexithymia on Somatization and Sleep Quality in Patients With Depression
(Aves, 2013) Aydin, Adem; Selvi, Yavuz; Guzel Ozdemir, Pinar
Background: The aim of the study was to determine the effect of alexithymia on sleep quality and tendency to somatization in patients with depression. Methods: Eighty-five patients with depression, who applied to the outpatient unit of psychiatry, were included in the study. The Beck Depression Inventory (BDI), Toronto Alexithymia Scale (TAS), Symptom Interpretation Questionnaire (SIQ), and the Pittsburgh Sleep Quality Index (PSQI) were administered to the patients. Results: Depressive patients were divided into two groups: alexithymic patients and non-alexithymic patients. There were significant differences in scores of BDI, psychologizing and somatizing subscale of the SIQ and daytime dysfunction subscale of the PSQI in alexithymic patients. Conclusion: It was found that depressive patients have higher levels of alexithymic features and somatization tendencies in this study. Moreover, alexithymic patients have more frequent psychological and somatic attributions and increased loss of daytime functionality. (Archives of Neuropsychiatry 2013; 50: 65-69)
Manic Episode With Psychotic Features Induced by a Herbalife Production
(Cumhuriyet Univ Tip Fak Psikiyatri Anabilim Dali, 2015) Guzel Ozdemir, Pinar; Ozdemir, Osman; Isik, Mesut
White Matter Hyperintensity in Patient With Treatment Resistant Obsessive Compulsive Disorder: a Case Report
(Cumhuriyet Univ Tip Fak Psikiyatri Anabilim Dali, 2015) Ozdemir, Osman; Guzel Ozdemir, Pinar; Cilingir, Vedat; Yilmaz, Ekrem; Bulut, Mehmet Deniz
Neurobiological models of obsessive compulsive disorder (OCD) suggest that there are structural and functional abnormalities in frontal-striatal-thalamic-cortical circuits. These cortical and subcortical microcircuits are physically and functionally connected through the white matter. Therefore, the disrupted white matter microstructure may be implicated in the pathophysiology of OCD. Neuroanatomical studies have reported various regional white matter abnormalities in patients with OCD. In this case, we present subcortical white matter lesions or hyperintensities in a patient with treatment resist ant OCD.