Browsing by Author "Guzey, Feyza Karagoz"

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Comparison of the Effect of Bipolar Coagulation and Fibrillar Structured Oxidized Cellulose on Formation Epidural Fibrosis in Rats
(Tubitak Scientific & Technological Research Council Turkey, 2021) CetIn, Eyup; Eren, Burak; Guzey, Feyza Karagoz; Tufan, Azmi; Tabs, Abdurrahim; ornek, Mustafa; cay, Tugce
Background/aim: Epidural fibrosis (El) is a common cause of failed back surgery syndrome seen after spinal surgeries. The most frequent reason for the formation of BF is accumulated blood and its products in the operation zone. On the development of ER the effect of bipolar coagulation and fibrillar oxidized cellulose, which are used frequently to control bleeding, was investigated. Materials and methods: In the study, 45 male Sprague Dawley rats were divided into three groups (control, fibrillar, and bipolar). Lumbar laminectomy was applied to all rats under sterile conditions. In the control group, the epidural area was washed with saline solution. Bleeding was controlled with fibrillar oxidized cellulose in the fibrillar group, with bipolar coagulation in the bipolar group. The area to which laminectomy had been applied was removed as a block 6 weeks later and evaluated histopathologically and genetically in terms of EF development. Fibrosis degree was determined histopathologically by counting fibroblasts using the modified Lubina and EF He grading systems. Interleukin-6 (IL-6), transforming growth factor beta-1 (TG beta-1), and mRNA levels were measured by the droplet digital polymerase chain reaction method. Results: The number of epidural fibroblasts, percentage of modified Lubina, amount of 11-6, and He grading rates were significantly lower in the fibrillar group than in the bipolar and control groups (p < 0.05). On the other hand, there was no significant difference among the control, fibrillar, and bipolar groups in terms of TGF beta-1 values (p = 0.525). Conclusion: The use of fibrillar oxidized cellulose was more effective for hemostasis than bipolar coagulation in reducing the development of EE.
Evaluation of Lumbosacral Angle ( Lsa) and Its Impact on Patients With Lumbar Disc Herniation
(derman Medical Publ, 2016) Aycan, Abdurrahman; Guzey, Feyza Karagoz; Ozkan, Nezih
Aim: One of the most common causes of low back pain is lumbar disc herniation (LDH). One of the treatments for patients with LDH is a surgical operation. Changes in the lumbar lordosis angle have a negative impact on patients, clinically. The significance of changes in the lordosis-sacral inclination angle that are associated with muscle spasms and are seen after LDH surgery is known. In this study, we would like to examine the clinical impact on patients due to changes in the lumbosacral angle measured before and after surgical operations in patients with LDH. Material and Method: Between 2005-2007, preoperative and postoperative lumbosacral angles of 139 patients operated on for a diagnosis of lumbar disc herniation were measured. Patients were evaluated with the Oswestry Scale, Visual Analogue Scale, Narcotic Score, and Patient Satisfaction Evaluation. Lumbar lordosis angle, sacral inclination angle, and disc height were calculated by direct radiography. Statistical analysis was performed with GraphPad Prisma V.3 software package. Results: In this study, increases of lordosis angles and sacral inclination angles have been observed, postoperatively. It has been shown that these have a positive impact on the clinical course. Discussion: The clinical effects of the biomechanics of angles of patients with LDH are clear. Biomechanical parameters should be considered at preoperative treatment, postoperative treatment, and postoperative controls. The patient's lordosis angle, neighboring disc structure, and relationship with the sacrum must be carefully evaluated for surgical decision.
L4-l5 Seviyesinde Kafes ve Otogreftle Yapılan İnterbody Füzyonunun Tek Başına Otogreftle Yapılan Füzyonla Morfometrik Karşılaştırılması
(2023) Tufan, Azmi; Guzey, Feyza Karagoz; Aycan, Abdurrahman
Amaç: Lomber interbody füzyon (LIF), diskektomi yapıldıktan sonra intervertebral boşluğa bir kafesle veya kafes olmaksızın kemik greft yerleştirilmesi işlemidir. Literatürde kafesli LIF yöntemlerini karşılaştıran birçok çalışma vardır. Buna rağmen kafesli ve kafessiz LIF yöntemlerini karşılaştıran çalışma çok azdır. Bu çalışmada peek kafesli ve kafessiz laminar otogreft kullanılarak yapılan interbody füzyonun geç dönem sonuçlarının karşılaştırılması amaçlanmıştır. Çalışma spesifik olarak L4-5 seviyesinde yapılmıştır. Yöntem: Bu retrospektif karşılaştırmalı çalışma 2011-2018 yılları arasında kurumumuz nöroşirurji kliniğinde opere edilen hastalar üzerinde aynı kurumdan etik kurul onayı alınarak yapılmıştır. L4-5 tek seviyeli lomber enstrümantasyon uygulanıp füzyon amacıyla otogreftle birlikte muz kafes kullanılarak transforaminal LIF operasyonu yapılan hastalar çalışma grubunu (Grup 1, n=27), sadece otogreft ile arka LIF operasyonu yapılan olgular kontrol grubunu oluşturdu (Grup 2, n=31). Otogreft olarak dekompresyon esnasında posterior yapılardan elde edilen kortikokanselloz kemik parçaları kullanıldı. Füzyon oranları, segmental ve lomber lordoz açısı, disk yüksekliği, ipsilateral ve kontralateral foramen yüksekliği ve kayma mesafesi ölçüldü. Bulgular: Yaptığımız çalışmada kafesli ve kafessiz gruplarda geç dönem füzyon oranları sırasıyla %96,3 ve %96,7 olarak bulundu. Segmental ve lomber lordozda iki grupta da değişiklik olmadı. Kafesli grupta geç dönem kafes gömülmesi, kafessiz grupta ise greft göçü en sık komplikasyonlardı. Sonuç: Hem kafesli hem de kafessiz LIF yüksek füzyon oranları olan cerrahi tekniklerdir. Füzyon açısından otogreft grubu, dizilim açısından ise kafesli grubun sınırlı bazı avantajları vardır. Kafessiz otogreftle LIF basit, sade ve düşük maliyet gibi özellikleriyle yeterince takdir edilmeyen bir cerrahi teknik olarak görünmektedir.
Rapidly Progressive Spontaneous Spinal Epidural Abscess
(Hindawi Ltd, 2016) Aycan, Abdurrahman; Aktas, Ozgur Yusuf; Guzey, Feyza Karagoz; Tufan, Azmi; Isler, Cihan; Aycan, Nur; Arslan, Harun
Spinal epidural abscess (SEA) is a rare disease which is often rapidly progressive. Delayed diagnosis of SEA may lead to serious complications and the clinical findings of SEA are generally nonspecific. Paraspinal abscess should be considered in the presence of local low back tenderness, redness, and pain with fever, particularly in children. In case of delayed diagnosis and treatment, SEA may spread to the epidural space and may cause neurological deficits. Magnetic resonance imaging (MRI) remains the method of choice in the diagnosis of SEA. Treatment of SEA often consists of both medical and surgical therapy including drainage with percutaneous entry, corpectomy, and instrumentation.