Browsing by Author "Haligur, Mehmet"

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Matrix Metalloproteinase Expression in Sheep With Listerial Meningoencephalitis
(Elsevier Sci Ltd, 2012) Ilhan, Fatma; Ulusoy, Yavuz; Haligur, Mehmet
Matrix metalloproteinases (MMPs) have been implicated in the pathogenesis of several central nervous system (CNS) diseases. In this study, we investigated the presence of Listeria monocytogenes antigens and detected the expression of MMP-9 and MMP-7 in the brains of 22 sheep with clinical signs and histopathological findings characteristic of listerial meningoencephalitis. Archived sections from the brainstem, cerebrum, and cerebellum were stained for immunohistochemistry. L. monocytogenes antigens were located mainly in the cytoplasm of neutrophils and some macrophages and/or extracellularly within microabscesses of the brainstem. MMP-9 was mainly immunolocalised in the endothelial cells, microglial cells, and neurons especially in inflammatory areas. MMP-7 immunoreactivity was detected in perivascular cuffs, microglial cells, and only a few neurons. Overall, immunohistochemistry in formalin-fixed, paraffin-embedded tissues is a useful tool for the diagnosis of encephalitic listeriosis caused by L. monocytogenes, and MMP-9 and MMP-7 may contribute to the pathogenesis of listerial meningoencephalitis. (C) 2011 Elsevier Ltd. All rights reserved.
Mucinous Cholangiocarcinoma With Metastases in a Turkish Van Cat - a Case Report
(Natl veterinary Research inst, 2008) Ilhan, Fatma; Yener, Zabit; Vural, Sevil Atalay; Haligur, Mehmet
The pathomorphological and immunohistochemical features of cholangiocarcinoma in an 11-year-old female Van cat were described. At necropsy, the primary tumour was determined in the liver. The tumour was greyish-white, firm, and multinodular. The size of these nodules ranged between 1 cm and 3 cm. There were metastases in the mesentery, portal lymph nodes, peritoneum, and lung. Immunohistochemically, the tumour cells showed positive immunoreactivity for S100 and cytokeratin, and negative for a-fetoprotein. According to morphological and immunohistochemical findings, this tumour was defined as a cholangiocarcinoma.